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Juxtafacet Spinal Synovial Cysts
Haitham El-Beltagy Abd El-Kader 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.1
Study Design: This was a retrospective study. Purpose: To study the surgical outcome of synovial cysts of the lumbar spine through posterior laminectomy in combination with transpedicular screw fixation. Overview of Literature: Synovial cysts of the lumbar spine contribute significantly to narrowing of the spinal canal and lateral thecal sac and nerve root compression. Cysts form as a result of arthrotic disruption of the facet joint, leading to degenerative spondylolisthesis in up to 40% of patients. Methods: Retrospective data from 6 patients, treated during the period of March 2007 to February 2011, were analyzed. All preoperative and postoperative manifestations, extension/flexion radiographs, magnetic resonance imaging, and computed tomography records were reviewed. All underwent surgery for synovial cysts with excision and decompression combined with posterior fixation. The result of surgery was evaluated with Macnab’s classification. An excellent or good outcome was considered as satisfactory. Japanese Orthopedic Association Scale was used for evaluation of back pain. Results: All patients included in this study had excellent outcomes as regarding to improvement of all preoperative manifestations and returning to normal daily activities. Only 2 cases developed postoperative transient cerebro-spinal fluid leak and were treated conservatively and improved during the follow up period. Conclusions: Although this study included a small number of cases and we could not have statistically significant results, the good outcome of decompression of synovial cysts combined with posterior fixation and fusion encouraged us to recommend this approach for patients with juxtafacet synovial cysts.
Transforaminal Lumbar Interbody Fusion for Management of Recurrent Lumbar Disc Herniation
Haitham El-Beltagy Abd El-Kader 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.1
Study Design: Retrospective study. Purpose: To study the surgical outcome of transforaminal lumbar interbody fusion (TLIF) combined with trans-pedicular screws fixation for management of selected cases of recurrent lumbar disc herniation. Overview of Literature: Recurrent lumbar disc herniation is a major cause of surgical failure, occurring in 5%–11% of cases. The optimal technique for treatment is controversial. Some authors believe that repeated simple discectomy is the treatment of choice, but approach-related complications can be considerable. Other surgeons prefer more removal of posterior elements (as lamina and facet joints) with posterior fusion. Methods: The study included 15 patients who presented with symptomatic recurrent lumbar disc herniation who underwent reoperation through posterior trans-pedicular screws and TLIF in our department from April 2008 to May 2010, with a 24-month followup. Japanese Orthopedic Association Scale (JOA) was used for low back pain. The results of surgery were also evaluated with the MacNab classification. Results: The mean JOA score showed significant improvement, increasing from 9.5 before surgery to 24.0 at the end of follow-up (p <0.001). Clinical outcome was excellent in 7 patients (46% of cases), good in 6 patients (40%) and fair in only 2 patients (14%). There was a significant difference (p <0.05) between patients presenting with recurrent disc at the ipsilateral side and those at the contralateral side. Conclusions: In spite of the small number of patients and the short follow-up period, the good clinical and radiological outcome achieved in this study encourage the belief that TLIF is an effective option for the treatment of selected cases of recurrent lumbar disc herniation.
ON INTUITIONISTIC FUZZY SUBSPACES
Ramadan, Ahmed Abd El-Kader,El-Latif, Ahmed Aref Abd Korean Mathematical Society 2009 대한수학회논문집 Vol.24 No.3
We introduce a new concept of intuitionistic fuzzy topological subspace, which coincides with the usual concept of intuitionistic fuzzy topological subspace due to Samanta and Mondal [18] in the case that $\mu=X_A$ for A $\subseteq$ X. Also, we introduce and study some concepts such as continuity, separation axioms, compactness and connectedness in this sense.
ON FUZZY BITOPOLOGICAL SPACES IN ŠOSTAK'S SENSE (II)
Ramadan, Ahmed Abd El-Kader,Abbas, Salah El-Deen,El-Latif, Ahmed Aref Abd Korean Mathematical Society 2010 대한수학회논문집 Vol.25 No.3
In this paper, we have use a fuzzy bitopological space (X, $\tau_1$, $\tau_2$) to create a family $\tau_{ij}^s$ which is a supra fuzzy topology on X. Also, we introduce and study the concepts of r-($\tau_i$, $\tau_j$)-generalized fuzzy regular closed, r-($\tau_i$, $\tau_j$)-generalized fuzzy strongly semi-closed and r-($\tau_i$, $\tau_j$)-generalized fuzzy regular strongly semi-closed sets in fuzzy bitopological space in the sense of $\check{S}$ostak. Also, these classes of fuzzy subsets are applied for constructing several type of fuzzy closed mapping and some type of fuzzy separation axioms called fuzzy binormal, fuzzy mildly binormal and fuzzy almost pairwise normal.
