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      • KCI등재
      • KCI등재

        Subclassification and Detection of New Markers for the Discrimination of Primary Liver Tumors by Gene Expression Analysis Using Oligonucleotide Arrays

        ( Holger G. Hass ),( Ulrich Vogel ),( Michael Scheurlen ),( Jurgen Jobst ) 대한간학회 2018 Gut and Liver Vol.12 No.3

        Background/Aims: The failure to correctly differentiate between intrahepatic cholangiocarcinoma (CC) and hepatocellular carcinoma (HCC) is a significant clinical problem, particularly in terms of the different treatment goals for both cancers. In this study a specific gene expression profile to discriminate these two subgroups of liver cancer was established and potential diagnostic markers for clinical use were analyzed. Methods: To evaluate the gene expression profiles of HCC and intrahepatic CC, Oligonucleotide arrays (AffymetrixU133A) were used. Overexpressed genes were checked for their potential use as new markers for discrimination and their expression values were validated by reverse transcription polymerase chain reaction and immunohistochemistry analyses. Results: 695 genes/expressed sequence tags (ESTs) in HCC (245 up-/450 down-regulated) and 552 genes/ ESTs in CC (221 up-/331 down-regulated) were significantly dysregulated (p< 0.05, fold change >2, ≥70%). Using a supervised learning method, and one-way analysis of variance a specific 270-gene expression profile that enabled rapid, reproducible differentiation between both tumors and nonmalignant liver tissues was established. A panel of 12 genes (e.g., HSP90β, ERG1, GPC3, TKT, ACLY, and NME1 for HCC; SPT2, T4S3, CNX43, TTD1, HBD01 for CC) were detected and partly described for the first time as potential discrimination markers. Conclusions: A specific gene expression profile for discrimination of primary liver cancer was identified and potential marker genes with feasible clinical impact were described. (Gut Liver 2018;12:306-315)

      • KCI등재

        ACCOUNTABILITY AND TRANSPARENCY IN THE GERMAN NONPROFIT SECTOR: A PARADOX?

        HELMUT K. ANHEIER,RABEA HASS,ANNELIE BELLER 한국행정학회 2013 International Review of Public Administration Vol.18 No.3

        The article draws on exploratory research on the accountability and transparency of nonprofit organizations, using Germany as an example. In terms of accountability and transparency requirements, so frequently put forth and debated in the U.S., the UK, and other countries where nonprofits play major roles in social service delivery and public sector reform, the German case presents somewhat of a puzzle: while nonprofits account indeed for a sizable share of social service delivery, and while some of the world´s largest nonprofit conglomerates are in Germany, initial findings suggest an apparent “non-problem.” Both accountability and transparency requirements in the German nonprofit sector are rather low and largely part of formalistic reporting to tax authorities. What is more, there is a general paucity of available information on nonprofit organizations, combined with low levels of awareness among stakeholders as to potential accountability and transparency problems, and a lack of political will among nonprofit representatives and policymakers to change the status quo. In conclusion, we propose five theses to help explain this seeming paradox.

      • KCI등재

        RAPID GEOMETRIC 3D MODELING FOR AUTOMATED CONSTRUCTION EQUIPMENT

        조용권,Jo, Yong-Gwon,Hass, Carl T. Korea Institute of Construction Engineering and Ma 2003 한국건설관리학회 논문집 Vol.4 No.1

        Unstructured workspaces which are typical in construction contain unpredicable activities as well as changing environments. Most automated and semi-automated construction tasks require real-time information about the local workspace in the form of 3D geometric models. This paper describes and demonstrates a new rapid, local area geometric data extraction and 3D visualization method for unstructured construction workspaces that combines human perception, simple sensors, and descriptive CAD models. The rapid approach will be useful in construction in construction in order to optimize automated equipment tasks and to significantly improve safety and a remote operator's spatial perception of the workspace.

      • TOPOLOGICALLY CONSISTENT TRIMMED SURFACE APPROXIMATIONS BASED ON TRIANGULAR PATCHES

        Rida T. FAROUKI,Chang Yong HAN,Joel HASS,Thomas W. SEDERBERG 한국산업응용수학회 2005 한국산업응용수학회 학술대회 논문집 Vol.- No.-

