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- 저자 : Gattani (검색결과 3 건)
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Prasad G. Jamkhande,Surendra G. Gattani,Shaikh Ayesha Farhat 한국한의학연구원 2016 Integrative Medicine Research Vol.5 No.4
Heart disease comprises a wide class of cardiovascular abnormalities, including ischemic heart disease, myocardial infarction, atherosclerosis, and coronary artery disease. It is the leading cause of death all over the world. Several traditional and novel risk factors, such as infectious and noninfectious agents, have been associated with heart disease. Out of these, Helicobacter pylori has been recently introduced as an important etiological factor for heart disease. Numerous seroepidemiological findings observed H. pylori antibodies in the blood of a patient with cardiovascular complications. The bacteria survive in the epithelial cells of gastric organs and cause digestive complications. Excess inflammatory pathogenesis and prognosis stimulate an immune response that further causes significant disturbances in various factors like cytokines, fibrinogen, triglycerides, high density lipoprotein, C-reactive protein, heat shock protein, and white blood cell count, and provoke a number of problems such as atherosclerosis and prothrombic state, and cross-reactivity which eventually leads to heart diseases. H. pylori releases toxigenic nutrients, chiefly vacuolating cytotoxin gen A (Vac A) and cytotoxin associated gene A (Cag A), of which Cag A is more virulent and involved in the formation of cholesterol patches in arteries, induction of autoimmune disorder, and release of immune mediated response. Although numerous mechanisms have been correlated with H. pylori and heart disease, the exact role of bacteria is still ambiguous.
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Pankaj Padmakar Nerkar,Surendra Ganeshlal Gattani 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7
Linseed is the crop that is used as a foodstuff inEuropean and Asian countries. The objective of the presentwork was to extract mucilage from linseed, utilize it asmucoadhesive gelling agent along with synthetic polymersand administration of venlafaxine by buccal route in the gelform. Buccal administration of venlafaxine will avoid firstpass metabolism, which will increase the bioavailability ofthe drug. Linseed mucilage based buccal mucoadhesive gelpreparations in combination with chitosan, carbopol 934P,carboxy methylcellulose and polyvinyl pyrrolidone wereformulated and the viscosity, gel strength, percentagemucoadhesion and in vitro diffusion of the formulation wasevaluated. Formulation (F2) was subjected to in vivoanalysis in rabbits. Formulation F2, which contained linseedmucilage (2 %) and chitosan (0.5 %), showed thehighest percentage of mucoadhesion, gel strength andsustained drug diffusion. The bioavailability by the oralroute and buccal route were compared with that of theintravenous route. The bioavailability of venlafaxine in theformulation F2 was 63.08 ± 1.28 % by buccal route,which was higher than by the oral route (39.21 ± 6.18 %). Based on these results, the combination of linseed mucilageand chitosan can be used to form a buccal mucoadhesivegel and increase the bioavailability of venlafaxine.
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Pradum Pundlikrao Ige,Surendra Ganeshlal Gattani 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.3
The aim of the current work was to design and develop matrix pellets of hydroxy propyl methyl cellulose K200M and microcrystalline cellulose in an admixture for a mucoadhesive gastroretentive drug delivery system. Pellets containing metformin hydrochloride (500 mg)were prepared by the pelletization technique using an extruder-spheronizer. Pellets were characterized by differential scanning calorimetry (DSC), x-ray diffraction (XRD), scanning electron microscopy (SEM), circularity, roundness, percent drug content, percent production yield, in vitro swelling, ex vivo mucoadhesion, in vitro drug release and in vivo x-ray imaging studies. Optimized pellets were sufficiently porous spheroids, free flowing, had smooth surfaces,had yields up to 75.45 ± 0.52% and had drug content up to 96.45 ± 0.19%. The average particle size of formulations MF2 and MF6 were 1.13 ± 0.41 mm and 1.22 ± 0.18 mm, respectively. Formulation MF6 exhibited strong adhesion, about 94.67%, to goat mucosal tissue, and the desired in vitro swelling, with a sustained drug release profile for 12 h and with retention in the upper small intestine of rabbits for 10 h. We conclude that hydroxy propyl methyl cellulose K200M and microcrystalline cellulose at a 2.80:1.00 w/w ratio could be an effective carrier for multiple unit controlled delivery of metformin hydrochloride.
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