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El-Gendy Fady Mohamed,Shehata Amira M.F.,El-Kawy Esam Awad Abd,El-Hawy Mahmoud Ahmed 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.3
Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by abnormalities of T cells subsets. Programmed death-1 (PD-1) is a co-signaling inhibitory molecule in T cells that is involved in many autoimmune diseases.Purpose: Here we aimed to measure changes in PD-1 expression and serum interferon-γ (IFN-γ) levels before and 1 month after treatment in pediatric patients with newly diagnosed ITP.Methods: We measured PD-1<sup>+</sup> CD4<sup>+</sup> T cells percentages using flow cytometry and the serum IFN-γ levels by enzyme-linked immunosorbent assay in 40 pediatric patients with ITP and 20 healthy controls.Results: Compared with healthy controls, the PD-1<sup>+</sup> CD4<sup>+</sup> T cells percentages and serum IFN-γ levels were significantly higher in ITP patients before and 1 month after therapy. A correlation study revealed that PD-1<sup>+</sup> CD4<sup>+</sup> T cells percentage was negatively associated with platelet count and positively associated with IFN-γ level in patients with ITP. Furthermore, serum IFN-γ levels were significantly decreased in patients after treatment, but no significant change was detected in the percentage of PD-1<sup>+</sup> CD4<sup>+</sup> T cells before or 1 month after therapy.Conclusion: PD-1<sup>+</sup> CD4<sup>+</sup> T cells expression and IFN-γ levels were increased in patients with ITP. These preliminary data suggest a potential role of PD-1<sup>+</sup> CD4<sup>+</sup> T cells as mediators of ITP. We also found a correlation between PD-1<sup>+</sup> CD4<sup>+</sup> T cells and both platelet counts and IFN-γ levels. These findings suggest a potential role of PD-1<sup>+</sup> CD4<sup>+</sup> T cells and IFN-γ in the pathogenesis of ITP. Further studies investigating PD-1 expression in different T-cell subsets, serum IFN-γ concentrations, and antiplatelet antibodies levels over a longer duration after therapy initiation could delineate the precise role of PD-1 in ITP pathogenesis. Consequently, novel nontraditional therapeutic strategies for ITP patients may become available.
Synthesis and Antimicrobial Activity of some New 2-Indolinone Derived Oximes and Spiro-Isoxazolines
El Gendy, Adel A.,Ahmedy, Aly M. The Pharmaceutical Society of Korea 2000 Archives of Pharmacal Research Vol.23 No.4
The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-[2-hydroxyimino-2-(substituted phenyl)ethyll-2H-indol-2-ones (21-32) and spiro[3H-indol-3,5'-(4'H)-isoxazol]-2(1 H)-ones (33-44) are described. Sixteen of the synthesized compounds were screened in vitro for their growth inhibitory activity against thirteen species of microorganisms, viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coli, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C. albicans and S. cervicae. Most of the compounds exhibited significant antimicrobial activity especially the oximes 28 and 29.
El Gendy, Adel A.,El Banna, Hosny A. The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.1
This manuscript reports the synthesis of two series of Mannich Bases 3-12 and 21-40 obtained respectively by the reaction of either 2- ethoxycarbonylindoles 1-2 or 5H-pyridazino [4,5-b]indoles 17-20 as a substrate with formalin and the appropriate $2^{\circ}C$amines under the suitable Mannich conditions. fourteen of the synthesized Mannich basese were screened as antihypetensive agents in normotensive anesthetized rats. The effect of compound 4 in normotensive anesthetized dogs was also studied.
Ayman El-Gendi,Farag A. Samhan,Nahla Ismail,Lara A. Nezam El-Dein 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-
We propose a new membrane of cellulose acetate/graphene/Ag nanoparticles and/or Cu nanorods (CA/G/Ag–Cu) composite, which improved the membrane desalination and biofouling simultaneously using membrane technology. The membrane was prepared from casting polymer dope solution containing 25 wt.% in acetone as solvent with different concentrations of graphene dispersed on it Ag:Cu at 18 °C. The membrane was then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM) and further tested for the separation of saline solutions (5 g/L and 10 g/L NaCl) by reverse osmosis system. The release of silver- and copper-nanoparticles from the membrane was monitored in a batch experiment by an atomic absorption spectrophotometer (AAS). The biofouling effects of addition G/nano-(Ag–Cu) on membrane performance were investigated against Gram +ve and Gram −ve bacterial test organisms. Membranes were assayed with an agar culture medium and by immersing in bacterial suspension. Bacterial activities were observed by inhibition zones formation and investigating biofilm formation by SEM. The reference membrane (without additions) had no antibacterial activity and bacterial growth was found on the membrane surfaces, while CA/G/nano-(Cu–Ag) membrane had shown antibacterial activity. Permeability tests showed a vast improvement of water flux and salt rejection.
