DESIGN AND CONSTRUCTION OF AN EXPERIMENTAL CHANNEL OF HYDRAULICS FOR HIGH FROUDE NUMBERS

FRAGOSO MANUEL MONTENEGRO 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

Functional specialization of<i>Nicotiana attenuata</i>phytochromes in leaf development and flowering time : Dominant role of<i>NaPHYB</i>-clade in plant development

Fragoso, Variluska,Oh, Youngjoo,Kim, Sang-Gyu,Gase, Klaus,Baldwin, Ian Thomas Wiley (Blackwell Publishing) 2017 Journal of integrative plant biology Vol.59 No.3

<P>Phytochromes mainly function in photoautotrophic organisms to adjust growth in response to fluctuating light signals. The different isoforms of plant phytochromes often display both conserved and divergent roles, presumably to fine-tune plant responses to environmental signals and optimize fitness. Here we describe the distinct, yet partially redundant, roles of phytochromes NaPHYA, NaPHYB1 and NaPHYB2 in a wild tobacco species, Nicotiana attenuata using RNAi-silenced phytochrome lines. Consistent with results reported from other species, silencing the expression of NaPHYA or NaPHYB2 in N. attenuata had mild or no influence on plant development as long as NaPHYB1 was functional; whereas silencing the expression of NaPHYB1 alone strongly altered flowering time and leaf morphology. The contribution of NaPHYB2 became significant only in the absence of NaPHYB1; plants silenced for both NaPHYB1 and NaPHYB2 largely skipped the rosette-stage of growth to rapidly produce long, slender stalks that bore flowers early: hallmarks of the shade-avoidance responses. The phenotyping of phytochrome-silenced lines, combined with sequence and transcript accumulation analysis, suggest the independent functional diversification of the phytochromes, and a dominant role of NaPHYB1 and NaPHYB2 in N. attenuata's vegetative and reproductive development.</P>

Prediction-observer Scheme for Linear Systems with Input-output Time-delay

Varinia Fragoso-Rubio,Martín Velasco-Villa,Miguel A. Hernández-Pérez,Basilio del Muro-Cuéllar,Juan Francisco Márquez-Rubio 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.8

This work deals with the prediction and control problems associated with a class of linear systems with time-delay at the input-output path. A general prediction observer scheme that estimates the future value of the delayed system from the output is proposed. Later, a full-information predictor-observer is introduced and the convergence of the estimated future values is formally proven for a time-delay τ of any size by increasing the dimension of the proposed predictor-observer. The estimated future state is used to design a feedback law that compensates the delay effects on the original system. The performance of the prediction-observation control strategy is shown by means of numerical simulations. Thus, it is illustrated that the performance of the proposed full-information predictor-observer is improved with respect to the sequential sub-predictors previously presented in the literature.

Systematic review of the published data on the worldwide prevalence of John Cunningham virus in patients with multiple sclerosis and neuromyelitis optica

Yara Dadalti Fragoso 한국역학회 2018 Epidemiology and Health Vol.40 No.-

OBJECTIVES: John Cunningham virus (JCV) is a polyoma virus that infects humans, mainly in childhood or adolescence, andpresents no symptomatic manifestations. JCV can cause progressive multifocal leukoencephalopathy (PML) in immunosuppressedindividuals, including those undergoing treatment for multiple sclerosis (MS) and neuromyelitis optica (NMO). PMLis a severe and potentially fatal disease of the brain. The prevalence of JCV antibodies in human serum has been reported to bebetween 50.0 and 90.0%. The aim of the present study was to review worldwide data on populations of patients with MS andNMO in order to establish the rates of JCV seropositivity in these individuals. METHODS: The present review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)guidelines and used the following search terms: “JCV” OR “JC virus” AND “multiple sclerosis” OR “MS” OR “NMO” OR “neuromyelitisoptica” AND “prevalence.” These terms were searched for both in smaller and in larger clusters of words. The databasessearched included PubMed, MEDLINE, SciELO, LILACS, Google Scholar, and Embase. RESULTS: After the initial selection, 18 papers were included in the review. These articles reported the prevalence of JCV antibodiesin the serum of patients with MS or NMO living in 26 countries. The systematic review identified data on 29,319 patientswith MS/NMO and found that 57.1% of them (16,730 individuals) were seropositive for the anti-JCV antibody (range, 40.0 to69.0%). CONCLUSIONS: The median worldwide prevalence of JCV among adults with MS or NMO was found to be 57.1%.

