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Antidepressant-Like Activity of Sonchus oleraceus in Mouse Models of Immobility Tests
Fabiana Cardoso Vilela,Marina de Mesquita Padilha,Geraldo Alves-da-Silva,Roseli Soncini,Alexandre Giusti-Paiva 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
The aim of the present work is to evaluate the putative antidepressant-like effects of hydroethanolic and dichloromethanic extracts from the aerial parts of Sonchus oleraceus (Family Asteraceae) on the performance of male mice in the forced swimming test (FST) and tail suspension test (TST) models predictive of depression. The hydroethanolic and dichloromethanic extracts, both in doses of 30, 100, and 300mg/kg, were orally administered 1 hour before carrying out the FST or the TST. The immobility time in both the FST and the TST was significantly reduced by acute oral treatment with the extracts (dose range, 100–300mg/kg), without accompanying changes in ambulation, as assessed in an open-field test. This excluded the possibility that the effect of the extracts is due to an activation of locomotion. The efficacy of the extracts was found to be comparable to that of amitriptyline (10mg/kg, p.o.). The present study provides evidence for an antidepressant-like effect of the active principle(s) present in the extracts of S. oleraceus in mice. Therefore, a standardized S. oleraceus extract or its purified constituents could be of potential interest for the treatment of depressive disorders.
Maria Eliza Castro Moreira,Rosemary Gualberto Fonseca Alvarenga Pereira,Marcelo Jose Dias Silva,Danielle Ferreira Dias,Vanessa Silva Gontijo,Alexandre Giusti-Paiva,Marcia Paranho Veloso,Antônio Carlos 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6
In the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the antiinflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90min of treatment. At doses of 10 and 20mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3 h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the mechanism of action of anti-inflammatory activity of the xanthone, a molecular docking was performed using the isoenzymes cyclooxygenase 1 and 2 and the results indicate that the molecule is capable of inhibiting both the enzymes. Therefore, it can be concluded that 2,8-dihydroxy-1,6-dimethoxyxanthone from H. paniculata demonstrates analgesic, anti-inflammatory, and antioxidant activities.
Antinociceptive Effect of the Extract of Morus nigra Leaves in Mice
Marina de Mesquita Padilha,Fabiana Cardoso Vilela,Marcelo José Dias da Silva,Marcelo Henrique dos Santos,Geraldo Alves-da-Silva,Alexandre Giusti-Paiva 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
Morus nigra has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of dichloromethane extract from leaves of M. nigra. The formalin, hot plate, and tail immersion tests as well as acetic acid-induced writhing were used to investigate the antinociceptive activity in mice. The extract at test doses of 100 and 300mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract administered at 300mg/kg, p.o. had a stronger antinociceptive effect than indomethacin (5mg/kg, p.o.) and morphine (10mg/kg, p.o.), which supports previous claims for its traditional use.