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Fanli Qu,Rui Chen,Yang Peng,Ying Ye,Zhenrong Tang,Yihua Wang,Beige Zong,Haochen Yu,Shengchun Liu 한국유방암학회 2020 Journal of breast cancer Vol.23 No.3
Purpose: Effective predictors of the response to neoadjuvant chemotherapy (NAC) are still insufficient. This study aimed to investigate the predictive value of serum lipid profiles for the response to NAC in breast cancer patients. Methods: A total of 533 breast cancer patients who had received NAC were retrospectively studied. The pretreatment of serum lipids, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipoprotein-α, and clinicopathological characteristics were collected to assess their predictive roles. Results: Breast cancer patients had significantly lower TC, TG, HDL-C, and LDL-C levels than normal individuals. Among these indicators, TG and LDL-C levels and HDL-C level increased and decreased significantly after NAC, respectively. In estrogen receptor (ER)-positive patients, increased LDL-C level was associated with better outcomes. Moreover, the receiver operating characteristic curve analyses suggested that TG and HDL-C levels at diagnosis can be used as predictors of the response to NAC only in the ER-positive subgroup. According to univariate analyses, patients with low TG level (< 1.155 mmol/L) or high HDL-C level (≥ 1.305 mmol/L) in the ER-positive subgroup had more favorable clinical responses than the other patients in the subgroup. Furthermore, according to multivariate analyses, a high HDL-C level (≥ 1.305 mmol/L, p = 0.007) was an independent predictor of NAC efficacy. Conclusion: High HDL-C level (≥ 1.305 mmol/L) before NAC and increased LDL-C level after NAC were associated with the better treatment response in ER-positive breast cancer patients. These results are potentially considered beneficial in establishing treatment decisions.
Fanli Zeng,Yanyan Tian,Shuliang Shi,Qiong Wu,Shanshan Liu,Hongxia Zheng,Lei Yue,Yu Li 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.3
MARVEL domain-containing 1 (MARVELD1) is a newly identified nuclear protein; however its function has not been clear until now. Here, we report that mouse MARVELD1(mMARVELD1), which is highly conserved between mice and humans, exhibits cell cycle-dependent cellular localization. In NIH3T3 cells, MARVELD1 was observed in the nucleus and at the perinuclear region during interphase,but was localized at the mitotic spindle and midbody at metaphase, and a significant fraction of mMARVELD1translocated to the plasma membrane during anaphase. In addition, treatment of cells with colchicine, a microtubuledepolymerizing agent, resulted in translocation of mMARVELD1to the plasma membrane, and association of mMARVELD1 and α-tubulin was confirmed by co-immunoprecipitation. Finally, overexpression of mMARVELD1 resulted in a remarkable inhibition of cell proliferation, G1-phase arrest, and reduced cell migration. These findings indicate that mMARVELD1 is a microtubule-associated protein that plays an important role in cell cycle progression and migration.
Design of a UWB Antenna with Band-Notch Function
Zeng Fanli,Jaewon Lee,Chulhee Kim,Jaehoon Choi 한국전자파학회JEES 2010 Journal of Electromagnetic Engineering and Science Vol.10 No.1
In this paper, a compact wideband antenna with a band-notch function is proposed. It operates over the UWB band with a band-stop characteristic. To increase the impedance bandwidth, a ring-shaped radiator is used. By attaching a circular stub to the ring-shaped radiator, the band-notch performance is obtained. The proposed antenna operates over a frequency range from 2.7 ㎓ to 11 ㎓ to satisfy the 10-㏈ return-loss requirement and provides band-stop performance in the frequency band from 5.15 ㎓ to 6.1 ㎓. Experimental results reveal that the proposed antenna exhibits good radiation performance and is suitable for UWB applications.