Circadian clock component, lhy, tells a plant when to respond photosynthetically to light in nature

Joo, Youngsung,Fragoso, Variluska,Yon, Felipe,Baldwin, Ian T.,Kim, Sang‐,Gyu Wiley-Blackwell 2017 Journal of integrative plant biology Vol.59 No.8

Bacterial Structure and Characterization of Plant Growth Promoting and Oil Degrading Bacteria from the Rhizospheres of Mangrove Plants

Flávia Lima do Carmo,Henrique Fragoso dos Santos,Edir Ferreira Martins,Jan Dirk van Elsas,Alexandre Soares Rosado,Raquel Silva Peixoto 한국미생물학회 2011 The journal of microbiology Vol.49 No.4

Most oil from oceanic spills converges on coastal ecosystems, such as mangrove forests, which are threatened with worldwide disappearance. Particular bacteria that inhabit the rhizosphere of local plant species can stimulate plant development through various mechanisms; it would be advantageous if these would also be capable of degrading oil. Such bacteria may be important in the preservation or recuperation of mangrove forests impacted by oil spills. This study aimed to compare the bacterial structure, isolate and evaluate bacteria able to degrade oil and stimulate plant growth, from the rhizospheres of three mangrove plant species. These features are particularly important taking into account recent policies for mangrove bioremediation,implying that oil degradation as well as plant maintenance and health are key targets. Fifty-seven morphotypes were isolated from the mangrove rhizospheres on Bushnell-Haas (BH) medium supplemented with oil as the sole carbon source and tested for plant growth promotion. Of this strains, 60% potentially fixed nitrogen, 16% showed antimicrobial activity, 84% produced siderophores, 51% had the capacity to solubilize phosphate, and 33% produced the indole acetic acid hormone. Using gas chromatography, we evaluated the oil-degrading potential of ten selected strains that had different morphologies and showed Plant Growth Promoting Rhizobacteria (PGPR) features. The ten tested strains showed a promising degradation profile for at least one compound present in the oil. Among degrader strains, 46% had promising PGPR potential, having at least three of the above capacities. These strains might be used as a consortium,allowing the concomitant degradation of oil and stimulation of mangrove plant survival and maintenance.

Phytochemical Profile, Toxicity, and Pharmacological Potential of Peels from Four Species of Tropical Fruits

Lilian Dolores Chel-Guerrero,Enrique Sauri-Duch,Mabel Clara Fragoso-Serrano,Laura Josefina Perez-Flores,Jose Luis Gomez-Olivares,Noe Salinas-Arreortua,Edgar del Carmen Sierra-Palacios,Jose Alberto Men 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.7

Tropical fruit peels are generally discarded as waste, yet they contain bioactive substances that could have various uses; in addition, their pharmacological potential remains unexplored. This study aims to characterize the phytochemical profile, toxicity, and pharmacological potential of methanol extracts obtained from the peels of the following tropical fruit species: Annona squamosa L. (purple sugar apple), Annona reticulata L. (custard apple), Chrysophyllum cainito L. (green star apple), and Melicoccus bijugatus Jacq. (mamoncillo). Methanol peel extracts were obtained by maceration. All extracts contained flavonoids, anthraquinones, and triterpenoids as determined by colorimetric methods. A. squamosa and C. cainito exhibited the highest content of total phenols as assayed by the Folin–Ciocalteu method. M. bijugatus showed the highest content of total sugars (fructose, glucose, and sucrose) as determined by high-performance liquid chromatography. A. squamosa and C. cainito presented the highest antioxidant capacities (according to 2,2′-diphenyl-1-picrylhydrazyl, 2,2′-azinobis(3-ethylbenzothiazoline−6-sulfonic acid, and cupric reducing antioxidant capacity assays), displayed moderate toxicity against HCT-116 cells, and increased the vinblastine susceptibility of MCF-7/Vin+. A. squamosa and M. bijugatus extracts demonstrated modulation of acetylcholinesterase activity, whereas those of A. reticulata showed anti-inflammatory activity by inhibiting protein denaturation. These results confirm that tropical fruit peels can be valuable sources of bioactive compounds, and our findings provide new information about their pharmacologic potential so that they can be used as raw material for the development of new drugs aimed at treating a variety of ailments.

