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Plant Regeneration from Turnip (Brassica rapa ssp. rapifera) Organs
Gendaram Sarantuya,Bae Chang-Hyu 한국자원식물학회 2005 Plant Resources Vol.8 No.3
Shoot induction system was developed in the recalcitrant plant species, Brassica rapa ssp. rapifera by using optimum selection of profit organ, phytohormone combination, seedling age and kind of culture container. Out of in vitro cultured leaf segment, petiole, hypocotyl, and cotyledon with petiole, only cotyledon with petiole derived from 4 day-old seedlings induced multiple shoot. The optimum combination of auxin and cytokinin for the multiple shoot induction was MS medium containing 5mg/L BA and 0.5mg/L NAA. The major factors for multiple shoot propagation were part of plant organ, age of seedling, and ratio of auxin and cytokinin. In addition, shoot regeneration was promoted in the 100ml Erlenmeyer flask compared with the 90㎜x20㎜ Petri-dish. The induced shoots formed roots easy on MS medium containing 0.1mg/L IBA and the whole plants were successfully cultivated in soil.
Gendaram Odontuya,Chultemsuren Yeruult 한국생약학회 2023 Natural Product Sciences Vol.29 No.2
Nepeta sibirica L. or Siberian catmint is a medicinal plant species used in Mongolian traditional medicine for curing human different disorders and veterinary practices. The previous study of the whole plant concentrated on the determination of its essential oil composition and reported that the major ones are sesquiterpenes, including nepetalactone. The aim of this study was to reveal a new biological activity of the above-ground parts of N. sibirica L. and compare the activity of different extracts correlating with the content of biologically active compounds and evaluate their toxicity. For this purpose, anti-oxidative and acetylcho- linesterase inhibitory activities of the above-ground parts of N. sibirica L. aqueous and ethanol (EtOH) (40%, 70%) extracts were assayed spectrophotometrically. The aqueous extract showed positive anti-oxidative activity by both tested DPPH and FRAP assays with IC50 134.24 ± 1.42 mg/mL and FRAP value 1385.15 ± 8.12 mmol/L at 200 mg/mL, in contrast to 40% and 70% EtOH extracts. The 70% EtOH extract presented the highest acetylcholinesterase inhibitory activity (IC50 77.29 ± 0.38 mg/mL) followed by 40% EtOH extract (176.72 ± 0.35 mg/mL) and aqueous extract (275.41 ± 0.23 mg/mL). Total phenolics were found to be gallic acid equivalent, % 3.74 ± 0.05 (70% EtOH), 3.94 ± 0.04 (40% EtOH), and 3.79 ± 0.16 (aqueous), whereas the total flavonoids as a rutin equivalent, % as 2.01 ± 0.12, 1.44 ± 0.17 and 1.99 ± 0.02, each. The aqueous extract showed the best anti-oxidative and lowest activity against the acetylcholinesterase; however, the 70% EtOH extract showed the opposite effects than that of the aqueous. No mortality incidence was visible at various doses, indicating that the oral median lethal dose of aqueous and 70% EtOH extracts were considered greater than 5000 mg/kg. N. sibirica L. belongs to the non-toxic category of the OECD 423 classification.
Anti-oxidative and Antibacterial Constituents from Sedum hybridum
Odontuya Gendaram,Yoen Hee Choi,김영섭,유시용 한국생약학회 2011 Natural Product Sciences Vol.17 No.4
Phytochemical studies on the whole extract of Sedum hybridum L., a Mongolian medicinal plant, has been undertaken to isolate active principles responsible for its anti-oxidative and antibacterial activities. Eighteen known compounds, i.e. (1) quercetin, (2) kaempferol, (3) herbacetin-8-O-b-D-xylopyranoside, (4) myricetin, (5) gossypetin-8-O-b-D-xylopyranoside, (6) gallic acid, (7) 2,4,6-tri-O-galloyl-D-glucopyranose, (8) 6-O-galloylarbutin, (9) myricetin-3-O-a-L-arabinofuranoside, (10) quercetin-3-O-a-L-arabinofuranoside, (11) caffeic acid, (12) ethylgallate, (13) (-) epigallocatechin-3-O-gallate, (14) palmitic acid, (15) stearic acid, (16) stearic acid ethyl ether, (17) b-sitosterol and (18) b-sitosteryl-O-b-D-glucopyranose have been isolated and their molecular structures identified by spectroscopic analysis. Thirteen substances including seven flavonol components (1, 2, 3, 4, 5, 9 and 10), five gallic acid derivatives (6, 7, 8, 12 and 13) and caffeic acid (11) exhibited significant, dose-dependent, DPPH radical scavenging activity. Galloyl esters 12 and 13 were revealed to be main active principles for the antibacterial property of the extract of Sedum hybridum L.
몽골 약용식물 추출물의 대장암 세포사멸 및 관련 스핑고지질 연구
서초희, 젠다람 오돈투야, 문동철, 이용문 충북대학교 약품자원개발연구소 2012 약학논문집 Vol.27 No.-
Plant secondary metabolites (PSM) Show promise for cancer chemoprevention based on previous studies. PSM related to chemopreventive reaction is both environmentally induced as well as genetically controlled and the plants growing under poor condition are more associated with chemoprevention. Mongolian plants are cultured in harsh conditions of extremely low and high temperature and consequently PSM contained in mongolian plants are expected to have diverse bioactivity. In this report, candidates which affect colorectal cancer cell viability and cell cycle are selected via WST-1 assay and PI staning. Stype extracts of 100type methanol extracts mongolian medicinal plant induced a dose dependently cell growth inhibition in HT29 (Human colon adenocarcinoma gradeII cell line) and selected candidates induced G2/M phase arrest and inhibited cell proliferation. Sphingolipids such as ceramide, sphingosine, spinganine, sphingosine-1-phosphate were analyzed using HPLC-FLD to find out relationship between 8 type potential mongolian plants extracts and spingolipid. Consequently ceramide, spingosine, sphinganine known as inducer of cancer cell apoptosis were increased while sphingosine-1-phoshate known as inducer of cancer cell proliferation was decreased. In conclusion, mongolian medicinal plants extracts induced cell death in colorectal cancer cells and that is related to sphingolipids.
Antimicrobial activity of Mongolian medicinal plants
Gonchig, Enkhmaa,Erdenebat, Sarnaizul,Togtoo, Ouyntsetseg,Bataa, Sukhkhuu,Gendaram, Odontuya,Kim, Young-Sup,Ryu, Shi-Yong The Korean Society of Pharmacognosy 2008 Natural Product Sciences Vol.14 No.1
The antimicrobial activity of seventy five ethanol extracts obtained from 67 different kinds of plant species of the Mongolian flora were evaluated by means of the disc diffusion method against five species of microorganisms, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Micrococcus luteus and Pseudomonas aeruginosa. Among the plant extracts examined, 34 kinds of extracts demonstrated significant antibacterial activity against one or more species of microorganisms, respectively. Especially, the root extract of Paeonia anomala, the whole herb extract of Myricaria alopecuroides, the whole herb extract of comarum zalesovianum, the whole herb extract of Agrimonia pilosa and some other plant extracts demonstrated a particularly potent antimicrobial activity. The ethylacetate fractions obtained from the whole herb extract of Myricaria alopecuroides and from those of Sedum aizoon, Paeonia anomala, Sedum hybridum and Dasiphora fruticosa exhibited a particularly potent antibacterial activity especially against Staphylococcus aureus and Micrococcus luteus.