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      • KCI등재

        Felisberto Hernández y el relato pendiente: el proceso narrativo en El caballo perdido

        ( Carlos Fernández González ) 한국스페인어문학회(구 한국서어서문학회) 2020 스페인어문학 Vol.0 No.96

        This article aims to analyze a very particular plot device, the narrative techniques used by Felisberto Hernández in the construction of one of his most best-known stories: El caballo perdido (1943). The focus is placed on the deliberate delay, interruption and fragmentation of the narrative process which inexorably turns against the traditional plot progression. The relative importance of the story, the child’s perspective in the narrative elaboration, the role of the secrets in the plot, the complexity of the character-narrator, and the writing of the otherness are also explored in detail.

      • KCI등재

        Non-vaccination Against COVID-19 Among Venezuelan Refugees and Migrants Adults in Peru: A Cross-sectional Study, 2022

        Hernández-Vásquez Akram,Vargas-Fernández Rodrigo 대한예방의학회 2023 예방의학회지 Vol.56 No.5

        Objectives: The purpose of this study was to determine factors associated with non-vaccination against coronavirus disease 2019 (COVID-19) among the Venezuelan immigrant population residing in Peru.Methods: A cross-sectional study was conducted using data obtained from the Second Survey of the Venezuelan Population Residing in Peru in 2022. The dependent variable was vaccination status against COVID-19. The independent variables included socio-demographic, economic, and migratory characteristics of the included population. Crude and adjusted generalized linear Poisson-family models were used to calculate prevalence ratios with 95% confidence intervals (CIs).Results: A total of 7739 Venezuelan migrants aged 18 years or older were included. The proportion of non-vaccination against COVID-19 was 5.7%. Regarding associated factors, unemployment (adjusted prevalence ratio [aPR], 1.31; 95% CI, 1.04 to 1.65) was linked to an increased likelihood of not being vaccinated against COVID-19. In contrast, women (aPR, 0.76; 95% CI, 0.61 to 0.95), possessing a migration permit (aPR, 0.41; 95% CI, 0.31 to 0.54), and having health insurance (aPR, 0.47; 95% CI, 0.27 to 0.81) were associated with a decreased likelihood of being unvaccinated.Conclusions: The primary governmental and non-governmental institutions responsible for supporting and protecting the Venezuelan migrant and refugee population should improve vaccination access by issuing migration permits and providing health insurance.

      • SCISCIESCOPUS

        Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers

        Ferná,ndez-Moreira, Vanesa,Song, Bo,Sivagnanam, Venkataragavalu,Chauvin, Anne-Sophie,Vandevyver, Caroline D. B.,Gijs, Martin,Hemmilä,, Ilkka,Lehr, Hans-Anton,,nzli, Jean-Claude G. Royal Society of Chemistry 2010 The Analyst Vol.135 No.1

        <P>The lanthanide binuclear helicate [Eu<SUB>2</SUB>(L<SUP>C2(CO<SUB>2</SUB>H)</SUP>)<SUB>3</SUB>] is coupled to avidin to yield a luminescent bioconjugate <B>EuB1</B> (<I>Q</I> = 9.3%, <I>τ</I>(<SUP>5</SUP>D<SUB>0</SUB>) = 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows one to determine a luminophore/protein ratio equal to 3.2. Bio-affinity assays involving the recognition of a mucin-like protein expressed on human breast cancer MCF-7 cells by a biotinylated monoclonal antibody 5D10 to which <B>EuB1</B> is attached <I>via</I> avidin-biotin coupling demonstrate that (i) avidin activity is little affected by the coupling reaction and (ii) detection limits obtained by time-resolved (TR) luminescence with <B>EuB1</B> and a commercial Eu-avidin conjugate are one order of magnitude lower than those of an organic conjugate (FITC-streptavidin). In the second part of the paper, conditions for growing MCF-7 cells in 100–200 µm wide microchannels engraved in PDMS are established; we demonstrate that <B>EuB1</B> can be applied as effectively on this lab-on-a-chip device for the detection of tumour-associated antigens as on MCF-7 cells grown in normal culture vials. In order to exploit the versatility of the ligand used for self-assembling [Ln<SUB>2</SUB>(L<SUP>C2(CO<SUB>2</SUB>H)</SUP>)<SUB>3</SUB>] helicates, which sensitizes the luminescence of both Eu<SUP><SMALL>III</SMALL></SUP> and Tb<SUP><SMALL>III</SMALL></SUP> ions, a dual on-chip assay is proposed in which estrogen receptors (ERs) and human epidermal growth factor receptors (Her2/<I>neu</I>) can be simultaneously detected on human breast cancer tissue sections. The Ln helicates are coupled to two secondary antibodies: ERs are visualized by red-emitting <B>EuB4</B> using goat anti-mouse IgG and Her2/<I>neu</I> receptors by green-emitting <B>TbB5</B> using goat anti-rabbit IgG. The fact that the assay is more than 6 times faster and requires 5 times less reactants than conventional immunohistochemical assays provides essential advantages over conventional immunohistochemistry for future clinical biomarker detection.</P> <P>Graphic Abstract</P><P>Lanthanide luminescent bioprobes (LLBs) combined with microfluidics and lab-on-a-chip technology lead to fast dual assays of cancerous tissue biomarkers. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b922124g'> </P>