ACTH-Independent Macronodular Adrenal Hyperplasia

Livia M. Mermejo,Tânia L. Mazzuco,Solange Grunenwald,Maria Candida B. V. Fragoso,Isabelle Bourdeau,André Lacroix 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.1

ACTH-independent macronodular adrenal hyperplasia (AIMAH) is an uncommon cause of Cushing’s syndrome (CS). The pathophysiology of this disorder is heterogeneous in its molecular origin and also in its clinical presentation. AIMAH can present mainly as an incidental radiological finding with sub-clinical CS or rarely with overt CS. In a few familial cases reported with AIMAH, specific aberrant G-protein coupled receptors were expressed in the adrenals of all affected members, but sporadic cases are more common. The aberrant adrenal function of G-protein coupled receptors can lead to cell proliferation and abnormal regulation of steroidogenesis. Unilateral or bilateral adrenalectomy has been the most frequently used treatment for this adrenal disorder; alternatively,the identification of aberrant receptors using in vivo protocol of investigation can offer specific pharmacological approach to control abnormal steroidogenesis and possibly prevent AIMAH progression.

Systematic review of the published data on the Systematic review of the published data on the patients with multiple sclerosis and neuromyelitis optica

Sonia Patricia Castedo Paz,Luciana Branco,Marina Alves de Camargo Pereira,Caroline Spessotto,Yara Dadalti Fragoso 한국역학회 2018 Epidemiology and Health Vol.40 No.-

OBJECTIVES: John Cunningham virus (JCV) is a polyoma virus that infects humans, mainly in childhood or adolescence, and presents no symptomatic manifestations. JCV can cause progressive multifocal leukoencephalopathy (PML) in immunosuppressed individuals, including those undergoing treatment for multiple sclerosis (MS) and neuromyelitis optica (NMO). PML is a severe and potentially fatal disease of the brain. The prevalence of JCV antibodies in human serum has been reported to be between 50.0 and 90.0%. The aim of the present study was to review worldwide data on populations of patients with MS and NMO in order to establish the rates of JCV seropositivity in these individuals. METHODS: The present review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and used the following search terms: “JCV” OR “JC virus” AND “multiple sclerosis” OR “MS” OR “NMO” OR “neuromyelitis optica” AND “prevalence.” These terms were searched for both in smaller and in larger clusters of words. The databases searched included PubMed, MEDLINE, SciELO, LILACS, Google Scholar, and Embase. RESULTS: After the initial selection, 18 papers were included in the review. These articles reported the prevalence of JCV antibodies in the serum of patients with MS or NMO living in 26 countries. The systematic review identified data on 29,319 patients with MS/NMO and found that 57.1% of them (16,730 individuals) were seropositive for the anti-JCV antibody (range, 40.0 to 69.0%). CONCLUSIONS: The median worldwide prevalence of JCV among adults with MS or NMO was found to be 57.1%.

Focal Dermal Hypoplasia (Goltz Syndrome): A Case Report Showing a Wide Variety of Systemic and Oral Manifestations

Átila Vinícius Vitor Nobre,Mário Taba Júnior,Alfredo Ribeiro Silva,Sérgio Luís Scombatti de Souza,Ana Carolina Fragoso Motta 대한피부과학회 2022 Annals of Dermatology Vol.34 No.4

Focal dermal hypoplasia (FDH), also known as Goltz syndrome, consists of an unusual genodermatosis that affects tissues of ectodermal and mesodermal origin and various or- gans and systems, especially skin, bones, eyes, and oral cavity. While systemic manifesta- tions of FDH have been well documented, the oral manifestations have not been extensively discussed. We present a 22-year-old female patient with history of FDH that showed a variety of systemic and oral manifestations. FDH was diagnosed at birth based on cutane- ous alterations. Extra and intraoral examination showed facial asymmetry, lip and perioral atrophy, upper lip papilloma, malocclusion, enamel hypoplasia, and gingival hyperplasia. Mucosal lesions, periodontal diseases, and malocclusion were treated by oral surgery, peri- odontal therapy and orthodontic treatment, respectively. Although FDH is an uncommon syndrome, health professionals should be aware of its systemic and oral manifestations to establish an early diagnosis and adequate treatment.