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Wide-Field Gamma-Spectrometer BDRG: GRB Monitor On-Board the Lomonosov Mission
Svertilov, S. I.,Panasyuk, M. I.,Bogomolov, V. V.,Amelushkin, A. M.,Barinova, V. O.,Galkin, V. I.,Iyudin, A. F.,Kuznetsova, E. A.,Prokhorov, A. V.,Petrov, V. L.,Rozhkov, G. V.,Yashin, I. V.,Gorbovskoy D. Reidel Pub. Co 2018 Space science reviews Vol.214 No.1
Juan Garona,Natasha T. Sobol,Marina Pifano,Valeria I. Segatori,Daniel E. Gomez,Giselle V. Ripoll,Daniel F. Alonso 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4Q5]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors. By acting as a selective agonist of arginine vasopressin type 2 membrane receptor (AVPR2) present in endothelial and tumor cells, [V4Q5]dDAVP is able to impair tumor aggressiveness and distant spread. Our aim was to evaluate the potential therapeutic benefits of [V4Q5]dDAVP on highly aggressive CRC disease using experimental models with translational relevance. Materials and Methods Murine CT-26 and human Colo-205 AVPR2-expressing CRC cell lines were used to test the preclinical efficacy of [V4Q5]dDAVP, both in vitro and in vivo. Results In syngeneic mice surgically implanted with CT-26 cells in the spleen, sustained intravenous treatment with [V4Q5]dDAVP (0.3 g/kg) dramatically impaired metastatic progression to liver without overt signs of toxicity, and also reduced experimental lung colonization. The compound inhibited in vivo angiogenesis driven by Colo-205 cells in athymic mice, as well as in vitro endothelial cell migration and capillary tube formation. [V4Q5]dDAVP exerted AVPR2-dependent cytostatic activity in vitro (IC50 1.08 M) and addition to 5-fluorouracil resulted in synergistic antiproliferative effects both in CT-26 and Colo-205 cells. Conclusion The present preclinical study establishes for the first time the efficacy of [V4Q5]dDAVP on CRC. These encouraging results suggest that the novel second generation vasopressin analog could be used for the management of aggressive CRC as an adjuvant agent during surgery or to complement standard chemotherapy, limiting tumor angiogenesis and metastasis and thus protecting the patient from CRC recurrence.
Prompt and Follow-up Multi-wavelength Observations of the GRB 161017A
Sadovnichy, V. A.,Panasyuk, M. I.,Svertilov, S. I.,Lipunov, V. M.,Bogomolov, V. V.,Gorbovskoy, E. S.,Bogomolov, A. V.,Castro-Tirado, A. J.,Gabovich, A.,Hu, Y.,Iyudin, A. F.,Jeong, H. M.,Jeong, S.,Kim, American Astronomical Society 2018 The Astrophysical journal Vol.861 No.1
<P>This paper presents data on the simultaneous and complementary observations of the gamma-ray burst (GRB) GRB 161017A for optical, X-ray, and gamma wavelengths obtained by the Russian multi-messenger Lomonosov space observatory and supplemented by additional data from the Swift satellite as well as the ground-based MASTER Global Robotic Net and the 10 m Gran Telescopio Canarias. Multifrequency spectra of this very powerful explosion indicate that it originated at a distance of 10 billion light years from Earth. Here, we present the results of the prompt, early, and afterglow optical observations. The light curves and spectra suggest that the prompt optical and high-energy emissions occur in the same region near the GRB source.</P>
Measurement of Prompt D0 Meson Azimuthal Anisotropy in Pb-Pb Collisions at sNN=5.02 TeV
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö,, J.,Flechl, M.,Friedl, M.,Frü,hwirth, R.,Ghete, V. M.,Grossmann, J. American Physical Society 2018 Physical Review Letters Vol.120 No.20
<P>The prompt D-0 meson azimuthal anisotropy coefficients, v(2) and ?v(3), are measured at midrapidity ( |y| < 1.0) in Pb-Pb collisions at a center-of-mass energy root s(NN) = 5.02 TeV per nucleon pair with data collected by the CMS experiment. The measurement is performed in the transverse momentum (p(T)) range of 1 to 40 GeV/c, for central and midcentral collisions. The v(2) coefficient is found to be positive throughout the p(T) range studied. The first measurement of the prompt D-0 meson v(3) coefficient is performed, and values up to 0.07 are observed for p(T) around 4 GeV/c. Compared to measurements of charged particles, a similar p(T) dependence, but smaller magnitude for p(T) < 6 GeV/r, is found for prompt D-0 meson v(2) and v(3) coefficients. The results are consistent with the presence of collective motion of charm quarks at low p(r) and a path length dependence of charm quark energy loss at high p(r), thereby providing new constraints on the theoretical description of the interactions between charm quarks and the quark-gluon plasma.</P>
Studies of Radiation-Induced Defects in Li2SiO3:Sm Phosphor Material
Singh, N.,Singh, V.,Watanabe, S.,Gundu Rao, T. K.,Chubaci, J. F.,Cano, N. F.,Pathak, M. S.,Singh, P. K.,Dhoble, S. J. Springer Science + Business Media 2017 Journal of electronic materials Vol.46 No.1
