Increased 26S proteasome non-ATPase regulatory subunit 1 in the aqueous humor of patients with age-related macular degeneration

( Hyun Gwoo Lee ),( Ae Jin Choi ),( Gum Yong Kang ),( Hyung Soon Park ),( Hyung Chan Kim ),( Hyun Jung Jade Lim ),( Hye Won Chung ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.5

Age-related macular degeneration (AMD) is the leading causeof blindness in the world. Evidence indicates that thesuppression of the ubiquitin-proteasome system (UPS) contributesto the accumulation of toxic proteins and inflammation inretinal pigment epithelium (RPE), the functional abnormalitiesand/or the degeneration of which are believed to be theinitiators and major pathologies of AMD. To identify newprotein associations with the altered UPS in AMD, we usedLC-ESI-MS/MS to perform a proteomic analysis of the aqueoushumor (AH) of AMD patients and matched control subjects. SixUPS-related proteins were present in the AH of the patients andcontrol subjects. Four of the proteins, including 26S proteasomenon-ATPase regulatory subunit 1 (Rpn2), were increasedin patients, according to semi-quantitative proteomic profiling. An LC-MRM assay revealed a significant increase of Rpn2 in 15AMD patients compared to the control subjects, suggesting thatthis protein could be a biomarker for AMD.[BMB Reports 2014; 47(5): 292-297]

Electrical Properties of Crystallized 30B2O3-70V2O5 Glass

Donggun Gwoo,김태희,한경석,Wongyu Choi,김종환,류봉기 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.3

30B2O3-70V2O5 binary-system glass was prepared, and variations in structural and electrical property were examined using crystallization. While different related research studies exist, few have evaluated the variations in the structure and properties with changes in the crystallization rate. 30B2O3-70V2O5 glass was annealed in the graphite mold above the glass transition temperature for 2 h and heat-treated at each crystallization temperature for 3 h. 30B2O3-70V2O5 glass showed predominantly electronic conductive characteristic. FTIR was preferentially used for analyzing the structural changes of B-O bond after crystallization, while XRD was utilized to verify the inferred changes in the structure array (BO3 + V2O5 ↔ BO4 + 2VO2). Structural changes induced by heat treatment were confirmed by analyzing the molecular volume determined from the sample density, and conductance was measured to correlate structural and property changes. Conductivity is discussed based on the migration of vanadate ions with different valence states because of the increase in VO2 crystallinity at 130°C, which, however, was not observed at 170°C. After VO2 structures were reinforced,a 1.8-fold increase in conductance was observed (as compared to the annealed sample) after crystallization at 130°C for 3 h.

Relationship between Structure and Optical Properties in the CdO-B2O3-SiO2 Glass System

Taehee Kim,Donggun Gwoo,김종환,Wongyu Choi,Kyungseok Han,Kyungbum Kee,황차원,류봉기 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.6

To study the compositional dependence of the optical properties and atomic structure of glasses, the CdOB2O3-SiO2 ternary glasses, which are known as highly photoconductive glasses, have been investigated. The photoconductivity of glasses containing CdO was investigated in a previous study, because of their potential applications in photoelectronic devices. The thermo-mechanical analysis and the Fourier transform infrared (FT-IR) spectra of the glass samples were measured to determine the structural variation of these glasses. Using transmittance measurements, we calculated the optical energy band gap. This paper presents results for control of the optical energy band gap 3.8 ~ 3.2 eV in cadmium-borosilicate glass system while the structural properties undergo monotonic changes.

