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- 저자 : Frutuoso (검색결과 4 건)
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Blood level of adipokines and nutritional status variables in adolescent pregnancy
Mirela Douradinho Fernandes,Silvia Daher,Luciana Moraes de Sousa,Indiomara Baratto,Thalita Frutuoso Lobo,Edward Araujo Júnior,Cristina Aparecida Falbo Guazzelli 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.6
ObjectiveTo evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables duringpregnancy in adolescents. MethodsThis prospective cohort study evaluated eutrophic pregnant adolescents (body mass index [BMI], 18.5–24.9 kg/m2) during the 3 gestational trimesters (first, 10–14 weeks; second, 24–28 weeks; and third, 30–34 weeks). Serumadiponectin and leptin concentrations were measured using the enzyme-linked immunosorbent assay method. Therelationship of these adipokines with the pre-gestational BMI, gestational weight gain, weight at the time of samplecollection, and newborn weight were evaluated. Analysis of variance and the Kruskal-Wallis test were used forstatistical analysis. ResultsThe study group comprised 62 pregnant adolescents. The serum concentration of adiponectin showed a significantdifference between the first and third trimesters (P=0.003), which decreased during pregnancy, but unrelated tonutritional variables. Serum leptin levels increased throughout the pregnancy (P<0.0001) and showed a positivecorrelation with pre-gestational BMI, total weight gain, pregnancy weight at the time of sample collection, andnewborns’ weight. ConclusionSerum levels of adiponectin and leptin vary inversely throughout pregnancy. This pattern in adolescents is similar tothat observed in adults. Moreover, leptin concentrations increased throughout pregnancy, and they were positivelycorrelated with all variables evaluated.
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Chemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
José A.A. Santos,Andrea Calheiros,Diogo D. Nascimento,Ana Luiza R. Bérenger,Fábio C. Amendoeira,Hugo C. Castro-Faria-Neto,Maria Raquel Figueiredo,Luiz A. Alves,Valber da Silva Frutuoso 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Different species of the family Clusiaceae, including Rheedia longifolia, are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
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Antinociceptive Activity of Aqueous Extract of Bowdichia virgilioides in Mice
Juliane P. Silva,Renato S. Rodarte,Andrea S. Calheiros,Cristiane Z. Souza,Fabio C. Amendoeira,Marco A. Martins,Patrı´cia Machado R. Silva,Valber S. Frutuoso,Emiliano Barreto 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
Bowdichia virgilioides Kunth (Family Fabaceae) is a plant that is distributed widely in the tropical and subtropical regions of the world. In the northeast region of Brazil, where B. virgilioides is called “sucupira-preta,” the stem bark is used in folk medicine to treatment of inflammatory and painful diseases. This study aimed to evaluate the antinociceptive activity of the aqueous extract of the dried stem bark of B. virgilioides. The aqueous extract of B. virgilioides in doses of 50, 100, 200, and 400mg/kg was administered orally 1 hour prior to pain induction. Only the doses of 200 and 400mg/kg produced an inhibition by 61% and 74%, respectively, in the number of abdominal writhings induced by acetic acid. This antinociceptive effect was not reversed by pretreatment with naloxone, indicating that the effect is not associated with the activation of opioid receptors. In the formalin test, using the two highest doses, the extract had no effect in the first phase but produced an analgesic effect on the second phase with the inhibition of licking time (P<.001). In the hot plate test, no effect was seen at the dose of 400mg/㎏ p.o. Our findings show that B. virgilioides contains pharmacologically active constituents that possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions.
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José A.A. Santos,Antonio Augusto Fidalgo-Neto,Robson X. Faria,Ana Simo˜es,Andrea S. Calheiros,Ana Luiza Be´renger,Hugo C.C. Faria-Neto,Maria Raquel Figueiredo,Valber S. Luiz Frutuoso,Luiz Anastacio Al 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Recently, the P2X_7 receptor has been reported to be associated with chronic inflammatory and neuropathic pain. Because Rheedia longifolia extract has analgesic and anti-inflammatory activity, we evaluated the in vitro inhibitory potential of methanol extract and fractions from its leaves on the P2X_7 purinergic receptor. The activity of P2X_7 was studied with a dye uptake assay and with the whole-cell patch clamp technique in mouse peritoneal macrophages treated with methanol extract of R. longifolia leaves and fractions. The dye uptake was evaluated by flow cytometry and fluorescence microscopy. The R. longifolia extract and some fractions showed an inhibitory effect on the P2X_7 purinergic receptor in a dose-dependent manner. The ethyl acetate fraction exhibited the most potent inhibitory effects. The methanol extract and the butanol fraction showed the same inhibitory effects, despite their lower potency compared with the other fractions. The R. longifolia extract and some of its fractions may be anti-inflammatory because of their inhibitory effect on the P2X_7 receptor. Further investigation is needed to determine the pattern of inhibition and selectivity. Chromatographic analysis indicated the presence of bisflavonoids in the methanol extract fractions. A member of this chemical family is the most probable active compound responsible for the P2X_7 inhibitory effects present in the R. Longifolia extract and fractions.
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