Vibration response analysis caused by rubbing between rotating blade and casing
Hui Ma,Fanli Yin,Xingyu Tai,Di Wang,Bang-chun Wen 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.5
Two types of blade-tip rubbing due to the static misalignment of the bladed-disk center and casing center and casing deformation are simulated. By applying aerodynamic load in the blade lateral/flexural direction, vibration responses due to blade-casing rubbing are analyzed under the run-up process with constant angular acceleration and the steady-state process at 10000 rev/min. The effects of some parameters, such as the static misalignment e c , casing stiffness k c and casing deformation n p , on the system vibration responses are also illustrated by spectrum cascades, time-domain waveforms of displacement, normal rubbing forces, amplitude spectra and the impulse P in a single blade-casing rubbing period. The results show that blade-tip rubbing will cause amplitude amplification and harmonic resonance phenomena when the multiple frequencies (nf r ) of rotational frequency (f r ) coincide with the first three flexural dynamic frequencies of the blade (f n1 , f n2 and f n3 ). For example, the displacement amplitudes at 3f r , 14f r and 38f r are large and the vibration is dominant near f n1 . In addition, the casing deformation mainly excites the dominant Blade passing frequency (BPF), which is related to the casing deformation coefficient n p . By comparing these impulse values, for the selected parameters in this paper, the casing stiffness has a greater effect on impulse than the static misalignment and casing deformation coefficient. The impulse shows a linear increase trend with the increasing static misalignment, and it decreases under the large n p because the contact time decreases with the increase of n p .
Guohu Chen,Xinyu Ye,Fanli Zeng,Jian Wang,Lingyun Yuan,Shidong Zhu,Jinfeng Hou,Yuan Cheng,Chenggang Wang 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.3
The novel male sterility line 12-14A of Wucai ( Brassica campestris ) was generated by backcrossing. In this study, morphological,molecular, and cytological analyses were performed to characterize this line. The phenotypes of fl ower organsof 12-14A were diff erent from those of its maintainer line 12-14B, as the fl owers of 12-14A were completely infertile. Molecular analysis confi rmed that the male sterility line 12-14A was classifi ed as the ogu CMS type. An analysis of antherdevelopment in the CMS line demonstrated that two types of abortion occur simultaneously: pollen mother cell abortionand tetrad-to-mononuclear microspore abortion. In addition, the mature anthers of 12-14A showed typical abortive features,such as appearing dry, shrunken, and scaly. A heterosis test of hybrids from CMS 12-14A and four inbred lines was carriedout, and the F 1 hybrids exhibited clear heterosis in plant weight, as well as in the protein, soluble sugar, and vitamin C content,suggesting high yields and high quality potential. These results indicate that this novel CMS line may have powerfulpotential in Wucai hybrid breeding.
Experimental Research for Performance and Noise of Small Axial Fan
Ito, Takahiro,Minorikawa, Gaku,Fan, Qinyin Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.2
Small axial fans have become widely used as cooling devices in recent years. Because of their increasing importance, studies have been conducted on ways to improve the performance and reduce the noise of such fans. In this report, a small axial fan with a diameter of 85 mm (a type popularity used in personal computer or workstation) was selected for further examination. The influence on aerodynamic performance and noise of such frame design parameters as blade tip clearance results in a decrease of discrete frequency noise and an increase of broad-spectrum noise. As for the most suitable design refinement in terms of fan efficiency, we found that the treatment of outlet corner roundness and altering spoke skew to the direction counter to that of fan rotation was effective.
Real-Time Repairable Interpolation Scheme for CNC Tool Path Processing
Wei Fan,Chen-Han Lee,Ji-Hong Chen 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.12
G01 trajectory is widely-adopted for CNC machining. The piecewise linear trajectory is geometrically discontinuous, bringing about drastic fluctuation of feedrate and acceleration, and causing low machining efficiency and quality. Many methods of trajectory smoothing are developed and applied in CNC system. However some shortcomings exist when these methods were applied in CNC machining. In the existing methods, the following requirements are not satisfied simultaneously: not less than G2 continuity, confined chord error, shape preservation, interpolating G01 points, spatial applicability, real-time performance of algorithm, free geometric form. Considering various requirements of CNC machining, this work develops an interpolation scheme with local repairing function to deal with the possible shape deficiencies of trajectory. The resulting tool path has G2 continuity and is optimized in bending energy under shape-preserving and chord error constraints. Combining with jerk-limited feedrate scheduling, a real-time tool path processing strategy is developed. The simulation demonstrates the proposed method eliminates shape deficiencies, and has apparent advantage in the reduction of contour error, curvature, bending energy and machining time, compared with Zhao’s and Fan’s methods. The experiment demonstrates the advantages of the proposed algorithm in improving the quality of machined surface and machining efficiency, compared with previous methods.