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( Gyeol Seong ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Hepatitis e antigen-positive patients with high serum hepatitis B virus (HBV) DNA but normal alanine aminotransferase (ALT) are presumed in immune-tolerant phase, and their risk of developing complication is still debatable. Recent guideline suggested to use ALT levels, liver biopsy, elastography or liver fibrosis biomarker (eg, FIB-4) to stratify risk of complication for patients presumed in immune-tolerant phase. Methods: We analyzed of 651 HBeAg positive patients with high serum HBV DNA levels (=7 log IU/mL) but normal or mildly elevated ALT levels (<80 U/L), age more than 18 years (male = 404) who were monitored for at least 1 year from 1998 to 2006. Normal ALT was defined as 35 U/L for men and 25 U/ L for women. The risk of developing hepatocellular carcinoma (HCC) was assessed. Results: During a median 11.2 years of follow-up (range: 1.1- 18.0 years), 42 patients (6.5%) developed HCC. Age, sex, ALT and FIB-4 levels were independent factors associated with HCC development. Those with mildly elevated ALT levels showed significantly higher risk of developing HCC than normal ALT levels (3.4% vs. 9.4% at 10 years for normal ALT vs. mildly elevated ALT, P=0.001). Among patients with normal ALT level (n = 301), FIB-4 level was independent factor associated with HCC development (hazard ratio 2.35; 95% confidence interval 1.54-3.58, P<0.001). Among 301 patients with normal ALT levels, 51 patients (16.9%) had FIB-4 = 1.453. The HCC risk at 10 years was significantly higher for those with high FIB-4 levels (1.3% vs. 13.6% for FIB-4 <1.453 vs. =1.453, P<0.001). Conclusions: Among patients presumed in immune tolerant phase, HCC risk was generally low but was not null. Among patients with normal ALT levels, some showed high FIB-4 levels, and their risk of developing HCC was high. Our data indicate that FIB-4 can be an useful non-invasive marker for stratifying HCC risk among patients presumed in immune tolerant phase, and those with high FIB-4 levels warrants close attention.
Ko, Gyeol,Seo, Yongwon American Chemical Society 2019 Environmental science & technology Vol.53 No.21
<P>SF<SUB>6</SUB> hydrate formation behaviors in various reaction media, such as bulk water, porous silica gel, and hollow silica, were investigated for hydrate-based SF<SUB>6</SUB> separation with a primary focus on thermodynamic stability and formation kinetics. The measured three-phase (H-L<SUB>W</SUB>-V) equilibria demonstrated that the types of reaction media used in this study had no effect on the thermodynamic stability of SF<SUB>6</SUB> hydrates. The dissociation enthalpy (Δ<I>H</I><SUB>d</SUB>) of SF<SUB>6</SUB> hydrate was measured using a high-pressure micro-differential scanning calorimeter, and it corresponded well with estimates from the Clausius-Clapeyron equation. The unstirred porous silica gel system showed a larger gas uptake and a higher growth rate at the early stage of SF<SUB>6</SUB> hydrate formation. However, the gas uptake and growth rate of SF<SUB>6</SUB> hydrates in stirred bulk water and unstirred hollow silica were significantly increased at a larger temperature driving force or in the presence of sodium dodecyl sulfate. The experimental results obtained in this study will be very helpful for a better understanding of the thermodynamic and kinetic characteristics of SF<SUB>6</SUB> hydrate formed in various reaction media and in surfactant-added solution, and are expected to contribute to further development of the hydrate-based SF<SUB>6</SUB> separation process.</P> [FIG OMISSION]</BR>
Han-Gyeol Lee 물리치료재활과학회 2021 Physical therapy rehabilitation science Vol.10 No.4
Objective: The purpose of this study was to investigate the effects of coordinative locomotor training(CLT) using elastic bands on dynamic balance and grip strength for Elementary school baseball players and to provide correct posture guidance and reference on the prevention and rehabilitation program of sports damage and injury in the future. Design: Two groups pre-post randomized controlled design. Methods: Forty-six subjects were randomly divided in two groups;1) CLT using Elastic Band group(Experimental group, n=23), 2) Routine baseball training group(Control group, n=23). The intervention was conducted total 16 times for sixty minutes a day, 2 times a week, for 8 weeks. Evaluations of dynamic balance ability and grip strength were performed with all subjects before the commencement of training and 8 weeks after training. Results: Compared to the control group after training, the dynamic balance ability and dominant handgrip strength of the experimental group were significantly more improved(p<0.05). Conclusions: We confirmed that the effects of CLT using elastic bands on dynamic balance ability and grip strength in Elementary school baseball player. This study should be used for improving the quality of the Elementary school baseball player’s training and would be contributed prevention and rehabilitation program of sports damage and injury.
Ko Gyeol,Kim Eunae,이동영,서용원 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
Fluorinated gases (F-gases), such as CHF3 and C2F6, which are used in the semiconductor industry and have considerable global warming potential, can be recovered after use through a gas hydrate-based separation method to prevent their release into the atmosphere. In this study, the guest distributions and dissociation enthalpy (ΔHd) of F-gas (CHF3 or C2F6)+N2 hydrates with different F-gas concentrations (CHF3: 20%, 80%, and 100% and C2F6: 20%, 60%, 80%, and 100%) were experimentally investigated using a powder X-ray diffractometer and a high-pressure micro-differential scanning calorimeter, respectively. At high N2 concentrations in the feed gas, the occupancy of N2 in the small (512) cages of the F-gas+N2 hydrates increased significantly. As a result, the F-gas+N2 hydrates exhibited reduced hydration numbers at high N2 concentration. The ΔHd values (in kJ/mol gas) of the F-gas (CHF3 or C2F6)+N2 hydrates decreased with increased N2 concentration. The overall experimental results provide useful insights into the design and operation of gas hydrate-based F-gas separation processes.