Synthesis and Characterization of CdS Nanocrystals in a Novel Phosphate Glass

Donghwan Kim,Chawon Hwang,Donggun Gwoo,Taehee Kim,Youngseok Kim,Namjin Kim,류봉기 대한금속·재료학회 2011 ELECTRONIC MATERIALS LETTERS Vol.7 No.4

Zinc-borophosphate glasses doped with various concentrations (≤ 5 wt. %) of cadmium sulfide (CdS) were synthesized. Nanocrystals of CdS were developed in the glass matrices at different concentrations, with emphasis on the quantum confinement effect. The effects of CdS content on the optical and various other properties were investigated. The optical characterization of the glasses was carried out using UV-Visible spectrophotometry. There was a red shift in the optical cut-off with increasing CdS content in the glass. The band gap of the CdS nanocrystals doped in the glass matrix ranged from 3.5 eV to 4.2 eV. The structural characterization,which was carried out using X-ray diffraction, shows the CdS to have hexagonal crystal structure. The average size and shape of the nanocrystals doped in the glass matrix were determined using transmission electron microscopy (TEM). The particle sizes of the doped CdS crystals were in the range of 3 nm to 6 nm for 2 wt. % CdS, and 15 nm to 20 nm for 5 wt. % CdS.

Effects of Substitution of K2O for Na2O on the Bioactivity of CaO-Na2O-SiO2-P2O5 Glasses

Taehee Kim,Chawon Hwang,Donggun Gwoo,Hoyyul Park,류봉기 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.5

The compositional dependences of bioactivity, thermal properties, atomic structure, and surface morphology have been investigated in the CaO-Na2O-SiO2-P2O5 system; this system is known as a bioglass. 45S5 Bioglass®is known to be a general and highly bioactive material. However, the bioactivity of this glassy material is expected to be improved by modifying the alkali-metal composition. Thermal properties, density, and molar volume were measured to investigate the structural packing. FT-IR spectra and X-ray diffraction were used to confirm the structures of these glasses. The morphology was examined using field emission electron microscopy,and the formation of a Ca-P layer was studied using an energy-dispersive system. This study shows that the tendency to form a calcium phosphate layer is increased with the substitution of K2O for Na2O.

Effect of Titanium on Structure of Sodium Borophosphate Glasses

Donghwan Kim,Chawon Hwang,Donggun Gwoo,Taehee Kim,Namjin Kim,류봉기 대한금속·재료학회 2011 ELECTRONIC MATERIALS LETTERS Vol.7 No.4

Glasses in the system 30P₂O_5-30B₂O₃-40Na₂O-xTiO₂ (0 ≤ x ≤ 25 mol %) have been prepared by the meltquenching technique. Increasing the TiO₂ content of the glass structure results in a decrease in the molar volume and an increase in the glass transition/softening temperatures. Structural changes were studied by Raman spectroscopy, and 11 B and 31P solid-state NMR. The observed changes in the spectra and the properties of the studied glasses can be ascribed to several reasons, such as the addition of TiO₂ that results in the formation of distorted Ti octahedral linked to pyrophosphate unit through P–O–Ti bonds. In these glass series,the overall glass network was enhanced by TiO₂ addition, although a depolymerization in the original P–O–P network occurred.

A Study of the Relationship between Structure and Properties of Cadmium Phosphate Glasses

Wongyu Choi,Taehee Kim,Donggun Gwoo,Kyungbum Kee,Jong-Hwan Kim,Kyung-Suk Han,류봉기 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.1

It analysed the structure and chemical durability which it follows in CdO content in Cadmium phosphate glasses. We prepared glasses with the composition, xCdO-(100-x)P2O5 (x = 10 mol. % to 50 mol. %), and analyzed their density (ρ), molar volume (VM), glass transition/softening temperature (Tg/Td), thermal expansion coefficient (α), fourier transform infrared spectroscopy, and dissolution rate. All of these of the values were found to vary with the CdO content of the glasses. It is observed that the dissolution rate increase with with CdO contents. This suggests that Cadmium ion breaks the p-o-p bonds.

