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Filippo Numeroso,Gianluigi Mossini,Giuseppe Lippi,Gianfranco Cervellin 대한응급의학회 2017 Clinical and Experimental Emergency Medicine Vol.4 No.4
This meta-analysis aimed to establish the role of standardized emergency department (ED) observation protocols in the management of syncopal patients as an alternative to ordinary admission. A systematic electronic literature search was performed to identify randomized controlled trials or observational studies evaluating syncopal patients managed in ED observation units. Data regarding mean length of stay, rate of etiological diagnosis, admission rate, and incidence of shortterm serious outcomes were extracted. Six mostly single-center, small sized studies characterized by high heterogeneity, were included. A total of 458 patients were included with a balanced sex distribution (male 50.2%), a mean age of 60.1 years, and a considerable prevalence of heart disease (32.4%). Pooled analysis of the outcomes showed a mean stay of 28.2 hours, an etiological diagnosis rate of 67.3%, an admission rate of 18.5%, and a very low incidence of short-term serious outcomes (2.8%). Due to elevated diagnostic yield and low incidence of short-term adverse events, ED observation units-based management strategy seems ideal for patients with syncope. Nevertheless, further research is needed to identify criteria for selecting patients to be managed with this approach, define evaluation protocols, and confirm the safety of this strategy
Prevention of suspension bridge flutter using multiple tuned mass dampers
Filippo Ubertini 한국풍공학회 2010 Wind and Structures, An International Journal (WAS Vol.13 No.3
The aeroelastic stability of bridge decks equipped with multiple tuned mass dampers is studied. The problem is attacked in the time domain, by representing self-excited loads with the aid of aerodynamic indicial functions approximated by truncated series of exponential filters. This approach allows to reduce the aeroelastic stability analysis in the form of a direct eigenvalue problem, by introducing an additional state variable for each exponential term adopted in the approximation of indicial functions. A general probabilistic framework for the optimal robust design of multiple tuned mass dampers is proposed, in which all possible sources of uncertainties can be accounted for. For the purposes of this study, the method is also simplified in a form which requires a lower computational effort and it is then applied to a general case study in order to analyze the control effectiveness of regular and irregular multiple tuned mass dampers. A special care is devoted to mistuning effects caused by random variations of the target frequency. Regular multiple tuned mass dampers are seen to improve both control effectiveness and robustness with respect to single tuned mass dampers. However, those devices exhibit an asymmetric behavior with respect to frequency mistuning, which may weaken their feasibility for technical applications. In order to overcome this drawback, an irregular multiple tuned mass damper is conceived which is based on unequal mass distribution. The optimal design of this device is finally pursued via a full domain search, which evidences a remarkable robustness against frequency mistuning, in the sense of the simplified design approach.
Geotechnical and Hydrological Data Assimilation in Numerical Slope Stability Models
( Filippo Catani ),( Elena Benedetta Masi ),( Guglielmo Rossi ),( Gabriele Bicocchi ),( Veronica Tofani ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
Numerical models of slope stability may be applied to large areas in a way that is useful for early warning applications provided that some basic requirements are met. Among them, very important is the correct assimilation of soil mechanical and hydrological parameters, such as saturated hydraulic conductivity, cohesion and friction angle. Almost every single numerical parameter used in the numerical models shows a strong variability in space and cannot be directly measured at the same resolution of the finite element model. Therefore, an averaging and interpolation scheme must be devised which relies on the field measurements and on some statistical analysis to determine suitable probability distributions to be used in Monte Carlo analysis. In this presentation we report on the application of a complete methodology for field and laboratory testing of geo-hydrological parameters, their statistical analysis in terms of probability distributions and data assimilation into the High Resolution Slope Stability Simulator (Rossi et al., 2013) with the aim of implementing a near-real-time application of an early warning system for shallow landslides induced by rainfall in the region of Tuscany, Italy. Statistics on the main model parameters are presented and discussed as related to the main soil types found in the region, including grain size, mineralogical composition, shear strength, matric suction and hydraulic conductivity. Some preliminary data on vegetation effects are also presented, with reference to root effects and apparent root cohesion implementation in the numerical model. Some simulation examples are also presented.
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
Filippo Giacone,Rossella Cannarella,Laura M. Mongioì,Angela Alamo,Rosita A. Condorelli,Aldo E. Calogero,Sandro La Vignera 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.2
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic inves-tigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs.
Optimal battery selection for hybrid rocket engine
Filippo, Masseni Techno-Press 2022 Advances in aircraft and spacecraft science Vol.9 No.5
In the present paper, the optimal selection of batteries for an electric pump-fed hybrid rocket engine is analyzed. A two-stage Mars Ascent Vehicle, suitable for the Mars Sample Return Mission, is considered as test case. A single engine is employed in the second stage, whereas the first stage uses a cluster of two engines. The initial mass of the launcher is equal to 500 kg and the same hybrid rocket engine is considered for both stages. Ragone plot-based correlations are embedded in the optimization process in order to chose the optimal values of specific energy and specific power, which minimize the battery mass ad hoc for the optimized engine design and ascent trajectory. Results show that a payload close to 100 kg is achievable considering the current commercial battery technology.
Seismic response control of buildings with force saturation constraints
Filippo Ubertini,A. Luigi Materazzi 국제구조공학회 2013 Smart Structures and Systems, An International Jou Vol.12 No.2
We present an approach, based on the state dependent Riccati equation, for designing non-collocated seismic response control strategies for buildings accounting for physical constraints, with particular attention to force saturation. We consider both cases of active control using general actuators and semi-active control using magnetorheological dampers. The formulation includes multi control devices, acceleration feedback and time delay compensation. In the active case, the proposed approach is a generalization of the classic linear quadratic regulator, while, in the semi-active case, it represents a novel generalization of the well-established modified clipped optimal approach. As discussed in the paper, the main advantage of the proposed approach with respect to existing strategies is that it allows to naturally handle a broad class of non-linearities as well as different types of control constraints, not limited to force saturation but also including, for instance, displacement limitations. Numerical results on a typical building benchmark problem demonstrate that these additional features are achieved with essentially the same control effectiveness of existing saturation control strategies.