        Topologically consistent algorithms for the intersection and trimming of free-form parametric surfaces are of fundamental importance in computer-aided design, analysis, and manufacturing. Since the intersection of (for example) two bicubic tensor-product surface patches is not a rational curve, it is usually described by approximations in the parameter domain of each surface. If these approximations are employed as "trim curves", their images in ?³ do not agree precisely, and the resulting trimmed surfaces may exhibit "gaps" and "overlaps" along their common edge, an artifact that often incurs failure of downstream applications. We present a direct and simple approach to the problem, wherein the intersection curve is described explicitly by the sides of a sequence of triangular Bezier patches. Instead of representing trimmed surfaces by trim curves in the surface parameter domain, together with appropriate control point perturbations to guarantee consistency, we use triangular patches to directly approximate the intersection curve and the trimmed surfaces it defines. The triangular patches are constructed so as to maintain smooth (i.e., tangent-plane continuous) connections to untrimmed patches of the original surface. We assume that the original intersecting surfaces are subject to a subdivision process, such that the intersection segment (if any) on each sub-patch is a smooth arc between diametrically opposite corners. This guarantees that all intersection segments, and the trimmed surfaces they delineate, are "simple" enough to admit accurate approximation using triangular Bezier patches. Ensuring position and tangent plane agreement of degree-n triangular trimmed patch approximations p(r, s, t) and q(u, v, w) with given degree-(m, m) tensor-product patches p(r, s) and q(u, v) along the boundaries r = 0, s = 0 and u = 0, v = 0, and that the curve p(??, 1-??, 0) = q(??, 1-??, 0) matches the end points and tangents of the exact intersection, entails solving a linear system of 8m + 4n - 14 equations in 12n - 28 scalar variables. Although much of the ensuing discussion will be cast in a general context, our primary emphasis is the case of greatest practical interest-namely, the approximation of trimmed bicubic patches by quintic triangular patches. In this case, the tangent-plane matching conditions on the common patch sides entail solution of a linear system of 30 equations in 32 unknowns. Subsequent to solving this system, the degrees of freedom that remain to improve the approximation accuracy are the end-derivative magnitudes of the approximate intersection curve and is its two middle control points, and one "interior" control point for each triangular patch. Additional degrees of freedom may be introduced, to further improve the approximation accuracy, by elevating the degree of the quintic triangular patches. The elegant simplicity of this method, and the well-conditioned nature of the linear system that expresses the boundary conditions, makes it eminently suited to practical implementation. Many of the basic principles hold in contexts other than interesting bicubic patches with trimmed surfaces approximated by quintic triangular patches, although we expect this combination will be of greatest practical interest. The final trimmed surfaces resulting from the procedure described herein are hybrid collections of tensor-product (rectangular) patches and triangular patches. If homogeneity of the patch types in the final surface representation is an important consideration, known algorithms for converting a triangular patch into a set of tree rectangular patches or for splitting a rectangular patch into two triangular patches may be invoked.

      • KCI등재

        Rationale and Approaches for Project Work in Instructor Training

        에른스트귄터실링(Ernst Guenter Schilling),예른하스(Joern Hass) 대한공업교육학회 1990 대한공업교육학회지 Vol.15 No.1

        과학 기술 대학에서 실시하고 있는 전문 교사 양성 과정은 산업 세계에 도전할 수 있는 보다 나은 자질을 학생들에게 구비해 주기 위하여 Project work 방법을 교과 과정의 기초로 삼고있다. 이 논문은 대학 수준의 교육에서 이러한 방법의 필요성을 위한 확실한 교육적·전문적 근거를 처음으로 넓은 범위에서 다루었다. 또한 단계적 접근 방법을 간단히 기술했는데 이 방법은 복잡한 Project work 업무를 수행하는 데 있어 필요한 사전 지식의 순차적 적용 방법도 학생들에게 제공하고 있다. 끝으로 본 교사 양성 과정에서 수업한 두 가지 예를 들었는데 두 가지 모두 공장 자동화에 관한 논제들이다. The instructor course at Korea Institute of Technology(KIT) considers project work as a cornerstone of its curriculum in order to prepare the students better for the challenges of the world of work. The presentation deals first and on a broader basis with the sound educational and professional reasons for this method in higher education. It then describes in brief a step-by-step approach which provides the students in a sequence of exercises with the necessary prerequisites for tackling the complex tasks of project work. Finally, two examples for working with projects in the instructor course are given, both related to topics of factory automation(Programmable Control Systems, Pneumatics) as acute cases of instruction.

      • KCI등재

        Evanescent-field Q-switched Yb:YAG Channel Waveguide Lasers with Single- and Double-pass Pumping

        배지은,최선영,Christian Kränkel,Kore Hasse,이상민 한국광학회 2021 Current Optics and Photonics Vol.5 No.2

        A femtosecond-laser inscribed Yb:YAG surface channel waveguide (WG) laser with single-walled carbon nanotubes deposited on the top surface of the WG was passively Q-switched by evanescent field interaction. Q-switched operation of the 14-mm-long compact Yb:YAG WG laser was achieved near 1031 nm with two different pumping schemes (single- and double-pass pumping) with an output coupling transmission of 91%. The Q-switched pulse characteristics depending on the absorbed pump power were investigated for both pumping geometries and analyzed in detail based on theoretical modeling. The best performances (energy/pulse duration) for each configuration were 204.4 nJ/75 ns at a repetition rate of 1.87 MHz, and 201.1 nJ/81 ns at 1.75 MHz for single- and double-pass pumping, respectively.

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