초음파 가이드를 통한 맥락막상강출혈의 치료

이기헌,유재호,김태원,이상준,김신동 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Purpose : Intraoperative suprachoroidal hemorrhage is one of the most serious complications. We report a case of suprachoroidal hemorrhage during phacoemulsification surgery, was managed properly. Methods : Suprachoroidal hemorrhage occurred during phacoemulsificaiton in other hospital. The patient was referred to our department immediately after closing the surgical wound. On initial examination, iris and vitreous were prolapsed through surgical wound. Ciliary body was closely place to anterior chamber, and retina was not visible. Results : Prolapased ocular tissue were reduced by emergency operation. We controlled the patient’s intraocular pressure and inflammation. Ultrasonography was repeatedly performed to check the degree of liquefaction of suprachoroidal hemorrhage. After 9 days of suprachoroidal hemorrhage onset, vitrectomy and drainage through sclera was performed. Postoperative state was stable with successful removal of suprachoroidal hemorrhage. After 2 weeks of secondary operation, retinal detachment has occurred on nasal retinal area, so we performed scleral buckling and endolaser photocoagulation. After 6 months, retina was attached well and intraocular pressure was in normal range. Conclusion : In suprachoroidal hemorrhage, drainage of suprachoroidal hemorrhage after liquefaction of thrombi is effective. After successful drainage, postoperative complications may accompany such as retinal detachment or elevation of intraocular pressure. 목적 : 술중 발생하는 맥락막상 출혈은 매우 심각한 합병증이다. 저자는 수정체 유화술 중에 발생한 맥락막상 출혈을 적절히 대처한 증례를 보고하는 바이다. 대상과 방법 : 수정체 유화술 중 발생한 맥락막상강 출혈환자가 수술창을 봉합 후 즉시 본원으로 전원되었다. 초진시 홍채와 유리체가 수술창을 통해 탈출되어 있었으며, 전방을 통해 모양체가 확인되었으나, 망막은 보이지 않았다. 탈출된 안구내 조직을 응급수술을 통해 복원 후 환자의 안압과 염증을 조절하였다. 초음파를 반복적으로 실시하여 맥락막상 출혈의 액화 정도를 확인하였으며, 출혈 9일 후 유리체 절제술과 공막을 통한 배액술을 시행하였다. 결과 : 맥락막상 출혈이 성공적으로 제거되었으며 술 후 상태는 안정적이었다. 수술 2주 후 비측 망막 박리가 발생하여 공막돌륭술과 안구내 삽관 레이저술을 시행하였다. 6개월 후 망막은 잘 붙어있었으며, 안압은 정상 범위를 유지하였다. 결론 : 맥락막상 출혈의 경우 출혈의 배액 시기를 결정하는 것이 어렵지만, 규칙적인 초음파를 통해 배액술의 시기를 결정할 수 있다. 또한 맥락막상강 출혈의 성공적인 배액 이후에도 망막박리 및 안압상승과 같은 합병증의 동반에 대해 유념해야한다.

Am-Be 선원을 통한 중성자의 전단면적 측정

민영기,오선영,노태익,박상태,이대원,이삼열 東亞大學校 1996 東亞論叢 Vol.33 No.-

Total cross sections was measured for 6.45MeV∼8.96MeV (average 7.7MeV) neutron on ??, ??, ?? absorber using ?? fast neutron source. The 2" ø×2" NE-213 organic liquid scitillation detector was used as a spectrometer of neutrons and gamma-rays. The zero crossing time analysis method was introduced in order to obtain the pulse heigh spectrum of neutrons and n-γ pulse-shape spectrum was investigated. The ratio of neutron peak for a Vally was 1:20. The total cross section resulting from the experiment enabled us to suppose a optical model as a neutron model, obtain the radius of a nuclei.