      • Experience of Virtual and Distance Training for Rural Teachers of Peru. Case study: Educational Robotics Course

        Fernández Morales, Cecilia,Iriarte Gómez, Fernando,Mejía Solano, Carmen,Revuelta Domínguez, Francisco Ignacio APEC국제교육협력원 2017 Asia-Pacific Cybereducation Journal Vol.13 No.2

        In Peru, according to the Census of Students (ECE) carried out by the Ministry of Education at 2016 (MINEDU), there are sustained differences between learning goals in rural and urban schools. There are more than 20 thousand educational robotic kits distributed nationwide. It requires trained teachers to develop their digital competence and integrate these resources into the teaching-learning process. In this context, a virtual course was designed and executed, showing rural teachers how to plan learning sessions that integrate Information and Communication Technologies (ICT) in their pedagogical practice. The course was validated with 2500 registered teachers. In the first court, 300 did not log into the virtual classroom, 500 did not to complete the course, 1170 remained active, 534 successfully completed the course and 473 gained a certificate through the virtual platform. In the second court, there are 667-registered teachers. The conclusions of the experience indicate that it is possible to implement strategies for electronic learning aimed at rural teachers in a sustainable and cost - effective way using ICT, which spontaneously create virtual communities of collaborative learning, which support the process allowing implementation the "Knowledge Management". This experience will allow us to make recommendations for rural education policy in Peru (Fernández Morales, Iriarte Gómez, Mejía Solano, & Revuelta Domínguez, 2017).

      • KCI등재

        Dietary encapsulated Bifidobacterium animalis and Agave fructans improve growth performance, health parameters, and immune response in broiler chickens

        Hernández-Granados María José,Ortiz-Basurto Rosa Isela,Jiménez-Fernández Maribel,García-Munguía Carlos Alberto,Franco-Robles Elena 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.4

        Objective: The present study was conducted to evaluate the effects of dietary supplementation with Bifidobacterium animalis, Agave fructans, and symbiotic of both encapsulated on growth performance, feed efficiency, blood parameters, and immune status in broiler chickens, and to compare these with diets including antibiotic growth promoters and without additives.Methods: A comparative experimental study was carried out with 135 male Ross 308 broiler chickens. Each trial was divided into 5 equal groups. Control group (CON) received a standard diet without growth promoter; GPA, a standard diet with colistin sulfate and zinc bacitracin (0.25 g/kg of feed); PRE, a standard diet with 1% Agave fructans; PRO, a standard diet with Bifidobacterium animalis (11.14±0.70 log CFU/g); SYM, a standard diet with B. animalis and Agave fructans.Results: A significant decrease in food consumption was found for the GPA, PRE, and SYM, compared to the CON group. The results show a better feed conversion index in PRE and GPA with respect to the CON group with the highest conversion index. Interestingly, the weight of the gastrointestinal tract shows a statistically significant difference between GPA and PRE groups. Moreover, the length of the gastrointestinal tract of the GPA group was less than the PRE group. In the total leukocyte count, there was a statistically significant increase in the GPA group compared to the CON, PRE, and PRO groups, and the heterophiles-lymphocytes index was lower in PRO. Regarding the cytokines, interleukin 10 (IL-10) decreased in PRO compared to CON and PRE, while IL-1β increased in the SYM group.Conclusion: Alternative treatments were shown to achieve similar productive results as growth-promoting antibiotics and showed improvement over diet without additives; however, they have immunomodulatory properties and improved the development of the gastrointestinal tract compared to the treatment of growth-promoting antibiotics. Objective: The present study was conducted to evaluate the effects of dietary supplementation with Bifidobacterium animalis, Agave fructans, and symbiotic of both encapsulated on growth performance, feed efficiency, blood parameters, and immune status in broiler chickens, and to compare these with diets including antibiotic growth promoters and without additives. Methods: A comparative experimental study was carried out with 135 male Ross 308 broiler chickens. Each trial was divided into 5 equal groups. Control group (CON) received a standard diet without growth promoter; GPA, a standard diet with colistin sulfate and zinc bacitracin (0.25 g/kg of feed); PRE, a standard diet with 1% Agave fructans; PRO, a standard diet with Bifidobacterium animalis (11.14±0.70 log CFU/g); SYM, a standard diet with B. animalis and Agave fructans. Results: A significant decrease in food consumption was found for the GPA, PRE, and SYM, compared to the CON group. The results show a better feed conversion index in PRE and GPA with respect to the CON group with the highest conversion index. Interestingly, the weight of the gastrointestinal tract shows a statistically significant difference between GPA and PRE groups. Moreover, the length of the gastrointestinal tract of the GPA group was less than the PRE group. In the total leukocyte count, there was a statistically significant increase in the GPA group compared to the CON, PRE, and PRO groups, and the heterophiles-lymphocytes index was lower in PRO. Regarding the cytokines, interleukin 10 (IL-10) decreased in PRO compared to CON and PRE, while IL-1β increased in the SYM group. Conclusion: Alternative treatments were shown to achieve similar productive results as growth-promoting antibiotics and showed improvement over diet without additives; however, they have immunomodulatory properties and improved the development of the gastrointestinal tract compared to the treatment of growth-promoting antibiotics.

