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Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity
Gerlach, David,Guo, Yinglan,De Castro, Cristina,Kim, Sun-Hwa,Schlatterer, Katja,Xu, Fei-Fei,Pereira, Claney,Seeberger, Peter H.,Ali, Sara,Codé,e, Jeroen,Sirisarn, Wanchat,Schulte, Berit,Wolz, Ch Springer Science and Business Media LLC 2018 Nature Vol.563 No.7733
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Angela Gerlach,Enrico Preuss,Paul Uwe Thamsen,Flemming Lykholt-Ustrup 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.4
We did a numerical study of the internal flow field of a vortex pump. Five operating points were considered and validated through a measured characteristic curve. The internal flow pattern of a vortex pump was analyzed and compared to the Hamel-Oseen vortex model. The calculated flow field was assessed with respect to the circumferential velocity, the vorticity and the axial velocity. Whereas the trajectories of the circumferential velocity were largely in line with the Hamel-Oseen vortex model, the opposite was true for vorticity. Only the vorticity at strong part load was in line with the predictions of the Hamel-Oseen vortex model. We therefore compared the circumferential velocity and vorticity for strong part load operation to the analytical predictions of the Hamel-Oseen vortex model. The simulated values were below the analytical values. The study therefore suggests that a vortex similar to the Hamel-Oseen vortex is only present at the strong part load operation.
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John Joseph Carney,Erik Gerlach,Mark Plantz,Peter Raymond Swiatek,Jeremy Marx,Matthew Saltzman,Guido Marra 대한견주관절학회 2022 대한견주관절의학회지 Vol.25 No.1
Background: Total shoulder arthroplasty (TSA) has been demonstrated to be an effective treatment for multiple shoulder pathologies. The purpose of our study was to compare the relative value units (RVUs) per minute of surgical time for primary and revision TSA. Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried to identify patients that underwent primary TSA, one-component revision TSA, and two-component revision TSA between January 1, 2015 and December 31, 2017 using current procedure terminology codes. RVUs were divided by mean operative time for each procedure to determine the amount of revenue generated per minute. Rates were compared between the groups using a one-way analysis of variance with post-hoc Tukey test. Statistical significance was set at p<0.05. Results: When dividing compensation by surgical time, we found that two-component revision generated more compensation per minute compared to primary TSA (0.284±0.114 vs. 0.239±0.278 RVU per minute or $10.25±$4.11 vs. $8.64±$10.05 per minute, respectively; p=0.001). Conclusions: The relative value of revision TSA procedures is weighted to account for the increased technical challenges and time associated with these procedures. This study confirms that reimbursement is higher for revision TSA compared to primary TSA.
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Acoustic Monitoring and Localization for Social Care
Goetze, Stefan,Schroder, Jens,Gerlach, Stephan,Hollosi, Danilo,Appell, Jens-E.,Wallhoff, Frank Korean Institute of Information Scientists and Eng 2012 Journal of Computing Science and Engineering Vol.6 No.1
Increase in the number of older people due to demographic changes poses great challenges to the social healthcare systems both in the Western and as well as in the Eastern countries. Support for older people by formal care givers leads to enormous temporal and personal efforts. Therefore, one of the most important goals is to increase the efficiency and effectiveness of today's care. This can be achieved by the use of assistive technologies. These technologies are able to increase the safety of patients or to reduce the time needed for tasks that do not relate to direct interaction between the care giver and the patient. Motivated by this goal, this contribution focuses on applications of acoustic technologies to support users and care givers in ambient assisted living (AAL) scenarios. Acoustic sensors are small, unobtrusive and can be added to already existing care or living environments easily. The information gathered by the acoustic sensors can be analyzed to calculate the position of the user by localization and the context by detection and classification of acoustic events in the captured acoustic signal. By doing this, possibly dangerous situations like falls, screams or an increased amount of coughs can be detected and appropriate actions can be initialized by an intelligent autonomous system for the acoustic monitoring of older persons. The proposed system is able to reduce the false alarm rate compared to other existing and commercially available approaches that basically rely only on the acoustic level. This is due to the fact that it explicitly distinguishes between the various acoustic events and provides information on the type of emergency that has taken place. Furthermore, the position of the acoustic event can be determined as contextual information by the system that uses only the acoustic signal. By this, the position of the user is known even if she or he does not wear a localization device such as a radio-frequency identification (RFID) tag.
