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권혁기 ( Kwon¸ Hyek Kee ),이종근 ( Lee¸ Jong Keun ),안상로 ( Ahn¸ Sang Ro ),신은우 ( Shin¸ Eun Woo ) 한국구조물진단유지관리공학회 2002 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.6 No.2
The purpose of this study is to suggest some references of maintenance and design of Gravity Concrete Dams by analyzing dynamic characteristics in x, y, z directions when earthquakes occur. We consider gravity concrete dams such as Chunchon, Paldang and Chungju dam in Han River basin as some cases.
( Young Su Joo ),( Chan Ho Kim ),( Youn Kyung Kee ),( Chang Yun Yoon ),( Eun Young Lee ),( In Mee Han ),( Seung Gyu Han ),( Jung Tak Park ),( Seung Hyek Han ),( Tae Hyun Yoo ),( Shin Wook Kang ),( Hyu 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Mean platelet volume (MPV) is suggested as an index of infi ammation and disease activity in addition to refi ecting the effi cacy of anti-infi ammatory treatment in chronic infi ammatory disorder patients. However, the prognostic value of MPV on mortality remains unclear in patients with severe sepsis. Methods: We prospectively enrolled 345 patients admitted to the emergency department (ED) who received standardized resuscitation for severe sepsis and/or septic shock between Nov. 2007 and Dec. 2011. The change in MPV between hospital admission and 72 hours after treatment (ΔMPV72h-adm) was evaluated as a prognostic factor for 28- day mortality. Linear mixed model and Cox proportional hazards analysis were used. Results: The mean age of the enrolled patients was 64.2±15.7 years, 169 (49.0%) of them were males. Thirty-fi ve (10.1%) patients died within 28 days after ED admission. During the fi rst 72 hrs of ED admission, MPV signifi cantly increased in both non-survivors (P = 0.001) and survivors (P < 0.001) compared to baseline. ΔMPV72h-adm was signifi cantly higher, indicating an increase in MPV during the fi rst 72 hours, in non-survivors compared to survivors (P = 0.003). However, the change in the number of platelets over the fi rst 72 hours did not differ signifi cantly between the two groups (P = 0.360). Multivariate analysis revealed that ΔMPV72h-adm was an independent predictor of 28-day mortality, even after adjusting for age, sex, body mass index, Sequential Organ Failure Assessment score, renal replacement therapy, platelet count, C-reactive protein level, albumin level, and lactate level (hazard ratio, 1.44; 95% confi dence interval, 1.01-2.06; P = 0.044). Conclusions: An increase in MPV during the fi rst 72 hours of hospitalization could be an independent risk factor for adverse clinical outcomes in severe sepsis.
원발성 담즙성 경변증 16예의 임상상 : 단일 센터 경험
박동일(Dong Il Park),고광철(Kwang Cheol Koh),이준혁(Jun Hyek Lee),최문석(Moon Seok Choi),강태욱(Tae Wook Kang),문원(Won Moon),류민규(Min Kyoo Ryu),이용욱(Yong Wook Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),장재권(Jae Kwon Jang) 대한내과학회 2000 대한내과학회지 Vol.59 No.6
N/A Background : Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology. The disease is relatively common in western countries, but so far, only about 20 cases have been reported in Korea. Thus, the purpose of our prospective study was to evaluate the clinical characteristics of PBC in Korea. Methods : Between October 1994 and February 1999, 16 patients diagnosed as PBC at our department were enrolled in this study. We analyzed these patients for the distribution of age and sex, initial symptoms and signs, associated disorders, laboratory, endoscopic, and radiologic and histologic findings. Results : Of the 16 patients, the ratio of male to female was 1:7 and the average age was 57.5 years. Pruritus (37.5%) was the most frequent presenting symptom followed by xerostomia and xerophthalmia (12.5%), jaundice (6.3%), chronic fatigue (6.3%), melena (6.3%). Associated disorders were Sj gren's syndrome (25%), arthropathy (12.5%), Raynaud's phenomenon (6.3%) and diabetes (6.3%). Abnormalities of liver function were found frequently. Antimitochondrial antibody (100%), antinuclear antibody (31.25%) and rheumatoid factor (31.25%) were found. Long-term administration of UDCA improved both clinical and biochemical signs in most patients, however, 2 patients experienced exacerbation during UDCA therapy. Conclusions : We experienced 16 cases of PBC within a short period. It is expected that we can find these patients more frequently if we suspect this disease in patients with pruritus and unexplained obstructive pattern of liver function abnormality.(Korean. J. Med 59:634-640, 2000)
고흥선,Kyung Hee Jang,Eui Dong Han,Jae Eun Jo,Seon Ki Jeong,Eui Jeong Ham,Seong Taek In,Jong Hyek Lee,Gu Hee Kweon,Kwang Seon Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2
To identify subspecies and stocks of minke whale meats purchased from Korean markets during 2005-2007, we first obtained their complete sequences of mitochondrial DNA cytochrome b and control region sequences, and compared these sequences to the corresponding sequences of the common minke whale (Balaenoptera acutorostrata), obtained from GenBank. From analyses with partial cytochrome b sequences (383 bp) and non-coding, partial control region sequences (463 bp), Korean mink whale meats are identified as the products from the North Pacific minke whale (B. a. scammoni). In addition, the sequences of the partial control region from these meats showed G at site no. 298 and G or A at site no. 463, and the meats appear to be originated from the J stock within this subspecies. Thus, it seems to be urgent to fulfill strict regulation measures to reduce their accidental fisheries bycatch because the J stock has been protected since 1986. Additionally, B. a. scammoni is distinct from B. a. acutorostrata, with average Jukes-Cantor distance of 2.21% in the complete control region sequence analysis (935 bp) and 1.31% distance in the complete cytochrome b gene sequence analysis, and these present results support the present subspecies classification, although further sequencing analyses with nuclear genes are necessary.
Koh, Hung Sun,Jang, Kyung Hee,Han, Eui Dong,Jo, Jae Eun,Jeong, Seon Ki,Ham, Eui Jeong,Lee, Jong Hyek,Kim, Kwang Seon,In, Seong Teek,Kweon, Gu Hee The Korean Society for Integrative Biology 2012 Animal cells and systems Vol.16 No.5
To reexamine taxonomic status of endemic Mogera wogura coreana from Korea, we first obtained partial 12S rRNA sequences (893 bp) and complete cytochrome b gene sequences (1140 bp) of this subspecies, and these sequences and partial cytochrome b sequences (402 bp) were compared to the corresponding haplotypes of M. wogura from East Asia, obtained from GenBank. The one of three 12S rRNA haplotypes in M. w. coreana was identical to one 12S rRNA haplotype of M. w. robusta from East Asia: 10 complete and 13 partial cytochrome b haplotypes of M. w. coreana formed a single clade with one complete and four partial cytochrome b haplotypes of M. w. robusta, respectively. We considered that M. w. coreana from Korea is an endemic subspecies with only morphological differences, although it is necessary to reexamine the subspecies status of M. w. coreana. Additionally, in the 12S rRNA and complete cytochrome b sequences, M. wogura from Japan was distinct from the two continental subspecies of M. w. coreana and M. w. robusta with average distances of 1.76 and 5.65%, respectively; insular M. wogura, with within-group distances of 2.09 and 4.38%, respectively, was also genetically more divergent than the mainland M. wogura, with within-group distances of 0.08 and 0.57%, respectively. Thus, we considered that insular M. wogura of Japan dispersed into neighboring East Asian continent, which is opposite to the traditional hypothesis on the origin of Japanese M. wogura.