주기적인 운동이 뒷다리 부유에 의해 유발된 쥐의 뒷다리근 위축경감에 미치는 영향

최명애,신기수 대한기초간호자연과학회 1999 Journal of korean biological nursing science Vol.1 No.1

The purpose of this study was to determine the effect of periodic low-intensity exercise during hindlimb suspension on the mass, relative weight, myofibrillar protein content in soleus, plantaris and gastrocnemius muscles. To examine the effectiveness of periodic low-intensity exercise on mass, and myofibrillar protein content of hindlimb muscles, adult female Wistar rats were suspended(HS) and half of these rats walked on a treadmill for 45min/day(15 min every 4h) at 5m/min and a 15˚ grade(HS-EX). Soleus wet weight was 33.51% significantly smaller(p<0.005) and relative soleus weight of hindlimb suspended rats was 31.96% smaller(p<0.005) compared with those of control rats following seven days of hindlimb suspension. Plantaris wet weight was 7.5% smaller(p<0.01) and relative plantaris weight was 11.83% smaller(p<0.05) compared with those of control rats following seven days of hindlimb suspension. Gastrocnemius wet weight was 11.31% significantly smaller(p<0.005) and relative gastrocnemius weight was 17.13% significantly smaller(p<0.005) compared with those of control rats following seven days of hindlimb suspension. Soleus wet weight while increased by relative soleus weight increased by 25.13%, 27.59% each through periodic low intensity exercise during hindlimb suspension(p<0.05, p<0.05). Plantaris wet weight and relative plantaris weight increased by 1.04%, 10.98%(p<0.05) each, and gastrocnemius wet weight and relative gastrocnemius weight increased by 1.98%, 12.02%(p<0.05) each through periodic low intensity exercise during hindlimb suspension. Wet weight of soleus, plantaris and gastrocnemius in HS-EX rats did not recover to control level. Myofibrillar protein content of soleus, plantaris and gastrocnemius was 48.24%, 40.85% and 37.33% significantly smaller(p<0.005) respectively compared with those of control rats following seven days of hindlimb suspension. Myofibrillar protein content of soleus, plantaris and gastrocnemius increased by 40.68%, 25.07% and 17.93%(p<0.005) each through periodic low intensity exercise during hindlimb suspension. Myofibrillar protein content of soleus, plantaris, and gastrocnemius in HS-EX rats did not recover to control level. The results suggest that periodic low intensity exercise can attenuate hindlimb muscle atrophy induced by hindlimb suspension.

토란의 황화경으로부터 캘러스 형성 및 식물체 재생

윤애화,이지영,임순희,김현정,안장순 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

토란의 기지 shoot를 암배양하여 절간이 신장한 황하경을 얻고 이황하경의 절편을 계대배양하여 기내증식을 시도하였다. 황하경은 NAA 0.2mg/ℓ가 첨가된 배지에서 가장 길게 신장하였다. 황하경은 자구형성형이 모구배대형보다 길게 신장하였다. 호르몬이 첨가된 거의 모든 배지에서 protocorm이 형성되었으나 0.2mg/ℓ NAA + 0.2mg/ℓ BA를 첨가한 배지에서 특히 많이 형성되었고 이 protocorm을 MS기본 배지에 옮겼을 때 8.5%의 재분화율을 보였다. Etiolated stems with elongated internodes were obtained from the in vitro culture of shoots of Colocasia esculenta schout under dark condition and plant differntiation was achived by subculturing the ethiolated stem segments. The etiolated stems elongates better on the media containing 0.2mg/ℓNAA than of those lacking it. Subculture of the etiolated stem segments produced protocorm-like structures in all the media examined. The medium containing 0.2mg/ℓNAA and 0.2mg/ℓBA produced the higest number of protocorm-like structure, which regenerated into plantets at 85% when transferred to phytohormone-free MS medium.

과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰

최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2

There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.

