Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels

Ersöz Gonca,Simona Rapposelli,Faruk Darıcı,Maria Digiacomo,Zehra Yılmaz 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9

‘Compound A’ (4ı-(N-(4-acetamidobenzyl))-2,2- dimethyl-2,3-dihydro-5ıH-spiro[chromene-4,2ı-[1,4]oxazinan]- 5ı-one) is a new spiro-cyclic benzopyran activator of the mitochondrial ATP-dependent potassium channels (mitoKATP). We researched the effect of compound A on ischemia/reperfusion (I/R)-induced ventricular arrhythmias. We also tested the hypothesis that the application of the activation of mitoKATP in combination with the inhibition of sarcolemmal ATP-dependent potassium channels (sarcKATP) may produce a stronger antiarrhythmic effect. In anesthetized rats, myocardial ischemia was performed by ligating the left main coronary artery followed by reperfusion. At a dose of 10 mg/kg, compound A significantly decreased arrhythmia scores and the total length of arrhythmias, whereas this was found to be ineffective at a dose of 3 mg/kg. Pre-treatment with 5-HD, a selective mitoKATP blocker, abolished the antiarrhythmic effect of compound A. Both diazoxide, a selective mitoKATP opener and HMR 1098, a selective sarcKATP blocker, significantly decreased the total length of arrhythmias. However, the combination of neither diazoxide nor compound A with HMR 1098 showed no additional therapeutic benefit. These results reveal that compound A may have a dose-dependent antiarrythmic effect, which is more pronounced than the antiarrhythmic effect of diazoxide. The antiarrhythmic effect of compound A may possibly depend on mitoKATP activation.

Green synthesis and characterization of Ag-doped ZnO nanofibers for photodegradation of MB, RhB and MO dye molecules

Ersöz Eda,Altintas Yildirim Ozlem 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.5

In this study, silver (Ag)-doped zinc oxide (ZnO) nanofiber photocatalysts were synthesized using electrospinning method. To understand the effect of Ag doping on the photocatalytic efficiencies, ZnO nanofibers were prepared with diff erent load- ing ratios (0, 0.3, 0.5, 1.0 at.% Ag). The synthesized nanofibers were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), ultraviolet–visible (UV–Vis) spectroscopy and photoluminescence (PL) spectroscopy techniques. The photocatalytic performances of the fibers were first evaluated by measuring the photodegradation of methylene blue (MB) under the UV light irradiation. It was found that the amount of dopant ions has a crucial effect on the degradation process of MB. The results show that 0.5 at.% Ag dopant dosage is the ideal to achieve maximum catalytic efficiency against MB dye molecules with nearly complete decolorization just after 75 min UV light irradiation. During the degradation process, the substitutional incorporation of dopant ions provides better photocatalytic efficiency due to forming higher number of charge carriers and so delaying the recombination process. The recycling experiments for MB dye degradation were performed to determine the conservation of the catalytic efficiency and chemical stability of the nanofibers. To compare the photocatalytic efficiency of nanofibers against different dye molecules, the degradation performance of 0.5 at.% Ag-doped ZnO nanofibers was also experimentally examined by the measuring the photocatalytic degradation rates of various harmful organic dyes such as Rhodamine B (RhB) and methylene orange (MO) under the UV light irradiation. It was found that the photodegradation rates of RhB and MO synthetic dye solutions are determined as follows: ~ 66% and ~ 51% decomposition after 120 min UV light irradiation, respectively. A possible mechanism for the improvement of the photocatalytic performance of ZnO nanofibers by Ag loading is proposed.

Effectiveness of active video games in overweight and obese adolescents: a systematic review and meta-analysis of randomized controlled trials

Erçelik Zübeyde Ezgi,Çağlar Seda 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.2

Purpose: The purpose of this review was to assess the effect of active video games among overweight and obese adolescents. Methods: A systematic review and meta-analysis were conducted using records from the English-language electronic databases MEDLINE, the Web of Science, and PubMed. These databases were searched from January 2010 to December 2020 using the keywords (adolescent*) AND (overweight OR obese *) AND (active video games OR exergaming * OR video game*). Results: Five articles met the inclusion criteria. Four studies were conducted in the United States of America and 1 study was conducted in Canada. In addition, all included articles had a randomized controlled trial study design. It was determined that the sample size of the studies was 30–46 participants and there were a total of 195 overweight and obese adolescents across the included studies. Active video gaming was negatively associated with changes in body mass index percentile (mean difference [MD], -1.77; 95% confidence interval [CI], -2.55 to -0.99; P<0.001) and total cholesterol (MD, -11.16; 95% CI, -16.64 to -5.68; P<0.001). Conclusion: Playing active video games can reduce both the body mass index percentile and total cholesterol in overweight and obese adolescents. Active video games can provide a different method for combating childhood obesity. High-quality randomized controlled trials are recommended to assess the impact of game-based interventions.