F.H. Abd El-kader,S.A. Gaafar,K.H. Mahmoud,S.I. Bannan,M.F.H. Abd El-kader 한국물리학회 2008 Current Applied Physics Vol.8 No.1
Differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), UV/visible spectra and colour detection of pristine and cirradiated undoped and eosin-doped 70/30 (wt/wt%) PVA/glycogen has been measured. The kinetic parameters such as the activation energy, entropy, enthalpy and free energy for all investigated samples were determined using Coats–Redfern relation. The shift of Tg position towards lower temperatures with increasing c-doses reflect that the degradation process is the predominant one. The values of absorbance and optical parameters in UV/visible range for c-irradiated blend sample doped with eosin showed no significant variation with increasing c-doses. This reflects that the addition of eosin to 70/30 (wt/wt%) PVA/glycogen makes it more resistant to c-radiolysis. The calculated colour parameters such as L*, U*, V*, C*, hue and Ye were found to be dependent on addition of eosin and c-irradiation. Differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), UV/visible spectra and colour detection of pristine and cirradiated undoped and eosin-doped 70/30 (wt/wt%) PVA/glycogen has been measured. The kinetic parameters such as the activation energy, entropy, enthalpy and free energy for all investigated samples were determined using Coats–Redfern relation. The shift of Tg position towards lower temperatures with increasing c-doses reflect that the degradation process is the predominant one. The values of absorbance and optical parameters in UV/visible range for c-irradiated blend sample doped with eosin showed no significant variation with increasing c-doses. This reflects that the addition of eosin to 70/30 (wt/wt%) PVA/glycogen makes it more resistant to c-radiolysis. The calculated colour parameters such as L*, U*, V*, C*, hue and Ye were found to be dependent on addition of eosin and c-irradiation.
Constituents of Erythrina caffra Stem Bark Grown in Egypt
Sawsan El-Masry,Hala M. Hammoda,Hala H. Zaatout,Saleh I. Alqasoumi,Maged S. Abdel-Kader 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
A new 3-indolyl propionate alkaloid; (-) abrine (1), was isolated from the alcohol extract of Erythrina caffra stem bark together with the alkaloid (-) hypaphorine (2). Phytochemical investigation of the chloroform extract led to the isolation of one fatty alcohol; 1-octacosanol, isolated for the first time from genus Erythrina, two dienoid alkaloids; erythraline and erysodine, and three isoflavonoids; 3S (+) 2'-O-methylphaseollidinisoflavan (3), (6aR, 11aR)- 3-hydroxy-10-dimethylallyl-9-methoxypterocarpan, known as sandwicensin (4) and 3R (-) erythbidin A (5). It is worth mentioning that this is the first report for the isolation of these isoflavonoids from E. caffra. The absolute configuration of 3S (+) 2'-O-methylphaseollidinisoflavan (3) was not previously reported. The isolated isoflavonoids showed promising antibacterial activity against Staphylococcus aureus. Keywords - Erythrina caffra, alkaloids, isoflavanoids, Staphylococcus aureus
Bioactivity Guided Phytochemical Study of Clematis hirsuta Growing in Saudi Arabia
Abdel-Kader, Maged S.,Al-Taweel, Areej M.,El-Deeb, Kadriya S. The Korean Society of Pharmacognosy 2008 Natural Product Sciences Vol.14 No.1
Bioactivity guided phytochemical study of the petroleum ether and butanol extracts of Clematis hirsuta resulted in the isolation of 12 compounds. Rat paw edema as a model of acute inflammation was used to evaluate the anti-inflammatory activity of the extracts and the chromatographic fractions. Five known sterols and triterpenes namely: ${\beta}-amyrin$ (1), lupeol (2), ${\beta}-sitosterol$ (3), oleanolic acid (4) and stigmasterol glycoside (5) were isolated from the petroleum ether extract. The n-butanol extract afforded two compounds reported for the first time from natural source: (S)-(+)-dihydro-5-(hydroxymethyl)-2(3H)-furanone (7) and (s)-(-)-5-hydroxymethyl-2(5H)-furanone (8). In addition, anemonin (6), dihydro-4-hydroxy-5-(hydroxymethyl)-2(3H)-furanone (2-deoxy-D-ribono-1,4-lactone) (9), biophenol (cimidahurin) (10), glucose (11) and sucrose (12) were also identified. The structures were determined from spectroscopic data including 1D- and 2D-NMR experiments.
