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Systemic Contact Dermatitis from Propolis Ingestion
Eujin Cho,이정덕,조상현 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1
Propolis, also known as bee glue, is a substance collected by worker bees and it is used as a material for constructing and maintaining their beehives. It has been used topically and orally by humans for its anti-inflammatory properties. However, the growing use of propolis has been paralleled by reports of allergic contact dermatitis as a reaction to the substance. Contact dermatitis with generalized cutaneous manifestations elicited by propolis ingestion has not been previously reported. Here we report on the first case of systemic contact dermatitis from propolis ingestion in a 36-year-old woman. (Ann Dermatol 23(1) 85∼88, 2011)
Genetic Basis of Steroid Resistant Nephrotic Syndrome
Eujin Park 대한소아신장학회 2019 Childhood kidney diseases Vol.23 No.2
Steroid-resistant nephrotic syndrome (SRNS) has long been a challenge for clinicians due to its poor responsiveness to immunosuppressants, and rapid progression to end-stage renal disease. Identifying a monogenic cause for SRNS may lead to a better understanding of podocyte structure and function in the glomerular filtration barrier. This review focuses on genes associated with slit diaphragm, actin cytoskeleton, transcription factors, nucleus, glomerular basement membrane, mitochondria, and other proteins that affect podocyte biology.
X-linked hypophosphatemic rickets: from diagnosis to management
Eujin Park,Hee Gyung Kang 대한소아청소년과학회 2024 Clinical and Experimental Pediatrics (CEP) Vol.67 No.1
X-linked hypophosphatemia (XLH), the most common cause of hypophosphatemic rickets, affects one in every 20,000 people. Although conventional therapy for XLH was introduced approximately 4 decades ago, the temporary replacement of oral phosphate salts and activated vitamin D cannot completely control chronic hypophosphatemia, leaving patients with incomplete healing and residual skeletal deformity as well as at risk of endocrine abnormalities and adverse drug reactions. However, understanding the pathophysiology has led to the development of a targeted therapy, burosumab, a fibroblast growth factor-23 inhibitor that was recently approved in Korea for the treatment of XLH. This review provides insight into the diagnosis, evaluation, treatment, and recommendedfollow-up for a typical case of XLH and reviews its pathophysiology.
A Case of Reactive Eccrine Syringofibroadenoma
Eujin Cho,이정덕,조상현 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1
Eccrine syringofibroadenoma is a rare adnexal tumor of eccrine ductal differentiation with variable clinical features. It manifests as either a solitary or multiple papules and nodules arranged in a symmetrical or linear pattern. The anatomical distribution is wide and includes the face, trunk,extremities, and rarely the nails. Histopathological findings show anastomosing cords and strands of uniform cuboidal cells surrounded by fibrovascular stroma. Herein, we report a case of reactive eccrine syringofibroadenoma which developed on the foot of a 37-year-old woman, after self-paring of tissue and subsequent infection and ulceration. (Ann Dermatol 23(1) 70∼72, 2011)
Immature dendritic cells navigate microscopic mazes to find tumor cells
Um, Eujin,Oh, Jung Min,Park, Juhee,Song, Taegeun,Kim, Tae-Eon,Choi, Yongjun,Shin, Changsik,Kolygina, Diana,Jeon, Jae-Hyung,Grzybowski, Bartosz A.,Cho, Yoon-Kyoung The Royal Society of Chemistry 2019 Lab on a chip Vol.19 No.9
<P>Dendritic cells (DCs) are potent antigen-presenting cells with high sentinel ability to scan their neighborhood and to initiate an adaptive immune response. Whereas chemotactic migration of mature DCs (mDCs) towards lymph nodes is relatively well documented, the migratory behavior of immature DCs (imDCs) in tumor microenvironments is still poorly understood. Here, microfluidic systems of various geometries, including mazes, are used to investigate how the physical and chemical microenvironment influences the migration pattern of imDCs. Under proper degree of confinement, the imDCs are preferentially recruited towards cancer <I>vs.</I> normal cells, accompanied by increased cell speed and persistence. Furthermore, a systematic screen of cytokines, reveals that Gas6 is a major chemokine responsible for the chemotactic preference. These results and the accompanying theoretical model suggest that imDC migration in complex tissue environments is tuned by a proper balance between the strength of the chemical gradients and the degree of spatial confinement.</P>
A microfluidic abacus channel for controlling the addition of droplets
Um, Eujin,Park, Je-Kyun Royal Society of Chemistry 2009 Lab on a chip Vol.9 No.2
<P>This paper reports the first use of the abacus-groove structure to handle droplets in a wide microchannel, with no external forces integrated to the system other than the pumps. Microfluidic abacus channels are demonstrated for the sequential addition of droplets at the desired location. A control channel which is analogous to biasing in electronics can also be used to precisely determine the number of added droplets, when all other experimental conditions are fixed including the size of the droplets and the frequency of droplet-generation. The device allows programmable and autonomous operations of complex two-phase microfluidics as well as new applications for the method of analysis and computations in lab-on-a-chip devices.</P> <P>Graphic Abstract</P><P>Microfluidic abacus channels are designed to demonstrate the sequential addition of droplets at the desired location. The number of added droplets can be controlled by a control channel which is analogous to biasing in electronics. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b814948h'> </P>
Um, Eujin,Nunes, Janine K.,Pico, Tamara,Stone, Howard A. The Royal Society of Chemistry 2014 Journal of Materials Chemistry B Vol.2 No.45
<P>We present a microfluidic method to continuously produce multicompartment microfibers, where embedded single or double emulsion droplets are regularly spaced along the length of the fiber. Both hydrophobic and hydrophilic compounds can be encapsulated in different microcompartments of the fiber for storage, selective dissolution, and delivery applications, as well as to provide multifunctionality.</P>