Effectiveness of active video games in overweight and obese adolescents: a systematic review and meta-analysis of randomized controlled trials

Erçelik Zübeyde Ezgi,Çağlar Seda 대한소아내분비학회 2022 Apem Vol.27 No.2

Purpose: The purpose of this review was to assess the effect of active video games among overweight and obese adolescents.Methods: A systematic review and meta-analysis were conducted using records from the English-language electronic databases MEDLINE, the Web of Science, and PubMed. These databases were searched from January 2010 to December 2020 using the keywords (adolescent*) AND (overweight OR obese *) AND (active video games OR exergaming * OR video game*).Results: Five articles met the inclusion criteria. Four studies were conducted in the United States of America and 1 study was conducted in Canada. In addition, all included articles had a randomized controlled trial study design. It was determined that the sample size of the studies was 30–46 participants and there were a total of 195 overweight and obese adolescents across the included studies. Active video gaming was negatively associated with changes in body mass index percentile (mean difference [MD], -1.77; 95% confidence interval [CI], -2.55 to -0.99; p<0.001) and total cholesterol (MD, -11.16; 95% CI, -16.64 to -5.68; p<0.001).Conclusion: Playing active video games can reduce both the body mass index percentile and total cholesterol in overweight and obese adolescents. Active video games can provide a different method for combating childhood obesity. High-quality randomized controlled trials are recommended to assess the impact of game-based interventions.

Biomechanical investigation of maxillary implant-supported full-arch prostheses produced with different framework materials: a finite elements study

Mirac Berke Topcu Ersöz,Emre Mumcu 대한치과보철학회 2022 The Journal of Advanced Prosthodontics Vol.14 No.6

PURPOSE. Four and six implant-supported fixed full-arch prostheses with various framework materials were assessed under different loading conditions. MATERIALS AND METHODS. In the edentulous maxilla, the implants were positioned in a configuration of four to six implant modalities. CoCr, Ti, ZrO2,and PEEK materials were used to produce the prosthetic structure. Using finite element stress analysis, the first molar was subjected to a 200 N axial and 45°oblique force. Stresses were measured on the bone, implants, abutment screw, abutment, and prosthetic screw. The Von Mises, maximum, and minimum principal stress values were calculated and compared. RESULTS. The maximum and minimum principal stresses in bone were determined as CoCr < ZrO2 < Ti < PEEK. The Von Mises stresses on the implant, implant screw, abutment, and prosthetic screws were determined as CoCr < ZrO2 < Ti < PEEK. The highest VonMises stress was 9584.4 Mpa in PEEK material on the prosthetic screw under 4 implant-oblique loading. The highest maximum principal stress value in bone wasfound to be 120.89 Mpa, for PEEK in 4 implant-oblique loading. CONCLUSION. For four and six implant-supported structures, and depending on the loading condition, the system accumulated different stresses. The distribution of stress was reduced in materials with a high elastic modulus. When choosing materialsfor implant-supported fixed prostheses, it is essential to consider both the number of implants and the mechanical and physical attributes of the framework material.

Synergistic effect of binanoenzyme and cryogel column on the production of formic acid from carbondioxide

Yi gitcan Sümbelli,Özlem Biçen Ünlüer,Arzu Ersöz,Rıdvan Say 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.76 No.-

In this study, binanoenzyme (BNE) was synthesized using FateDH and Cyt-C in same bionano-interface;by formation of formate dehydrogenase-co-cytochrome C by using ANADOLUCA method. Thesynthesized novel binanoenzyme was embedded into HEMA based cryogel column and the conversionof CO2 to formic acid was investigated by using this cryogel column. To maintain the conversion, CO2saturated water was passed through the cryogel column and the converted formic acid was analyzedusing HPLC. The parameters which has an effect on conversion such as pH, sample volume and CO2concentration were analyzed. The results showed that the conversion process was succeeded effectively.

Comparison of synthesis methods for BiOI/g-C3N4 heterojunction photocatalysts and testing their visible light activity in sugar processing wastewater treatment

Gülen Tekin,Gülin Ersöz,Süheyda Atalay 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-

The study focused on synthesis of BiOI/g-C3N4 heterojunction photocatalysts by various methods toinvestigate their physicochemical properties as well as their performances on photocatalytic treatmentof sugar processing wastewater. The heterojunction catalysts possessed enhanced catalytic activity comparedto the pristine BiOI and g-C3N4. In-situ growth of BiOI on g-C3N4 was determined as the mostpromising method when the pH of the synthesis medium was adjusted to 10. This method provided amore homogeneous distribution and smaller size for the BiOI clusters that formed a unique flower shapewhich enhanced the catalytic activity remarkably. This depicts that synthesis conditions are especiallyimportant to obtain desired physicochemical properties for a photocatalyst since it has a key role inthe crystal structure of BiOI. The optimum nominal weight ratio was determined as 75:25 for BiOI andg-C3N4, respectively by considering the superior morphology and the highest photocatalytic activityfor 45.30% and 23.40% total saccharide (TSC) and total organic carbon (TOC) removal, respectively. Thephotocatalytic mechanism depicted that charge separation in the heterojunction structure was accomplishedvia the new S-scheme and the oxidation of saccharides and intermediates followed differentpathways by reacting with different radicals.

