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Prostate Cancer Epidemiology in a Rural Area of North Western Greece
Grivas, N.,Hastazeris, K.,Kafarakis, V.,Tsimaris, I.,Xousianitis, Z.,Makatsori, A.,Raptis, P.,Aspiotis, S.,Ioachim, E.,Ntemou, A.,Kitsiou, E.,Malamou-Mitsi, V.,Sofikitis, N.,Kordela, V.,Papandreou, C. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Epirus is a rural area of North-Western Greece. We reviewed data from 4 hospitals for 4.975 patients who underwent prostate biopsy in Epirus in the twelve year period from 1999 to 2010. Two six -year periods were compared (1999-2004 and 2004-2010). All cases of prostate cancer confirmed by biopsy were recorded and age-standardized incidence rates per 100,000 males were calculated. We also recorded the clinical stage for patients diagnosed in our hospital and correlated this with PSA and Gleason scores. Percentage of positive prostate biopsies was also calculated. There were a total of 1714 new cases during 1999-2010 and the mean annual age-adjusted incidence was 34/100.000. The mean incidences during 1999-2004 and 2005-2010 were 26/100,000 and 42/100,000, respectively. The mean age at diagnosis was 74. The most common Gleason score was 6 and the prevalent clinical stage was T2. Median PSA at diagnosis was 10.8 ng/ml. There was a significant difference between stage cT4 and all other stages regarding PSA value (p=0.000). A positive correlation was found between Gleason score and PSA (p=0.013). These results are in accordance with the incidence rise recorded in neighboring countries of South-East Europe. However we should keep in mind the risk of overdiagnosis and the detection of low-risk cancers that would not have caused morbidity or death during a man's lifetime anyway.
Grivas, Nikolaos,Hastazeris, Konstantinos,Kafarakis, Vasileios,Tsimaris, Ioannis,Aspiotis, Spiridon,Stratis, Antonios,Stavropoulos, Nikolaos Efthimios Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
The aim of the study was to investigate the results of bladder irrigation with Water for Injection (WFI) after transurethral resection of bladder tumours for comparison with those for adjuvant use of BCG. A total of 239 patients (158 with single tumours, group A, and 81 with multiple tumours, group B) received continuous intravesical postoperative irrigation with WFI. Some 128 patients received intravesical irrigation with WFI, followed by weekly instillations of BCG (group C). Recurrence-free rate (RFR) and recurrence-free intervals (RFI) were recorded. RFR for those patients who received only intravesical irrigation with WFI (groups A and B) was 75.8%, 66.2% and 63.2% at the 1st, 2nd and 3rd year of follow up, respectively. Corresponding rates for group C were 61.7%, 55.4% and 49%. Median RFI in group B were 18, 11, 15, 15 and 12 months for Ta, T1, grade 1, grade 2 and grade 3 tumours, respectively. In group C corresponding intervals were 20, 33, 8, 20 and 42 months. BCG improved RFR only in T1 (p=0.014) and grade 3 tumours (p=0.007). In conclusion, postoperative bladder irrigation with WFI could increase RFR during the first and second year of follow up.
Cerchio M.,Griva G.,Profumo F.,Tenconi A. The Korean Institute of Electrical Engineers 2005 KIEE International Transactions on Electrical Mach Vol.b5 No.3
After more than 100 years of development, rotating electric machines are a mature industrial product. Nevertheless, improvements are still possible for specific applications, and it is likely that the major evolution will be promoted by new materials and unconventional structures. Till now, plastic materials are an infrequent choice for the electric machines structural parts, but pioneering applications, such as aeronautical components, let some technological scouting: a low-weight/high-efficiency plastic axial flux motor for a solar flying platform is presented as an example of combined new-material/new-geometry development. The basic design aspects and the prototyping choices are presented and discussed together with the first experimental results.
Synchronized PWM Control of Symmetrical Six-Phase Drives
V. Oleschuk,G. Griva,F. Profumo,A. Tenconi 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-
In order to avoid asynchronism of standard schemes of space-vector modulation, new method of synchronized pulsewidth modulation (PWM) has been applied for scalar control of symmetrical six-phase (dual three-phase) induction motor drives fed by two three-phase inverters. Basic schemes of synchronized continuous and discontinuous PWM, and also its combinations, disseminated for control of symmetrical dual three-phase systems, have been analyzed. Simulations give the behavior of symmetrical dual three-phase system with low switching frequency, controlled by algorithms of synchronized PWM. The spectra of the phase voltage of sixphase drives with synchronized pulsewidth modulation do not contain even harmonics and sub-harmonics during the whole control range, which is especially important for the high power/high current applications.
