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José A.A. Santos,Antonio Augusto Fidalgo-Neto,Robson X. Faria,Ana Simo˜es,Andrea S. Calheiros,Ana Luiza Be´renger,Hugo C.C. Faria-Neto,Maria Raquel Figueiredo,Valber S. Luiz Frutuoso,Luiz Anastacio Al 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Recently, the P2X_7 receptor has been reported to be associated with chronic inflammatory and neuropathic pain. Because Rheedia longifolia extract has analgesic and anti-inflammatory activity, we evaluated the in vitro inhibitory potential of methanol extract and fractions from its leaves on the P2X_7 purinergic receptor. The activity of P2X_7 was studied with a dye uptake assay and with the whole-cell patch clamp technique in mouse peritoneal macrophages treated with methanol extract of R. longifolia leaves and fractions. The dye uptake was evaluated by flow cytometry and fluorescence microscopy. The R. longifolia extract and some fractions showed an inhibitory effect on the P2X_7 purinergic receptor in a dose-dependent manner. The ethyl acetate fraction exhibited the most potent inhibitory effects. The methanol extract and the butanol fraction showed the same inhibitory effects, despite their lower potency compared with the other fractions. The R. longifolia extract and some of its fractions may be anti-inflammatory because of their inhibitory effect on the P2X_7 receptor. Further investigation is needed to determine the pattern of inhibition and selectivity. Chromatographic analysis indicated the presence of bisflavonoids in the methanol extract fractions. A member of this chemical family is the most probable active compound responsible for the P2X_7 inhibitory effects present in the R. Longifolia extract and fractions.
Brazilian young dental practitioners' use and acceptance of digital radiographic examinations
Rovaris, Karla,de Faria Vasconcelos, Karla,do Nascimento, Eduarda Helena Leandro,Oliveira, Matheus Lima,Freitas, Deborah Queiroz,Haiter-Neto, Francisco Korean Academy of Oral and Maxillofacial Radiology 2016 Imaging Science in Dentistry Vol.46 No.4
Purpose: The aim of this study was to investigate the use and acceptance of digital radiographic examinations by Brazilian dental practitioners in daily practice and to evaluate the advances that have occurred over the past 5 years. Materials and Methods: Dental practitioners enrolled in extension courses at the Piracicaba Dental School, University of Campinas, Brazil, responded to a selfadministered questionnaire in the years 2011 and 2015. They were asked about sociodemographic factors and their knowledge and use of digital radiographic examinations. Descriptive analysis was performed, as well as the chi-square and Fisher exact tests, with a significance level of 5% (${\alpha}=0.05$). results: A total of 181 participants responded to the questionnaire in the years 2011 and 2015. Most of the respondents worked in private practice, had graduated within the last 5 years, and were between 20 and 30 years old. In 2011, 55.6% of respondents reported having ever used digital radiographic examinations, while in 2015 this number increased significantly to 85.4% (p<.0001), out of which 71.4% preferred it to conventional images. Moreover, 21.4% of respondents reported having used digital radiographic examinations for more than 3 years. A significant increase in use of intraoral digital radiography (p = 0.0316) was observed in 2015. In both years, image quality and high cost were indicated, respectively, as the main advantage and disadvantage of digital radiographic examinations. conclusion: This study showed that digital radiology has become more common in Brazil over the past 5 years. Most of the Brazilian dental practitioners evaluated in 2015 used digital radiographic examinations.
Brazilian young dental practitioners’ use and acceptance of digital radiographic examinations
Karla Rovaris,Karla de Faria Vasconcelos,Eduarda Helena Leandro do Nascimento,Matheus Lima Oliveira,Deborah Queiroz Freitas,Francisco Haiter-Neto 대한영상치의학회 2016 Imaging Science in Dentistry Vol.46 No.4
Purpose: The aim of this study was to investigate the use and acceptance of digital radiographic examinations by Brazilian dental practitioners in daily practice and to evaluate the advances that have occurred over the past 5 years. Materials and Methods: Dental practitioners enrolled in extension courses at the Piracicaba Dental School, University of Campinas, Brazil, responded to a self-administered questionnaire in the years 2011 and 2015. They were asked about sociodemographic factors and their knowledge and use of digital radiographic examinations. Descriptive analysis was performed, as well as the chi-square and Fisher exact tests, with a significance level of 5% (α=0.05). Results: A total of 181 participants responded to the questionnaire in the years 2011 and 2015. Most of the respondents worked in private practice, had graduated within the last 5 years, and were between 20 and 30 years old. In 2011, 55.6% of respondents reported having ever used digital radiographic examinations, while in 2015 this number increased significantly to 85.4% (p<.0001), out of which 71.4% preferred it to conventional images. Moreover, 21.4% of respondents reported having used digital radiographic examinations for more than 3 years. A significant increase in use of intraoral digital radiography (p=0.0316) was observed in 2015. In both years, image quality and high cost were indicated, respectively, as the main advantage and disadvantage of digital radiographic examinations. Conclusion: This study showed that digital radiology has become more common in Brazil over the past 5 years. Most of the Brazilian dental practitioners evaluated in 2015 used digital radiographic examinations.
