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Fang, Hong,Lin, Rong-Yan,Sun, Ming-Xia,Wang, Qian,Zhao, Yu-Liang,Yu, Jing-Lin,Tian, Yan,Wang, Xiao-Yun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Objective: To analyze the efficacy and survival associated factors of gefitinib combined with cisplatin and gemcitabine for advanced non-small cell lung cancer. Materials and Methods: A total of 57 patients with advanced non-small cell lung cancer (NSCLC), who received platinum-based chemotherapy regimens for more than 1 cycle, were treated with gefitinib combined with cisplatin and gemcitabine until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. Results: The patients were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 patients, there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three-year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and diarrhea and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain metastasis was foudn in 31.6% (18/57). Conclusions: Gefitinib combined with cisplatin andgemcitabine, is effective for patients with IIIb~IV NSCLC who received multiple cycles of chemotherapy.
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Uniqueness of Meromorphic Functions Concerning the Difference Polynomials
LIU, FANGHONG,YI, HONGXUN Department of Mathematics 2015 Kyungpook mathematical journal Vol.55 No.2
In this article, we main study the uniqueness problem of meromorphic function which difference polynomials sharing common values. We consider the entire function $(f^n(f^m-1)\prod_{j=1}^{s}f(z+c_j)^{{\mu}j})^{(k)}$ and the meromorphic function $f^n(f^m-1)\prod_{j=1}^{s}f(z+c_j)^{{\mu}j}$ to get the main results which extend Theorem 1.1 in paper[5] and theorem 1.4 in paper[6].
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Thermally Healable Polyurethanes Based on Furfural-Derived Monomers via Baylis-Hillman Reaction
Qinghua Huang,Fanghong Yang,Xingxing Cao,Zhongyu Hu,Chuanjie Cheng 한국고분자학회 2019 Macromolecular Research Vol.27 No.9
Two novel acrylate monomers with diol group, 2-hydroxyethyl 2-(furan- 2-yl(hydroxy)methyl)acrylate and methyl 2-(hydroxy(5-(hydroxymethyl)furan-2- yl)methyl)acrylate, were synthesized via Baylis-Hillman reaction in moderate yields. The monomer 2-hydroxyethyl 2-(furan-2-yl(hydroxy)methyl)acrylate was obtained from furfural and 2-hydroxyethyl acrylate (HEA); methyl 2-(hydroxy(5-(hydroxymethyl)furan- 2-yl)methyl)acrylate was prepared from 5-hydroxymethl furfural (HMF) and methyl acrylate. The monomer 2-hydroxyethyl 2-(furan-2-yl(hydroxy)methyl)acrylate reacted with toluene diisocyanate (TDI)-derived or hexamethylene diisocyanate (HDI)-derived diisocyanate oligomers to obtain the corresponding linear polyurethane oligmers PU-1T and PU-1H. Similarly, the diol methyl 2-(hydroxy(5-(hydroxymethyl)furan- 2-yl)methyl)acrylate reacted with TDI- or HDI-derived diisocyanate oligomers to obtain the corresponding linear polyurethane oligmers PU-2T and PU-2H. The numberaverage molecular weights of the linear polyurethane oligomers are approximately 300-350 Da. There are furan groups in the linear polyurethane oligomers PU-1T, PU-1H, PU-2T and PU-2H, which makes them capable of undergoing reversible Diels-Alder reaction with 4,4'- bismaleimidodiphenylmethane (BMI) to form the corresponding crosslinked polyurethanes CPU-1T, CPU-1H, CPU-2T and CPU-2H. Pencil hardness of CPU-1T, CPU-1H, CPU-2T and CPU-2H are 3H, 2H, 2H and HB, respectively. Glass transition temperatures of CPU-1T, CPU- 1H, CPU-2T and CPU-2H are 104.8, 97.6, 5.1 and 1.2 oC, respectively. TGA analysis shows that Td90 values of the CPUs range from 180 to 250 oC. Furthermore, the reversible crosslinked polyurethanes CPU-1T and CPU-1H can be completely self-healed at 90 oC for 3 h, while CPU-2T and CPU-2H can self-heal at 80 oC for 3 h presumably due to their low glass transition temperatures.
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Yunong Li,Dening Zou,Wanwan Chen,Yingbo Zhang,Wei Zhang,Fanghong Xu 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8
To study and understand the solidification behavior of super austenitic stainless steel under different cooling rates and segregationlaws of alloying elements is of great significance to optimize the subsequent diffusion annealing homogenizationtreatment process and improve product quality. According to Thermo-Calc thermodynamic simulation results and combinedwith high temperature laser confocal scanning electron microscope (HT-CSLM), the tissue morphology of 904L superaustenitic stainless steel was observed in-situ during solidification. The solidification path of the test steel was determinedvia calculation with the Scheil-Gulliver model. Microscopy techniques, including true color microscopy, scanning electronmicroscopy (SEM), energy dispersive spectrometer (EDS), and electron probe microanalyzer (EPMA) were used to analyzethe influence of different cooling rates (6 ℃/min, 50 ℃/min, and 100 ℃/min) on the solidification structure and determine themain distribution law of alloying elements. This analysis determined that the solute distribution coefficient (K) of Cr, Mn,Mo, Cu, and Si elements is less than 1 during the solidification process, which means that they will accumulate in the liquidphase. Among them, elemental Mo segregation is the most severe, while elemental Ni hardly segregates. As the cooling rateincreases, the crystallization temperature of the test steel decreases, and the secondary dendrite arm spacing λ2 decreases,the concentration of Mo in the residual liquid phase increases.
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