Pelleting in Associated with Sodium Monensin Increases the Conjugated Linoleic Acids Concentration in the Milk of Dairy Cows Fed Canola Seeds

Francilaine Eloise De Marchi,Jakeline Vieira Romero,Julio Cesar Damasceno,Paula Adriana Grande,Lucia Maria Zeoula,Geraldo Tadeu dos Santos 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.8

To evaluate the effects of the pelleting and the addition of sodium monensin on production, the chemical and lipid composition of milk and butter physical characteristics, 4 Holstein dairy cows (135 days of lactation) with an average milk production of 14.7 kg/d, were supplemented with a concentrate containing ground canola seeds. The cows were assigned to a 4×4 Latin square design with a 2×2 factorial arrangement of treatments: i) ground maize, soybean meal, mineral and vitamin supplements, and ground canola seeds (CG); ii) CG concentrate with 31.5 mg of monensin added per kg of dry matter (DM); iii) CG pelleted concentrate; iv) CG concentrate with monensin addition pelleted. There was no difference in milk production and composition. The addition of monensin increased milk concentration of polyunsaturated fatty acids (PUFA), the PUFA/saturated fatty acids (SFA) ratio, and omega 6. The pelleting increased the concentration of monounsaturated fatty acids, the PUFA/SFA ratio, and the omega 6/omega 3 ratio, but decreased the concentration of SFA. The association between pelleting and the addition of monensin increased the concentration of conjugated linoleic acids by 46.9%. The physical characteristics of butter were not affected by the evaluated diets. We concluded that the concentrate with 31.5 mg of monensin added per kg DM basis combined with the pelleting improves the lipid composition of milk from Holstein cows that are on pasture and supplemented with ground canola seeds, without changing the production, milk composition, and spreadability of butter.

Pelleting in Associated with Sodium Monensin Increases the Conjugated Linoleic Acids Concentration in the Milk of Dairy Cows Fed Canola Seeds

De Marchi, Francilaine Eloise,Romero, Jakeline Vieira,Damasceno, Julio Cesar,Grande, Paula Adriana,Zeoula, Lucia Maria,dos Santos, Geraldo Tadeu Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.8

To evaluate the effects of the pelleting and the addition of sodium monensin on production, the chemical and lipid composition of milk and butter physical characteristics, 4 Holstein dairy cows (135 days of lactation) with an average milk production of 14.7 kg/d, were supplemented with a concentrate containing ground canola seeds. The cows were assigned to a $4{\times}4$ Latin square design with a $2{\times}2$ factorial arrangement of treatments: i) ground maize, soybean meal, mineral and vitamin supplements, and ground canola seeds (CG); ii) CG concentrate with 31.5 mg of monensin added per kg of dry matter (DM); iii) CG pelleted concentrate; iv) CG concentrate with monensin addition pelleted. There was no difference in milk production and composition. The addition of monensin increased milk concentration of polyunsaturated fatty acids (PUFA), the PUFA/saturated fatty acids (SFA) ratio, and omega 6. The pelleting increased the concentration of monounsaturated fatty acids, the PUFA/SFA ratio, and the omega 6/omega 3 ratio, but decreased the concentration of SFA. The association between pelleting and the addition of monensin increased the concentration of conjugated linoleic acids by 46.9%. The physical characteristics of butter were not affected by the evaluated diets. We concluded that the concentrate with 31.5 mg of monensin added per kg DM basis combined with the pelleting improves the lipid composition of milk from Holstein cows that are on pasture and supplemented with ground canola seeds, without changing the production, milk composition, and spreadability of butter.

Safety of ovarian preservation in premenopausal women with stage I uterine sarcoma

Dimitrios Nasioudis,Eloise Chapman-Davis,Melissa Frey,Kevin Holcomb 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4

Objective: To evaluate the oncologic safety of ovarian preservation (OP) in premenopausalwomen diagnosed with the International Federation of Gynecology and Obstetrics (FIGO)stage I uterine sarcoma. Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Resultsdatabase was accessed and a cohort of women aged ≤50 diagnosed between 1988–2013 witha sarcoma limited to the uterus was drawn. Based on site-specific surgery codes, womenwho underwent hysterectomy with or without oophorectomy and did not receive radiationtherapy were selected for further analysis. Overall (OS) and cancer-specific (CSS) survivalwere determined following generation of Kaplan-Meier curves; comparisons were made withthe log-rank test. A Cox-proportional hazard model was constructed to control for possibleconfounders. Results: A total of 1,482 women were included in the analysis; 800 (54.0%) were diagnosedwith leiomyosarcoma (LMS), 520 (35.1%) with low-grade endometrial stromal sarcoma(LG-ESS), and 162 (10.9%) with adenosarcoma (AS). The OP group included 418 women(28.2%). Differences in the rate of OP were noted based on histology (p=0.014), year ofdiagnosis (p=0.001), patient age (p<0.001) and race (p=0.012). There was no difference in OS(p=0.220) or CSS (p=0.210) between women who had OP and those who did not. Multivariateanalysis confirmed that OP was not associated with a worse mortality. Conclusion: In this population-based cohort of women with sarcoma limited to the uterus,OP was not associated with worse oncologic outcomes. OP could be considered for womenwith LMS, sparing them from the morbidity associated with iatrogenic menopause. Noconclusions could be made for those with LG-ESS or AS.