( Hayam El Aggan ),( Mona Salem ),( Wessam El Gendy ),( Wageh El Gebaly ),( Eman El Gohary ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic infection with schistosomiasis is associated with down-regulation of T-cell immune responses that require activation by innate immune cells like dendritic cells (DCs). The present work was designed to study the DC subsets (myeloid and plasmacytoid) in peripheral blood and serum levels of interleukin (IL)-12 in patients with schistosomal hepatic fibrosis (SHF) in relation to severity of liver disease and renal injury. Methods: Forty five patients with SHF and 15 healthy subjects were included in the study. The severity of liver disease was assessed using Child-Pugh classification and the Model of End Stage Liver Disease (MELD) score. Renal injury was assessed by measuring urinary albumin excretory rate (UAER) and estimated glomerular filtration rate (eGFR). The percentages of CD11c+ myeloid and CD123+ plasmacytoid DC subsets in peripheral blood were identified using 3-color flow cytometry. Quantitative determination of IL-12p70 heterodimer in serum was performed using enzyme-linked immunosorbent assay. Renal biopsies from patients with macroalbuminuria were examined by immunohistochemical technique for DCs and angiogenesis using antibodies against OX62 and factor VIII-related antigen respectively. Results: The percentages of circulating CD11c+ and CD123+ DC cells, CD11c+DC/CD123+DC ratio and serum IL-12 levels showed significant decreases in patients with SHF compared with healthy subjects (P<0.01). Renal tissues from patients with macroalbuminuria showed significant increases in the number of DCs and angiogenesis compared with normal renal tissues (P<0.01). The percentages of circulating DC subsets and serum IL-12 levels were inversely correlated with Child-Pugh score, MELD score, number of renal DCs, renal angiogenesis and UAER and were positively correlated with eGFR. The number of renal DCs showed positive correlations with UAER and renal angiogenesis and negative correlation with creatinine clearance (P<0.05). Conclusions: Dendritic cell dysfunction with a deficient IL12 production seems to play a role in the progression of liver disease and renal injury in SHF. DC-based vaccines may provide a potential new goal for immunotherapy in SHF.
Evaluation of Turbulence Models in a High Pressure Turbine Cascade Simulation
M.M. El-Gendi,K.-U. Lee(이경언),W.J. Chung(정의준),C.-Y. Joh(조창열),C.H. Son(손창호) 한국전산유체공학회 2012 한국전산유체공학회지 Vol.17 No.3
Steady flow simulations through a high pressure turbine guide vanes were carried out. The main objective of the present work is to study the performance of turbulence models on the steady flow prediction from aerodynamic and aerothermal points of view. Three turbulence models were compared, namely SST, k-ω and ω-Reynolds stress models. The laminar results were also compared. The comparison was done with emphasis on the isentropic Mach number and heat transfer coefficient along the blade, and total pressure loss in the wake region. The calculated isentropic Mach number showed reasonable agreement with experimental data along the blade surface for all three turbulent models. For the total pressure loss in the wake region, ω-Reynolds stress model showed the best agreement with the experimental data. However, unless using an appropriate transition model, the heat transfer coefficients of all three turbulent models showed poor agreement with experimental data.
Elliptic Trailing Edge for a High Subsonic Turbine Cascade
Mahmoud M. El-Gendi,Mohammed K. Ibrahim,Koichi Mori,Yoshiaki Nakamura 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
The flow through a turbine cascade was numerically simulated for an exit isentropic Mach number of 0.79 and a Reynolds number of 2.8 × 10? The objective of the present study is to improve the base pressure distribution at this high subsonic Mach number. Calculation was carried out using the in-house numerical code, where the 2<SUP>nd</SUP> order Roe scheme for inviscid numerical fluxes. the 2<SUP>nd</SUP> order implicit dual lime method for time integration, and Delayed Detached Eddy Simulation for turbulence are employed. Time-averaged pressure distributions through the cascade have been presented with more attention paid to the trailing edge region. Calculated results show the non-uniform pressure distribution along the trailing edge, which is close to experimental data and different from almost uniform pressure distributions at moderate subsonic Mach numbers. To improve the trailing edge pressure distribution, we use an elliptic trailing edge instead of a circular one as a proposal for a new, practical trailing edge shape. The elliptic trailing edge make not only the trailing edge pressure distribution uniform but also increase the average base pressure by 5.26%.
Numerical Simulation of Transonic Flow through High Pressure Turbine Cascade
Mahmoud M. El-GENDI(엘긴디 마흐무드),Kyoung-Un Lee(이경언) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
Steady flow simulations through a transonic turbine vanes were carried out for an isentropic Mach number of 1.02 and a Reynolds number of 10<SUP>6</SUP>. The main objective of the present study is to the effect of turbulence model on the steady flow in transonic regime. Three turbulence models were compared namely SST, k-ω, and ω Reynolds Stress(ωRS). Also, the laminar result was considered. The comparison was carried out on the whole computational domain with more emphasis on the Isentropic Mach number along the blade and total pressure loss at the wake. The turbulent results of all turbulent models have a reasonable agreement with experimental data along the blade surface. ωRS has the best agreement on the cascade exit.