OenNtn 합성수지를 이용한 Sm, Co, U의 흡착에 관한 연구

노기환,김준태 광주보건대학 1994 論文集 Vol.19 No.-

The ion exchange resins have been synthesized from chloromethyl styrene-1,4-divinylbenzene(DVB) with 1%, 5%, and 20%-crosslinking and macrocyclic ligand of cryptand type by copolymerization method and the adsorption characteristics of uranium(Ⅵ), cobalt(Ⅱ) and samarium(Ⅲ) metallic ions have been investigated in various experimental conditions. The correlation between the adsorption characteristics of rare earths and transition metal on the resins and stability constants of complexes with macrocyclic ligand have been examined. The UO_2^(2+) aqueous solutions are not adsorbed on the resins below pH 3.0 but the power of adsorption of UO_2^(2+) increased rapidly above pH 4.0. The adsorption power was in the order of 1%, 5% and 20%-crosslinked resin, but adsorptive characteristics of resins decreased in proportion to the order of dielectric constants of solvents.

부유대역 용융응고법으로 제조된 YBa_2Cu_3O_x 산화물초전도체의 미세구조와 전기적 특성

노태형,송정환,장규철,한이섭,김소정,구본급,김호기 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-

The YBa_2Cu_3O_x-20 wt% Y_2BaCuO_5 composition designed in YBCO system was synthesized by solid state reaction method. The optimum condition of hot zone temperature and growth rate in floating-zone melt were 1080 ℃ and 2.5 mm/hour, respectively. In samples growth as these condition, the low angel boundaries in grain direction and small amount of amorphous phase known as decreasing characteristics of superconducting materials between grain boundaries in microstructure are investigated by polarized light microscopy on the whole. The critical current density(Jc) at 77k of sample using powder fabricated with no CeO_2 and doped 5 wt%CeO_2 were 8,000 A/㎠(Jc : 561A) and 12,000 A/㎠(Jc: 826A) at 0 T by direct current transport method, respectively.