Truncal Changes in Patients Suffering Severe Hip or Knee Osteoarthritis: A Surface Topography Study
Vasileios A. Kechagias,Theodoros B. Grivas,Panayiotis J. Papagelopoulos,Vasileios A. Kontogeorgakos,Konstantinos Vlasis 대한정형외과학회 2021 Clinics in Orthopedic Surgery Vol.13 No.2
Background: Osteoarthritis (OA) of the hip and knee is a degenerative disease with complications, including reduced range of motion and pain. Although OA of the hip and knee is common, there are few studies that investigated if patients with this condition had affected morphological truncal parameters. The objectives of this study were to compare the morphology of the spine and the pelvis of patients with hip or knee OA to that of a control group (CG) and to comment on the proposed mechanisms of these changes and the clinical effects on patients. Methods: This study included three groups of individuals. The first group consisted of 34 patients (15 men and 19 women with a mean age of 67.62 ± 8.28 years) suffering from hip OA. The second group consisted of 45 patients (11 men and 34 women with a mean age of 72.47 ± 7.0 years) suffering from knee OA. These patients were compared with a CG, which consisted of 25 individuals (13 men and 12 women with a mean age of 69.28 ± 10.11 years). The DIERS formetric 4D analysis system was used to calculate several truncal parameters in all planes. All analyses were accomplished using the SPSS ver. 17.0, and p < 0.05 was used to determine statistical significance. Results: Patients with hip OA presented with significantly increased values than those in the CG for sagittal imbalance, scoliosis angle, vertebral rotation, trunk torsion, and pelvic obliquity, and decreased values than those in the CG for fleche lombaire. Patients with knee OA presented with significantly increased values than those in the CG for sagittal imbalance, apical deviation, scoliosis angle, vertebral rotation, trunk torsion, and pelvic obliquity. Patients with hip or knee OA, compared to the CG, had greater forward inclination of the spine, greater scoliosis, greater vertebral rotation and trunk torsion, and greater obliquity of the pelvis at the frontal plane. Conclusions: Patients with severe hip or knee OA could have truncal morphology alterations, in addition to reduced hip or knee range of motion and pain. These alterations could cause significant negative effects, which may then seriously affect the patients’ quality of life.
Ahmadreza Amirahmadi,Mohammadreza Rafiei,Kambiz Tehrani,Giovanni Griva,Issa Batarseh 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.1
This paper presents a method of designing optimal integer- and fractional-order proportional?integral-derivative (FOPID) controllers for a boost converter to gain a set of favorable characteristics at various operating points. A Pareto-based multi-objective optimization approach called strength Pareto evolutionary algorithm (SPEA) is used to obtain fast and low overshoot start-up and dynamic responses and switching stability. The optimization approach generates a set of optimal gains called Pareto set, which corresponds to a Pareto front. The Pareto front is a set of optimal results for objective functions. These results provide designers with a trade-off look-up table, in which they can easily choose any of the optimal gains based on design requirements. The SPEA also overcomes the difficulties of tuning the FOPID controller, which is an extension to the classic integer-order PID controllers and potentially promises better results. The proposed optimized FOPID controller provides an excellent start-up response and the desired dynamic response. This paper presents a detailed comparison of the optimum integer- and the fractional-order PID controllers. Extensive simulation and experimental results prove the superiority of the proposed design methodology to achieve a wide set of desired technical goals.
Amirahmadi, Ahmadreza,Rafiei, Mohammadreza,Tehrani, Kambiz,Griva, Giovanni,Batarseh, Issa The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.1
This paper presents a method of designing optimal integer- and fractional-order proportional-integral-derivative (FOPID) controllers for a boost converter to gain a set of favorable characteristics at various operating points. A Pareto-based multi-objective optimization approach called strength Pareto evolutionary algorithm (SPEA) is used to obtain fast and low overshoot start-up and dynamic responses and switching stability. The optimization approach generates a set of optimal gains called Pareto set, which corresponds to a Pareto front. The Pareto front is a set of optimal results for objective functions. These results provide designers with a trade-off look-up table, in which they can easily choose any of the optimal gains based on design requirements. The SPEA also overcomes the difficulties of tuning the FOPID controller, which is an extension to the classic integer-order PID controllers and potentially promises better results. The proposed optimized FOPID controller provides an excellent start-up response and the desired dynamic response. This paper presents a detailed comparison of the optimum integer- and the fractional-order PID controllers. Extensive simulation and experimental results prove the superiority of the proposed design methodology to achieve a wide set of desired technical goals.
Osman Tarig,Lew Eileen,Sng Ban L.,Dabas Rajive,Griva Konstadina,Car Josip 대한마취통증의학회 2022 Korean Journal of Anesthesiology Vol.75 No.2
Background: The American Society of Anesthesiologists (ASA) score is generated based on patients’ clinical status. Accurate ASA classification is essential for the communication of perioperative risks and resource planning. Literature suggests that ASA classification can be automated for consistency and time-efficiency. To develop a rule-based algorithm for automated ASA classification, this study seeks to establish consensus in ASA classification for clinical conditions encountered at a tertiary women’s hospital.Methods: Thirty-seven anesthesia providers rated their agreement on a 4-point Likert scale to ASA scores assigned to items via the Delphi technique. After Round 1, the group’s collective responses and individual item scores were shared with participants to improve their responses for Round 2. For each item, the percentage agreement (‘agree’ and ‘strongly agree’ responses combined), median (interquartile range/IQR), and SD were calculated. Consensus for each item was defined as a percentage agreement ≥ 70%, IQR 1.0, and SD < 1.0.Results: All participants completed the study and none had missing data. The number of items that reached consensus increased from 25 (51.0%) to 37 (75.5%) in the second Delphi round, particularly for items assigned ASA scores of III and IV. Nine items, which pertained to alcohol intake, asthma, thyroid disease, limited exercise tolerance, and stable angina, did not reach consensus even after two Delphi rounds.Conclusions: Delphi consensus was attained for 37 of the 49 study items (75.5%), facilitating their incorporation into a rule-based clinical support system designed to automate the prediction of ASA classification.