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Cody Goedderz,Mark A. Plantz,Erik B. Gerlach,Nicholas C. Arpey,Peter R. Swiatek,Colin K. Cantrell,Michael A. Terry,Vehniah K. Tjong 대한견주관절학회 2022 대한견주관절의학회지 Vol.25 No.1
Background: Distal biceps rupture is a relatively uncommon injury that can significantly affect quality of life. Early complications following biceps tendon repair are not well described in the literature. This study utilizes a national surgical database to determine the incidence of and predictors for short-term complications following distal biceps tendon repair. Methods: The American College of Surgeons’ National Surgical Quality Improvement Program database was used to identify patients undergoing distal biceps repair between January 1, 2011, and December 31, 2017. Patient demographic variables of sex, age, body mass index, American Society of Anesthesiologists class, functional status, and several comorbidities were collected for each patient, along with 30-day postoperative complications. Binary logistic regression was used to calculate risk ratios for these complications using patient predictor variables. Results: Early postoperative surgical complications (0.5%)—which were mostly infections (0.4%)—and medical complications (0.3%) were rare. A readmission risk factor was diabetes (risk ratio [RR], 4.238; 95% confidence interval [CI], 1.180–15.218). Non-home discharge risk factors were smoking (RR, 3.006; 95% CI, 1.123–8.044) and ≥60 years of age (RR, 4.150; 95% CI, 1.611– 10.686). Maleness was protective for medical complications (RR, 0.024; 95% CI, 0.005–0.126). Surgical complication risk factors were obese class II (RR, 4.120; 95% CI, 1.123–15.120), chronic obstructive pulmonary disease (COPD; RR, 21.981; 95% CI, 3.719–129.924), and inpatient surgery (RR, 8.606; 95% CI, 2.266–32.689). Conclusions: Complication rates after distal biceps repair are low. Various patient demographics, medical comorbidities, and surgical factors were all predictive of short-term complications.
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Christian Ostheimer, Patrick Hübsch, Martin Janich, Reinhard Gerlach, Dirk Vordermark 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.4
Purpose: Total scalp irradiation (TSI) is a rare but challenging indication. We previously reported that non-coplanar intensitymodulated radiotherapy (IMRT) was superior to coplanar IMRT in organ-at-risk (OAR) protection and target dose distribution. This consecutive treatment planning study compared IMRT with volumetric-modulated arc therapy (VMAT). Materials and Methods: A retrospective treatment plan databank search was performed and 5 patient cases were randomly selected. Cranial imaging was restored from the initial planning computed tomography (CT) and target volumes and OAR were redelineated. For each patients, three treatment plans were calculated (coplanar/non-coplanar IMRT, VMAT; prescribed dose 50 Gy, single dose 2 Gy). Conformity, homogeneity and dose volume histograms were used for plan. Results: VMAT featured the lowest monitor units and the sharpest dose gradient (1.6 Gy/mm). Planning target volume (PTV) coverage and homogeneity was better in VMAT (coverage, 0.95; homogeneity index [HI], 0.118) compared to IMRT (coverage, 0.94; HI, 0.119) but coplanar IMRT produced the most conformal plans (conformity index [CI], 0.43). Minimum PTV dose range was 66.8%-88.4% in coplanar, 77.5%-88.2% in non-coplanar IMRT and 82.8%-90.3% in VMAT. Mean dose to the brain, brain stem, optic system (maximum dose) and lenses were 18.6, 13.2, 9.1, and 5.2 Gy for VMAT, 21.9, 13.4, 14.5, and 6.3 Gy for non-coplanar and 22.8, 16.5, 11.5, and 5.9 Gy for coplanar IMRT. Maximum optic chiasm dose was 7.7, 8.4, and 11.1 Gy (non-coplanar IMRT, VMAT, and coplanar IMRT). Conclusion: Target coverage, homogeneity and OAR protection, was slightly superior in VMAT plans which also produced the sharpest dose gradient towards healthy tissue.