      • KCI등재
      • HIGHEST REDSHIFT IMAGE OF NEUTRAL HYDROGEN IN EMISSION: A CHILES DETECTION OF A STARBURSTING GALAXY AT <i>z</i> = 0.376

        Ferná,ndez, Ximena,Gim, Hansung B.,Gorkom, J. H. van,Yun, Min S.,Momjian, Emmanuel,Popping, Attila,Chomiuk, Laura,Hess, Kelley M.,Hunt, Lucas,Kreckel, Kathryn,Lucero, Danielle,Maddox, Natasha,Oo American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.824 No.1

        <P>Our current understanding of galaxy evolution still has many uncertainties associated with the details of the accretion, processing, and removal of gas across cosmic time. The next generation of radio telescopes will image the neutral hydrogen (H I) in galaxies over large volumes at high redshifts, which will provide key insights into these processes. We are conducting the COSMOS H I Large Extragalactic Survey (CHILES) with the Karl G. Jansky Very Large Array, which is the first survey to simultaneously observe H I from z = 0 to z similar to 0.5. Here, we report the highest redshift H I 21 cm detection in emission to date of the luminous infrared galaxy COSMOS J100054.83+023126.2 at z = 0.376 with the first 178 hr of CHILES data. The total H I mass is (2.9 +/- 1.0) x 10(10) M-circle dot and the spatial distribution is asymmetric and extends beyond the galaxy. While optically the galaxy looks undisturbed, the H I distribution suggests an interaction with a candidate companion. In addition, we present follow-up Large Millimeter Telescope CO observations that show it is rich in molecular hydrogen, with a range of possible masses of (1.8-9.9) x 10(10) M-circle dot. This is the first study of the H I and CO in emission for a single galaxy beyond z similar to 0.2.</P>

      • KCI등재

        REAL-TIME VISION-BASED BLIND SPOT WARNING SYSTEM: EXPERIMENTS WITH MOTORCYCLES IN DAYTIME/NIGHTTIME CONDITIONS

        C. FERNÁNDEZ,D. F. LLORCA,M. A. SOTELO,I. G. DAZA,A. M. HELLÍN,S. ÁLVAREZ 한국자동차공학회 2013 International journal of automotive technology Vol.14 No.1

        This paper describes a real-time vision-based blind spot warning system that has been specially designed for motorcycles detection in both daytime and nighttime conditions. Motorcycles are fast moving and small vehicles that frequently remain unseen to other drivers, mainly in the blind-spot area. In fact, although in recent years the number of fatal accidents has decreased overall, motorcycle accidents have increased by 20%. The risks are primarily linked to the inner characteristics of this mode of travel: motorcycles are fast moving vehicles, light, unstable and fragile. These features make the motorcycle detection problem a difficult but challenging task to be solved from the computer vision point of view. In this paper we present a daytime and nighttime vision-based motorcycle and car detection system in the blind spot area using a single camera installed on the side mirror. On the one hand, daytime vehicle detection is carried out using optical flow features and Support Vector Machine-based (SVM) classification. On the other hand, nighttime vehicle detection is based on head lights detection. The proposed system warns the driver about the presence of vehicles in the blind area, including information about the position and the type of vehicle. Extensive experiments have been carried out in 172 minutes of sequences recorded in real traffic scenarios in both daytime and nighttime conditions, in the context of the Valencia MotoGP Grand Prix 2009.

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