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Evaluation of alloying effect on the formation of Ni-Fe nanosized powders by pulsed wire discharge
Park, Gyu-Hyeon,Lee, Gwang-Yeob,Kim, Hyeon-Ah,Lee, A-Young,Oh, Hye-Ryeong,Kim, Song-Yi,Kim, Do-Hyang,Lee, Min-Ha Elsevier 2016 Materials science and engineering B. Advanced Func Vol.212 No.-
<P>This study investigates the effects of varying the explosion time and charging voltage of pulsed wire discharge (PWD) on the mean particle size, dispersibility and alloying reliability of powders produced from pure Ni and Ni-plated Fe wires. It was found that with increasing charging voltage, the mean particle size of Ni powders is reduced from 40.11 +/- 0.23 to 25.63 +/- 0.07 nm, which is attributed to a change in the extent of super heating with particle size. Nanosized powders of Ni-Fe alloy with a mean particle size between 25.91 +/- 0.24 and 26.30 +/- 0.26 nm were also successfully fabricated and found to consist of particles with a gamma-(Ni/Fe) core and FeO shell. The reliability for the optimization of processing parameters to control particle sizes is also evaluated. (C) 2016 Elsevier B.V. All rights reserved.</P>
방사선치료를 위한 CT 검사 시 3DCT와 4DCT에 대한 피폭선량 고찰
박령황(Ryeong-Hwang Park),김민정(Min-Jung Kim),이상규(Sang-Kyu Lee),박광우(Kwang-Woo Park),전병철(Byeong-Cheol Jeon),조정희(Jeong-Hee Cho),유병규(Beong-Gyu Yoo),이종석(Jong-Seok Lee) 대한방사선과학회(구 대한방사선기술학회) 2011 방사선기술과학 Vol.34 No.4
방사선치료를 위한 CT 검사 시 동일 환자에 대하여 3차원영상과, 호흡주기영상을 획득하기 위한 컴퓨터단층촬영에서 환자의 피폭선량을 측정하고자 SOMATON SENSATION OPEN(SIEMENS, GERMANY)을 이용하여 내원환자 중 폐암환자 10명, 간암환자 10명의 CT 검사 시 피폭선량을 측정했다. 환자가 받는 피폭선량은 The volume CT dose index(CTDIvol), Dose Length Product(DLP)를 이용하여 분석하였으며 각각의 장기들이 받는 피폭선량의 실측은 환자의 장기를 대상으로 할 수 없어 Rando 팬텀을 이용 흉부검사 시 폐와 심장, 척수를, 복부검사 시 간과 신장의 위치를 선택하여 in-vitro와 in-vivo 계측이 가능한 광유도발광선량계(Optically Stimulated Luminescent Dosimeter, Landauer, Inc., USA)를 이용하여 측정하였다. 폐암환자의 CT 검사 시 10명의 CTDIvol값은 5.7배, DLP값은 약 2.4배, 간암환자의 CTDIvol값은 3.8배, DLP값은 약 1.6배의 값을 나타내었고, OSLD를 이용한 실측정치 역시 폐암환자의 경우 6배, 간암환자의 경우 5.5배의 차이를 보이는 등 4DCT 검사에서 전체적인 피폭선량의 증가를 볼 수 있었다. 방사선치료 시 호흡에 의한 치료부위의 위치변화를 4DCT 검사를 이용하여 움직임을 보정하여 치료계획시 치료용적의 정확성을 높일 수 있으나 4DCT 검사로 인한 환자의 피폭선량 증가를 고려하여 검사시간과 검사범위를 줄여 피폭선량을 감소시키기 위한 노력이 필요하다. This study was to measure the patient dose difference between 3D treatment planning CT and 4D respiratory gating CT. Study was performed with each 10 patients who have lung and liver cancer for measured patient exposure dose by using SOMATON SENSATION OPEN(SIMENS ,GERMANY). CTDIvol and DLP value was used to analyze patient dose, and actual dose was measured in the location of liver and kidney for abdominal examination and lung, heart and spinal cord for chest examination. Rando phantom were used for the experiment. OSLD was used for in-vitro and in-vivo dosimetry. Increasing overall actual dose in 4D respiratory gated CT-simulation using OSLD increase the dose by 5.5 times for liver cancer patients and 6 times for lung cancer patients. In CT simulation of 10 lung cancer patients, CTDIvol value was increased by 5.7 times and DLP 2.4 times. For liver cancer patients, CTDIvol was risen by 3.8 times and DLP 1.6 times. The accuracy of treatment volume could be increased in 4D CT planning for position change due to the breaths of patient in the radiation therapy. However, patients dose was increased in 4D CT than 3D CT. In conclusion, constant efforts is required to reduce patients dose by reducing scan time and scan range.
노혜령 ( Hye-ryeong Noh ),강주영 ( Ju-yeong Kang ),김봉규 ( Bong-gyu Kim ) 한국응용생명화학회 2021 Journal of Applied Biological Chemistry (J. Appl. Vol.64 No.3
Trifolin (kaempferol 3-O-galactoside)는 플라보놀 그룹에 속하는 물질로 아토피, 항균, 폐암에 효과가 있는 것으로 알려져 있다. Trifolin은 다양한 식물에서 추출하여 사용하고 있지만 추출 과정이 복잡하고, 수율이 낮으며, 추출을 위한 바이오매스를 얻는데 계절적 어려움이 있다. 생물전환은 저렴한 화합물에서 고부가가치 화학물질을 생산할 수 있는 대체 수단으로 이용된다. 본 연구에서는 naringenin으로부터 trifolin을 생합성하기 위해 3개의 유전자(PeFLS 및 OsUGE-PhUGT)를 각각의 대장균에 도입한 BL-FLS균주와 BL-UGTE균주를 이용하여 공조배양시스템을 개발하였다. Naringenin으로부터 trifolin을 생합성하기 위해 세포의 밀도, 생물전환 온도, 재조합 단백질 유도의 적정 IPTG농도 및 시간, 기질 공급 농도 등의 최적화를 실시하였다. 최적화된 공동 배양 발효 시스템을 통해 67.3 mg/L의 trifolin을 성공적으로 생합성 하였다. Kaempferol 3-O-galactoside (Trifolin), a member of the flavonol group, has been reported to have anticancer effects against promyelocytic leukemia, histocytic lymphoma, skin melanoma and lung cancer. Trifolin has been extracted and used from several plants, but the extraction process is complicated and the final yield is low. Biotransformation is an alternative tool to produce high value-added chemicals from inexpensive compounds. To synthesis trifolin from naringenin, three genes (PeFLS and OsUGE-PhUGT) were introduced into Escherichia coli, respectively. In order to synthesis trifolin from naringenin, a coculture fermentation system was established by optimizing the cell concentration, biotransformation temperature and medium, isopropyl-β-D-thiogalactoside (IPTG) concentration, substrate supply concentration, and recombinant protein induction time. The established optimal conditions for trifolin production were a 3:1 ratio of BL-UGTE to BL-FLS, induction of recombinant protein at 25 ℃ for 4 h after addition of 2.0 mM IPTG, biotransformation at 30 ℃, and supply of 300 μM naringenin. Through the optimized co-culture fermentation system, trifolin was biosynthesized up to 67.3 mg/L.