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      • KCI우수등재

        TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

        Faith Fore,Cut Indriputri,Janet Mamutse,Jusak Nugraha 대한면역학회 2020 Immune Network Vol.20 No.3

        TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.

      • A Biblical-Theological Analysis of Matthew 6:19-34 and Implications for Contemporary Christians

        ( Faith Ochenia Opade ) 삼육대학교 선교와사회문제연구소 2019 Asia-Africa Journal of Mission and Ministry(AAMM) Vol.20 No.-

        The Preaching of Jesus usually refered to as the Sermon on the Mount (SOM) covers chapters 5-7 of the Matthian Gospel. Various issues were addressed by Jesus in this proclamation, but the focus of this paper is the issue addressed about the expected Christian’s disposition to money (mammon). There have been diverse perspectives to how practicable are Jesus’ presentations in the SOM: First that the Sermon is impossible praxis; second that the Sermon is apocalyptic in nature, so, it is not expected to be practiced now; third, that the sermon is only applicable during the millennia reign of Christ; fourth, that the Sermon is a representation of the ideal but not reality. And the fifth position is that the Sermon is practicable both in the public and private spheres of mankind. Thus, this paper alludes to the fifth position, and thus presents the admonition of Jesus in Matthew 6:19-34 as practicable for Christians. Jesus addressed the issue of material wealth in this passage, but the literary analysis did not show that Jesus was referring to money explicitly. However, in Jesus’ addressing the relationship between His disciples and material wealth, it was noted that money was implied. Therefore, there is a demand on the Christian disciple to neglect allegiance to money in favour of allegiance to God.

      • KCI등재

        Anal Adenocarcinoma Can Masquerade as Chronic Anal Fistula in Asians

        Faith Qi-Hui Leong,Dedrick Kok Hong Chan,Ker-Kan Tan 대한대장항문학회 2019 Annals of Coloproctolgy Vol.35 No.1

        Purpose: Perianal adenocarcinoma arising from a chronic anorectal fistula is a rare condition for which the natural history and optimal management are not well established. For that reason, we conducted a retrospective analysis of 5 consecutive patients with a perianal adenocarcinoma arising from a chronic anorectal fistula managed at our institution from January 2014 to December 2015. Methods: The patients were identified from a prospectively collected colorectal cancer database that included all patients managed for colorectal cancer at our institution. Results: The median age at diagnosis was 64 years (range, 55–72 years). Magnetic resonance imaging (MRI) was the initial investigation for all patients and showed a hyperintense T2-weighted image. One patient underwent an abdominoperineal resection following neoadjuvant chemoradiotherapy and remained disease free during the 12-month follow-up. Three patients received neoadjuvant therapy with intent for surgery, but did not undergo surgery due to either worsening health or metastatic spread. One patient declined intervention. The median overall survival was 10.5 months (range, 2–19 months). Conclusion: A high index of suspicion is required to make a clinical diagnosis of an anal adenocarcinoma arising from a chronic fistula. Histologic diagnosis must be achieved to confirm the diagnosis. Multimodal therapy with neoadjuvant chemoradiotherapy followed by abdominoperineal resection is the treatment of choice.

      • KCI등재

        Radiological Environmental Consequence Analysis of Hypothetical Severe Accidents at Nuclear Power Plants

        Faith Rukundo,Juyoul Kim(김주열) 대한환경공학회 2019 대한환경공학회지 Vol.41 No.8

        본 연구에서는 국내 원자력발전소의 가상 중대사고시 RASCAL 및 HYSPLIT 코드를 사용해 방사선 환경영향분석을 수행하였다. 후쿠시마 사고와 벤치마킹 분석을 통해 대기로 유출된 방사선원항이 기존의 연구결과와 동일한 크기 자릿수로 합리적인 범위 내에 있음을 입증하였다. 또한 후쿠시마 사고와 유사한 장기전원상실사고를 가정하여 신고리 3, 4호기의 노심용융에 따른 영향평가를 수행한 결과, 사고로 인해 대기환경으로 유출된 방사성물질의 양은 상당하였으며 총 방사선원항은 4.1×10<SUP>16</SUP> Bq로 평가되었다. 국내 방사능방재 규제기준은 사고후 예상 주민피폭선량이 2일에 10 mSv를 초과하면 옥내대피를, 1주일에 50 mSv를 초과하면 주민소개를 권고한다. 총유효선량당량은 신고리 원자력발전소로부터 반경 4.83 km에서 11 mSv, 1.61 km에서 50 mSv로 평가되었으며 비상시 주민보호조치가 신속히 이행되어야 하는 것으로 확인되었다. Analysis of radiological environmental consequences for hypothetical severe accidents at Korean nuclear power plants (NPPs) was performed using radiological assessment system for consequence analysis (RASCAL) and hybrid single particle Lagrangian integrated trajectory (HYSPLIT) code. Through the benchmarking study of radiological source terms released to the atmosphere in case of Fukushima Daiichi NPP (FDNPP) accident, it was proved that the results of this study would fall within a reasonable range of the same order of magnitude compared with existing research results. Assuming a long-term station blackout (LTSBO) similar to FDNPP accident, we also analyzed the potential consequences of Shin Kori units 3 and unit 4 following postulated reactor core meltdown accidents which would lead to large releases of radioactive materials to the atmospheric environment and total source terms were estimated to be 4.1×10<SUP>16</SUP> Bq. Korean regulatory standards of emergency management recommended immediate protective actions of sheltering-in-place and evacuation if the projected radiation doses to the population exceeded 10 mSv and 50 mSv in the first 2 days and 1 week after the accident, respectively. It was found that total effective dose equivalent (TEDE) ranged from 11 mSv at 4.83 km to 50 mSv at 1.61 km around Shin Kori NPPs and therefore urgent public protective actions should be implemented in case of an emergency.

