에이전트 기반의 맞춤형 교육 시스템

김은경,허선영 한국기술교육대학교 2006 論文集 Vol.12 No.1

According to the rapid popularization of the internet, recently the number of web-based remote education systems are rapidly increased. And demand for the customized educational service suitable for individual learner's level and learning pattern is increasing. Meanwhile, most remote education systems do not provide adequately customized educational service fit for each learner's level and lots of learners easily lose their interest in studying. Therefore, many researchers have used agents to provide personalized educational service by analyzing learner's level and learning pattern automatically. In this paper, we designed and implemented an agent-based customized education system(ACE) for individual learning. ACE tries to provide more suitable and individually customized learning contents by dividing learners' level into 5 stages and reproduces new learning contents on section unit instead of chapter unit. Also, ACE encourages learners' participation by providing proper feedback and sending e-mails including each learner's studying stage and learning target regularly.

IntraCytoplasmic Sperm Injection(ICSI)치료의 임상적 유용성

양회생,이은주,심재철 동국대학교 경주대학 1998 東國論集 Vol.17 No.2

IntraCytoplasmic Sperm Injection(ICSI) as treatment for male-factor infertility has been introduced worldwide on the past few years in many laboratories using assisted reproduction techniques. In spite of much progress in in vitro fertilization and embryo transfer(IVF-ET) program, the pregnancy rate remains at 20-30% and the endometrial implantation rate per embryo transferred at 10%. Although IVF-ET is widely applied in the treatment of couples with male factor infertility, it may fail in many infertile couples with normal seman parameters, and certain couples cannot be accepted for standard IVF-ET due to unfertilization or extremely low fertilization rate of oocytes. Recently, several procedures of microassisted fertilization(MAF) using micromanipulation have been introduced, and pregnancies and births have been obtained after IntraCytoplasmic Sperm Injection(ICSI). In conclusion, MAF of human oocytes with ICSI is a promising fertilization method for IVF-ET patients, especially with few spermatozoa for the conventional methods of in vitro insemination and with the past history of failure in fertilization or low fertilization rate in the previous cycles, and ICSI using micromanipulation procedures applied to human oocytes will provide a range of novel technique which may dramatically improve the pregnancy rate in IVF-ET program and contribute much to the effective management of infertile couples.

좌심실 장축 운동의 기능적 의의 (Ⅰ)

박종훈,전은석,구대회 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To assess the functional significance of long axis movement which would reflect the fiber orientation of the ventricular muscle, we examined the mitral annulus motion and compared it with standard minor axis movement. M-mode echocardiogram were performed in 24 healthy individuals and 17 mitral valve replaced (MVR) patients with simultaneous EKG and phonocardiogram recordings. The results were as follows : 1. In the controls, the onset of shortening of long axis preceeds that of minor axis (phase difference : 20±3msec, mean± SEM) but in MVR patients this phase difference was reversed (-33±8msec). It means that the spherical shape changes which can be observed in normal controls during isovolumic contraction period were lost in MVR patients. 2. In MVR patients, the time intervals from A2 to the end of shortening of long axis were significantly delayed compared with normal controls (54±3 VS 90±8 msec, P<0.01). 3. In MVR patients, the delayed shortening of long axis was observed in amplitude as well as in time. In summary. we observed the regional nonuniformity between long axis and short axis in normal control and interpreted that it could play a role in modulating ventricular function which was lost in MVR patients.

고지혈증에 대한 Lovastatin (Mevacor ??)의 치료효과

김영건,전은석,구대회 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To evaluate the lipid lowering effect of lovastatin a hydroxy methylglutaryl coenzyme A(HMG CoA) reductase, 18 hyperlipidemic patients were medicated with Mevacor^?? (20-40mg q. d) for 4 weeks in Chungnam National University Hospital. The results were as follows : 1. The serum total cholesterol decreased after 2 and 4 weeks of medication. (278±29 vs 220±37, 190±29mg/dl, p<0.05). 2. The serum triglyceride also decreased after medication(244±102 vs 210±118, 158±72 mg/ml, p<0.05). 3. The HDL cholesterol increased after 4 weeks medication(47±15 vs 60±16mg/dl, p<0.05). 4) The calculated LDL cholesterol decreased after medication(183±29 vs 125±39, 99±28 mg/dl, p<0.05). 5. There were no significant side effects except headache in one patient. As the results above, lovastatin(Mevacor^??)is a safe and very effective lipid lowering agent for the treatment of hyperlipidemia.

