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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
Guadalupe, Tulio,Mathias, Samuel R.,vanErp, Theo G. M.,Whelan, Christopher D.,Zwiers, Marcel P.,Abe, Yoshinari,Abramovic, Lucija,Agartz, Ingrid,Andreassen, Ole A.,Arias-Vá,squez, Alejandro,Aribi Springer US 2017 Brain imaging and behavior Vol.11 No.5
<P>The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s11682-016-9629-z) contains supplementary material, which is available to authorized users.</P>
Pizarro, Guadalupe Del C.,Marambio, Oscar G.,Jeria-Orell, Manuel,Huerta, Margarita R.,Rodrí,guez, Oscar O.,Rivas, Bernabé,L.,Geckeler, Kurt E. Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of applied polymer science Vol.105 No.5
<P>This article reports the synthesis of poly(N-maleoylglycine-co-itaconic acid) by radical copolymerization under different feed mole ratios and its properties to remove various metal ions, such as Cu(II), Cr(III), Co(II), Zn(II), Ni(II), Pb(II), Cd(II), and Fe(III), in aqueous phase with the liquid-phase polymer-based retention(LPR) technique. The interactions of inorganic ions with the hydrophilic water-soluble polymer were determined as a function of pH and filtration factor. Metal ion retention was found to strongly depend on the pH. Metal ion retention increased as pH and MG content units in the macromolecular backbone increased. The copolymers were characterized by elemental analysis, FTIR, <SUP>1</SUP>H-NMR, and <SUP>13</SUP>C-NMR spectroscopy. Additionally, intrinsic viscosity, molecular weight, and polydispersity have been determined for the copolymers. Copolymer and polymer–metal complex thermal behavior was studied using differential scanning calorimetry (DSC) and thermogravimetry (TG) techniques under nitrogen atmosphere. The thermal decomposition temperatures (TDT) were influenced by the copolymer composition. The copolymers present lower TDT than the polymer–metal complex with the same copolymer composition. All copolymers present a single T<SUB>g</SUB>, indicating the formation of random copolymers. A slight deviation of the T<SUB>g</SUB> for the copolymers and its complexes can be observed. The copolymer T<SUB>g</SUB> is higher than the T<SUB>g</SUB> value for the polymer–metal complexes. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007</P>
Nutraceutical Potential of New Alfalfa (Medicago sativa) Ingredients for Beverage Preparations
Maria Guadalupe Soto-Zarazua,Moustapha Bah,Anabela Silvia Gomes Costa,Francisca Rodrigues,Filipa Botelho Pimentel,Isela Rojas-Molina,Alejandra Rojas,Maria Beatriz Prior Pinto Oliveira 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.10
Alfalfa (Medicago sativa) has been extensively used as animal feed, due to its fiber, protein, minerals, and vitamins, being also a useful source of phenolic compounds with potential therapeutic benefits. Nevertheless, its potential use as human ingredient is scarce. The aim of this work was to assess the nutritional composition, amino acid profile, and antioxidant capacity (AOC) of freeze-dried juice (FDJ) and fibrous residual material (RM), two new alfalfa-derived products (Adps) recently launched as ingredients for beverage preparations. Results demonstrated a high content of proteins (23–30 g/100 g FDJ and 13–17 g/100 g RM), crude fiber (29 g/100 g RM), and minerals (such as sodium, calcium, iron, and zinc). No significant difference was found in caloric content (4 kcal/g). Essential and nonessential amino acids were quantified in both Adps being leucine and lysine the most abundant. Total phenolic and total flavonoid contents (TPC and TFC, respectively) and their changes along the different harvesting periods of the year were also examined. FDJ presented the highest TPC in May (19 mg gallic acid equivalents/g dry weight [dw]), while in October TFC had the maximum value (4 mg catechin equivalents/g dw). Both products exhibited an interesting AOC by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power assays. This study reports the nutraceutical potential of two new types of Adps.
Antibacterial effect of biodegradable gelatin methacryloyl loaded with ginger rhizome extract
Regina Guadalupe Arbizú-Trigueros,김서영,김유경,장용석,최애진,배태성,이민호 대한치과재료학회 2022 대한치과재료학회지 Vol.49 No.4
Gelatin methacryloyl 3d mesh mimics the natural extracellular matrix which allow loading as promising drug delivery systems. However, insufficient mechanical and degradation properties remain the biggest obstacle for this material application. In thisstudy, a modified hydrogel with natural phytochemical was developed to improve the antibacterial effect by the additionof ginger extract, a natural spicy used in traditional medicine. GelMA hydrogels with ginger extract were fabricated and theirchemical and morphological characteristics were analyzed by Fourier transformer infrared spectroscopy and scanning electronmicroscopy, structural characteristic were evaluated by compressive test and surface wettability analysis. S. mutans, S. aureusand P. gingivalis were used to confirm the antibacterial effect of the modified hydrogels. The FT-IR spectra of the hydrogelsmodified with ginger presented an increase in intensity of some peaks in comparison with the 10% GelMA hydrogel. Thepores of ginger-modified hydrogels decreased it size which affected the hydrogels physical properties, decreasing the compressivemodulus and increasing the durability, swelling ratio and, hydrophobicity of the surface. The ginger-modified hydrogels exhibitedexcellent antibacterial properties against S. mutans and S. aureus at high concentrations of ginger extract, while P. gingivalispresented a higher sensitivity at all tested concentrations. Hence, this study concludes that ginger-modified GelMA hydrogelspresented better antibacterial effect, durability over time and, swelling stability.
Guillermo Cristian Guadalupe M,Louise Wicker,Cristobal Noe Aguilar,Raul Rodriguez-Herrera,Juan Carlos Contreras-Esquivel 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3
An acidic polygalacturonase (PG) from Aspergillus kawachii was produced by solid state fermentation employing a polyurethane foam support. The conditions used for the production of acidic PG were particle size of support (0.6 or 500 ㎣) and fermentation time. From the factors studied, the particle size had important influence on enzyme production. The best conditions for acidic PG production were 0.6 ㎣ particle size, 18 hr at 30℃ and initial pH of 5.0. In addition, pectin was extracted from citrus pomaces (grapefruit, lime, and tangerine) by acidic PG at 50℃ for 24 hr with citric acid solution. Infrared spectroscopy showed that lime pomace had more high-methoxylated (65%) endogenous pectin than was obtained than from grapefruit or tangerine pomaces. The enzymatically extracted pectin yield in dry basis (d.b.) for grapefruit and lime pectins were 6.95 and 4.25%, respectively. The citric acid solution alone also contributed to pectin extraction from citrus pomaces (7-9%, d.b.). Limited pectin extraction by acidic PG from tangerine pomace was most likely due to the presence of low-methoxylated endogenous pectin. The enzymatic method for pectin extraction using acidic PG from A. kawachii is a promising technique for releasing highly polymerized pectic substances from high-methoxylated lime or grapefruit pomaces.