Ferreira Alysson Dantas,Ferreira Suzana Dantas,Rodrigues de Farias Neto Severino 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.12
Pyrolysis has been one of the technologies used to convert biomass into biofuels. Therefore, mathematical models that can represent its phenomena are of fundamental importance in understanding the reaction progression and optimizing the process. In this sense, this study compared the results obtained from the lumped-capacitance thermal model proposed in this work with the thermal discretization model that considers thermal conductivity as a function of temperature. Then, the effect of operational parameters such as temperature, gas velocity, and biomass particle diameter, was compared on the reaction conversion rate. To describe the behavior and interaction between the phases, we utilized an Eulerian-Lagrangian CFD modeling approach, solving the continuity, momentum, energy, species, and turbulence equations using OpenFOAM. A factorial design of the type 2k was used to manipulate the model’s input parameters, with biomass conversion as the response variable. The numerical results of biomass conversion from the lumped-capacitance model showed good agreement with the data reported in the literature for the discretized model. However, we observed a difference of 9.13% in the particle mass behavior and 7.63% in the particle residence time. The design of experiments (DoE) enabled us to determine the impact of individual parameters and their interactions on the pyrolysis conversion rate with temperature identified as the most sensitive parameter. Therefore, despite the observed errors when comparing the two models, the lumped-capacitance model accurately represented the reaction yields and proved to be suitable for simulations involving a large number of particles, facilitating optimization studies.
Intelligent control system for extractive distillation columns
Thiago Gonçalves das Neves,Wagner Brandão Ramos,Gilvan Wanderley de Farias Neto,Romildo Pereira Brito 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.4
We developed and implemented an intelligent control system to be used in an extractive distillation column that produces anhydrous ethanol using ethylene glycol as solvent. The concept of artificial neural networks (ANN) was used to predict new setpoints after disturbances, and proved to be a fast and feasible solution. The developed control system receives data from temperature, flowrate and composition measurements of the azeotrope feed, and the ANN estimates the new set-points of the controllers to maintain 99.5mol% of ethanol at the top and less than 0.1mol% at the bottom; feed composition was also estimated using an ANN. All ANN were trained to provide output data corresponding to an optimized operating condition. The results showed that the intelligent control system can predict a new operating condition for any disturbance in the column feed and presented superior performance when compared with the control system without ANN.
Clinical and radiographic characteristics of pycnodysostosis: A systematic review
Goes Gonzaga Amanda Katarinny,de Oliveira Costa Carla Samily,de Farias Morais Hannah Gil,da Fonseca Neto Braz,Pinto Leão Pereira,Maciel Dantas Wagner Ranier,de Oliveira Patricia Teixeira,de Melo Danie 대한영상치의학회 2024 Imaging Science in Dentistry Vol.54 No.1
Purpose: Pycnodysostosis (PYCD), an autosomal recessive syndrome, is characterized by an imbalance in bone remodeling that produces various clinical and radiographic craniofacial manifestations. This review represents a systematic examination of these manifestations, as well as oral features associated with PYCD. Materials and Methods: A systematic review was conducted across 8 databases from February to March 2023. The search strategy focused on studies reporting cases of PYCD that examined the clinical and radiographic craniofacial and oral characteristics associated with this syndrome. Results: The review included 84 studies, encompassing a total of 179 cases of PYCD. More than half of the patients were female (55.3%), and the mean age was 14.7 years. Parental consanguinity was reported in 51.4% of the cases. The most common craniofacial clinical manifestation was a prominent nose, observed in 57.5% of cases. Radiographically, the most frequently reported craniofacial characteristics included the presence of an obtuse mandibular angle (84.3%) and frontal cranial bosses (82.1%). Clinical and radiographic examinations revealed oral alterations, with micrognathia present in 62.6% of patients and malocclusion in 59.2%. Among dental anomalies, tooth agenesis was the most commonly reported, affecting 15.6% of patients. Conclusion: Understanding the clinical and radiographic craniofacial features of PYCD is crucial for dental professionals. This knowledge enables these clinicians to devise effective treatment plans and improve patient quality of life.
Mauro Cosme de Carvalho Góes,Marcos Paulo Ribeiro Garcez,Andréa Roberta Ferreira Siqueira,Thiago Palhares Farias,Claudemir Gomes de Santana,Jonas de Jesus Gomes da Costa Neto,Cicero Wellington Brito B 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.8
Textile wastewaters currently remain as one of the major sources of environmental pollution. In addition to the presence of several recalcitrant species, the volume of the effluent to be treated is usually quite high, due to the excessive consumption of water in this kind of processing. To avoid all the negative impacts associated with the discharge of these untreated effluents, effective remediation techniques should be applied. Although there are currently several methods available, due to complexity and volume of the wastewater, combined technologies can provide better efficiency, lower cost and less time consumption. In this work, electrocoagulation (EC) combined with the conventional flocculation process was studied for the removal of methylene blue dye (MB) in aqueous medium. Under specific EC conditions (4 pairs of electrodes, 2.5 cm spacing, electrolysis time of 203min, pHinitial 4, 32 V, 1.5 A) it was possible to remove 63% of the dye. Combining EC with conventional flocculation, a notable reduction in electrolysisrequired time (203 to 60 min), dye (99.8%), color (100%) and turbidity (99.2%) was observed.
Chemical Profile and Antinociceptive Efficacy of Rheedia longifolia Leaf Extract
José A.A. Santos,Andrea Calheiros,Diogo D. Nascimento,Ana Luiza R. Bérenger,Fábio C. Amendoeira,Hugo C. Castro-Faria-Neto,Maria Raquel Figueiredo,Luiz A. Alves,Valber da Silva Frutuoso 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Different species of the family Clusiaceae, including Rheedia longifolia, are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.