파라핀에 포매한 형질세포종양 조직에서의 CD56의 발현 증가와 진단적 유용성

김석형,박찬식,최은영,강현욱,박성희,정두현 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.3

요양병원 환자분류체계 개발

이지윤,윤주영,김정회,송성희,주지수,김은경 대한간호학회 간호행정학회 2008 간호행정학회지 Vol.14 No.3

Purpose: To develop the patient classification system based on the resource utilization for reimbursement of long-term care hospitals in Korea. Method: Health Insurance Review & Assessment Service (HIRA) conducted a survey in July 2006 that included 2,899 patients from 35 long-term care hospitals. To calculate resource utilization, we measured care time of direct care staff (physicians, nursing personnel, physical and occupational therapists, social workers). The survey of patient characteristics included ADL, cognitive and behavioral status, diseases and treatments. Major category criteria was developed by modified delphi method from 9 experts. Each category was divided into 2-3 groups by ADL using tree regression. Relative resource use was expressed as a case mix index (CMI) calculated as a proportion of mean resource use. Result: This patient classification system composed of 6 major categories (ultra high medical care, high medical care, medium medical care, behavioral problem, impaired cognition and reduced physical function) and 11 subgroups by ADL score. The differences of CMI between groups were statistically significant (p<.0001). Homogeneity of groups was examined by total coefficient of variation (CV) of CMI. The range of CV was 29.68-40.77%. Conclusions: This patient classification system is feasible for reimbursement of long-term care hospitals.

A Study on the Image Quality According to the Change of Flip Angle in Flow-Related Enhancement Magnetic Resonance Angiography

Eun-Hoe Goo(구은회) 한국방사선학회 2018 한국방사선학회 논문지 Vol.12 No.2

본 연구는 Image J 프로그램을 사용하여 유속증가 자기공명영상기법의 숙임각 변화에 따른 SNR와 CNR 을 측정하여 최적의 숙임각을 알아보기 위해 연구하였다. 총 30명의 정상인 지원자를 대상으로 1.5T 자기공명영상기기(Philips, Medical System, Achieva)를 이용하여 뇌동맥검사 후 평가를 실시하였다. 분석 방법으 로 유속증가 자기공명 혈관 조영술에 대하여 4 부위에 관심영역을 설정하고 SNR와 CNR을 평가하였다. 5가지 숙임각에서의 정량적 분석으로 SNR과 CNR에 대한 통계적 유의성은 일원분산분석으로 계산되었으며, 사후 분석으로는 Bonferroni 법을 적용하였고, 통계에 사용된 프로그램은 SPSS 14.0을 이용하여 p 값을 0.05 이하일 때 유의성을 두었다. 본 실험에 대한 결과로서 전교통동맥(SNR:876.59 ± 14.22, CNR:1999.7 ± 12.5), 후교통동맥 (SNR: 863.48 ± 13.29, CNR:1870.18 ± 12.56), ICA(SNR: 1116.87 ± 08.34, CNR:2979.37 ± 14.69), 중대뇌동맥(SNR:848.66 ± 15.25, CNR:2199.25 ± 13.48)의 값으로 25°에서 가장 높은 신호강도를 보였다(p<0.05). 작은 혈관 묘출로서 a1, a2, a3, p1, p2, p3, m1, m2, m3 값 또한 동일한 결과 이었다(p<0.05). 사후분석결과로, 숙임각에서 25° 기준으로 10°, 15°, 20°에서 유의성 있는 결과를 얻었지만(p=0.000) 30° 에서는 유의한 차이가 없었다(p>0.05). 결론적으로, 본 연구에서 30° 에서는 신호강도가 떨어지기 때문에 뇌혈관 자기공명조영술에서 최적의 숙임각은 25°로 나타냈다. The purpose of this study was to investigate the optimal flip angle by measuring the SNR and CNR according to the angle of changes of the MRI technique using the Image J program. A total of 30 normal volunteers were assessed by using a 1.5T magnetic resonance imaging system (Philips, Medical System, Achieva). For the MRI angiography, we set the region of interest in four regions and evaluated the SNR and CNR. The statistical significance of SNR and CNR was calculated by one-way ANOVA using quantitative analysis at five different positions. The Bonferroni method was used for post-hoc analyzes. Statistical significance was determined by using ANOVA analysis at p<0.05 and Bonferroni method was used as a post-hoc analysis. The results of this study, the measurement values o f ACA(SNR:876.59 ± 14.22, CNR:1999.7 ± 12.5), PCA(SNR:863.48 ± 13.29, CNR: 1870.18 ± 12.56), ICA(SNR:1116.87 ± 08.34, CNR:2979.37 ± 14.69) and MCA(SNR:848.66 ± 15.25, CNR: 2199.25 ± 13.48) were obtained with the high signal intensity at 25°(p<0.05). The values of a1, a2, a3, p1, p2, p3, m1, m2 and m3 were also the same (p<0.05). Post-hoc analysis results, There was a statistically significant difference (p=0.000) between 10°, 15°, 20° on the 25° reference for the flip angle, but no significant results were obtained with 30°(p<0.05). In concision, because the signal intensity decreased at 30°, this study revealed that the optimal flip angles were 25° in cerebrovascular MR angiography.