'삼국사기'와 '삼국유사' : 역사와 문학의 만남

김기봉,김미애,김혜경 경기대학교 2009 시민인문학 Vol.16 No.-

모든 학문이 추구하는 것은 진실이다. 역사학이 사실서사를 통해 진실을 밝힌다면, 문학은 허구서사를 통해 진실을 드러낸다. 그런데 이 둘 가운데 무엇이 진실로 들어가는 더 큰 문일까? 아리스토텔레스는 󰡔시학󰡕에서 실제로 일어난 일을 이야기하는 역사보다는 일어날 법한 일을 이야기하는 시가 진실에 이르는 더 큰 문이라고 주장했다. 시는 보편적인 것을 말하지만 역사는 개별적인 것을 말하기 때문에 그렇다는 것이다. 아리스토텔레스가 설정한 문학과 역사의 우선순위는 동아시아 서사전통에서는 역전되었다. 예컨대 역사서사인󰡔삼국사기󰡕가 문학서사인󰡔삼국유사󰡕보다 더 진실에 가까운 것으로 여겨졌다. 서사가 서구에서는 허구에서 역사가 분리하는 방향으로 전개됐다면, 동아시아에서는 반대로 역사로부터 허구가 분화하는 방향으로 나갔다. 근대에 이르러 동서양 모두에서 사실과 진실을 일치시키는 근대 사실주의는 허구를 통해 진실로 들어가는 문을 차단했다. 사실주의 문법에 따라 문학이 역사를 모방하는 역사소설과 같은 장르가 생겨났다. 탈근대에서 팩션의 등장은 사실만이 진실이라는 근대 사실주의 문법의 해체를 의미한다. 이 같은 맥락에서 본 논문은 사실과 허구는 진실과 거짓의 등식이 아닌 현실서사와 꿈의 서사로 이해돼야 한다는 것을 󰡔삼국사기󰡕와󰡔삼국유사󰡕에 대한 비교연구를 통해 해명한다. 탈근대주의 문법에 따르면, 󰡔삼국사기󰡕가 역사서사라면󰡔삼국유사󰡕는 팩션이라는 것이 본 논문의 테제다.

일 간호대학의 지역사회 방문간호사업 사례

강윤숙,최양자,고영애,전시자,조갑출,이옥철,주혜경,신기수,안은숙 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

국내육성 오차드그라스 품종들의 캘러스 형성율 및 식물체 재분화 효율

김기용,강경민,배은경,이인애,임용우,최기준,박근제,손대영,조진기 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Comparisons of callus formation ratios from seed explants, callus sizes, regeneration ratios from callus and regeneration efficiency for 4 orchardgrass (Dactylis glomerata L.) varieties (Three were developed in Korea and one was imported from foreign nation) are as follows; Jangbeol 102 (67.0%) has the highest callus formation ratio in 4 weeks incubated callus after bedding the seed explants, but Potomac (68.4%) has the highest ratio in 6-seek callus. Potomac (3.93cm) has the highest callus size in 4-week callus, but Jangbeol 101 (4.32cm) has the highest size in 6-week callus. Jangbeol 101 (17.7%) has the highest plant regeneration ratio in 4-week callus, but Potomac (37.4%) has the highest raion in 6-week callus. Jangbeol 102 (11.5%) has the highest plant regeneration efficiency in 4-week callus, but Potomac (25.6%) has the highest efficiency in 6-week callus.

[PG-0009] Antioxidant activities and phytochemical contents of diverse representative tea germplasm

Gi-An Lee(Gi-An Lee),Nayoung Ro(Nayoung Ro),Do Yoon Hyun(Do Yoon Hyun),Gwang-Yeon Gi(Gwang-Yeon Gi),Kyung Jun Lee(Kyung Jun Lee),Weilan Li(Weilan Li),Eun Ae Yoo(Eun Ae Yoo),SooKyeong Lee(SooKyeong Lee 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Non-Alcoholic Fatty Liver Is Associated with Incidence of Dementia: A National Health Cohort Study in Korea

( Gi-ae Kim ),( Han Hee Lee ),( Su Jin Jeong ),( Jin San Lee ),( Key-Chung Park ),( In-hwan Oh ),( Jae-jun Shim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Fatty liver disease and dementia are emerging health problems in many countries. Hepatic steatosis is a feature of abnormal fat metabolism in the body. Fat dysregulation in the brain might also increase risk for dementia. The aim of this study was to investigate whether hepatic steatosis is associated with development of dementia in the middle-aged population. Methods: A nationwide population-based cohort study was conducted using customized data from the National Health Insurance Service of Korea. We identified subjects (40 to 69 years) who conducted two or more health examinations between 2004 and 2007, who were free of chronic viral hepatitis, alcoholic liver disease, cirrhosis, cancers, stroke, and dementia. Fatty liver was defined using hepatis steatosis index (HSI) > 36. Control was defined when all HSIs were less than 30 between 2004 and 2007. Dementia was identified using disease classification codes (F00, F01, F02, F03, G30, G31, or G32) and prescription data of an antidementia drug. Enrolled subjects (n=3,811,942) were observed until 2017 and incidence of dementia was evaluated according to fatty liver. Results: Among the control group (all HSI < 30, n=651,481), dementia was identified in 37,182 persons (5.4%) during follow-up (2007 - 2017). Among subjects with all HSI > 36 (n=439,654), dementia was identified in 36,093 persons (7.59%, P< 0.0001). After adjusting for sex, age, liver enzymes, body mass index, smoking status, diabetes, hypertension, cholesterol, and disability, the multivariate analysis showed non-alcoholic fatty liver (any HSI > 36) was significantly associated with incidence of dementia (adjusted HR 1.08; 95% CI 1.06- 1.10). In subgroup analysis, dementia was not associated with improved fatty liver (initial HSI > 36, last HSI < 30), (adjusted HR 1.05; 95% CI 0.99-1.11). However, aggravated fatty liver (initial HSI < 30, last HSI > 36) was significantly associated with dementia (adjusted HR 1.10; 95% CI 1.03-1.17). Sustained fatty liver (all HSI > 36) was also associated with dementia (adjusted HR 1.03; 95% CI 1.01-1.16). Conclusions: Non-alcoholic fatty liver is associated with development of dementia in middle-aged Korean population.