Anthraquinones with Antibacterial Activities from Crucianella maritima L. Growing in Egypt
Abdalla M. El-Lakany,Maha A. Aboul-Ela,Maged S. Abdel-Kader,Jihan M. Badr,Nawal N. Sabri,Yousry Goher 한국생약학회 2004 Natural Product Sciences Vol.10 No.2
From the extracts of Crucianella maritima L. (Rubiaceae), five new anthraquinones namely; 1-hydroxy- 2-methyl-6-methoxy anthraquinone, 6-methoxy-2-methyl quinizarin, 6-methyl-anthragallol-2,3-dimethyl ether, 6-methyl-anthragallol-2-methyl ether, and 1-hydroxy-2-carbomethoxyanthraquinone were isolated and identified. In addition, deacetyl asperulosidic acid 6'-glucoside sodium salt, a new iridoid diglucoside, along with twelve known anthraquinones, three flavonols, three sterols, and one triterpene were also isolated and identified for the first time from this plant. Their chemical structures were established by physical, chemical and spectroscopic data, including UV, MS, ID- and 2D-NMR analyses. The antimicrobial, cytotoxic activities and a preliminary clinical trial of the crude extracts and some isolates are also presented. Chemotaxonomical aspects are briefly discussed.
Two New Flavonol Glycosides From The Aerial Parts of Lotus lalambensis Growing in Saudi Arabia
Hanan M. El-Youssef,Brian T. Murphy,Masouda E. Amer,Adnan J. Al-Rehaily,Maged S. Abdel-Kader,David G. I. Kingston 한국생약학회 2008 Natural Product Sciences Vol.14 No.2
Phytochemical study of the aerial parts of Lotus lalambensis Schweinf resulted in the isolation and identification of two new flavonol glycosides; kaempferol 3-O-(5"-acetyl)-apioside-7-O-α-L-rhamnopyranoside (1) and kaempferol 3-O-α-[β-D-xylosyl-(1"" → 2")-L-rhamnopyranoside]-7-O-α-L-rhamnopyranoside (2). Structures were determined utilizing different physical, chemical, spectroscopic data including 2D-NMR experiments and HRFABMS.
Azim, Hamdy Abdel,Abdal-Kader, Yasser Salah el din,Mousa, Mohamed Mahmoud,Malek, Raafat Abdel,Abdalmassih, Michael Kheir,Ibrahim, Noha Yehia Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: To evaluate the impact of adding taxanes to anthracycline-based regimens in the adjuvant setting in localized young female breast cancer patients on the overall survival (OS) and the disease free survival (DFS). Materials and Methods: This retrospective study included all female breast cancer patients who were candidates for adjuvant chemotherapy presenting to Kasr Al Ainy centre of clinical oncology and Cairo oncology centre (Cairo Cure) in the period from January 2005 till December 2010. Results: Our study included 865 patients, 732 of whom received anthracycline based regimens and 133 taxane based regimens. The mean age of patients was 39 years. After a median follow up of 50 months the median DFS was 48.4 months. Survival analysis indicated that the tumor size (>5cm vs. <5cm) p=0.001), nodal involvement (Yes vs. No) p=0.0001) and pathology (invasive lobular vs. ductal) p=0.048) affected DFS. As regards hormonal status, ER, PR and HER 2neu positive patients had longer DFS (p=0.001, 0.003, 0.106). On multivariate analysis DFS was affected by tumor size and lymph node involvement (p=0.014, 0.007). Subgroup analysis showed improvement in arms treated with taxanes in terms of DFS with positive Her2neu, ER and PR, but this was not statistically significant. Conclusions: Adding adjuvant taxanes to anthracyclines is beneficial for treatment of localized breast cancer among all subgroups, especially higher risk groups. The type of adjuvant chemotherapy regimens and tumor characteristics have direct effects on DFS.