The Study on Correlation between Carotid IMT and Colon Polyps

Eun-Hoe Goo 한국방사선학회 2018 한국방사선학회 논문지 Vol.12 No.7

본 연구에 목적은 연령별 대장용종의 발생과 경동맥 내중막 두께와의 상관관계를 알아보고자 하였다. 대장내시경과 경동맥 초음파를 동시에 시행한 환자를 대상으로 연령별로 나누어 경동맥 내중막 두께에 따라 대장용종 발생의 상관관계를 교차분석을 토대로 확인하였다. 분석결과 대사증후군 환자 중 연령별로 대장용종과 경동맥 내중막 두께와의 연관성은 고령일수록 높은 일치결과를 나타냈고, 경동맥 내중막 두께가 1.1mm이상일 때 용종발생비율이 높게 나타났다. 결론적으로 대사증후군 환자의 용종발생비율은 경동맥 초음파 검사와 대장내시경과 높은 상관관계가 있었고, 고령일수록 경동맥 내중막 두께가 두꺼울수록 높았다. This study aims to investigate the correlation between the occurrence of colon polyps and carotid IMT by age. This study checked the correlation between the occurrence of colon polyps and carotid IMT, grouping patients who had a colonoscopy and carotid ultrasonography simultaneously by age based on cross-tabulation. As a result of the analysis, by age, the older the patients with metabolic syndrome, the higher the correlation between the occurrence of colon polyps and carotid IMT became. Also, when carotid IMT was more than 1.1mm, the incidence of polyps was high. In conclusion, there was a high correlation of the occurrence rate of colon polyps with carotid ultrasonography and colonoscopy, and the older the patient and the thicker the carotid IMT, the higher the correlation became.

A Study on Development of Phase Array Coil for MRI of Mouse in the 3.0 T High Magnetic Field

Eun-Hoe Goo,이재승,김문집,Dae-Cheol Kweon,Kyung-Rae Dong,정운관,Jin-Kook Lee,Keun-Jo Jang,임종득 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.4

<P>In this study, we manufactured an animal-dedicated radio frequency (RF) coil with a small diameter and multiple channels that could improve both image uniformity and signal-to-noise ratio (SNR). Quality of images from the manufactured coil was assessed compared to the loop coil used primarily for animal experiments and that had the same diameter. For our experiments, we used Balb/C nude mice that are most commonly used, and 3.0 T systems. The mouse body coil was a receive-only (Rx-only) coil with four channels. The coil had a diameter of 40 mm, length of 100 mm, and an overlapped distance between channels of 4 mm. A dual echo steady state (DESS) 2D pulse sequence, the type most frequently used for animal experiments, was applied. To evaluate the SNR of the coil cylinder that had a different number of channels, we used the loop coil typically designated for human use and the manufactured coil specific for animal use to obtain and compare phantom and mouse images. According to the results the image analysis, image uniformity and SNR were high for the image obtained from the animal-specific coil that had many channels. In conclusion, our experiment demonstrated that a 3.0 T phase array coil with multiple channels designed for animal use only produced images with excellent uniformity and SNR.</P>

Comparison of Image Quality in Magnetic Resonance Imaging of the Abdominal Organ at 1.5T and 3.0T before the Gadolinium Injection

Eun-Hoe Goo(구은회) 한국방사선학회 2017 한국방사선학회 논문지 Vol.11 No.7

본 연구는 조영제 주입 전 복부 검사 시 필수적으로 적용되고 있는 HASTE, HASTE(f/s), FFE(in, out)를 중심으로 두 기기에 대한 복부장기의 신호 대 잡음비(SNR; Signal to Noise Ratio)와 대조도 대 잡음비(CNR;Contrast to Noise Ratio)를 정량적으로 평가함으로서 최적의 장비선택을 알아보고자 하였다. 데이터분석은 1.5T 와 3.0T 자기공명영상기기(Philips medical system, Netherland)를 이용하여 검사한 복부영상을 무작위로 선정하여 분석을 하였다. 정량적 분석결과 간(Liver), 신장(Kidney), 비장(Spleen)에서는 1.5와 비교했을 때 3.0T가 SNR, CNR 값이 높게 나타났고(p<0.05), 위(Stomach), 복부지방(Abdominal Fat), 췌장(Pancreas)에서는 1.5T 가 높은 결과를 얻었다(p<0.05). 결론적으로 두기기별 장기에 대한 정량적 평가를 했을 때 인체의 바같 부분 조직은 전반적으로 3.0T 가 높게 나타났고 가스를 포함하여 자화율의 차이를 많이 발생시키는 안쪽부 분의 장기는 1.5T 가 높은 결과를 얻었다. 이러한 결과는 환자상태에 따라 조영제를 사용하지 못하고 MRI 검사를 하는 경우 정확한 진단학적 정보를 제공하는데 가이드라인이 될 것이다. The sudy was intended to evaluate the optimal equipment selection by quantitatively assessing the SNR(signal to noise ratio) and CNR(contrast to noise ratio) on the abdominal organ. This study performed on 1.5 T and 3.0 T MRI units focusing on HASTE, HASTE(f/s) and FFE(in of phase), FFE(out of phase) without using the contrast medium(Gadolinium). The data analysis was performed by randomly selecting on 1.5 T and 3.0 T abdominal MRI images. As a results, SNR and CNR values of 3.0 T is higher than 1.5 T at liver, kidney and spleen(p<0.05). Stomach, abdominal fat and pancreas was obtained a higher value at 1.5 T(p<0.05). On conclusion, the organs of outer part in the body showed generally a high value at 3.0 T, and the organs of inner part in the body including the gas showed a high value at 3.0 T because of a large difference on magnetic susceptibility.