Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

갑상선 유두암이 병발된 가족성 대장 용종증 1예

백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.

국내외 저명학술지에 발표된 무작위대조연구 초록의 질적 연구

김효선,김은영 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

In this study, the quality of reporting the Randomized Controlled Trial (RCT) abstracts was investigated. It was compared between abstracts in four major Korean medical journals, covered by SCI(E), and in the New England Journal of Medicine (NEJM), the most cited medical journal in 2010 (IF=53.484), published from 2007/01 to 2011/06. There were 57 abstracts in Korean SCIs and 50 in NEJM included in the investigation; among them, three from Korean SCIs and one from NEJM were excluded. A modification of CONSORT for abstract was used as criteria, including 16 checklist items. The conformity of the abstracts to each item was assessed, and the χ2 (chi-square) analysis was used to analyze the significance of difference between the two. As a result, the two groups of journals were statistically equivalent in six items; Korean journals were significantly better in two items, and NEJM were in eight. In conclusion, the quality of reporting of RCT abstracts was better in general in NEJM than in Korean SCIs. This does not mean the full RCT reports of NEJM are superior to that of Korean SCI; rather, it highlights the need for Korean journals to adopt the CONSORT for abstracts in reporting of RCT in abstracts.

100m 달리기시 최고 속도 구간과 감속 구간의 동작 비교 연구

은선덕,정철수,배성제 한국운동역학회 1996 한국운동역학회지 Vol.6 No.1

본 연구의 목적은 100m 달리기에서 최고 속도 구간과 감속 구간에서의 동작을 비교하여 감속의 원인을 규명하는 데 있다. 두 구간에 대한 주요 운동학적 변인인 신체 중심의 속도와 변위, 보속과 보폭, 상체의 전경각, 관절각, 각속도를 분석하여 다음과 같은 결론은 얻었다. 감속 구간에서의 지면 접촉 기간 동안과 체공 기간 동안의 신체 중심의 수평 속도는 최고 속도 구간에 비해 느린 것으로 나타났다. 보속은 최고 속도 구간에 비해 느린 것으로 나타났고, 지지 시간은 긴 것으로 나타났으며, 체공 시간은 차이가 나타나지 않았다. 보폭은 최고 속도 구간에 비해 짧은 것으로 나타났고, 착지시 신체 중심과 발끝의 수평 거리는 최고 속도 구간에 비해 긴 것으로 나타났다. 또한 상체의 전경각은 착지시에만 차이가 있었으며 최고 속도 구간에 비해 작고, 무릎 관절각은 착지시와 이지시에 있어서 최고 속도 구간에 비해 작았다. 그리고 고관절각은 반대발의 이지시와 착지시, 그리고 최소값에 있어서 최고 속도 구간에 비해 크고, 운동 범위에 있어서는 작은 것으로 나타났다. 또한 무릎 관절 각속도는 최고 속도 구간과의 비교에서 차이가 나타나지 않았다. The study was conducted to make a comparative analysis of running motion and to examine the difference in the deceleration phase(80∼90m) and the Max-speed phase(30∼40m) during the 100-meter Sprint. In this study, data was analyzed with variables including velocity and displacement of center of gravity, stride frequency, stride length, foward angle of upper body, joint angle, angular velocity in the deceleration phase and the max-speed phase. The conclusions of the study were as follows ; 1. Horizontal velocity of the center of gravity in the deceleration phase was found to be slower than that in the max-speed phase in the supporting period and non-supporting period. 2. Stride frequency in the deceleration phase was found to be slower than that in the max-speed phase, and supporting time n the deceleration phase was longer than that in the max-speed phase, also there was no difference between each phase in nonsupporting time. 3. Stride length in the deceleration phase was to be found shorter than that in the max-speed phase. 4. Horizontal distance between the center of gravity and toe in the deceleration phase was to be found longer than that in the max-speed phase. 5. Forward angle of upper body at the moment of touch down in the deceleration phase was found to be smaller than that in the max-speed phase. 6. Knee angle at the moment of touch down and take off in the deceleration phase were found to be smaller than in the max-speed phase. 7. Hip angle at the moment of touch down and take off of the other foot, and minimum hip angle in the deceleration phase were found to be larger than that in the max-speed phase, and range of, motion in the deceleration phase was smaller than that in the max-speed phase. 8. Knee angular velocity at the moment of touch down of the other foot toward flection in the deceleration phase was found to be larger than that in the max-speed phase.

