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Impact of Global Capitalism on the Environment of Developing Economies: The Case of Nigeria
God’stime Osariyekemwen Igiebor 서울대학교행정대학원 2014 Journal of Policy Studies Vol.29 No.3
Globalization may have generated gains in some countries of theworld; it is nevertheless associated with increased insolvency, inequalities, workinsecurities, weak institutions, and corrosion of established values. Against thisbackdrop, the paper takes a cursory look at the global flow of capital and how ithas impacted the Nigerian economy. It posit that the system of global governanceis not consistent with the objective of the domestic economy given that globalizationresults in the weakening of state capacity through dominance of the transnationalflow of capital and investment. Hence, the transnational network ofproduction and services is orchestrated beyond the regulation of policies ofdomestic countries. Consequently this paper offers recommendations on howthe Nigerian economy should develop in order to keep pace with globalization. These include developing local technology, promoting domestic industry andmanufacture of goods for exports as well as managing domestic affairs free fromextraneous foreign intrusion.
Frequency spectra characterization of noncoding human genomic sequences
O. Paredes,Rebeca Romo‑Vázquez,Israel Román‑Godínez,Hugo Vélez‑Pérez,Ricardo A. Salido‑Ruiz,J. Alejandro Morales 한국유전학회 2020 Genes & Genomics Vol.42 No.10
Background Noncoding sequences have been demonstrated to possess regulatory functions. Its classifcation is challenging because they do not show well-defned nucleotide patterns that can correlate with their biological functions. Genomic signal processing techniques like Fourier transform have been employed to characterize coding and noncoding sequences. This transformation in a systematic whole-genome noncoding library, such as the ENCODE database, can provide evidence of a periodic behaviour in the noncoding sequences that correlates with their regulatory functions. Objective The objective of this study was to classify diferent noncoding regulatory regions through their frequency spectra. Methods We computed machine learning algorithms to classify the noncoding regulatory sequences frequency spectra. Results The sequences from diferent regulatory regions, cell lines, and chromosomes possessed distinct frequency spectra, and that machine learning classifers (such as those of the support vector machine type) could successfully discriminate among regulatory regions, thus correlating the frequency spectra with their biological functions Conclusion Our work supports the idea that there are patterns in the noncoding sequences of the genome.
Toxic effect of titanium dioxide nanoparticles on human mesenchymal stem cells
Peralta‑Vega Adriana‑Berenice,Parra‑Barrera Alberto,Ramos‑Godínez María del Pilar,López‑Marure Rebeca,Arellano‑Galindo José,Gisela Gutiérrez‑Iglesias 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Titanium dioxide ( TiO2) is employed in the production of cosmetics, sunscreen, food, and drugs; however, TiO2 is toxic at the nanometric scale. Objective To analyze the in vitro toxic effect of TiO2 NPs on mesenchymal stem cells (hMSCs). Methods The hMSCs from Wharton`s jelly were exposed to 4, 62.5 and 500 μg/mL of TiO2 NPs. Viability and cell proliferation tests were carried out at 2, 5 and 7 days of exposure. Additionally, the osteogenic and adipogenic differentiation capacity was evaluated. Results TiO2 NPs had a perinuclear arrangement and internalized in vesicles into cytosol, diminished significantly the viability (40% and 30% and 30%) and the proliferation cellular (35%, 50% and 55%), differentiation to osteoblast (38%) and adipoblasts (20%). Conclusion TiO2 NPs affect viability, proliferation, and differentiation of hMSCs. Our result suggests more regulation of the use of TiO2.
Excessive Weight and Obesity Are Associated to Intra-Ventricular Asynchrony: Pilot Study
Nydia Ávila-Vanzzini,Cyntia Zulema Machain Leyva,Luis Eduardo Rodríguez Castellanos,José Antonio Arias Godínez,María Eugenia Ruiz Esparza,Hector Herrera Bello 한국심초음파학회 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.2
Background: Excessive weight and obesity (EwO) are independent factors in the development of heart failure; they lead toa state of myocardiopathy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a proinflammatorystate. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. Theobjective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured byechocardiography, in healthy individuals with EwO. Methods: We included 55 healthy individuals between the ages of 18 and 35, 17 had a BMI < 25 kg/m2 (30.9%) and 38 had aBMI > 25 kg/m2 (EwO group) (69.09%), anthropometric measurements, transthoracic echocardiogram and synchrony evaluationwere obtained. Results: Left atrial volume, telediastolic and telesystolic left ventricular volumes and the baseline volume of the right ventriclewere greater in the EwO group (20 mL/m2 vs. 15 mL/m2, p = 0.001; 106 mL vs. 82 mL, p = 0.0149 vs. 32 mL, p = 0.001 and34 mm vs. 31 mm, p = 0.02, respectively). The Yu index also correlated with epicardial fat, r = 0.53, p < 0.01, whereby thegreater the amount of epicardial fat, the greater the dispersion timing of ventricular activation. The systolic synchrony index alsocorrelated with the BMI, p = 0.01. Conclusion: Mechanical intraventricular asynchrony is associated to EwO and the amount of epicardial fat; hence, asynchronymay be one more factor leading to heart failure in EwO individuals.
Ivana Matić,Zeljko Zizak,Mladen Simonovic,Branislav Simonovic,Dejan God-evac,Katarina Savikin,Zorica Juranic 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Red and white wine polyphenols have been reported to provide substantial health benefits. In this study, the cytotoxic activity of red and white wine polyphenolic extracts and of resveratrol was evaluated against different cancer cell lines—human cervix adenocarcinoma HeLa, human breast adenocarcinoma MDA-MB-361, and human breast carcinoma MDA-MB-453—and normal human peripheral blood mononuclear cells (PBMCs). Qualitative and quantitative compositions of wine polyphenolic extracts obtained by fractional vacuum distillation of corresponding wines were determined using spectrophotometric methods and high-performance liquid chromatography with diode array detection and liquid chromatography with electrospray ionization-time of flight mass spectrometry analysis. It was demonstrated that wine polyphenolic extracts and resveratrol exerted higher cytotoxic activity against HeLa and MDA-MB-453cells in comparison to MDA-MB-361cells and unstimulated and stimulated PBMCs. Furthermore, white wine polyphenolic extract exhibited a significantly higher antiproliferative action on cancer cell lines than red wine extract. The presence of condensed or fragmented nuclei in HeLa cells, pretreated with extract of white wine and stained with a mixture of acridine orange and ethidium bromide, pointed to the morphological signs of apoptosis. In addition, HeLa cells in late stages of apoptosis or secondary necrosis were also observed. Results from our study suggest that polyphenolic extracts from red and white wine may have anticarcinogenic potential.