Could fertility-sparing surgery be considered for women with early stage ovarian clear cell carcinoma?

Dimitrios Nasioudis,Eloise Chapman-Davis,Melissa K. Frey,Steven S. Witkin,Kevin Holcomb 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.6

Objective: The aim of the present retrospective population-based study was to investigate the oncologic impact of uterine and ovarian preservation (OP) in premenopausal women with stage IA or IC ovarian clear cell carcinoma (OCCC). Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed and a cohort of surgically-staged premenopausal women (age <50 years) diagnosed with unilateral stage IA or IC OCCC was drawn. Based on site-specific surgery codes, women who did not undergo hysterectomy and/or bilateral salpingo-oophorectomy (BSO) were identified. Overall survival (OS) and cancer-specific survival (CSS) rates were calculated following generation of Kaplan-Meier curves; comparisons were made with the log-rank test. Multivariate Cox analysis was performed to control for possible confounders. Results: A total of 741 premenopausal women who met the inclusion criteria were identified. Based on available information, rate of uterine preservation was 14.5% (96/663) while the rate of OP was 28.1% (71/253). Five-year CSS rates were 90.8% for women who did not undergo hysterectomy compared with 87.7% for those who did (p=0.290). Similarly, 5-year CSS rates in the OP and BSO groups were 92.6% and 85%, respectively (p=0.060). After controlling for disease sub-stage (IA vs. IC), uterine or OP was not associated with a worse overall or cancer-specific mortality. Conclusion: In the present cohort, uterine and OP did not have a negative impact on oncologic outcomes. Selection criteria for fertility-sparing surgery (FSS) could be expanded to include women with stage IA OCCC.

Biphasic Tumor Oxygenation during Respiratory Challenge may Predict Tumor Response during Chemotherapy

Songhyun Lee,Hyeryun Jeong,Eloise Anguluan,Jae Gwan Kim 한국광학회 2018 Current Optics and Photonics Vol.2 No.1

Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10 minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation, oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2, respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated. These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We believe that by reducing the time of the respiratory challenge, we have taken a step forward to translating our previous study into clinical application.

Role of adjuvant chemotherapy in the management of non-granulosa cell ovarian sex cord-stromal tumors

Dimitrios Nasioudis,Theofano Orfanelli,Melissa K. Frey,Eloise Chapman-Davis,Thomas A. Caputo,Steven S. Witkin,Kevin Holcomb 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2

Objective: To investigate the role of adjuvant chemotherapy (CT) in the management of ovarian non-granulosa cell (GC) sex cord-stromal tumors (SCSTs). Methods: The National Cancer Database was accessed and patients diagnosed between 2004 and 2013 with a malignant non-GC SCST were selected. Overall survival (OS) was evaluated with Kaplan-Meier curves and compared with the log-rank test. Multivariate survival analysis was performed with Cox regression. Factors associated with the administration of CT were evaluated with the chi-square test and binary logistic regression. Results: A total of 391 patients were identified. The majority had a Sertoli-Leydig cell tumor (SLCT) (73.2%) and early stage disease (84.8%). A total of 203 (51.9%) patients received CT. Advanced disease stage, younger age, high-grade histology, White race, large tumor size and SLCT histology were associated with administration of CT. For patients with early stage disease, there was no difference in OS between those who did (n=134) and did not receive CT (n=157), p=0.40; 5-year OS rates were 81.7% and 84.6%, respectively. No mortality benefit was observed (hazard ratio=0.73; 95% confidence interval=0.38–1.4) after controlling for tumor histology. Median OS of women with advanced stage disease who received CT (n=41) was 34.96 months compared to 15.51 months for those who did not (n=11), p=0.013. Conclusion: Adjuvant CT was associated with improved survival for patients with advanced stage non-GC SCSTs. No clear benefit was found for those with early stage disease.