계단 오르기 동작시 계단 높이에 따른 하지 관절 모멘트의 변화 분석

은선덕 한국운동역학회 2003 한국운동역학회지 Vol.13 No.1

Eun, S-D. The effect of the stair heights on lower extremity joint moment in stair-ascent activity. Korean Journal of Sport Biomechanics, Vol. 13, No. 1, pp. 121-138. The purpose of this study was to investigate the effect of the stair heights on lower extremity joint moment in stair-ascent activity. Data were collected by 3-D cinematography, force platform. six normal males were participated in this experiment. All subjects performed a stair-ascent in four different heights of stairs (10, 14, 18, 22cm) having a 5 step staircase. The moment of lower extremity joint was analyzed during stance phase. The results were as follows: First, the second increase of plantar flexion moment of ankle joint in the 'forward continuance' phase was not occurred for stair A and B. But it occurred for stair C and D. And the maximum plantar flexion moment increased as the stair height become higher. Second, it was shown that the maximum inversion moment of the ankle joint was the smallest at stair B and it increased significantly at stair C. Third, maximum extension moment appeared in the 'pull-up' phase. And it increased as the stair height become higher. Fourth, it was shown that the maximum abduction moment of the knee joint was the smallest at stair C and it increased significantly at stair C. Fifth, maximum extension moment of hip joint increased significantly at stair C. Sixth, remarkable value of adduction moment occurred at hip joints and maximum adduction moment increased at stair D.

트레드밀의 속도 변화에 따른 노년기 성인의 보행패턴 연구

은선덕 서울대학교 체육연구소 2001 서울大學校 體育硏究所論集 Vol.22 No.1

The purpose of this study was to investigate the effect of speed conditions on the gait pattern in old age. Data were collected using video camera and video analyzing system. Six males in their sixty to seventies were tested during slow(3.5km/h), moderate(4.0km/h), fast(4.5km/h) speed on treadmill wish 10% grade. They were videotaped using a high speed video camera with the frame rate being 60Hz, Variables computated using the method of two-dimensional video analysis. One-way ANOVA was used to evaluating the statistical significance. The results obtained from this study were as follows: The stance phase was increased and swing phase was decreased as the speed uras increased in all subjects. But there was no significant difference statistically. All subjects did not show a significant difference in speed conditions at major events jn mean ankle angle. However, max. ankle angle and ROM(range of motion) during stance phase was augmented as the speed was increased(P<.05). All subjects did not show a significant difference in speed conditions at major event in mean knee angle. However min. ankle angle during stance phase and ROM during swing phase was augmented as the speed was increased(P<.05).

