http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bacillus licheniformis EMR 균주에서 린코사마이드계 항생물질에 의한 유도내성
최응칠(Eung Chil Choi),우정원(Jung Won Woo),B. 와이스브럼(Bernard Weisblum) 대한약학회 1986 약학회지 Vol.30 No.6
To clarify resistance mechanisms of lincosamide antibiotics, it was examined whether lincosamide antibiotics was able to induce high resistance to macrolide and lincosamide antibiotics against EMR-1 strain of Bacillus species. And it was also examined whether the inducible resistance was plasmid-mediated or chromosome-mediated. This strain was identified as Bacillus licheniformis by its morphological and physiological characteristics. The subinhibitory concentrations of lincomycin and clindamycin induced high resistance in the strain to lincosamide antibiotics, but not to macrolide antibiotics. The inducible resistance was not eliminated by treating the strain with ethidium bromide, and plasmid was not identified by the alkaline lysis method of plasmid preparation. These results indicate, therefore, that the inducible resistance to macrolide and lincosamide antibiotics in the strain may be chromosome-mediated, not plasmid-mediated.
한국산 생약자원 개발연구 (제2보) : prunus tomentosa의 약효성분에 관하여
최응칠(Eung-Chil Choi),한대석(Dae-Suk Han),김영호(Young-Ho Kim),홍인혁(In-Hyuk Hong) 한국생약학회 1983 생약학회지 Vol.14 No.2
HPLC is a useful method for identifying amygdalin which has been the subject of considering controversy for cancer remedy. The resolution of amygalin was satisfactory and the separation of amygdalin was accomplished using carbohydrate analysis column, mobile phase of acetonitrile: H₂O (90 : 10), and UV detector. Quantitative analysis showed that amygdalin contents of Prunus tomentosa, P. serrulata, and P. ishidoyana(Amygdalaceae) were 2.18, 2.41, and 2.26%, respectively. It was suggested that the seed of Prunus species was worth useful resource of amygdalin.
리팜피신에 내성인 Streptococcus faecalis 균주의 개발
최응칠(Eung Chil Choi),김승호(Seung Ho Kim),권애란(Ae Ran Kwon),이미정(Mi Jeong Lee),오정자(Jeong Ja Oh),김병각(Byong Kak Kim) 대한약학회 1993 약학회지 Vol.37 No.4
The preparation of Streptococcus faecalis RSI is used as a medicinal preparation for human intestinal disorders. But the microbe in this preparation is very sensitive to rifampicin. If this preparation is taken with rifampicin, its therapeutic effect can not be expected. To develope rifampicin resistant mutants, the rifampicin sensitive strain S. faecalis RSI was treated with N-methyl-N''-nitro-N-nitrosoguanidine(MNNG). Twelve strains of the MNNG-induced mutants showed distinct resistance to rifampicin and five mutants were selected for further studies. They also exhibited identical characteristics with the parent S. faecalis RSI when they were tested for lactic acid formation and growth inhibition of E. coli. From in vitro test, it was identified that rifampicin is not inactivated by certain factors of the rifampicin resistant mutants. Conclusively, the rifampicin resistant mutants are efficient strains that have insensitivity against rifampicin and original biochemical characteristics of the parent strain.
리팜피신에 내성인 Bifidobacterium bifidum 균주개발
최응칠(Eung Chil Choi),고성열(Sung Youl Ko),김희선(Hee Sun Kim),최성숙(Sung Sook Choi),김숙경(Sook Kyung Kim),김병각(Byoung Kak Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Bifidobacterium bifidum, one strain of medical preparations being on the market for human intestinal disorder, is very sensitive to rifampicin. If this preparation is taken with rifampicin, its therapeutic effect can't be expected. To develope rifampicin resistant mutants, B. bifidum was treated with N-methyl-N''-nitro-N-nitrosoguanidine(MNNG). All of thirty strains grown on the plates containing 10 mcg/ml rifampicin were over 1,000 times more resistant to rifampicin than parental strain and they were identified as B. bifidum by fructose-6-phosphoate phosphoketolase test. Three strains out of thirty, which produced almost same amount of organic acid as parental strain, were selected for further studies. They showed identical growth inhibition activity aganist E. coli compared with that of parental strain. And rifampicin was not inactivated.
최응칠(Eung Chil Choi),김병각(Byong Kak Kim),정경수(Kyeong Soo Chung) 대한약학회 1988 약학회지 Vol.32 No.5
394 strains of soil microorganism were isolated from the Korean soil samples. The isolated strains were shake-cultured in oat-meal medium. The filtrates of the cultures were screened for the production of alpha-amylase inhibitors. Five strains were identified to produce alpha-amylase inhibitors. And these strains were identified as Actinomycetes.