<P>Li2SiO3:Sm was synthesized by the solution combustion method. Powder x-ray diffraction technique was used to find the phase formation. Li2SiO3:Sm exhibits thermoluminescence (TL) peaks at approximately 140 degrees C, 155 degrees C, 190 degrees C, 250 degrees C, and 405 degrees C. Three defect centers contribute to the observed electron spin resonance spectrum from the gamma irradiated phosphor. Center I with principal g-values g(parallel to) = 2.0206 and g(perpendicular to) = 2.0028 is identified as an O-2(-) ion while center II, with an isotropic g-factor 2.0039, is assigned to an F+-type center. Center III is assigned to a Ti3+ center. The Ti3+ center is related to the 250 degrees C TL peak while the O-2(-) ion also correlates with the main TL peak at 250 degrees C. An additional defect center is observed during thermal annealing experiments, and the center (assigned to F+ center) seems to originate from an F center. The F center appears to be associated with the high temperature TL peak in a Li2SiO3: Sm phosphor. The luminescence spectrum reveals the dominant emission peaks at 605 ((4)G(5/2) -> H-6(7/2)) nm under the excitation wavelength of 402 nm.</P>
Al-Saeedi F.H.F.,Sayyed M.I.,Kapustin F.L.,Al-Ghamdi Hanan,Kolobkova E.V.,Tashlykov O.L.,Almuqrin Aljawhara H.,Mahmoud K.A. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.8
In the present work, untreated Iraqi sand with grain sizes varied between 100 and 200 mm was used to produce a colored glass sample that has shielding features against the low gamma-ray energy. Therefore, a weight of 70e60 wt % sand was mixed with 9e14 wt% B2O3, 8e10 wt% Na2O, 4e6 wt% of CaO, 3e6 wt% Al2O3, in addition to 0.3% of Co2O3. After melting and annealing the glass sample, the X-ray diffraction spectrometry was applied to affirm the amorphous phase of the fabricated glass samples. Moreover, the X-ray dispersive energy spectrometry was used to measure the chemical composition, and the MH-300A densimeter was applied to measure the fabricated sample's density. The Makishima-Makinzie model was applied to predict the mechanical properties of the fabricated glass. Besides, the Monte Carlo simulation was used to estimate the fabricated glass sample's radiation shielding capacity in the low-energy region between 22.1 and 160.6 keV. Therefore, the simulated linear attenuation coefficient changed between 10.725 and 0.484 cm1 , raising the gamma-ray energy between 22.1 and 160.6 keV. Also, other shielding parameters such as a half-value layer, pure lead equivalent thickness, and buildup factors were calculated
Thomas, Eva S.,Gomez, Henry L.,Li, Rubi K.,Chung, Hyun-Cheol,Fein, Luis E.,Chan, Valorie F.,Jassem, Jacek,Pivot, Xavier B.,Klimovsky, Judith V.,de Mendoza, Fernando Hurtado,Xu, Binghe,Campone, Mario,L Grune & Stratton 2007 Journal of clinical oncology Vol.25 No.33
<B>Purpose</B><P>Effective treatment options for patients with metastatic breast cancer resistant to anthracyclines and taxanes are limited. Ixabepilone has single-agent activity in these patients and has demonstrated synergy with capecitabine in this setting. This study was designed to compare ixabepilone plus capecitabine versus capecitabine alone in anthracycline-pretreated or -resistant and taxane-resistant locally advanced or metastatic breast cancer.</P><B>Patients and Methods</B><P>Seven hundred fifty-two patients were randomly assigned to ixabepilone 40 mg/m<SUP>2</SUP>intravenously on day 1 of a 21-day cycle plus capecitabine 2,000 mg/m<SUP>2</SUP>orally on days 1 through 14 of a 21-day cycle, or capecitabine alone 2,500 mg/m<SUP>2</SUP>on the same schedule, in this international phase III study. The primary end point was progression-free survival evaluated by blinded independent review.</P><B>Results</B><P>Ixabepilone plus capecitabine prolonged progression-free survival relative to capecitabine (median, 5.8 v 4.2 months), with a 25% reduction in the estimated risk of disease progression (hazard ratio, 0.75; 95% CI, 0.64 to 0.88; P = .0003). Objective response rate was also increased (35% v 14%; P < .0001). Grade 3/4 treatment-related sensory neuropathy (21% v 0%), fatigue (9% v 3%), and neutropenia (68% v 11%) were more frequent with combination therapy, as was the rate of death as a result of toxicity (3% v 1%, with patients with liver dysfunction [≥ grade 2 liver function tests] at greater risk). Capecitabine-related toxicities were similar for both treatment groups.</P><B>Conclusion</B><P>Ixabepilone plus capecitabine demonstrates superior efficacy to capecitabine alone in patients with metastatic breast cancer pretreated or resistant to anthracyclines and resistant to taxanes.</P>
Dadalt, J.C.,Gallardo, C.,Polycarpo, G.V.,Budino, F.E.L.,Rogiewicz, A.,Berto, D.A.,Trindade Neto, M.A. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.10
