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송성헌,김우제,장은령,이정욱 한국로지스틱스학회 1998 로지스틱스연구 Vol.6 No.2
이 논문의 목적은 광양항 컨테이너부두 배후부지의 개발방향과 활성화 방안을 제시하는 것이다. 이를 위해서 우선, 배후부지의 개발과 운영에 관련된 계획, 법규 및 국내외 사례를 검토한 후, 배후부지 유치대상 기능과 주요시설을 규명하고, 개발 기본구상도와 단계별 개발계획안을 제시한다. 배후부지 개발사업의 활성화를 위해 정부의 정책적 지원방안 및 관련조직간의 협조방안과 배후부지 입주업체의 유치방안을 제시한다. 아울러 배후부지 개발의 기대효과 및 최근 경제상황에 따른 건의사항을 제시한다. In this paper we try to make suggestions for the development and promotion for the hinterland of the Kwangyang container port. First, we investigated the development plan, the law and several cases related to the development and operation of the port hinterland. Then we propose a scheme to develop the hinterland and define major functions and facilities for the hinterland. For the promotion of the hinterland, we suggest several roles of the government organizations to activate functions of the hinterland and ideas to attract customers. Finally, we suggest an expected effect according to the development of the hinterland and propose a proper way of the development considering the recent Korean economic situation.
이상복,김춘희,유은정,이원령,구원옥 대구대학교 특수교육재활과학연구소 2004 특수교육재활과학연구 Vol.43 No.1
The purpose of this study was to provide suggestions for the future 2year educational services based on the on-going education services for the persons with disabilities in the facilities. The results of the study were as follows. First, the facilities manly provided the persons with disabilities with the educational programs for improving basic functional skills in their daily living lives. Second, the recording data showed that average 2 out of 10 short-term plans were reached to above 80% of successful performance levels, and the rest of the 8 plans were reached to between 11% and 79% of the unsatisfactory levels.
Eun-Ryeong Hahm,Su-Hyeong Kim,Sivapar V. Mathan,Rana P. Singh,Shivendra V. Singh 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.2
Diallyl trisulfide (DATS), a metabolic by-product of processed garlic, is highly effective in inhibiting growth of human breast cancer cells in vitro and in vivo, but the underlying mechanisms are still not fully understood. In this study, we performed RNA-seq analyses using luminal-type (MCF-7) and basal-like (MDA-MB-231) human breast cancer cells to identify mechanistic targets of DATS. The Reactome Pathway Analysis revealed upregulation of genes associated with SLIT/ROBO tumor suppressor signaling following DATS treatment in both MCF-7 and MDA-MB-231 cells. However, the expression of SLIT2 and ROBO1 proteins or their downstream target C-X-C motif chemokine receptor 4 was not affected by DATS treatment in both cell lines. The Reactome as well as the Gene Ontology Pathways Analyses of the RNA-seq data from DATS-treated cells indicated downregulation of genes associated with G2/M phase cell cycle arrest in comparison with vehicle-treated control cells. Consistent with the RNA-seq data, DATS treatment caused a significant increase in the fraction of the G2/M population in both cell lines when compared to corresponding control cells. In addition, Ser10 phosphorylation of histone H3, a mitotic marker, was also increased significantly following DATS treatment in MCF-7 and MDA-MB-231 cells. These results indicate that while SLIT/ROBO signaling is not affected by DATS treatment, cell cycle arrest likely contributes to the antitumor effect of this phytochemical.
Eun Ji Lee,Kuk Bin Ji,Kang Sun Park,Kyeong Yeob Kim,Beom Sik Kim,Kyu hyun Kim,Ryeong Eun Kim,Eun Young Kim,Ji Hye Lee,Ju Lan Chun,Min Kyu Kim 한국동물생명공학회(구 한국동물번식학회) 2018 발생공학 국제심포지엄 및 학술대회 Vol.2018 No.06
Somatic cell nuclear transfer(SCNT) using micromanipulator have been used as a traditional cloning technique and applied various researches during the last decades. However the micromanipulator is expensive and relatively longer training period is required to operate it efficiently. Handmade cloning(HMC) is an alternative cloning method in a simplified way compared to the traditional cloning. Here, we suggested modified porcine handmade cloning(mHMC) as a new approach to clone porcine embryos as a substitute of the traditional SCNT. In mHMC, a nucleus was removed by an aspiration method by using a glass pipette, instead of bisection method. In this study, we investigated the efficiency of the enucleation method in mHMC by assessing the developmental competence of embryos in comparison with the traditional SCNT. The efficiency of enucleation was evaluated based on the rate of the accuracy and oocyte survivability. The accuracy of enucleation was lower in mHMC compared to those in SCNT(98.01±0.57 vs. 83.83±2.47), and the rate of survived oocytes was also lower in mHMC(96.50±0.84 vs. 90.10±2.11, respectively). And the developmental competence was assessed. The blastocyst rate was significantly higher in mHMC group(13.53±2.08 vs. 20.48±0.99). The levels of apoptosis and ROS were investigated to evaluate embryo quality. The expression of ROS and apoptosis-related genes showed no difference between groups. And the relative expressions of mRNA of pluripotency genes and reprogramming genes were evaluated. Although DNMT1 and DNMT3α were not differently expressed in two groups, the expression of the one of pluripotent gene, Oct4 was significantly higher in mHMC. In conclusion, based on the comparable results of mMHC and SCNT, the mHMC could be a suitable alternative technique to clone embryos in cost effective way compared to traditional SCNT.
Eun Ryeong Jun,Sung Hi Kim,Yoon Jeong Cho,Yun-A Kim,Joo Young Lee 대한가정의학회 2019 Korean Journal of Family Medicine Vol.40 No.5
Background: Several studies have shown that negative mental health increases risky health behavior and mortality risk. We investigated the relationship between mental health and health behavior, and the causal association between mental health and mortality risk. Methods: We used data from the 8-year (2006–2014) Korean Longitudinal Study of Aging with a cohort of 10,247 individuals (whom we divided into a younger group aged <65 years and an older group aged ≥65 years). Mental health was assessed with the following factors: depression, social engagement, and satisfaction of life. Health behavior was assessed with smoking, alcohol use, and regular exercise. Mortality risk was calculated using survival status and survival months as of 2014. Multiple logistic regression and Cox proportional hazard analysis were performed. Results: Negative mental health was associated with current smoking and sedentary life style, but not with alcohol consumption. In addition, it was associated with an increase in all-cause mortality risk. The increase in mortality risk in the highest quartile (vs. lowest) was 1.71 times (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.12– 2.62) and 2.07 times (HR, 2.07; 95% CI, 1.60–2.67) for the younger and older group, respectively. Conclusion: Our results show that mental health affects health behavior and mortality risk. A key inference from this study is that improving mental health can lead to positive changes in health behavior and reduce the risk of mortality.