한국산 고등균류의 성분 연구(Ⅳ) : Lactarius Piperatus (Fr.) S.F. Gray로 부터 Gultorin 의 분리
최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1975 생약학회지 Vol.6 No.1
In order to isolate constituents of Lactarius piperatus(FR.) S.F. GRAY, the fresh carpophore was homogenized with ethanol in a blendor, stored for three years and subsequently extracted with ethanol. From the concentrated ethanol solution, a mixture of compounds was precipitated, from which a white needle crystal, named gultorin, (mp.160∼162°) was obtained. The physical and chemical characteristics of gultorin were determined.
이응호,오광수,구재근,정수열,권칠성 한국수산학회 1983 한국수산과학회지 Vol.16 No.4
A vacuum-packed seasoned-dried product of sea mussel, Mytilus edulis, caught in the southern coasts of Korea, was prepared and stored at 35℃for 70 days to test quality stability. Sea mussel, purchased from Jagalchi fish market in Busan, was steamed, shucked and eliminated byssus. The sea mussel meat was seasoned with the seasening solution prepared with sugar, salt, sorbitol, glycerol, monosodium glutamate, 5'-ribonucleotide and smoke flavor (Smoke-EZ, Alpha Foods Co.,Ltd.). After seasoning, the meat was dried at 52-58℃ for three hours, vacuum-packed in the laminated plastic film bag (14×15cm), and finally sterilized at 120℃ for 26 minutes in hot water circulating retort. The moisture, water activity, color value (L, a and b value), texture, TBA value and viable bacterial count of the products were determined during the period of storage at 35℃. From the results obtained, it became clear that the product could be preserved in an good quality for 70 days at 35℃, though a slight decrease in moisture content and development of a pale brown color was resulted. Judging from the sensory evaluation on flavor, the products containing smoke flavor were most desirable.
이응호,오광수,차용준,하재호,권칠성 한국수산학회 1984 한국수산과학회지 Vol.17 No.4
진주담치와 멸치를 보다 효율적으로 이용하기 위한 방안의 하나로서 진주담치와 시판 마른멸치를 건조하여 분말화한 후 조미료를 배합하여 건조분말 수우프를 만들었으며, 또한 이것을 적층필름용기(cellophane/polyester/aluminium foil/polyester:20㎛/15㎛/7㎛/20㎛, 13×14㎝)에 含氣包裝하여 상온저장 중의 품질안정성을 검토하였다. 진주담치 및 마른 멸치를 건조분말화한 다음 이것에 설탕 3%, 식염 20%, 글루탐산나트륨 5%, 마늘가루 및 후추가루 각각 0.2%를 배합하는 것이 즉석분말수우프로서 가장 좋은 배합비이었다. 분말수우프 제품의 수분활성은 진주담치의 경우 0.41, 마른 멸치의 경우는 0.31 정도이었다. 진주담치제품의 총 카로테노이드함량은 저장중 약간 감소하였고, 휘발성염기질소와 아미노질소는 전제품이 저장 중 거의 변화가 없었으며, TBA값은 저장 30일까지 약간 증가하다가 그 후 서서히 감소하는 경향을 나타내었다. 관능검사 결과 멸치분말수우프 및 진주담치분말수우프 제품은 모두 저장 100일 동안 품질에 큰 변화가 없었으므로 즉석분말수우프로 이용가능하다는 결론을 얻었다. As one trials to utilize sea mussel and anchovy effectively, powdered instant soups were prepared and then their quality stability were examined during storage. Powdered instant soup was made by adding 3% sugar, 20% table salt, 5% monosodium glutamate, 0.2% black pepper and garlic powder to the pulverized dried sea mussel or anchovy. Powdered instant soup products, powderd products, and dried round state sea mussel or anchovy were packed with air in laminated film bag (cellophane/polyester/aluminium foil/polyester: 20㎛/15㎛/7㎛/20㎛, 13×14㎝). The contents of amino-nitrogen and volatile basic nitrogen of these products were showed little significant variations and also water activity and color value (L, a, b) of these products were little changed during storage. Thiobarbituric acid value increased up to 30 days of storage and then decreased slightly. Comparing the quality of powdered-seasoned products with that of dried round state products, there were no significant differences in stability during storage. Judging from the experimental results, the quality of powdered instant soup of sea mussel and anchovy were stable for 100 days at room temperature(25±3℃).