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이용호,하헌용,이동초,김미경,서필승,김남송 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
본 연구는 2004년 1월부터 2008년 10월까지 원광대학교 병원 피부과에 내원한 원형 탈모증 환자 126명중 치료 결과를 확인 할 수 있었던 95명을 대상으로 인구학적 특성 및 치료 방법에 따른 치료 효과의 차이를 알아보고자 빈도 분석 및 교차분석을 통하여 유의성을 검정하였다. 탈모반면적은 성별에서 남자와 여자가 각각 26-50%일 때 53.5%, 71.4%로 가장 많았으나 유의한 차이는 없었고, 연령별로는 20대 이하와 30대, 40대 이상이 각각 26-50%일 때 54.1%, 51.9%, 58.6%로 가장 많았으나 유의한 차이는 없었다. 치료방법은 성별에서 남자와 여자 각각 부신피질호르몬 국소방법을 94.3%, 85.7%로 가장 많았으나 유의한 차이는 없었고, 연령별로는 20대 이하, 30대, 40대 이상이 각각 스테로이드 국소 주사요법을 89.7%, 100%, 93.1%로 가장 많았으나 유의한 차이는 없었다. 치료효과는 성별에서 남자와 여자 각각 완치하였다가 64.8%, 71.4%로 가장 많았으나 유의한 차이가 없었고, 연령별로는 20대 이하와 30대의 경우 완치되는 경우가 각각 71.8%, 85.2%로 가장 많았고, 40대 이상은 부분반응 하는 경우가 58.6%로 가장 많았으며 통계적으로 유의한 차이를 보였다(p<0.05) 치료방법에 따른 치료효과에는 유의한 차이가 있었다(p=0.003). 스테로이드 pulse therapy를 사용한 경우 완치가 100%, DPCP 요법은 완치가 77.8%, minoxidil 국소요법은 완치가 73.8%, 스테로이드 pulse therapy의 경우 완치가 100%로 가장 많았다. Background: We embarked on this research in order to gain fundamental information and knowledge on the key differences in the effectiveness of various treatments and factors, such as key clinical conditions and demographic traits through the descriptive research-based procedures, on patients with alopecia areata. Methods: Based on the comprehensive data of 95 patients with verifiable treatment records out of 126 alopecia areata patients who have visited the department of dermatology of Wonkwang University Hospital from January 2004 to October 2008, We examined the significance tests through the analysis of frequency and range of the differences in the effectiveness of various treatments using demographic traits and medical treatments. Results: In terms of the treatment effectiveness, 64.8% of the male patients and 71.4% of the female patients showed the full recovery, with virtually no significant clinical data difference. In terms of the age group variations, 71.8% of the patients in 20's and under and 85.2% of the patients in 30's showed the full recovery, and 58.6% of 40's showed only partial recovery, rendering this difference quite significant.(p<0.05). There was a noticeable difference in effectiveness of various treatments.(p<0.01). Through the steroid pulse therapy, 100% of the patients fully recovered, 77.8% through the DPCP(Diphencyprone) method, 73.8% through the minoxidil application treatment, 65.2% through the steroid injection treatment, and finally 33.3% of the steroid application treatment fully recovering from the hair loss. Conclusion: In terms of the effectiveness, the steroid pulse therapy were most dominant and clear treatment, followed by DPCP treatment, the minoxidil application treatment, the steroid injection treatment, and the steroid application treatment in this order. In terms of the distribution of the gender factor of the observed patients, the number of female patients was far smaller than that of male patients, and tremendous barriers and challenges lie in the quest to make a conclusive finding through the use of the raw data of hospital patients. As such, a variety of rigorous and dynamic clinical research endeavors and the large sample of patients are necessary and strongly recommended at this point.
생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구
김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.
USRP RIO SDR을 이용한 5G 밀리미터파 LTE-TDD HD 비디오 스트리밍 시스템 설계 및 구현
곽경훈(Gyoung-Hun Gwag),신봉득(Bong-Deug Shin),박동욱(Dong-Wook Park),어윤성(Yun-Seong Eo),오혁준(Hyuk-Jun Oh) 한국전자파학회 2016 한국전자파학회논문지 Vol.27 No.5
본 논문은 3GPP LTE(Long Term Evolution)-TDD(Time Division Duplexing) 표준을 기반으로 NI(National Instruments)의 USRP RIO SDR(Software Defined Radio) 플랫폼을 이용해 28 GHz 밀리미터파 대역에서 HD 비디오를 무선으로 송수신하는 1T-1R(1 Transmitter-1 Receiver) 시스템을 설계 및 구현하였다. 해당 시스템은 Verilog로 설계한 LTE-TDD 송수신 모뎀을 USRP RIO에 내장된 Xilinx Kintex-7칩에 구현하여 USRP RIO를 베이스밴드로 사용하였으며, USRP RIO에서 송수신되는 신호는 자체 설계한 28 GHz RF 송수신 모듈로 업․다운 변환을 수행한 후 자체 설계한 4×8 서브 배열 안테나를 통해 최종적으로 HD 비디오 데이터를 통신하게 된다. USRP RIO와 Host PC의 통신 방식은 데이터 송수신시 발생되는 지연을 최소화하기 위해 PCI express(Peripheral Component Interconnect express)×4를 사용하였다. 구현한 시스템은 25.85 dBc 이상의 높은 EVM(Error Vector Magnitude) 성능을 보였으며, 실험환경 내 어디서든 HD 비디오를 성공적으로 송수신하였다. This paper presents the implementation and design of the 1T-1R wireless HD video streaming systems over 28 GHz mmWave frequency using 3GPP LTE-TDD standard on NI USRP RIO SDR platform. The baseband of the system uses USRP RIO that are stored in Xilinx Kintex-7 chip to implement LTE-TDD transceiver modem, the signal that are transceived from USRP RIO up or down converts to 28 GHz by using self-designed 28 GHz RF transceiver modules and it is finally communicated HD video data through self-designed 4×8 sub array antennas. It is that communication method between USRP RIO and Host PC use PCI express ×4 to minimize delay of data to transmit and receive. The implemented system show high error vector magnitude performance above 25.85 dBc and to transceive HD video in experiment environment anywhere.
길경섭(Gyoung-Sub Kil),고현석(Hyeon-Seok Kho),김병훈(Byung-Hun Kim),조인현(In-Hyun Cho) 한국추진공학회 2008 한국추진공학회 학술대회논문집 Vol.2008 No.11
KSLV-I 2단 추진기관에 적용될 킥모터는 고고도용 고체 추진기관으로 인공위성을 궤도에 진입시킬 때 반드시 필요한 하드웨어이다. 킥모터는 연소 시 내부에 내열재가 삭마되고 추진제가 소진되며 반면에 슬래그 적층으로 인해 무게가 변하게 된다. 본 문서는 지상연소시험 시 케이스, 추진제, 노즐, 점화기, 슬래그 등으로 구성된 킥모터의 무게 변화량을 분석하여 실제 비행시간에 따른 무게 변화량을 예측하였다. 킥모터의 비행 시 무게 변화 예측은 KSLV-I 2단의 무게 및 무게중심 변화를 계산하는데 활용될 수 있다. Kick motor(KM) for KSLV-I second stage propulsion system is the main hardware that is necessary for launching satellite to it"s track. The mass of the kick motor changes with combustion time because the heat insulator is ablated and propellant is used and slag is piled up. We predicted mass change with the flight time using ground combustion data of KM composed of case, propellant, nozzle, ignitor and slag. The mass prediction of kick motor can be used for calculating the two stage mass and center of gravity history.