Most of amino acid (AA) digestibility values for feed ingredients are obtained using pigs cannulated in the distal ileum. The ileal-cannulated pig model uses pigs older than six weeks due to difficulties related to implanting the T-cannula in distal ileum of younger pigs and complications during the post-surgical recovery. However, to properly formulate the diet of weaned pigs, the nutritive value of feed ingredients should be determined with younger pigs. Thus, 25 weaned pigs were used to determine the apparent total tract digestibility (ATTD) of nutrients, energy, and apparent ileal digestibility (AID) and standardized ileal digestibility (SID) ileal AA digestibility of broken rice (BR), with or without multicarbohydrase (MC) and phytase (Phy) supplementation. Piglets were weaned at 23 d of age and individually housed in digestibility cages until 45 d of age. The trial consisted of 7 d of adaptation to the experimental diets and 3 d of excreta (feces and urine) collection. Ileal digesta was collected at slaughter (about 6 weeks of age). A completely randomized experimental design was used to determine the effects of MC and Phy. Reference diets (RD, 5% casein) was replaced by 30% of BR with or without MC, Phy, or MC+Phy. The RD was used to quantify endogenous AA losses. BR with Phy supplied had increased the ATTD of dry matter (p<0.05) and SID of histidine (p = 0.05), arginine, leucine, lysine, valine, alanine, and proline (p<0.05). BR with MC had been increased digestible energy and protein and SID for histidine (p<0.05). There was no interaction between Phy and MC on the BR nutrient digestibilities. Standardized amino acid digestibilities of BR, without enzymes, were lower than those values reported in the literature. The MC and Phy improved the digestibility of some nutrients and energy of BR in post-weaned piglet diets.
Manriquez, O.M.,Montano, M.F.,Calderon, J.F.,Valdez, J.A.,Chirino, J.O.,Gonzalez, V.M.,Salinas-Chavira, J.,Mendoza, G.D.,Soto, S.,Zinn, R.A. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.6
Eight Holstein steers ($216{\pm}48kg$ body weight) fitted with ruminal and duodenal cannulas were used to evaluate effects of wheat straw processing (ground vs pelleted) at two straw inclusion rates (7% and 14%; dry matter basis) in dry rolled or steam-flaked corn-based finishing diets on characteristics of digestion. The experimental design was a split plot consisting of two simultaneous $4{\times}4$ Latin squares. Increasing straw level reduced ruminal (p<0.01) and total tract (p = 0.03) organic matter (OM) digestion. As expected, increasing wheat straw level from 7% to 14% decreased (p<0.05) ruminal and total tract digestion of OM. Digestion of neutral detergent fiber (NDF) and starch, per se, were not affected (p>0.10) by wheat straw level. Likewise, straw level did not influence ruminal acetate and propionate molar proportions or estimated methane production (p>0.10). Pelleting straw did not affect ($p{\geq}0.48$) ruminal digestion of OM, NDF, and starch, or microbial efficiency. Ruminal feed N digestion was greater (7.4%; p = 0.02) for ground than for pelleted wheat straw diets. Although ruminal starch digestion was not affected by straw processing, post-ruminal (p<0.01), and total-tract starch (p = 0.05) digestion were greater for ground than for pelleted wheat straw diets, resulting in a tendency for increased post-ruminal (p = 0.06) and total tract (p = 0.07) OM digestion. Pelleting wheat straw decreased (p<0.01) ruminal pH, although ruminal volatile fatty acids (VFA) concentration and estimated methane were not affected ($p{\geq}0.27$). Ruminal digestion of OM and starch, and post-ruminal and total tract digestion of OM, starch and N were greater (p<0.01) for steam-flaked than for dry rolled corn-based diets. Ruminal NDF digestion was greater (p = 0.02) for dry rolled than for steam-flaked corn, although total tract NDF digestion was unaffected (p = 0.94). Ruminal microbial efficiency and ruminal degradation of feed N were not affected (p>0.14) by corn processing. However, microbial N flow to the small intestine and ruminal N efficiency (non-ammonia N flow to the small intestine/N intake) were greater (p<0.01) for steam-flaked than for dry rolled corn-based diets. Ruminal pH and total VFA concentration were not affected ($p{\geq}0.16$) by corn processing method. Compared with dry rolled corn, steam-flaked corn-based diets resulted in decreased acetate:propionate molar ratio (p = 0.02). It is concluded that at 7% or 14% straw inclusion rate, changes in physical characteristics of wheat straw brought about by pelleting negatively impact OM digestion of both steam-flaked and dry-rolled corn-based finishing diets. This effect is due to decreased post-ruminal starch digestion. Replacement of ground straw with pelleted straw also may decrease ruminal pH.