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Anuj G. Agrawal,Ashok Kumar,Paraag S. Gide 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Coenzyme Q10 (CQ10) is known as an endogenouscellular antioxidant, naturally found in every cell ofthe human body and plays an important role in maintaininghuman health. It is widely used as a nutritional supplementand pharmaceutical drug for various disorders like diabetesmellitus, carcinomas, neurodegenerative disorders etc. However, CQ10 is practically insoluble even in the presenceof 5 % sodium lauryl sulfate in water and poorlyabsorbed from the gastrointestinal tract. The presentresearch is aimed to formulate and evaluate self nanoemulsifyingdrug delivery system (SNEDDS) of CQ10primarily to improve its aqueous solubility, dissolutionvelocity as well as hepatoprotective activity and thusenhancing its nutraceutical and pharmaceutical values. Robustness to dilution, thermodynamic stability study,droplet size analysis and drug release were adopted tooptimize liquid SNEDDS. Droplet size of the SNEDDSwas found to be size less than 200 nm and appeared roundin shape without aggregation under transmission electronmicroscopy examination. Liquid SNEDDS were adsorbedon porous carrier to get solid SNEDDS (S-SNEDDS). S-SNEDDS gave rapid ([90 %) drug release within30 min while pure drug was not practically dissolvedwithin 1 h. In vivo hepatoprotective activity showed thatS-SNEDDS achieved the most liver protection as comparedto the pure drug. Further S-SNEDDS was successfullyconverted to self nanoemulsifying mouth dissolving tablet. The enhanced solubility, dissolution velocity as well ashepatoprotective activity of CQ10, unravels the potential ofS-SNEDDS as suitable carrier for enhancing nutraceuticaland pharmaceutical values of CQ10.