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RISS 인기검색어
- 검색키워드
- 저자 : Elmeligie (검색결과 3 건)
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Salwa Elmeligie,Azza T. Taher,Nadia A. Khalil,Ahmed H. El-said 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1
Novel series of 1,3,4-trisubstituted azetidin-2-one derivatives 8a–p were synthesized and proposed ascytotoxic agents acting via inhibition of tubulin at thecolchicine binding site. The design of the target compoundswas based upon modification in the structure of the vasculartargeting agent combretastatin A-4 (CA-4). The cisdouble bond linker in CA-4 was replaced with the azetidin-2-one ring aiming to prevent the cis/trans isomerizationthat suppresses the activity of CA-4, thereby enhancing itsantiproliferative activity. All new compounds were investigatedin vitro against MCF-7 and HCT-116 cell lines. Theinhibition of tubulin polymerization by four most potentcompounds 8g, 8j, 8n and 8o was also evaluated. Thesynthesis of the final targets was achieved adopting Staudingerreaction. Molecular modeling studies were performedto rationalize the biological results.
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Arafat Khalphallah,Nasr-Eldin M. Aref,Ashraf M. Abu-Seida,Enas Elmeligy,Sara A. Bayoumi,Al-lethie A. Al-lethie,Doaa Salman 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.4
This study describes ultrasonographic observations of five hepatobiliary diseases in buffalo (Bubalus bubalis). Fifty buffalo, including 20 clinically normal and 30 hepatobiliary diseased buffalo were enrolled in the study. Complete clinical, radiographic and ultrasonographic examinations and laboratory analyses were conducted. Focal parenchymal lesions including liver abscess (n = 12) and hepatic cyst (n = 6), diffuse parenchymal lesion (hepatobiliary cirrhosis, n = 5) and obstruction of hepatobiliary passages including cholestasis (n = 4), and hepatocholelithiasis (n = 3) were successfully imaged by ultrasonography. Hepatic abscess imaged as a hypoechoic to echogenic circumscribed mass of various diameters with a distinct echogenic capsule. Hepatic cyst imaged as a pear-shaped sac with a bright echogenic margin, anechoic content, and distal acoustic enhancement. In hepatobiliary fibrosis, the liver showed linear bands of increasing echogenicity with less distinct imaging of the portal vasculature. Cholestasis was imaged as dilatation of the gallbladder (GB) with wall thickening and homogeneous or heterogeneous contents. Hepatocholelithiasis imaged as an echoic structure within the hepatic parenchyma, or within and around the GB and bile duct, with more echogenicity of the hepatic parenchyma than normal. Ultrasonography can be an efficient rapid, noninvasive tool for screening of common hepatobiliary diseases in buffalo under field conditions.
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Mosaad Mohamed,Khozamy Ali,Barakat Ahmed Samir,Emran Ihab,Elmeligy Yasser,Abulhamd Alaa 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.5
Study Design: randomized, prospective, and level I clinical study.Purpose: To compare the clinical outcomes and radiological findings of revision discectomy alone versus revision discectomy with fusion as surgical treatment for recurrent lumbar disc herniation (RDH).Overview of Literature: RDH is a common complication following a primary discectomy. The optimal surgical procedure for RDH is still debated.Methods: Sixty patients with RDH were randomly divided into two equal groups: the first group underwent revision discectomy alone and the second underwent revision discectomy with fusion. The primary outcomes evaluated were Visual Analog Scale (VAS) for low back and limb pains, Oswestry Disability Index (ODI), disc height indexes, foraminal height index, and disc height subsidence. Secondary outcomes included operative time, blood loss, postoperative hospital stay, and complications.Results: Revision discectomy with fusion showed superior pain relief and improved functional outcomes, including better VAS scores for both back and leg pain and ODI at 24-month follow-up. Additionally, it restored the stability of the spine better with lower disc height subsidence without significant complications. However, these advantages came at the cost of increased blood loss and longer operative time and hospital stays.Conclusions: Revision discectomy with fusion is recommended for RDH; however, the choice of the procedure should be made caseby- case basis, considering many factors related to the patient and surgical facilities.
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