Effects of Substituting B2O3 for P2O5 on the Structures and Properties of V2O5-P2O5 Glass Systems

Kyungseok Han,황차원,Dong Hwan Kim,Donggun Gwoo,Taehee Kim,Wongyu Choi,Kyungbum Kee,김종환,류봉기 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.6

V2O5-B2O3-P2O5 glasses with various compositions were prepared using a normal melt quenching technique,and their characteristics and structural properties were investigated using different techniques. Replacement of P2O5 by B2O3 was found to improve the thermal properties, chemical durability, and room-temperature conductivity. The observed variations in the properties may be correlated with changes in the internal glass network as a result of changes in the chemical composition. Vanadium ions are believed to be present in three possible valence states, namely V3+, V4+, and V5+, and the ratios of these states depend on the glass composition. The observed increases in chemical durability and room-temperature conductivity are assumed to be related to increases in the mean crosslinking density, increases in the number of bridging oxygens,and electron hopping between vanadate ions in different valence states.

고령지역 국채보상운동의 전개과정에 관한 고찰- 홍와 이두훈 가(家)의 고문서를 중심으로 -

구본욱 ( Koo Bon-wook ),이경규 ( Lee Keong-gwoo ) 대구가톨릭대학교 인문과학연구소 2017 인문과학연구 Vol.0 No.31

This thesis deals with how the National Debt Redemption Movement, which had originally gotten started in Daegu, spread to and developed in the Goryeong area, how the donation for the cause materialized and how the donated fund found its way for the redemption. Up to the present time, most of the studies concerning the movement have been conducted around secondary sources such as newspapers clips published at the time of the movement. Then came a turning point in 2013 in the study when primary sources were unearthed in the Yi Doo-hoon`s household. What were found there were not only original official documents exchanged between Daegu, the then head place of the movement, and Goryeong but also those sent to the United National Debt Assembly in Seoul. Their excavations brought about calls requesting a transfer in the way of the studies from around secondary sources to around primary ones which are, of course, original texts. Capitalizing on these original texts, this thesis focuses on the national debt redemption movement in the Goryeong area. Since the texts were written nearly a century ago, there are quite a number of differences in the linguistic usages between now and then. In that context, this thesis has translated and contemplated the original texts with the texts marked in the footnotes. It is ture that this thesis limits its study sphere to the Goryeong area, but a further application of this case is sure to provide a clue to finding out how such movements spread out to other areas and eventually to the nation.

위장관 ; 절제 불가능한 Stage IV 진행성 식도암의 치료방법에 따른 효과 비교

이규진 ( Gyu Jin Lee ),박무인 ( Moo In Park ),구상건 ( Sangeon Gwoo ),정현주 ( Hyun Joo Jung ),김주훈 ( Joo Hoon Kim ),박선자 ( Seun Ja Park ),문원 ( Won Moon ),김형훈 ( Hyung Hun Kim ),김양수 ( Yang Soo Kim ),박성달 ( Sung Dal P 대한소화기학회 2012 대한소화기학회지 Vol.59 No.4

Background/Aims: The aim of this study was to compare palliative treatments such as chemotherapy, chemoradiotherapy or radiotherapy with best supportive care in patients with inoperable advanced esophageal cancer. Methods: A total of 67 patients with inoperable advanced esophageal cancer visiting Kosin University Gospel Hospital between January 2000 and July 2010 were included in a retrospective analysis. Patients were categorized as having palliative treatment or best supportive care to compare their prognosis. Results: The median survival was 6.4 months in 67 patients. There was significant difference in median survival between the palliative and best supportive treatment (9.8 months vs. 4.5 months, p=0.01). The patients who underwent palliative treatment had superior 1-year and 3-year overall survival rate than those with best supportive treatment (27%, 10% vs. 5%, 5%, respectively). The 1-year and 3-year overall survival rate of palliative treatment was 18% (1-year overall survival rate) in chemotherapy, 33% (1-year overall survival rate) in radiotherapy, 45% and 9% in concurrent chemoradiotherapy, and 20% and 20% in sequential chemoradiotherapy, respectively. Conclusions: These results may suggest that palliative treatments are more effective than best supportive care. Further prospective studies are still needed to elucidate beneficial effect of palliative treatments on inoperable advanced esophageal cancer. (Korean J Gastroenterol 2012;59:282-288)