최인훈 소설 <구운몽>의 해체의식과 타자 인식 연구

서은선 釜山大學校 1996 人文論叢 Vol.49 No.1

지역 여성복지자원 시스템 구축을 위한 분석 : Analysetalt Kimi 분석사례지역: 구미시

윤선오,이경은 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.4 No.1

발육중인 영구치의 파노라마 방사선 사진 계측을 이용한 연령 추정

최은영,양규호,최남기,김선미 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

본 연구는 혼합치열기 아동에 있어서 연령을 추정하는데 치아의 발육을 이용하면서 치아발육의 평가에 객관적인 수치를 이용하여 방정식을 도출함으로써 간단하게 연령을 추정할 수 있는 방법을 연구하고자 하였다. 이를 위해 2002년에서 2004년까지 전남대학교 병원에 내원한 환아 중 7~9세 어린이 120명을 대상으로 얻어진 파노라마 방사선사진을 이용하여 Mornstad에 의해 제시된 발육치아의 치관 길이, 치근 길이, 치근단공 너비를 측정하여 다음과 같은 결과를 얻었다. 1. 연령과 상관성이 높은 계측치로 남아에서는 제 2대구치 치관 길이, 제 1대구치 치근 길이, 제 1소구치 치근단공 너비가 높은 상관성을 보인 반면 여아에서는 제 2소구치 치관 길이, 제 2대구치 치근 길이, 제 1대구치 치근단공 너비가 높은 상관성을 보였다. 2. 상관성이 높은 계측치를 중다선형회귀분석을 사용하여 역령과 연관시켜 연령추정 방정식을 산출하였다. 남아(개월) = 43.958 + 하악 제 2대구치 치관 길이× 4.392 + 하악 제 1대구치 치근 길이× 2.255 - 하악 제 1소구치 치근단공 너비× 2.046 여아(개월) = 75.213 + 하악 제 2소구치 치관 길이× 3.910 + 하악 제 2대구치 치근 길이× 2.280 - 하악 제 1대구치 치근단공 너비× 6.217 위 식을 토대로 측정에 사용되지 않은 남녀 각각 10명의 파노라마 방사선사진을 이용하여 나이를 추정한 결과 남아에서는 -2.1± 6.8개월의 편차를, 여아에서는 6.1± 6.2개월의 편차를 보였다. 이처럼 연령을 모르는 우리나라의 혼합치열기 아동에서 파노라마 방사선 사진을 이용하여 연령 추정 시 위의 방정식을 사용한다면 비교적 정확하게 연령을 추정할 수 있으리라고 사료된다. The aim of this study was to test whether metric measurements of crown length, root length and apex width during tooth development could be a better basis for correlation with age than the classical methods based on subjective estimations of various stages of tooth development. Panoramic radiographs of 120 children, aged 7 to 9 years, were collected from the department of the pediatric dentistry of Chonnam National University Hospital, Korea. The methods of Mornstad was used to estimate age. The structures measured were crown length, root length and apex width in panoramic radiographic. The results were as follows : 1. In the boys, it showed higher correlation between lower 2nd molar crown length, lower 1st molar root length or lower 1st permolar apical width and age. In the girls, it showed higher correlation between lower 2nd premolar crown length, lower 2nd molar root length or lower 1st molar apical width and age. 2. With the aid of a multiple regression model, a linear relationship between some of these distances and age was shown. Boy(months) = 43.958 + lower 2nd molar crown length× 4.392 + lower 1st molar root length× 2.255 - lower 1st permolar apical width× 2.046 Girl(months) = 75.213 + lower 2nd premolar crown length× 3.910 + lower 2nd molar root length× 2.280 - lower 1st molar apical width× 6.217 Age was estimated in boys and girls using the mathematic model; the mean difference between chronological and estimated ages was -2.1± 6.8 months for boys and 6.1± 6.2 months for girls. Therefore, it seems to be more accurate and easier than the earlier methods.

멕시코와 네팔도입 고추 유전자원의 두 가지 점무늬병에 대한 저항성

조은형,김정훈,전수경,이지선,김병수 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-

Pepper genetic resources consisting of introductions from Mexico and Nepal and susceptible and resistant controls were tested for resistance to gray leaf spot and to bacterial spot by serially inoculating the two disease pathogens, Stemphylium spp. first and Xanthomonas campestris pv. vesicatoria next, with application of fungicide after evaluation of resistance to gray leaf spot first. KC866, KC872, KC902, KC905 were resistant to gray leaf spot in addition to known resistance sources, KC43, KC47, KC220, KC319, KC320, KC380. KC897 was on the top of the resistance sources list, even better than KC177(163192), and was followed by KC889, KC896, KC898, all of which were introductions from Nepal.