비외상성 두개내 출혈 환자에서 심근손상의 발생과 예후에 미치는 영향

강구현,황성호,이강현,조준휘,김성환,문중범,박해상,이서영,이성수,김헌주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Objective: The aim of this study was to investigate the clinical significance of myocardial injuries in patients with nontraumatic intracranial hemorrhage by identifying the occurrence of myocardial injury and defining its correlation with subsequent cardiovascular events. Subjects and methods: One hundred twenty-four patients with nontraumatic intracraninal hemorrhage presented to the emergency department within six hours from onset of symptoms were enrolled. Brain CT, serial electrocardiography, and echocardiography were done at the emergency center. Blood samples for troponin I and creatine kinase(CK)-MB were drawn immediately and eight hours after admission, Troponin I and CK-MB were measured using a chemiluminescent immunoassay, respectively. Results: Electrocardiographic and echocardiography abnormalities were found in 65 cases(52.4%) and 21 cases(17%), respectively. Serum troponin I and creative kinase-MB were increased in 35 cases (28.2%) and in 58 cases(46.8%), respectively. Abnormal findings of echocardiography and ECG, as well as elevated levels of serum troponin I and creative kinase-MB, were associated with an increased risk of cardiovascular event and survival. Logistic regression analysis revealed that an abnormal echcocardiographic finding and elevation of serum troponin I were factors associated with the occurrence an adverse cardiovascular event and that electrocardiographic abnormalities and initial mental status were factors associated with poor prognosis. Conclusion: This study reveals that actual myocardial injury develops in a significant proportion of patients with nontraumatic intracranial hemorrhage and that the development of the myocardial injury is associated with an adverse cardiovascular event that occurs during admission.

코일과 클립을 선택적으로 적용해서 성공적으로 치료했던 다발성뇌동맥류 1례 : A case report

이덕구,김범태,황선철,임수빈,이세영,신원한 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The author report a case of multiple cerebral aneurysm successfully treated with an appropricate selection of surgical clipping and coil embolization. A 64 years old female patient was admitted with stuporous consciousness. Initial 3D CT angiography showed diffuse subrarachnoid hemorrhage on the basal cisterns, saccular aneurysms on the terminal basilar artery and right middle cerebral artery(MCA). Converntional angiography confirmed the ruptured aneurysm was basilar one. Coil embolization was perfromed on the basilar aneurysm with 6 Guglielmi detachable coils(GDC) on the 3 days after ictus. Sugical clipping was done on the unruptured right MCA aneurysm on 10 days after ictus without any morbidity. Each treatment modalities can be appropriate indicated for the coiling or clipping aneurysms.

흰쥐 해마에서 경련에 의해 발현 유도된 MKP-1에 의한 MAPK 활성 조절

유범희,강웅구,안용민,정선주,전송희,박주배,김용식 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 전기경련 충격(Electroconvulsive shock, ECS) 및 카이닌산(kainic acid)에 의한 경련은 흰쥐 해마에서 mitogen activated protein kinase(MAPK)를 활성화시키며, 동시에 MAPK 불활성화 효소인 MAPK phosphatase-1(MKP-1)의 발현을 일으킨다. 이 연구의 목적은 경련에 의해 발현된 MKP-1이 역시 경련에 의해 활성화된 MAPK의 불활성화에 관여하는지를 알아보고자 하는 것이다. 방 법 : 흰쥐에 ECS를 가하여 해마에서 MKP-1 발현을 일으킨 뒤 다시 ECS를 가하고, 두 번째 ECS에 의한 MAPK의 일시적 활성화가 MKP-1의 발현상태에 의해 영향받는지를 알아보았다. 또한 흰쥐에 지속적인 MAPK 활성화 및 MKP-1 발현을 일으키는 카이닌산을 투여한 뒤 해마에서 MKP-1의 발현과 MAPK 활성과의 관계를 알아보았다. 결 과 : ECS후 해마에서 타이로신 인산화 면역블롯 및 효소활성으로 측정한 MAPK의 인산화 및 활성은 MKP-1의 발현이 일어나 있는 경우와 그렇지 않은 경우 사이에 차이를 보이지 않았다. 카이닌산의 투여에 의해 MAPK 활성화가 일어나는 경우, 뒤이어 MKP-1 발현이 일어나지만, 이렇게 발현된 MKP-1은 MAPK 활성을 충분히 감소시키지 못하였다. 결 론 : MKP-1은 흰쥐 해마에서 ECS 및 카이닌산에 의한 MAPK의 활성화를 차단하는데 큰 역할을 하지 않는다. Objectives : Both electroconvulsive shock(ECS)- and kainic acid-induced seizures activate mitogen-activated protein kinases(MAPKs) in rat hippocampus. They can also induce the expression of MAPK phosphatase-1(MKP-1) in rat hippocampus. MKP-1 is known as a specific MAPK deactivator. This study aimed to elucidate the role of MKP-1 in the deactivation of MAPKs in rat hippocampus. Methods : In order to induce MKP-1 in the hippocampus, ECS was given to the rats. At the time points when MKP-1 was sufficiently induced, the second ECS was given to them and the subsequent phosphorylation or activation of MAPKs were measured in the hippocampus. A second group of rats were injected with kainic acid and the relationship between MKP-1 expression and MAPK phosphorylation was examined in their hippocampi. Results : The expression of MKP-1 did not influence the phosphorylation or activation of MAPKs following ECS in rat hippocampus. Kainic acid-induced expression of MKP-1 did not significantly reduce the phosphorylation of MAPKs. Conclusion : MKP-1 did not play a significant role in the deactivation of MAPKs which were activated by ECS or kainic acid in rat hippocampus.

