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Organs-on-chips at the frontiers of drug discovery
Esch, Eric W.,Bahinski, Anthony,Huh, Dongeun Nature Publishing Group, a division of Macmillan P 2015 Nature reviews. Drug discovery Vol.14 No.4
Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs — known as organs-on-chips — that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology.
Jan Schulte am Esch,Nadja Lehwald-Tywuschik,Fabian Steinfurth,Feride Kröpil,Andreas Krieg,Hülya Sarikaya,Wolfram Trudo Knoefel,Martin Krüger,Tahar Benhidjeb,Morris Beshay 대한위암학회 2019 Journal of gastric cancer Vol.19 No.4
Surgical therapy for adenocarcinoma of the esophagogastric junction II requires distal esophagectomy, in which a transhiatal management of the lower esophagus is critical. The ‘dorsal track control’ (DTC) maneuver presented here facilitates the atraumatic handling of the distal esophagus, in preparation for a circular-stapled esophagojejunostomy. It is based on a ventral semicircular incision in the distal esophagus, with an intact dorsal wall for traction control of the esophagus. The maneuver facilitates the proper placement of the purse-string suture, up to its tying (around the anvil), thus minimizing the manipulation of the remaining esophagus. Furthermore, the dorsally-exposed inner wall surface of the ventrally-opened esophagus serves as a guiding chute that eases anvil insertion into the esophageal lumen. We performed this novel technique in 21 cases, enabling a safe anastomosis up to 10 cm proximal to the Z-line. No anastomotic insufficiency was observed. The DTC technique improves high transhiatal esophagojejunostomy.
Jan F. Klein,Tomas Falk,Franz-Rudolf Esch,Alexei Gloukhovtsev 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06
Despite the growing need for marketers in luxury retail to provide memorable customer experiences via their retail outlets, research investigating the effectiveness of experiential stores on brand and behavioral outcomes is scarce. To address this gap, we investigate the effectiveness of pop up brand stores, which we define as temporary stores that are open for a limited period of time, representing an increasingly popular experiential store format in the luxury fashion and automotive industry. However, pop up brand stores not only reflect one of the latest developments in experiential retailing, but they are also seen as an effective marketing tool to reach new target groups which might perceive traditional luxury as antiquated or obsolete. Collecting data from 345 visitors of two pop up brand stores of a luxury car brand in the US and the UK, we find that three store characteristics – hedonic shopping value, store uniqueness, and store atmosphere – either directly or through brand experience exert a positive effect on word of mouth (WOM) intentions towards the brand. Whereas hedonic shopping value and store atmosphere strengthen the customer’s experience with the luxury brand, store uniqueness, surprisingly, does not. Using brand familiarity as a moderating variable, we further unveil that pop up brand stores create positive WOM in both existing and new target groups. Our empirical results offer novel insights for researchers and marketers, as we quantify the effects of experiential store characteristics on brand experience and WOM, shed light on the role of brand experience in inducing behavioral intentions, as well as illustrate that pop up brand stores are an exceptional opportunity for luxury brands to reach existing and new target groups alike. We argue that pop up brand stores should thoughtfully be considered as a complement to traditional luxury retail and as an alternative to flagship stores.