성장호르몬 분비성 뇌하수체 선종에서 소마토스타틴 수용체 (제2아형, 제5아형), G_i2α 및 Pit-1 유전자 발현

류미숙,양인명,박철영,우정택,김성운,김진우,김영설,최영길,김은희,박승준,김국기 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Mutation of Gs protein subunit (gsp oncogene), detected in about 30∼40% of growth hormone (GH)-secreting pituitary tumors, is associated with an increased long-acting somatostatin analog octreotide sensitivity. However, the mRNA expression of somatostatin receptor (sst) was not changed in the GH-secreting pituitary tumor, regardless of whether they were gsp oncogene positive or negative. This suggests that the expression of genes coding for G_i2α, Pit-1 and the other factors involved in the regulation of secretory activity in somatotrophs is likely to be altered in gsp oncogene positive tumors. We observed the impact of the gsp oncogene on the expression of the genes coding for Gi2, Pit-1 and sst (2&5) in GH-secreting pituitary tumors. Methods: The GH response to octreotide was examined in 13 acromegalic patients before transsphenoidal adenomectomy. Genomic DNA and RNA were extracted from fresh frozen tumor tissues. PCR was performed to amplify and sequence the region between codon 184 and 251 that includes exons 8 and 9 of the Gs gene. Sst2, sst5, G_i2α and Pit-1 mRNA levels were measured by semi-quantitative RT-PCR. Results: Sst2 and sst5 mRNA transcripts were detected in all tumors (7 gsp +, 6 gsp-). The amount of sst transcripts varied considerably varied between the tumors. There were no significant differences in sex, age, tumor size, grade or basal GH levels. Pit-1 and sst2 mRNA levels were not different. In contrast, G_i2 mRNA levels were significantly higher in gsp (+) while sst5 mRNA levels were higher in gsp (-). Conclusion: These data suggests that gsp oncogene may increase Gi2α levels but decrease sst5 mRNA levels. However, Pit-1 and sst2 mRNA expression may not be affected by gsp oncogene. The increased expression of the G_i2α gene might be an inhibitory compensatory response to the action of gsp oncogene

잡견에서 Rapid Atrial Pacing에 의한 심방의 전기적 재현성과 이의 회복

남기병,김동운,차성일,이석재,홍종면,임승운,나기정,조명찬 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

수종의 apical plug 재료의 근단 폐쇄성에 관한 실험적 연구

최기운,허은정 大韓齒科保存學會 1994 Restorative Dentistry & Endodontics Vol.19 No.1

만곡근관에서 Thermafil 의 근단폐쇄성에 관한 실험적 연구

최기운,하주희 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.2

풍선 도뇨관을 이용한 식도 둔형 이물제거

김기운,김시영,이종서,김철,정윤석 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: In most cases of a foreign body in the esophagus, an ENT specialist is consulted, which may be time consuming if not evaluated in a timely fashion. The patients are admitted to the hospital and sent to the operating room, where they are placed under anesthesia and the object is removed by using an esophagoscope. Methods: A prospective randomized trial was conducted during the period from January 1998 to June 2000. All patients presenting to emergency department with blunt objects in the esophagus were included. In one group, with fluoroscopic guidance, a Foley catheter was placed to remove the blunt foreign bodies. And in the other group, we removed them by using the esophagoscpe. We used the t-test for statistical analysis in this study. Results: Total number of patients enrolled in this study was 38.22 patients were enrolled in the Foley Catheter removal group, and the remaining 16 were enrolled in the esophagoscope removal group. The success rate for the Foley catheter was 21/22(95.5%), and that for the esophagoscope was 15/16(93.8%). The average time of removal for the Foley catheter group was 0.70± 0.28 hours while that for the esophagoscope group was 5.96 ± 2.22 hours. One side effect, nonfatal hypoxia, was noted in the Foley catheter removal group. The average cost for the Foley catheter group were 78,800 won(approximately 600 US dollars) while that for the esophagoscope group took 722,800 won(approximately 600 US dollars). Conclusion: In our study, we found that the success rate for removing blunt foreign bodies from the esophagus by using a simple Foley catheter was high, also the Foley catheter was a time saving and cost effective procedure with an excellent safety profile.

아웃 블록을 찾기 위한 제약조건을 갖지 않는 상수시간 RMESH 알고리즘

우진운,김기원 단국대학교 1999 論文集 Vol.34 No.-

A linear quadtree representation as a way to store a quadtree is efficient to save space compared with other representations. It, therefore, has been widely studied to develop efficient algorithms to execute operations related with quadtrees. In this paper, we present an O(1) time algorithm without constraints for finding neighbor blocks of locational codes representing linear quadtrees, using three-dimensional n×n×n RMESH.

경남 일부 지역 간흡충 감염 주민에 대한 혈청 생화학검사 소견 분석

손운목,조영표,김기진,김미영,이종욱,박도흠 한국건강관리협회 1999 건협 Report Vol.2 No.-

골프운동 참여와 여가만족 관계

조영권,윤기운 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The purpose of this study was to examine the leisure satisfaction and golf participation. Subjects of this study was 230 priest between 20 - 65 years old in Seoul, Gwang ju, Inchon, Kyung gi, Dae jun. The scales of leisure satisfaction used in the studies of Sungryong Jin(1999). Damsuk Han (1993), Ieejoong Ioon(199G) and so forth were used in this questionnaire. A preliminary investigation was made on the completed survey sheets to see if the contents of the survey were suitable and were able to apply for the study. and then the reliability and the validity were examined. The completed survey sheets were examined with the preliminary investigation on the content feasibility and applicability and then ensured with reliability and validity. The data were analysed without the others which had poor qualities or were unreliable were excluded. The statistical methods for the data analysis in this research were. ANOVA, and Regression Analysis. Results of this research is as following. 1. Gender shows significant difference among the physical, social, psychological leisure satisfactions. 2. Age shows significant difference among the environmental satisfactions. 3. Satisfaction frequency in indoor shows significant difference among the environmental, social. psychological leisure satisfactions. 4. Satisfaction frequency in outdoor shows significant difference among the physical, social, psychological leisure satisfactions. 5 Handicap shows significant difference among the physical, environmental, social, psychological leisure satisfactions. 6. The group of higher satisfaction frequency or duration in satisfaction method of golfer shows significant difference among leisure satisfactions.

