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Gulen Guler,Veli Yildirim,Meryem Ozlem Kutuk,Fevziye Toros 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.1
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with common comorbidities that include oppositional defiant disorder, conduct disorder, anxiety disorder, and affective disorders. Because of these comorbidities, drug combination treatments and drug-drug interactions are becoming increasingly more frequent. The present case report describes an acute dystonic reaction following the abrupt discontinuation of methylphenidate from a drug regimen with risperidone. The patient experienced acute dystonic reactions on three separate occasions when he forgot to take his methylphenidate medication. The present report informs clinicians about the possible side effects, such as dystonia, when psychostimulant and antipsychotic drug combinations are altered and suggests that the abrupt cessation of stimulants may lead to the development of movement disorders. Therefore, appropriate care is necessary when changing the dose of a drug or abruptly discontinuing a drug from a combination of psychostimulants and antipsychotics.
Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case
Gulen Guler,Meryem Ozlem Kutuk,Halil Kara 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3
Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder. Additionally, this case showed that the patient recovered from the amenorrhea with replacement of aripiprazole with quetiapine.
ON A SEQUENCE OF KANTOROVICH TYPE OPERATORS VIA RIEMANN TYPE q-INTEGRAL
Gulen Bascanbaz-Tunca,Fatma Tasdelen,Aysegul Erencin 대한수학회 2014 대한수학회보 Vol.51 No.2
In this work, we construct Kantorovich type generalization of a class of linear positive operators via Riemann type q-integral. We obtain estimations for the rate of convergence by means of modulus of continuity and the elements of Lipschitz class and also investigate weighted approximation properties.
ON A SEQUENCE OF KANTOROVICH TYPE OPERATORS VIA RIEMANN TYPE q-INTEGRAL
Bascanbaz-Tunca, Gulen,Erencin, Aysegul,Tasdelen, Fatma Korean Mathematical Society 2014 대한수학회보 Vol.51 No.2
In this work, we construct Kantorovich type generalization of a class of linear positive operators via Riemann type q-integral. We obtain estimations for the rate of convergence by means of modulus of continuity and the elements of Lipschitz class and also investigate weighted approximation properties.
Sule Tas Gulen,Ufuk Eryilmaz,Mustafa Yilmaz,Fisun Karadag 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.3
Background/Aims: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the echocardiographic parameters in COPD patients with or without pre-diagnosed CVD and to investigate the relationship between echocardiographic parameters and systemic inflammation markers. Methods: A total of 60 stable COPD patients (23 patients with CVD, group 1; 37 patients without CVD, group 2) and 21 healthy controls (group 3) were included in the study. Six-minute walking test (6MWT), COPD assessment test (CAT), and Body mass index, airflow Obstruction, Dyspnea, and Exercise (BODE) index results were recorded. High-sensitivity C-reactive protein (HsCRP), interleukin 8 (IL-8), fetuin-A, Clara cell protein (CCL-16), N-terminal pro-brain natriuretic peptide levels were studied in serum. Parameters of left and right ventricular systolic and diastolic function were measured by echocardiography. Results: Patients with COPD had higher levels of systemic inflammation markers and lower level of inflammation inhibitor fetuin-A. When three groups were compared, group 1 had lower 6MWT result. HsCRP was highest in group 2 while other inflammatory markers were similar in groups 1 and 2. Regarding echocardiographic parameters, left ventricular ejection fraction (LVEF) was lower and left ventricle end-diastolic diameter (LVED), left ventricle end-systolic diameter (LVES) diameters were higher in group 1. The aortic diameter was higher in COPD patients. Fetuin-A was correlated with diameter of aorta and LVES. LVEF, LVED, and LVES were found to be correlated with functional parameters of COPD cases. Conclusions: In COPD, left ventricular functions are affected as well as right ventricle before prominent clinical findings of cardiac disease and these echocardiographic parameters correlate with functional parameters of COPD patients.