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Meng Luo,Yaning Li,Joerg Gerlach,Tomasz Wierzbicki 한국소성가공학회 2010 기타자료 Vol.2010 No.6
Advanced High Strength Steels (AHSS) draws enormous attentions in automotive industry because it has great potential in reducing weight and improving fuel efficiency. Nonetheless, their relatively low formability also causes many problems in manufacturing processes, such as shear-induced fracture during deep drawing or stamping. This type of fracture could not be predicted using traditional necking-based Forming Limit Diagram (FLD), which is commonly used by the forming community. In the present paper, a recently developed Modified Mohr-Coulomb (MMC)[1] ductile fracture model is employed to make up the deficiency of FLD. In the limiting case of plane stress, the MMC fracture locus consists of four branches when represented on the plane of the equivalent strain to fracture and the stress triaxiality. A transformation of above 2D fracture locus to the space of principal strains was performed which revealed the existence of two new branches not known before. The existence of those branches explains the formation of shear-induced fracture. As an illustration of this new approach, initiation and propagation of cracks in a series of deep drawing tests is predicted and compared with the experimental observations. It was shown that the location of fracture as well as the magnitude of punch travel corresponding to first fracture was correctly predicted by MMC fracture model for both square and circular punch cases.
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Christian Ostheimer,Patrick Hübsch,Martin Janich,Reinhard Gerlach,Dirk Vordermark 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.4
Purpose: Total scalp irradiation (TSI) is a rare but challenging indication. We previously reported that non-coplanar intensitymodulated radiotherapy (IMRT) was superior to coplanar IMRT in organ-at-risk (OAR) protection and target dose distribution. This consecutive treatment planning study compared IMRT with volumetric-modulated arc therapy (VMAT). Materials and Methods: A retrospective treatment plan databank search was performed and 5 patient cases were randomly selected. Cranial imaging was restored from the initial planning computed tomography (CT) and target volumes and OAR were redelineated. For each patients, three treatment plans were calculated (coplanar/non-coplanar IMRT, VMAT; prescribed dose 50 Gy, single dose 2 Gy). Conformity, homogeneity and dose volume histograms were used for plan. Results: VMAT featured the lowest monitor units and the sharpest dose gradient (1.6 Gy/mm). Planning target volume (PTV) coverage and homogeneity was better in VMAT (coverage, 0.95; homogeneity index [HI], 0.118) compared to IMRT (coverage, 0.94; HI, 0.119) but coplanar IMRT produced the most conformal plans (conformity index [CI], 0.43). Minimum PTV dose range was 66.8%– 88.4% in coplanar, 77.5%–88.2% in non-coplanar IMRT and 82.8%–90.3% in VMAT. Mean dose to the brain, brain stem, optic system (maximum dose) and lenses were 18.6, 13.2, 9.1, and 5.2 Gy for VMAT, 21.9, 13.4, 14.5, and 6.3 Gy for non-coplanar and 22.8, 16.5, 11.5, and 5.9 Gy for coplanar IMRT. Maximum optic chiasm dose was 7.7, 8.4, and 11.1 Gy (non-coplanar IMRT, VMAT, and coplanar IMRT). Conclusion: Target coverage, homogeneity and OAR protection, was slightly superior in VMAT plans which also produced the sharpest dose gradient towards healthy tissue.
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Acoustic Monitoring and Localization for Social Care
Stefan Goetze,Jens Schroder,Stephan Gerlach,Danilo Hollosi,Jens-E. Appell,Frank Wallhoff 한국정보과학회 2012 Journal of Computing Science and Engineering Vol.6 No.1
Increase in the number of older people due to demographic changes poses great challenges to the social healthcare systems both in the Western and as well as in the Eastern countries. Support for older people by formal care givers leads to enormous temporal and personal efforts. Therefore, one of the most important goals is to increase the efficiency and effectiveness of today’s care. This can be achieved by the use of assistive technologies. These technologies are able to increase the safety of patients or to reduce the time needed for tasks that do not relate to direct interaction between the care giver and the patient. Motivated by this goal, this contribution focuses on applications of acoustic technologies to support users and care givers in ambient assisted living (AAL) scenarios. Acoustic sensors are small, unobtrusive and can be added to already existing care or living environments easily. The information gathered by the acoustic sensors can be analyzed to calculate the position of the user by localization and the context by detection and classification of acoustic events in the captured acoustic signal. By doing this, possibly dangerous situations like falls, screams or an increased amount of coughs can be detected and appropriate actions can be initialized by an intelligent autonomous system for the acoustic monitoring of older persons. The proposed system is able to reduce the false alarm rate compared to other existing and commercially available approaches that basically rely only on the acoustic level. This is due to the fact that it explicitly distinguishes between the various acoustic events and provides information on the type of emergency that has taken place. Furthermore, the position of the acoustic event can be determined as contextual information by the system that uses only the acoustic signal. By this, the position of the user is known even if she or he does not wear a localization device such as a radio-frequency identification (RFID) tag.
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