러프 집합을 이용한 관계데이터베이스 모델의 구성 및 해석

정환묵,정구범 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.5 No.-

In this paper, we construct rough relational database model using approximation concepts of rough set. Also, we analyze the relation between objects, attributes and attribute values and, propose the method that can generate flexible retrieval results.

Two Small Intravenous Catheters for High-Rate Contrast Medium Injection for Computed Tomography in Patients Lacking Superficial Veins to Accommodate a Large Catheter

Bum Gu Son,Min Jung Kim,Myeung Hwa Park,Kyoungsook Kim,Jiyu Kim,Se-Young Kim,이경진,Sang Hyun Choi,Ah Young Kim,박성호 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.3

Objective: To prospectively investigate the feasibility of using 2 small intravenous catheters for high-rate computed tomography (CT) contrast injection in patients lacking superficial veins capable of accommodating ≤ 20-gauge catheters. Materials and Methods: Sixty-eight consecutive eligible adults referred for dynamic liver CT were enrolled; 58 had previously undergone liver CT, including 8 that experienced extravasation. Two 22- or 24-gauge catheters were placed in all patients after 2−5 venipunctures, and 2 mL/kg of contrast agent (370 mg I/mL) was split-administered through both catheters to achieve total flow rate of 4 mL/s. Patients’ experience and examination success rate, defined as uneventful scans completed at 4 mL/s or at < 4 mL/s achieving standard image quality in all phases, were analyzed. Quantitative hepatic signal-to-noise and hepatic vascular contrast-to-noise ratios (CNRs) were compared with 30 control examinations scanned at 4 mL/s using an 18-gauge catheter. Results: One case each of extravasation and severe injection pain caused the examination to be aborted. Success rate was 88.2% (60/68; 54 patients scanned at 4 mL/s, 6 at 3.5−3.9 mL/s). Fifty-five of 58 patients (94.8%) that had past CT regarded the venipuncture as more tolerable than (n = 36) or similar to (n = 19) past experiences; 45 of 58 patients (77.6%) found contrast injection less painful than (n = 35) or similar to (n = 10) past experiences. When compared with control examinations, signal-to-noise ratio was similar in all phases (p ≥ 0.502), but the hepatic arterial CNR in arterial phase was slightly inferior (p ≤ 0.047). Conclusion: Using 2 small intravenous catheters can effectively achieve high-rate CT contrast injection in patients lacking adequate superficial veins.

규칙베이스와 사례베이스 추론의 불확실한 지식의 표현

정구범(Gu-Bum Chung),노은영(Eun-Young Roh),정환묵(Hawn-Mook Chung) 한국지능시스템학회 2011 한국지능시스템학회 학술발표 논문집 Vol.21 No.1

규칙베이스 추론과 사례베이스 추론의 통합에 의해 보다 유연한 추론을 위한 효율적인 방법의 실현이 기대된다. 본 논문에서는 MVL오토마타 모델을 적용하여 규칙베이스 추론과 사례베이스 추론의 협조추론과 이에 따른 불확실성 처리가 가능한 방법을 제안한다.

규칙베이스와 사례베이스 추론의 불확실한 지식의 표현

정구범(Gu-Bum Chung),노은영(Eun-Young Roh),정환묵(Hawn-Mook Chung) 한국지능시스템학회 2011 한국지능시스템학회논문지 Vol.21 No.2

규칙베이스 추론과 사례베이스 추론의 협조에 의해 보다 유연한 추론을 위한 효율적인 방법의 실현이 기대된다. 본 논문에서는 MVL 오토마타 모델을 적용하여 규칙베이스와 사례 베이스의 통합 추론모델과 이에 따른 불확실성 처리 방법을 제안한다. It is expected that the cooperation between rule-based reasoning and case-based reasoning gives us an efficient approach for flexible reasoning. In this paper, we present an integrated model of rule-base reasoning and case-base reasoning using the MVL automata model. In addition, we introduce how to handle the uncertainty in the integrated model.

플라즈마중합법에 의한 고분자 겔 막의 제조와 구조특성에 관한 연구

朴球範(Gu-Bum Park),李德出(Duck-Chool Lee),長田義仁(Yoshihito Osada) 대한전기학회 1997 전기학회논문지 Vol.46 No.11

대퇴골 전자부 골절의 임상적 고찰

이범구(Bum Gu Lee),권칠수(Chil Su Kwon),서광윤(Kwang Yoon Seo) 대한정형외과학회 1983 대한정형외과학회지 Vol.18 No.3

ESL Writers’ Topical Depths in Persuasive Essays

Yun Bum (Mill) Kim, Hyun Gu Lee 한국영어교과교육학회 2013 영어교과교육 Vol.12 No.2

The purpose of this study is to analyze L2 learners’ writing with diverse cultural backgrounds studying in ESL classes and to identify different aspects in using topical depths of the topical subjects. A total of 53 Asian adult L2 students who applied for the entrance exam for a theological seminary in the Philippines participated in this research. They consisted of 17 Myanmars, 7 Chinese, 18 Koreans, and 11 Filipinos. This study assumed that there would be some different aspects in using topical depths of the topical subjects, as one of the factors that make the writing to be coherent, among the nationality groups and between the lower and higher scored groups. The findings of this study are as follows. First, there was no difference in the percentage of topical depths relatively computed by the number of clauses in any compared groups. Secondly, in correlation analysis, no significant relation was taken noted in relation to the topical depths or the percentage of the topical depths over the number of the clauses. Thirdly, the number of words affects positively on the number of clauses, the number of topical depths, and the scores. It means that sufficient number of words may cause the healthy number of topical depths, which may be positively reflected in the scores.