Risperidone이 백서의 Schedule-Induced Polydipsia에 미치는 영향

이기철,이정호,윤도준,최영민,전성일,김태수,정홍경,하준명,정재현 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 강박장애의 원인론중 세로토닌-도파민 가설에 기초하여 강박장애 동물모형으로 고려되는 고정된 시간 간격으로 평소의 먹이섭취량보다 작은 양의 음식물을 백서에게 장기간 공급하여 다음중(schedule-induced polydipsia : SIP)을 유발시켰다. SIP모형에 강박장애에 효과적이라고 알려진 선택적 세로토닌 재흡수 차단제로서 fluoxetine을 장기 투여하고, 신경절후 5-HT²와 도파민 D² 수용체를 동시에 차단하는 risperidone을 투여하고, 신경절후 도파민 수용체 차단제인 haloperidol을 투여하였다. 그결과로서 risperidone이 강박장애 동물모형으로 고려되는 SIP에서 어떤 영향을 미치는지 알아보았다. 방 법 : SIP를 유발하기 위해 각각의 사육상자에 1정당 90㎎의 사료를 자동급이장치 (automatic dispenser)에서 60초당 1정씩 고정된 시간 간격으로 하루에 150분씩 공급하였다. 4주간 고정된 시간 간격으로 머기를 공급하고 매주 음수량과 체중을 측정한 실험 동물과 동등한 사료의 양을 한번에 덩어리로 공급받은 통제 집단의 체중과 음수량을 비교하였다. SIP 행동변화를 보인 실험 동물들을 fluoxetine 5㎎/㎏(N=8), risperidone 0.1㎎/㎏(N=8), haloperidol 0.1㎎/㎏(N=8), 그리고 vehicle 대조군 1㏄/㎏(N=8)으로 나누고 각각의 실험 동물군에서 3주간에 걸쳐서 실험 약물을 매일 복강내 주사하였다. 매주 실험 동물의 음수량과 체중을 측정, 비교하였다. 결 과 : 1) 고정된 시간 간격으로 제한된 먹이를 공급한 실험 동물군은 1주부터 4주에 걸쳐서 기저치보다 유의한 음수량의 증가를 보였다. 반면 통제 집단은 2주째 음수량이 일시적으로 증가한 소견 이외에 4주간의 실험 기간중 유의한 변화는 보이지 않았다. 실험 동물과 통제 집단간의 음수량에서 3주와 4주째에 실험 동물이 통제 집단보다 유의하게 높은 음수량을 보였지만 양군간에 체중의 차이는 보이지 않았다. 2) 각각의 실험 동물군 내에서 risperidone 0.1㎎ 투여군은 약물 투여 2주부터 3주까지 기저치 음수량과 비교하여 유의한 저하를 보였다. Risperidone 0.5㎎ 투여군은 약물터여 3주에서 기저치의 음수량과 비교하여 유의한 저하를 보였다. Fluoxetine 투여군은 약물 투여 시작 1주부터 3주에서 기저치의 음수량과 비교하여 유의한 저하를 보였다. 한편, haloperidol 투여군과, vehicle은 3주간에 걸친 약물 투여에서 각각의 기저치 음수량과 비교하여 차이를 보이지 않았다. 3) 실험 동물 각 군간에 약물 투여 시간 경과에 따른 음수량을 비교한 바, 약물투여 1주에서 각 군간에 유의한 차이는 없었다. 약물 토여 2주에서 fluoxetine 투여군, risperidone 0.1㎎ 투여군, 그리고 risperidone 0.5㎎투여군이 haloperidol 투여군과 비교하여 유의한 차이를 보였다. 약물투여 3주째에 fluoxetine투여군, risperidone 0.1㎎ 투여군, 그리고 risperidone 0.5㎎투여군이 haloperidol 투여군, vehicle과 비교하여 유의한 음수량의 저하를 보였다. 결 론 : 백서의 강박 행동은 fluoxetine, risperidone에 의해 효과적으로 억제되었으나 haloperidol에는 반응이 없었으므로, 임상에서 난치성 강박장애의 치료에 비정형 항정신병 약물 투여를 고려해 볼 수 있다고 제안한다. Objectives : This study was designed to evaluate the effects of risperidone on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered risperidone as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol as a dopamine antagonist to rats which showed schedule-induced polydipsic behaviour. Methods : Sprage-Dawley rats weighing 200∼250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90㎎ pellets on a fixed-time 60 seconds(FT 60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered risperidone(0.1㎎/㎏, i.p), risperidone(0.5㎎/㎏, i.p), fluoxetine(5㎎/㎏, i.p), haloperidol(0.1㎎/㎏, i.p), and vehicle(1㏄/㎏, i.p) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a post-hoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) was individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake at 1st, 2nd, and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The risperidone 0.1㎎ group and the risperidone 0.5㎎ group showed significant decrease in the amount of water intake at the 3rd weeks of drug treatment as compared with their baseline of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their baseline of polydipsic water intakes. 3) The fluoxetine group(22.5±10.4ml) showed significantly lower amounts of water intake than haloperidol group(41.3±7.1ml) at 2nd weeks of drug treatment. And also the fluoxetine group(18.8±3.5ml) showed significantly lower amounts of water intake than the haloperidol group(35.0±11.7ml) and the vehicle control(34.4±6.8ml) at 3rd weeks of drug treatment. The risperidone 0.1㎎ group and the risperidone 0.5㎎ group showed significantly lower amounts of water intake than the haloperidol group(35±11.7ml) at 2nd weeks and the vehicle control(37.5±12.5, 34.4±6.8ml) at 2nd and 3rd weeks of drug treatment. Conclusions : Above findings suggest that the fixed time feeding procedure for schedule induced polydipsia could be applied as an effective animal model of obsessive compulsive disorder for the evaluation of pharmacological challenge study. We confirmed that chronic treatment with risperidone revealed antipolydipsic effect as effective as fluoxetine on the schedule-induced polydipsic behaviour but the onset of effect was later than fluoxetine.

대식세포주 RAW264.7에서 Nitric oxide에 의해 과발현되는 CD53의 기능분석

김태림,이혜영,김인규,백상기 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.2

The CD53 antigen is a member of the tetraspanin membrane protein family that is expressed in the lymphoid-myeloid lineage. It is highly expressed in Radio-resistant tumor cells. Recently, it was reported that CD53 associates with the GSH-metabolizing protein γ-glutamyl transpeptidase. Its biological roles however remains unknown. Macrophages activated by microbial lipopolysaccharides (LPS) produce a burst of nitric oxide and reactive oxygen species. Nitric oxide plays important roles in macrophage activation as a toxic agent towards infectious organisms, an inducer or suppressor of apoptosis or an immunoregulator, whether nitric oxide can induce or inhibit apoptosis is highly dependent on different cell types at different stages of the inflammatory process. Using cDNA microarrays, we identified CD53 as one of the principal genes up-regulated by exposure of macrophages to LPS. We found that mRNA and protein levels of CD53 were increased by nitric oxide as well as LPS treatment in macrophages. Cells stably transfected with sense CD53 cDNA had lower levels of peroxide, and were more resistant to γ-irradiation. The stably transfected RAW264.7 cells with antisense CD53 recombination had the opposite properties. Activation of CD53 by cross-linking with monoclonal anti-CD53 antibody (OX-79) showed the expression of the inducible nitric oxide synthase. We propose that the induction of CD53 is one of major self-protection mechanisms of macrophages against LPS induced-oxidative stress and irradiation.