Polyphosphate가 함유된 근관충전재가 구강세균의 성장에 미치는 영향

박석범,최기운,최호영 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.2

Eliminating the infecting bacteria of the root canal system and preventing reinfection must be the main objectives of all endodontic works. None of commercially available root canal sealers have the properties of desirable tissue compatibility and strong antibacterial activity. The purpose of this study is to develope an ideal root canal sealer using commercially available polyphosphate (polyP), Calgon, which is known to be antibacterial and safe. For the study, resin-type AH26, zinc oxide eugenol-type Tubli-Seal, Ca(OH)2-type Apexit as base sealers for polyp (0∼3%) and para formaldehyde-containing N2 as a control base were selected. Specimens (3×4mm) of the sealers were prepared in a 37℃ incubator far 3 and 10 days and their antibacterial activity against streptococci and black-pigmented anaerobic rods was observed using an agar diffusion method. The result were as follows : 1.Among 3-day-old root canal sealers, N2 as a positive control showed the strongest antibacterial effect, followed by AH26, Tubli-Seal and, Apexit which barely showed antibacterial activity against the test bacteria. In contrast, 10-day-old AH26 showed a greater antibacterial activital than 10-day-old N2. 2.All sealer specimens showed a greater antibacterial activity against black-pigmented anaerobic rods than streptococci. Three-day-old ones appeared to be more antibacterial than 10-day-old ones except for Apexit. 3.As compared to N2, 3-day-old AH26 demonstrated a similar antibacterial activity against black-pig-mented anaerobic rods but to a lesser extent to streptococci. Ten-day-old AH26 showed a greater antibacterial activity against black-pigmented anaerobic rods than 10-day-old N2. 4.As compared to AH26, Tubli-Seal generally revealed a lower antibacterial activity but it showed a greater antibacterial activity aginst S. gordonii Challis. 5.Enhancement of antibacterial activity by polyp was more clearly observed when it was added to Ca(OH)2-based root canal sealers, Tubli-Seal and N2. 6.The addition of polyP enhanced the antibacterial activity of 3-day-old AH26 against S. gordonii G9B (16%) and Challis (29%), and P. gingivalis 2561 (24%) only. Moreover, polyp failed to increase antibacterial activity of 10-day-old AH26 against the test strains but P. gingivalis A7A1-28 (13%). 7.The addition of polyp increased the antibacterial effect of 3-day-old Tubli-Seal on several test bacteria including S. mutans GS-5 (50%), S. gordonii G9B (47%) and Challis (122%), and all the test strains of P. gingivalis (13∼35%) except for 9-14K-1. The addition of polyp to 10-day-old Tubli-Seal increased antibacterial activity of the root canal sealer against most test strains. 8.3-day-old Apexit failed to show antibacterial activity, if any very little against S. mutans GS-5 and Pr. intermedia ATCC 49046. However, polyP increased its antibacterial activity by 50 and 69%, respectively. Increase of antibacterial activity of 10-day-old Apexit by polyP was more clearly observed than that of 3-day-old one. The overall results suggest that polyP may be used in clinic as an antibacterial agent in root canal sealers. However, in order to maximize its antibacterial effect, the composition of sealers should be considered.

주파수 선택성 레일리 페이딩 환경에서 부호화 기법을 이용한 직교 멀티캐리어 시스템의 오율 해석

정재필,박기식,한성운,조성준 한국항공대학교 1997 論文集 Vol.35 No.-

본 논문에서는 주파수 선택성 레일리 페이딩 환경에서 RS부호화, 컨벌루션 부호화, 연접부화를 이용하는 직교 멀티캐리어 BDPSK시스템과 QDPSK시스템의 오율특성을 구하였다. 오율특성은 정규화된 지연시간(??), 비트에너지 대 잡음전력 스펙트럼 밀도비(??), 희망 신호전력 대 지연되 비희망 신호전력비(D/U)를 파라미터로 하여 나타내었다. 검토한 결과, BDPSK 신호인 경우 D/U가 20[dB]일 대 오율을 ??으로 유지하기 위해 필요한 Eb/No는 Rs부호화, 컨벌루션 부호화 및 연접부호화에서느 각각 대략 20.8[dB], 16.0[dB], 14.5 [dB]가 필요하며, QDPSK신호인 경우 Rs부호화, 컨벌루션 부호화 및 연접부호화에서 각각 대략 24.0[dB], 18.9[dB], 13.5[dB]가 필요함을 알 수 있었다. This paper has evaluated the error performance of orthogonal multicarrier BDPSK and QDPSK systems which use Reed Solomon coding, convolutional coding, and concatenated coding technique in a frequency selective Rayleigh fading environment. The results show that when D/U (desired wave's power to undesired delayed wave's power ratio)=20dB at error rate of ??, Reed Solomeon coded BDPSK signal, convolutional coded BDPSK signal, and concatenated coded BDPSK signal need about 20.8[dB], 16.0[dB], 14.5[dB] respectively in terms of Eb/No, and Reed Solomon coded QDPSK signal, convolutional coded QDPSK signal, and concatenated coded QDPSK signal need about 24.0[dB], 18.9[dB], 13.5[dB] respectively.