Erkan Caglar,Gulen Doğusoy,Levent Kabasakal,Ahmet Dobrucali 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.5
Internal radioembolization with yttrium-90 is a promising treatment method, predominantly for liver tumors. However, the shifting of yttrium-90-loaded spherules into the arteries and veins that supply the duodenum and stomach, leading to ulceration, hemorrhage, perforation, and outlet obstruction of these organs, is one of the major undesirable consequences of this technique. We report a case of gastric outlet obstruction (GOO) due to antropyloric stenosis with ulceration, edema, and inflammation following transarterial yttrium-90 treatment for a metastatic neuroendocrine tumor in a 58-year-old man. Stenting was used for palliation in this case. GOO improved after stenting and recovery of oral intake was permanent after stent removal.
Hydatid Disease Involving Some Rare Locations in the Body: a Pictorial Essay
Murvet Yuksel,Gulen Demirpolat,Ahmet Sever,Sevgi Bakaris,Ertan Bulbuloglu,Nevra Elmas 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.6
Hydatid disease (HD) is an endemic illness in many countries, and it poses an important public health problem that's influenced by peoples' socioeconomic status and migration that spreads this disease. Although rare, it may occur in any organ or tissue. The most common site is the liver (59 75%), followed in frequency by lung (27%), kidney (3%), bone (1 4%) and brain (1 2%). Other sites such as the heart, spleen, pancreas and muscles are very rarely affected. Unusual sites for this disease can cause diagnostic problems. This pictorial essay illustrates various radiological findings of HD in the liver, spleen, kidney, pancreas, peritoneal cavity, omentum, adrenal, ovary, lung, mediastinum and retroperitoneum. Familiarity with the imaging findings of HD may be helpful in making an accurate diagnosis and preventing potential complications.
Acarturk, Esmeray,Attila, Gulen,Bozkurt, Abdi,Akpinar, Onur,Matyar, Selcuk,Seydaoglu, Gulsah Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.4
Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean $54.3{\pm}9.8$ years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %). However, in patients with CAD the frequency of II genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95% CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.
( Yesim Ozguler ),( Vedat Hamuryudan ),( Gulen Hatemi ),( Ayse Selcen Pala ),( Sebahattin Yurdakul ),( Hasan Yazici ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We surveyed the causes and outcome of hospitalisations among Behcet Syndrome (BS) patients in a dedicated center. Methods: The records of all inpatients in our clinic between 2002-2011 were retrospectively reviewed to identify patients hospitalised with a diagnosis of BS. We reviewed both the inpatient and outpatient charts to identify the demographic and clinical features, causes of hospitalisation and outcome. We also contacted the patients to determine their current condition. Results: 178 BS patients (74% men, mean age 42. 9±11. 3) had been hospitalised for a total of 211 times during the last ten years. We were able to contact 104(58%) of them. The reasons for hospitalisation were directly related to BS organ involvement in 118(56%) and to complications in 93(44%). The most common BS related reasons were vascular involvement in 74/118(63%) (including 21 patients with pulmonary artery aneurysms, 10 with peripheral artery aneurysms and 11 with serious venous thrombosis such as vena cava superior and Budd-Chiari syndrome), neurologic involvement in 14/118(12%), gastrointestinal involvement in 6/118(5%) and eye involvement in 6/118(5%). Hospitalisations caused by complications of BS were infections in 39/93(42%), and other drug related adverse events in 15/93(16%). Neoplasias were diagnosed in 5 patients. Among the 178 patients, 16(9%) had died. Most common causes of death were vascular involvement (n=5), infections (n=4) and malignancies (n=4). Conclusions: Vascular involvement is the leading cause of hospitalisation among BS patients, followed by infections related to therapy. Adverse events related to immunosuppressives are problematic. The predominance of men among hospitalized patients underlines the more severe course of BS in this sex. The relatively low frequency of gastrointestinal involvement among hospitalisations is in line with our previous observation that this type of involvement is rare in our BS patients.