Clinical comparison of intraoral CMOS and PSP detectors in terms of time efficiency, patient comfort, and subjective image quality

Kamburoğlu Kıvanç,Samunahmetoğlu Erçin,Eratam Nejlan,Sönmez Gül,Karahan Sevilay 대한영상치의학회 2022 Imaging Science in Dentistry Vol.52 No.1

Purpose: This study compared the effectiveness of complementary metal-oxide semiconductors (CMOS) and photostimulable phosphor (PSP) plates as intraoral imaging systems in terms of time efficacy, patient comfort, and subjective image quality assessment in real clinical settings. Materials and Methods: Fifty-eight patients (25 women and 33 men) were included. Patients were referred for a full-mouth radiological examination including 1 bitewing radiograph (left and right) and 8 periapical radiographs for each side (left maxilla/mandible and right maxilla/mandible). For each patient, 1 side of the dental arch was radiographed using a CMOS detector, whereas the other side was radiographed using a PSP detector, ensuring an equal number of left and right arches imaged by each detector. Clinical application time, comfort/pain, and subjective image quality were assessed for each detector. Continuous variables were summarized as mean±standard deviation. Differences between detectors were evaluated using repeated-measures analysis of variance. P<0.05 was accepted as significant. Results: The mean total time required for all imaging procedures with the CMOS detector was significantly lower than the mean total time required for imaging procedures with PSP (P<0.05). The overall mean patient comfort scores for the CMOS and PSP detectors were 4.57 and 4.48, respectively, without a statistically significant difference (P>0.05). The performance of both observers in subjectively assessing structures was significantly higher when using CMOS images than when using PSP images for all regions (P<0.05). Conclusion: The CMOS detector was found to be superior to the PSP detector in terms of clinical time efficacy and subjective image quality.

Double-imprinted potentiometric sensors based on ligand exchange for the determination of dimethoate

Eyüp Bektaşoğlu,Ebru Birlik Özkütük,Arzu Ersöz,Rıdvan Say 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.8

This paper describes a dimethoate imprinted polymeric potentiometric sensor for the determination of dimethoate that was designed by dispersing the dimethoate-imprinted polymer in dibutyl phthalate plasticizer and then embedded in polyvinyl chloride matrix. The method is based on molecularly imprinted polymer (MIP), which can be synthesized by using dimethoate as a template molecule, chitosan-Cd(II), and 3-mercaptopropyl-trimethoxysilane as a functional monomer and TEOS, and ephychlorohydrin as a cross-linking agent. We have studied a method for the selective binding behavior of dimethoate compounds on the surface of imprinted polymers which is prepared using ligand-exchange (LE) (chitosan-Cd(II)) monomer. The MIP-LE-1 and MIP-LE-2 based membranes have shown a detection limit of 4.3×10−6mmolL−1 and 3.5.10−5 mmolL−1, respectively. The sensor has exhibited a response time of 35min for MIP-LE-1 and 120min for MIP-LE-2. They are stable for more than three months.

The Preparation of Transparent Organic Field Effect Transistor Using a Novel EDOT Functional Styrene Copolymer Insulator With a PEDOT:PSS Gate Electrode

Okan Gunaydin,Ahmet Demir,Gülçin Ersöz Demir,İbrahim Yücedağ,Bünyemin Çoşut 한국고분자학회 2018 Macromolecular Research Vol.26 No.2

In this study, we have purposed to combine both polystyrene (PS) and 3,4-ethylenedioxythiophene (EDOT) groups as a gate dielectric and to fabricate a transparent organic field effect transistor (OFET) device with polymeric gate electrode using this novel organic dielectric material. The focus point of this work is to obtain a transparent OFET and to minimize the interface states between gate insulator and gate electrode. Firstly, we have synthesized EDOT functional polystyrene (PS-EDOT) copolymer as gate insulator via “click” chemistry between azide-functional styrene copolymer and propargyl-functionalized EDOT. We used the poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) conductive polymer mixture as a suitable alternative gate electrode instead of inorganic contacts, which is a new topic in the organic electronics. The contact resistance value was measured as 1/600 (S/cm)-1. At the end of the process transparent OFETs with different channel length were fabricated using spin coating method by which poly(3-hexylthiophene) (P3HT), novel PS-EDOT copolymer insulator and PEDOT:PSS were coated on prepatterned OFET substrate. Electrical characterizations of OFET devices were held in total darkness and in air ambient in order to achieve output and transfer current-voltage (I-V) characteristics. The main parameters such as the threshold voltage (VTh), field effect mobility (μFET) and current on/off ratio (Ion/off) of the devices were extracted from capacitance-frequency (C-f) plot. It was found that fabricated PS-EDOT OFETs exhibit good device performances such as low VTh, remarkable mobility, and Ion/off values.