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Metabolic effects of recombinant ovine placental lactogen and growth hormone in pregnant ewes
Min, S H,Mackenzie, D D S,Breier, B H,McCutcheon, S N,Gluckman, P D 中央大學校 食糧資源硏究所 1998 食糧資源硏究所 論文集 Vol.10 No.1
The effects of recombinant ovine placental lactogen (oPL) and bovine growth hormone (bGH) on maternal metabolism, mammary gland development and fetal growth were examined in singleton bearing ewes at day 101 of gestation. Ewes were treated by twice daily subcutaneous injection for 7 days with oPL(n=7) or bGH (n=8) at a dose of 0.15 mg/kg LW/day or with saline (n=8). Jugualr blood samples were taken on days 1 and 7 of treatment. Relative to those of salinetreated ewes, bGH treatment significantly (P<0.01) reduced maternal plasma concentrations of oPL at day 7 of treatment. Administration of bGH also increased maternal circulating concentrations of insulinlike growth factor (IGF)Ⅰ (P<0.001), insulin (P<0.01), glucose (P<0.01) and nonesterified fatty acids (NEFA) (P<0.10) and decreased IGFⅡ (P<0.001) and urea (P<0.05) concentrations relative to those in oPL or salinetreated ewes. None of these parameters was affected by oPL treatment (vs saline treatment) except for maternal circulating oPL concentration which was increased by 50%(P<0.001). Neither bGH nor oPL had significant effects on dimension or trimmed weight of the mammary gland. Similarly, oPL treatment had no effects on weights of uterine components, whereas treatment with bGH increased the total weight of the gravid uterus (P<0.05) and weights of the uterine fluids, fetal membranes and myoendometrium (P<0.05). oPL, but not bGH treatment, also reduced maternal spleen (P<0.05) and heart (P<0.10) weights relative to those in salinetreated ewes. These results suggest that oPL acts in a distinctly different manner from bGH and that effects of oPL in the ewe are not mediated via changes in circulating concentrations of either IGFI or IGFII.