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Er-Yun Zhang,Bo Gao,Hai-Lian Shi,Ling-Fang Huang,Li Yang,Xiao-Jun Wu,Zheng-Tao Wang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Impaired angiogenesis is one of the crucial factors that impede the wound healing process in diabetic foot ulcers (DFUs). In this study, we found that 20(S)-protopanaxadiol (PPD), an aglycone of ginsenosides in Panax notoginseng, stimulated angiogenesis and benefited wound healing in genetically diabetic mice. In HUVECs, PPD promoted cell proliferation, tube formation and VEGF secretion accompanied by increased nuclear translocalization of HIF-1α, which led to elevated VEGF mRNA expression. PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059. Furthermore, these two pathways had crosstalk through p70S6K, as LY294002, PD98059 and p70S6K siRNA abolished the angiogenic responses of PPD. In the excisional wound splinting model established in db/db diabetic mice, PPD (0.6, 6 and 60 mg ml− 1) accelerated wound closure, which was reflected by a significantly reduced wound area and epithelial gaps, as well as elevated VEGF expression and capillary formation. In addition, PPD activated PI3K/Akt/ERK signaling pathways, as well as enhanced p70S6K activity and HIF-1α synthesis in the wounds. Overall, our results revealed that PPD stimulated angiogenesis via HIF-1α-mediated VEGF expression by activating p70S6K through PI3K/Akt/mTOR and Raf/MEK/ERK signaling cascades, which suggests that the compound has potential use in wound healing therapy in patients suffering from DFUs.
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뉴 미디어를 활용한 전시공간의 체험적 특성에 관한 연구 - 디지털 미디어 미술관 사례를 중심으로 -
유단경(Liu, Dan-Qiong),유정(Liu, Ting),소미(Lian, Zhuo-Er),황연숙(Hwang, Yeon-Sook) 한국실내디자인학회 2019 한국실내디자인학회 학술대회논문집 Vol.21 No.1
In order to provide effective reference materials for the future development of display space. This paper studies four art galleries in urban areas that use new media, especially familiar with media, and understands the characteristics of new media art. In addition, we also understand the experience types and characteristics of modern experience art galleries under the use of new media. Through the preliminary study and analysis of a large number of specific cases, it reveals the characteristics of the space experience under the use of new media: First, the sensation is irritating. Second, interaction. Third, the application of association and digital technology makes the work more realistic. Fourth, the induction and induction of voluntary experience. The fifth is connectivity, where space enhances reality, and based on the specific spatial nature of a specific region, the display of the entire space is easy to connect. Through projection, 3D technology, digital media, LED display, lighting, color, sound, sound, sound, voice, etc. Using new media techniques makes the display space very much interactive and sensory stimulation. Due to the relatively long range of participants " participation in the experimental museum or experience facility, some space is not enough to guide the visitor to the next room, which leads to a lesser connection.In order to utilize the new media, it is also more diverse and diverse, and the experience of display space is more diverse.
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Mu, Xiao-Yan,Dong, Xue-Li,Sun, Jie,Ni, Yu-Hua,Dong, Zhang,Li, Xi-Li,Sun, Er-Lian,Yi, Zhou,Li, Gao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
The effects of erlotinib combined with celecoxib in a lung cancer xenograft model were here explored with a focus on possible mechanisms. A xenotransplanted lung cancer model was established in nude mice using the human lung cancer cell A549 cell line and animals demonstrating tumour growth were randomly divided into four groups: control, erlotinib, celecoxib and combined (erotinib and celecoxib). The tumor major axis and short diameter were measured twice a week and after 40 days tissues were collected for immunohistochemical analyses of Bcl-2 and Bax positive cells and Western-blotting analyses for the epidermal growth factor recepto (EGFR), P-EGFR, and cyclooxygenase-2 (COX-2). Tumor size in the combined group was smaller than in the others (p<0.01) and the percentage of Bcl-2 positive cells was fewer in most cases (p<0.01), while that of Bax positive cells was greater than in the erlotinib and celecoxib groups (P>0.05). Western blotting showed decreased expression of P-EGFR and COX-2 with both erlotinib and celecoxib treatments, but most pronouncedly in the combined group (P<0.05). Simultaneous blockage of the EGFR and COX-2 signal pathways exerted stronger growth effects in our human xenotransplanted lung cancer model than inhibition of either pathway alone. The anti-tumor effects were accompanied by synergetic inhibition of tumor cell apoptosis, activation of p-EGFR and expression of COX-2.
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