Moderate Levels of Serum HBV DNA Are Associated with the Highest Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients

( Gi-ae Kim ),( Seungbong Han ),( Gwang Hyeon Choi ),( Jonggi Choi ),( Young-suk Lim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Studies have shown a higher risk of hepatocellular carcinoma (HCC) with higher baseline serum hepatitis B virus (HBV) DNA levels in chronic hepatitis B (CHB) patients. However, the association between very high HBV DNA levels (>6 log₁₀ IU/mL) and HCC risk remains unclear, especially in middle-aged and old HBeAg-positive patients. Methods: We conducted a historical cohort study in Korea involving 6949 non-cirrhotic, treatment-naïve CHB patients with alanine aminotransferase (ALT) < 2x upper limit of normal for >1 year. HBV DNA was >6 log₁₀ IU/mL in 2029 (29.2%) patients. Follow-up was censored when the antiviral therapy was initiated. Results: The mean age of the patients was 45 years. During 8.0 years of median follow-up, 363 patients (5.2%) developed HCC. By multivariable Cox regression analysis, HCC risk was highest with baseline HBV DNA levels of 6-7 log₁₀ IU/mL (adjusted hazard ratio [aHR] 4.98; P< 0.001), and lowest with >8 log₁₀ IU/mL (aHR 0.90; P=0.71) and ≤4 log₁₀ IU/mL (aHR 1.00; reference), which was independent of other predictive factors. The similar association between HBV DNA levels and HCC risk was consistently observed in all age subgroups (age <40 years, 40-49 years, and ≥50 years). Conclusions: HCC risk was highest with medium serum HBV DNA levels of 6-7 log₁₀ IU/mL in CHB patients without significant ALT elevation. Extending treatment indication to CHB patients with moderate levels of HBV DNA may be considered to further prevent HCC, regardless of ALT levels.

Plenary Session 1 : PS-1-5 ; Is HBsAg seroclearance following nucleoside analogue therapy durable in patients with chronic hepatitis B?

( Gi Ae Kim ),( Young Suk Lim ),( Ju Hyun Shim ),( Kang Mo Kim ),( Han Chu Lee ),( Yung Sang Lee ),( Young Hwa Chung ),( Dan Bi Lee ),( Ji Hyun An ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Spontaneous or interferon-induced HBsAg seroclearance is durable in most patients with chronic hepatitis B (CHB). However, little is known about the durability of HBsAg seroclearance following nucleoside analogue (NUC) therapy. Methods: Among 4,578 patients who were treated with either lamivudine (n=1,924) or entecavir (n=2,654) at a tertiary referral hospital in Korea between 2000 and 2010, 121 achieved HBsAg seroclearance. Fifty-eight patients were included in this study after exclusion of 63 patients; acute hepatitis B (n=19), hepatocellular carcinoma (n=8), prior treatment with interferon (n=6), prior immunosuppressive therapy (n=17), liver transplantation (n=6), follow-up loss immediately after HBsAg seroclearance (n=5), and continued NUC therapy (n=2). Results: Mean age of 58 patients were 42 (SD 11) years and 41 (71%) were males. All were assumed to have HBV genotype C. At the initiation of NUC therapy, median levels of ALT and HBV DNA were 153 IU/L (interquartile range [IQR], 48-340 IU/L) and 7.0 log10 copies/mL (IQR, 3.8-8.0 log10 copies/mL), respectively. Twenty-seven (47%) had HBeAg. The median duration of NUC therapy (56 with lamivudine and 2 with entecavir) before HBsAg seroclearance was 42 months (IQR, 24-66 months). During a median follow-up period of 20 months (IQR, 12-32 months), HBsAg reversion occurred in 5 of 58 (8.6%) patients. Three of those 5 patients achieved re-clearance of HBsAg without treatment during further follow-up. The other 2 patients remained HBsAg-positive, but with low titer (< 1.0 IU/mL) and undetectable HBV DNA by PCR. Virologic recurrence (detectable HBV DNA by PCR) occurred in 12 of 58 (20.7%) patients. However, all of these patients maintained HBV DNA <10,000 copies/mL. No patient experienced biochemical relapse (ALT flare > x5 ULN). Conclusion: HBsAg seroclearance following NUC therapy is rare but durable in most patients with CHB after treatment discontinuation. Therefore, HBsAg seroclearance would be an ideal treatment endpoint during NUC therapy.