Glyoxal yield from isoprene oxidation and relation to formaldehyde: chemical mechanism, constraints from SENEX aircraft observations, and interpretation of OMI satellite data

Chan Miller, Christopher,Jacob, Daniel J.,Marais, Eloise A.,Yu, Karen,Travis, Katherine R.,Kim, Patrick S.,Fisher, Jenny A.,Zhu, Lei,Wolfe, Glenn M.,Hanisco, Thomas F.,Keutsch, Frank N.,Kaiser, Jennif Copernicus GmbH 2017 Atmospheric Chemistry and Physics Vol.17 No.14

<P>Abstract. Glyoxal (CHOCHO) is produced in the atmosphere by the oxidation of volatile organic compounds (VOCs). Like formaldehyde (HCHO), another VOC oxidation product, it is measurable from space by solar backscatter. Isoprene emitted by vegetation is the dominant source of CHOCHO and HCHO in most of the world. We use aircraft observations of CHOCHO and HCHO from the SENEX campaign over the southeast US in summer 2013 to better understand the CHOCHO time-dependent yield from isoprene oxidation, its dependence on nitrogen oxides (NOx ≡ NO + NO2), the behavior of the CHOCHO-HCHO relationship, the quality of OMI CHOCHO satellite observations, and the implications for using CHOCHO observations from space as constraints on isoprene emissions. We simulate the SENEX and OMI observations with the Goddard Earth Observing System chemical transport model (GEOS-Chem) featuring a new chemical mechanism for CHOCHO formation from isoprene. The mechanism includes prompt CHOCHO formation under low-NOx conditions following the isomerization of the isoprene peroxy radical (ISOPO2). The SENEX observations provide support for this prompt CHOCHO formation pathway, and are generally consistent with the GEOS-Chem mechanism. Boundary layer CHOCHO and HCHO are strongly correlated in the observations and the model, with some departure under low-NOx conditions due to prompt CHOCHO formation. SENEX vertical profiles indicate a free-tropospheric CHOCHO background that is absent from the model. The OMI CHOCHO data provide some support for this free-tropospheric background and show southeast US enhancements consistent with the isoprene source but a factor of 2 too low. Part of this OMI bias is due to excessive surface reflectivities assumed in the retrieval. The OMI CHOCHO and HCHO seasonal data over the southeast US are tightly correlated and provide redundant proxies of isoprene emissions. Higher temporal resolution in future geostationary satellite observations may enable detection of the prompt CHOCHO production under low-NOx conditions apparent in the SENEX data. </P>

Physical Education Teachers’ Technology Practices and Challenges

Jun-Hyung Baek,Adam Keath,Eloise Elliott 한국체육학회 2018 International journal of human movement science Vol.12 No.2

The purposes of this study were to investigate a) current technology practices in physical education, b) learning sources for technology integration, and c) influential factors for PE teachers’ use of technology. One hundred nine participants were recruited from multiple sources and completed a web-based survey. Among them, responses of 97 were analyzed using descriptive statistics and inductive qualitative analysis. The study found current K-12 PE teachers have a higher tendency to use technologies that are typically used for teacher productivity, rather than student learning. Regarding learning sources for technology integration, participants primarily learn to use technology through informal learning sources. Four themes concerning the influential factors emerged from the open-ended question. They include a) access to technology, b) lack of training and time to learn, c) perceived value of technology integration and d) knowledge to integrate technology. This study indicates the need for quality technology integration training to help PE teachers for successful technology integration for student learning.

Dystonia Responsive to Dopamine: POLG Mutations Should Be Considered If Sensory Neuropathy Is Present

Jessica Qiu,Kishore Raj Kumar,Eloise Watson,Kate Ahmad,Carolyn M. Sue,Michael W. Hayes 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.2

The POLG gene encodes mitochondrial DNA polymerase, and mutations in this gene cause a spectrum of disorders related to mitochondrialDNA depletion or deletion. Dystonia has only rarely been reported as an early and prominent manifestation of POLGmutations. We report a case of a 30-year-old male presenting with lower limb dystonia with peripheral neuropathy and demonstratethat the dystonia was levodopa responsive (with video findings). Whole-genome sequencing revealed biallelic variants inthe POLG gene: a known pathogenic variant [NM_001126131.2:c.2209G>C (p.Gly737Arg)] and a novel likely pathogenic variant[NM_001126131.2:c.3305A>C (p.Gln1102Pro)]. A genetic diagnosis was made before the appearance of more readily recognizablefeatures of mitochondrial disease, allowing us to avoid invasive tissue biopsies or potentially deleterious treatments, such assodium valproate. A POLG-related disorder should be suspected in cases of dystonia with peripheral neuropathy, and this diagnosismay have implications for further investigations and management.