폐경기여성의 체력유지, 증진을 위한 운동프로그램 최근 연구동향 분석

최문기,김태운,김진홍 부산대학교 과학교육연구소 2005 교사교육연구 Vol.44 No.-

All women eventually experience the Menopause. After doing research for the last 10 years, I would like to suggest some sports programs for maintaining physical condition, training, improvement, and for keeping their bone density for women in their menopause. First, a resistant sports program will not only have influence on women's health during the menopause, but it also changes cardiovascular efficiency and body flexibility a lot. Second, women can maintain and keep bone density by doing weight resistance sports during the menopause. Third, if aerobic exercise and resistant sports would be mixed in a balanced way, women can maximize effectiveness of sports during the menopause. In conclusion, even when women don’t exercise before menopause and if they start working out, the possibility of danger after menopause will be less and less and visa versa. The results are even better though when women exercise before menopause.

나이지리아 스마트 SOC 투자를 통한 국가 브랜드 가치 상승 및 산업 경쟁력 제고 방안

안기돈,조희태 동의대학교 경제경영전략연구소 2011 經濟經營硏究 Vol.6 No.1

The smart SOC industry which is the SOC industry combined with IT industry has been become more important since the 2008 global economic crises. The smart SOC industry has a big effect on the industrial spillover, technological advance, employment and so on. The countries in the Southwest African regions, especially Nigeria, have been making a great effort to develop the smart SOC. Therefore, Korea needs to make an investment in the smart SOC in the southwest Africa. This paper analyzes the current status of smart SOC in the southwest Africa, especially Nigeria. This paper suggests that the policy strategies which invests and develops the smart SOC in Nigeria. This papers also presents the strategies that finance investing the smart SOC by using the Official Development Assistance.

평판 및 쉘 구조물의 유한 요소해석을 위한 프로그램 개발

이기천,이태원 國立金烏工科大學校附設生産技術硏究所 1997 産業技術開發硏究 Vol.13 No.-

The original Mindlin-type degenerated plate and shell elements perform reasonably well for moderately thick shell structure. However, for thin shells when full integration is used to evaluate the stiffness matrix, overstiff solutions are often produced due to shear and membrane locking. To overcome the locking phenmena of the degenerated shell element, the assumed strain method is introduced. Using this approach, the finite element analysis program has been developed for the plate and shell under elastic conditions. The program are accommodated in a simple and effective manner by using a layered approach, where in two Gauss point integration scheme is adopted for each layer. Numerical tests for linear elastic problems show an improved performance of this program.

全州市 大規模 住宅開發이 三川에 미치는 影響

金煥起,李基完,裸悳寬,丁泰燮 全北大學校 附設 都市및環境硏究所 1988 都市 및 環境硏究 Vol.3 No.-

A site plan for 16,110 persons and area of 308,569㎡ was planned by Chonju City. This paper is to study the effects of the site development on Sam-cheon. Average water quality of Sam-cheon was BOD_5 46.0㎎/ℓ in Jan. and Feb., which exceeded the class levels of legislated water quality obviously. If the site were developed by plan, amounts of estimated overall sewage, BOD and SS loads to Sam-cheon would be about 2,954 ㎥/day, 702 ㎏ BOD/day and 409 ㎏SS/day respectively. Even if the sewage of developed area is treated through the legislated purification system, BOD concentration of the stream would be 2.2 ㎎/ℓ more than the present by effluent of purification facilities. Therefore, to prevent more degradation of water quality at least, the pollutional regulation of total emission for the stream could be applied to Sam-cheon with a time-limit.