Effect of Ditaxin and Heteranthin and Inhibitory Effect of Ditaxis heterantha Extract on L5178Y Tumor Development in Mice

María Eugenia Jaramillo-Flores,Herry Heriyati Permady,Ana Maria Puebla-Pérez,Eduardo Padilla,Eugenia del Carmen Lugo-Cervantes,Jorge Ivan Delgado-Saucedo,Eva Ramón-Gallegos 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5

Ditaxis heterantha seeds are used as spices for flavoring and coloring food. Two new apocarotenoids derived from the seeds, heteranthin and ditaxin, were evaluated for their in vitro cytotoxic effects in murine lymphoma cells lines. Bioabsorption in mice and preventive and antitumor effects of the apocarotenoids were determined. Ditaxin and heteranthin showed cytotoxic effects in vitro against murine malignant cells and normal splenocyte cells. The 50% inhibitory concentration (IC_50) for ditaxin in splenocytes was 0.1825 mM; in L5178Y, the IC_50 was 0.1923 mM. The heteranthin IC_50 in splenocytes was 0.1325 mM; in L5178Y, the value was 0.3889 mM. The maximum ditaxin plasma concentration was found after 2 hours of administration (mean±standard deviation, 7.5±2.05 μg/mL). Oral administration of the D. heterantha extract (100 mg/kg per day) for 14 days after the L5178Y lymphoma cell implantation showed no significant effect compared with groups that were not pretreated. However, tumor inhibition in groups treated intraperitoneally before inoculation with the L5178Y cells showed a significant difference (P<.001) compared with the groups not pretreated.

Continuing Professional Education for Audit Partners and Audit Quality

( Eugenia Y. Lee ),( Jong-hag Choi ),( Moon Ki Chung ) 한국회계학회 2018 會計學硏究 Vol.43 No.2

This study examines the effect of continuing professional education (CPE) for audit partners on audit quality. In Korea, as in many other countries, certified public accountants are required to attend at least 40 hours of CPE annually to perform external audits. However, the effect of CPE on audit quality is not clear and we are not aware of any prior studies that directly investigate such an effect. Using a unique dataset on the annual CPE hours of audit partners from 2006 to 2015, we fail to find evidence that greater CPE is significantly related to improved audit quality. Through several cross-sectional analyses, we fail to identify any specific circumstances in which greater CPE improves audit quality. Despite important empirical limitations, this study provides practical implications on the role of CPE in determining audit quality. The findings suggest that regulators, professional bodies, and academics need to pay attention to the issue and develop ways to improve the effectiveness of the CPE.

Association Between the Neurogenic Bladder Symptom Score and Urodynamic Examination in Multiple Sclerosis Patients With Lower Urinary Tract Dysfunction

Eugenia Fragalà,Giorgio Ivan Russo,Alessandro Di Rosa,Raimondo Giardina,Salvatore Privitera,Vincenzo Favilla,Francesco Patti,Blayne Welk,Sebastiano Cimino,Tommaso Castelli,Giuseppe Morgia 대한배뇨장애요실금학회 2015 International Neurourology Journal Vol.19 No.4

Purpose: To determine the relationship between the neurogenic bladder symptoms score (NBSS) and urodynamic examination in patients affected by multiple sclerosis (MS) and related lower urinary tract dysfunction (LUTD). Methods: We recruited 122 consecutive patients with MS in remission and LUTD from January 2011 to September 2013 who underwent their first urodynamic examination. Neurological impairment was assessed using the Expanded Disability Status Scale (EDSS) and bladder symptoms were studied with the NBSS. Results: Median NBSS was 20.0 (interquartile range, 12.75–31.0). Neurogenic detrusor overactivity (NDO) was discovered in 69 patients (56.6%). The concordance between patients with NDO and maximum detrusor pressure during involuntary detrusor contraction (PdetmaxIDC)≥20.0 cm H2O was 0.89 (κ-Cohen; P<0.05). Patients with EDSS scores of ≥4.5 had a greater NBSS (25.41 vs. 20.19, P<0.05), NBSS-incontinence (8.73 vs. 4.71, P<0.05), NBSS-consequence (4.51 vs. 3.13, P<0.05) and NBSS-quality of life (2.14 vs. 1.65, P<0.05). The NBSS was not associated with PdetmaxIDC≥20 cm H2O (P=0.77) but with maximum cystometric capacity<212 mL (odds ratio, 0.95; P<0.05). Conclusions: The NBSS cannot give adequate information the way urodynamic studies can, in patients with MS and LUTD.

The Consumption of Cultural Experiences in City Tourism

Eugenia Wickens 한국문화관광학회 2021 문화관광연구 Vol.23 No.1

Whilst considerable attention has been given to the role of cultural tourism in city development and the ‘gentrification’ of inner city areas, there has been little research into the experiences of cultural tourists. Past research shows that their experience is conceptualised as a ‘pre-programmed’ product made especially for mass consumption. It is often assumed that the commoditization of urban tourism results in ‘standardised’ city environments, loss of culture and traditions, loss of place distinctiveness and subsequent loss of ‘authenticity’. According to this line of reasoning, cultural tourists consume ‘specimens of the artificial’ which are mass produced, predictable,standardised and superficial. By implication the commoditization of cultural tourism destroys the ‘authenticity’ of the traveller’s experience (see Featherstone, 1991, Sheller and Urry, 2004). This logic raises questions about the hermeneutic problem entailed in any conceptualisation of ‘authenticity’ The central focus of this theoretical paper is the debate concerning the consumption oftourists’ cultural experiences within the context of city tourism. Issues associated with the various dimensions of ‘authenticity’ that inform cultural tourism studies are critically assessed. Finally, by way of conclusion the paper offers a fresh perspective for understanding the consumption of urban cultural experiences.