      • KCI등재

        Trend and Future of Virtual Reality for Addiction Treatment of Substance Use Disorders: A Systematic Review

        Narcie Faith Amista,KIM JINSOO JASON,김나미 한국디지털콘텐츠학회 2017 한국디지털콘텐츠학회논문지 Vol.18 No.8

        The aim of this review is to analyze the trend of using Virtual Reality (VR) in addiction treatment by categorizing the types of addictions and methods of Virtual Reality Therapy (VRT) for substance use disorders. VR has been utilized as a new paradigm for treating various mental and psychological problems. In recent years, a number of researches have been done to demonstrate the effectiveness of VRT for addiction treatment, specifically substance use disorders. In order to comprehend the tendency of these researches, the current study performed a systematic review of published book and journal articles using the following bibliographical databases: ScienceDirect, MEDLINE, ProQuest, and Embase. Forty-five (45) articles were retrieved; out of these researches, nicotine/smoking has garnered the highest number of studies (73%, n=33); alcohol (18%, n=8); cannabis/marijuana (2%, n=1); and other drugs such as heroin, cocaine and methamphetamine (7%, n=3). This paper analyzed the results of those studies, found some limitations as well as strengths, and made suggestions for further research on VRT for addiction treatment.

      • KCI등재

        Characterizing malaria spatial distribution in the province of Palawan, Philippines

        Nicole Faith D. Blanco,Arnold R. Salvacion,Ma. Catriona E. Devanadera,Edwin R. Abucay,Ricardo A. Sandalo 대한공간정보학회 2022 Spatial Information Research Vol.30 No.2

        Palawan, an island province in the Philippines, accounts for ninety percent of the country’s malaria cases. A total of 18 of 23 municipalities and one city in Palawan remain malaria-endemic, placing the population at risk of infection despite continuous preventive measures. This study describes trends and analyzes the spatial distribution of confirmed malaria cases in Palawan during eleven-year period (2005–2015). The reported monthly positive malaria cases per municipality from 2005 to 2015 were obtained from the Provincial Health Office, which was aggregated and used in trend and spatial analysis. High malaria risk areas were determined using the Moran’s I and Getis-Ord Gi*. The Mann–Kendall test results revealed that there had been a significant downward trend of confirmed positive cases from 2005 to 2015, with transmission peaks in 2007 and 2010. Among the three districts in the province, district 2 reported the highest total cases comprising 65 percent of the province’s total reported malaria cases, followed by district 3 with 20 percent, and 15 percent were from district 1. High malaria concentration was observed in municipalities located in the southern part of the province, including Rizal, Narra, Brooke’s Point, Sofronio Espan˜ola, and Bataraza (in district 2). Puerto Princesa City (in District 3) was among the municipalities with high malaria transmission during 2005–2011. The results of this study could help in determining targeted malaria control interventions and prioritizing resource allocation for areas with high malaria transmission for future public health planning. This would also contribute to efforts of the public and private sectors to eliminate malaria in Palawan Province by 2030.

      • KCI등재

        Relationship between Alcohol Purchasing Time and Alcohol Use Disorder in South Korea

        Narcie Faith Amista,전성수,윤미은 질병관리본부 2017 Osong Public Health and Research Persptectives Vol.8 No.6

        Objectives: Currently, time of alcohol purchase is not part of the policies to regulate alcohol consumption in South Korea. This study was conducted to determine the relationship between alcohol purchasing time and alcohol use disorder. Methods: The survey for this study was conducted in geographically diverse regions of South Korea in 2012. Respondents’ purchasing behaviors for both on-licensed (i.e., allows for consumption within the premises) and off-licensed (i.e., where alcohol is consumed off the premises) outlets and time of alcohol consumption were collected. Alcohol consumption patterns were examined using the Rapid Alcohol Problem Screen 4 (RAPS4). Data were also analyzed by age, gender and purchasing time. Results: Results showed that among the off-licensed premises, supermarkets appear to be the most popular venue while for on-licensed premises; alcohol was generally consumed inside hotels/ pubs regardless of age and gender of the purchaser. Purchasing of alcohol was highest during the day and early evening period (9:00 a.m. to 9:59 p.m.). Females are most likely to abuse alcohol than males during the early morning period and is that period after 12:00 midnight. Conclusion: Analysis suggests that the survey instrument used in the International Alcohol Control Study is being used to collect data on alcohol purchasing time consumption; therefore, the potential is there to provide accurate results to contribute appropriate policy responses to reduce alcohol related-harm.

      • KCI등재

        American Attitudes toward Japan and China, Decades of Polls

        Laken, Faith,Kim, Jibum,Smith, Tom W. Center for Asian Public Opinion ResearchCollaborat 2014 Asian journal for public opinion research Vol.2 No.1

        Gathering polling items about China and Japan from 1937 to 2011, we examine how Americans think about these two powerful East Asian countries. Our study investigates American attitudes from two perspectives. First, we analyze the content of polling items asked in the US about China and Japan to track changes in salient issues over a period of over 60 years. Second, by tracking repeated items, we show how American attitudes toward China and Japan have changed over time, both in long-term general favorability, and shorter-term perception of geopolitical, ideological, and economic threat in response to historical events.

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