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Federico Coccolini,Luca Campanati,Fausto Catena,Valentina Ceni,Marco Ceresoli,Jorge Jimenez Cruz,Marco Lotti,Stefano Magnone,Josephine Napoli,Diego Rossetti,Pierandrea De Iaco,Luigi Frigerio,Antonio P 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.1
Objective: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been recently reported with favorable oncological outcomes as treatment of advanced epithelial ovarian cancer (EOC). The aim of this study was to demonstrate the feasibility of CRS+HIPEC with cisplatin and paclitaxel for the treatment of advanced EOC. Methods: This is a prospective observational study of 54 patients, from April 2007 to October 2013, with primary or recurrent peritoneal carcinomatosis due to EOC. The mean age was 54.51±9.34. Thirty patients (59%) had primary EOC, and 24 patients (41%) had recurrent disease. Results: Mean peritoneal cancer index was 10.11 (range, 0 to 28), complete cytoreduction (CC0) was achieved for 47 patients (87%), CC1 for seven patients (13%). Patients with suboptimal cytoreduction (CC2 and CC3) were not included in the study. The mean stay in intensive care unit was 4.73±5.51 days and the mean hospitalization time was 24.0±10.03 days. We did not observe any intraoperative death. Seven patients (13%) required additional operations. Three patients (5.6%) died within 30 days from the procedure. Severe complications were seen in 19 patients (35.2%). During the follow-up period, disease recurred in 33 patients (61.1%); the median disease-free survival time was 12.46 months and the median overall survival time was 32.91 months. Conclusion: CRS+HIPEC with cisplatin and paclitaxel for advanced EOC is feasible with acceptable morbidity and mortality. Additional follow-up and further studies are needed to determine the effects of HIPEC on long term survival.
The European Union's Need for an International Auxiliary Language
Federico Gobbo 세종대학교 언어연구소 2005 Journal of Universal Language Vol.6 No.1
In the last few years, debate has centered around European Union language policy. Many people, language specialists and laymen alike, argue that the European Union should adopt a comon tongue for practical purposes, at institutional and educational levels, while respecting the cultural richness of other languages. Although English, or sometimes Latin, has been proposed, an International Auxiliary Language (IAL) would seem to accomplish this aim better. In this paper we will compare, structurally and sociolinguistically, three major IALs: Esperanto, Ido, and Interlingua, as candidates to serve as the comon language of the EU, on account of their language vigour and vitality.
Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?
( Federico Cacciapuoti ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.3
Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be responsible for hyperuricemia. The mechanisms underlying the association between these two conditions are unclear, but increased UA serum levels can be a consequence of renovascular atherosclerosis, with reduced UA excretion. An alternative hypothesis is the over-production of UA from adenosine (originating from S-adenosyl-homocysteine). Genetic polymorphism (C677T) of methyl-enetetrahydrofolate reductase (MTHFR) may contribute. A possible mechanism is purines biosyinthesis originating from this gene variant. However, the results obtained from several studies and meta-analyses of the relationship between H-Hcy and hy-peruricemia are ambivalent, and broader research is needed. (J Rheum Dis 2017;24:127-130)
30kW DC-DC Converters with Regenerative Mode for Electric Cars
Federico Ibanez,Javier Vadillo,Miguel Martinez-Iturralde Maiz,Jose Martin Echeverria 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2
This paper presents a design of a 30kW 250V/530V bidirectional DC-DC converter to be used in an electrical car. A detailed explanation of the design is given. The system uses two phase shifted half bridge (boost and buck) topologies to reduce the ripple current in the output capacitor. The converter has an efficiency of 95% at nominal power. It works as a constant voltage in one direction and as a constant current in the other to charge the batteries. Simulations and measurement are done at high power to test the efficiency.
The Calling of Asian Christian Scholars : A Biblical Scholar’s Perspective
( Federico G. Villanueva ) 아세아연합신학대학교 ACTS 신학연구소 2018 ACTS 신학저널 Vol.37 No.-
This article is an attempt to answer the question, what are we being called to do as biblical scholars in Asia today? What is our calling? Deriving inspiration from the story of the healing of the paralytic in Mark 2, this article critiques the traditional western biblical studies we inherited from the west. This approach sees the task of biblical studies as mere determination of “what the text meant in ancient times.” There is now acknowledgment that biblical studies is contextual. But this realization is also insufficient. There is a need to identify calls for a way of doing biblical studies that goes beyond the modern western approach to the discipline, which confines the text's meaning to the ancient time. Instead, as reflected in the view of the Bible as Scripture.
Federico Caobelli,Sara Vincenzina Gabanelli,Antonio Brucato,Claudio Pizzocaro,Alberto Soffientini,Raffaele Giubbini,Ugo Paolo Guerra 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.3
Sarcoidosis is a systemic chronic inflammatory disease of unknown aetiology, characterised by granulomatous lesions with heterogeneous clinical manifestations affecting multiple organs and tissues. Although the respiratory system is most commonly affected, the disease may also present with bone lesions. We report the case of a 31-yearold woman who presented with low back pain and no history of cancer and who was found to have suspicious lesions involving the entire spine on magnetic resonance imaging (MRI). The patient underwent 18F-fluorodeoxyglucose (FDG) PET/CT to search for a primary tumour and for staging purposes. 18F-FDG PET/CT revealed a pattern of hypermetabolic activity in widespread skeletal lesions and in a single left cervical lymph node. The primary tumour was not found, thus suggesting a haematologic disorder. Subsequent biopsies of a cervical lymph node and of bone tissue from L4revealed active sarcoidosis with no evidence of cancer. This underlines the importance of considering all alternatives when hypermetabolic lesions are found on 18F-FDG PET/CT. Furthermore, 18F-FDG PET can be very useful to indicate accessible sites for guiding fine-needle aspiration cytology (FNAC).