Unveiling the Traffic Dynamics of A Virtual Community

Eugenia Y . K . Huang 한국경영정보학회 2001 한국경영정보학회 학술대회논문집 Vol.2001 No.-

TOURISTS, MOTIVATIONS AND EXPERIENCES

Eugenia WICKENS 세계문화관광학회 2006 Conference Proceedings Vol.7 No.0

The central focus of this paper is the ongoing debate concerning the nature of the touristic experience and the factors identified by various writers as motivating people to leave their home environment for a holiday. The paper examines critically the arguments of diverse thinkers, assesses the strengths and weaknesses of their various positions, and explores their concept of 'the tourist'. It commences with a review of the literature and then outlines a fresh perspective on tourists' experiences. This critique is informed by research of tourists' experiences in Chalkidiki, Greece. A central conclusion to emerge from this discussion is that understanding tourists' experiences of their hosts and the visited community is a key element for the planning and promotion of the host community as an individual place.

A NEW METHOD FOR MODELING COMPLEX SYSTEMS BY CONVERSION OF THE LAPLACE TRANSFORM TO THE Z-TRANSFORM

Eugenia Rasskazova Penn,Leo Schelovanov 대한전자공학회 1994 대한전자공학회 Proceedings Vol.1994 No.-

Preoperative implant planning considering alveolar bone grafting needs and complication prediction using panoramic versus CBCT images

Maria Eugenia Guerrero,Jorge Noriega,Reinhilde Jacobs 대한영상치의학회 2014 Imaging Science in Dentistry Vol.44 No.3

Purpose: This study was performed to determine the efficacy of observers’ prediction for the need of bone grafting and presence of perioperative complications on the basis of cone-beam computed tomography (CBCT) and panoramic radiographic (PAN) planning as compared to the surgical outcome. Materials and Methods: One hundred and eight partially edentulous patients with a need for implant rehabilitation were referred for preoperative imaging. Imaging consisted of PAN and CBCT images. Four observers carried out implant planning using PAN image datasets, and at least one month later, using CBCT image datasets. Based on their own planning, the observers assessed the need for bone graft augmentation as well as complication prediction. The implant length and diameter, the need for bone graft augmentation, and the occurrence of anatomical complications during planning and implant placement were statistically compared. Results: In the 108 patients, 365 implants were installed. Receiver operating characteristic analyses of both PAN and CBCT preoperative planning showed that CBCT performed better than PAN-based planning with respect to the need for bone graft augmentation and perioperative complications. The sensitivity and the specificity of CBCT forimplant complications were 96.5% and 90.5%, respectively, and for bone graft augmentation, they were 95.2% and 96.3%, respectively. Significant differences were found between PAN-based planning and the surgery of posterior implant lengths. Conclusion: Our findings indicated that CBCT-based preoperative implant planning enabled treatment planning with a higher degree of prediction and agreement as compared to the surgical standard. In PAN-based surgery, the prediction of implant length was poor.

Does cone-beam CT alter treatment plans? Comparison of preoperative implant planning using panoramic versus cone-beam CT images

Maria Eugenia Guerrero,Jorge Noriega,Carmen Castro,Reinhilde Jacobs 대한영상치의학회 2014 Imaging Science in Dentistry Vol.44 No.2

Purpose: The present study was performed to compare the planning of implant placement based on panoramic radiography (PAN) and cone-beam computed tomography (CBCT) images, and to study the impact of the image dataset on the treatment planning. Materials and Methods: One hundred five partially edentulous patients (77 males, 28 females, mean age: 46 years, range: 26-67 years) seeking oral implant rehabilitation were referred for presurgical imaging. Imaging consisted of PAN and CBCT imaging. Four observers planned implant treatment based on the two-dimensional (2D) image datasets and at least one month later on the three-dimensional (3D) image dataset. Apart from presurgical diagnostic and dimensional measurement tasks, the observers needed to indicate the surgical confidence levels and assess the image quality in relation to the presurgical needs. Results: All observers confirmed that both imaging modalities (PAN and CBCT) gave similar values when planning implant diameter. Also, the results showed no differences between both imaging modalities for the length of implants with an anterior location. However, significant differences were found in the length of implants with a posterior location. For implant dimensions, longer lengths of the implants were planned with PAN, as confirmed by two observers. CBCT provided images with improved scores for subjective image quality and surgical confidence levels. Conclusion: Within the limitations of this study, there was a trend toward PAN-based preoperative planning of implant placement leading towards the use of longer implants within the posterior jaw bone.

외국어 교육에 대한 고찰

Rosa Eugenia Rivas Hurtado 한국외국어대학교 1996 한국외국어대학교 논문집 Vol.29 No.1