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鍼鎭痛이 中樞神經系의 5-HT와 endorphin에 미치는 影響에 對한 考察
金利和,金昊顯 세명대학교 한의학연구소 2001 韓醫學硏究所 論文集 Vol.3 No.-
The recent scientific interest in acupuncture and its mechanisms shows a timewise coincidence with the discovery of the endogenous opioids, the endorphins and 5-HT. It has been commonplace to assume that acupuncture acts via release of these substances and research along this line has provided ample evidence for the existence of such a connection. However, it has also become clear that other neuronal systems are involved. This is not unexpected in view of the complex and integrated nature of the nervous system. It may therefore be more appropriate to discuss pathways and circuits activated by acupuncture rather than single systems.
AURICULAR ACUPUNCTURE INCREASES CELL PROLIFERATION IN THE DENTATE GYRUS OF SPRAGUE-DAWLEY RATS
Kim, Ee-Hwa,Chung, Joo-Ho,Kim, Chang-Ju 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
In a previous study, we have reported that acupuncture increases cell proliferation in the dentate gyrus after transient global ischemia in gerbils. In the present study, the effect of auricular acupuncture (AA) on dentate cell proliferation was examined in appropriately fed and food-deprived adult Sprague-Dawley (S-D) rats. 5-Bromo-2'-deoxyuridine-5'-monophosphate (BrdU) immunohistochemistry revealed a significant increase in cell birth in the dentate gyrus of both groups after AA treatment. In addition, the effect of AA on cell proliferation in the dentate gyrus was more profound in the food-supplied group. These findings demonstrate that AA enhances cell proliferation in the dentate gyrus of adult rats.
Kim, Ee-Hwa,Kim, Younhee,Jang, Mi-Hyun,Lim, Baek-Vin,Kim, Youn-Jung,Chung, Joo-Ho,Kim, Chang-Ju 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
The aim of the present study was to investigate whether stimulation of auricular acupuncture point has any effects on the expression of neuropeptide Y (NPY), appetite-inducing factor particularly abundant in the mammalian hypothalamus. In food-deprived condition, enhanced NPY expression was detected in both the arcuate nucleus (ARN) and the paraventricular nucleus (PVN) of the hypothalamus via immunohistochemistry in Sprague-Dawley rats. Needling the unfed rats on the auricular point resulted in decreased NPY levels in both the ARN and PVN, while it increased NPY levels in the ARN and PVN offed rats. The present findings indicate auricular acupuncture may affect NPY expression in the ARN and PVN of the hypothalamus. ⓒ 2001 Elsevier Science lreland Ltd. All rights reserved.
Aqueous Extract of Ma huang Suppresses Neuropeptide Y Expression in Food-Deprived Rat Hypothalamus
Kim, Ee-Hwa,Shin, Mal-Soon,Chang, Hyun-Kyung,Lee, Taeck-Hyun,Jang, Mi-Hyeon,Shin, Min-Chul,Lee, Sam-Jun,Kim, Chang Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Ma huang, the dried plant stem of Ephedra Intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of Ma huang an the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-deprivation enhanced the NPY expression in the hypothalamus. Ma huang suppressed the food-deprivation-induced enhancement of NPY expression. Present results suggest that Ma huang curbs the food desire by suppressing the NPY expression under food-deprivation conditions.
Kim, Ee-Hwa,Jang, Mi-Hyeon,Shin, Min-Chul,Lim, Baek-Vin,Kim, Hyun-Bae,Kim, Youn-Jung,Chung, Joo-Ho,Kim, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
In this study, effects of acupuncture at zusanli acupoint on cell proliferation and expression of neuropeatide Y(NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozo-tocin-induced diabetes group, the mean 5-bromo-2'-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affert cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression. ⓒ 2002 Elsevier Science Ireland Ltd. All rights reserved.
Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils
Kim, Ee-Hwa,Kim, Youn-Jung,Lee, Hee Jae,Huh, Youngbuhm,Chung, Joo-Ho,Seo, Jung-Chul,Kang, Ji-Eun,Lee, Hye-Jung,Yim, Sung-Vin,Kim, Chang-Ju 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
The effects of acupuncture on cell proliferation in the dentate gyrus of gerbils after transient global ischemia were investigated in this study. Acupuncture was performed on Zusanli(ST36), which is a well known acupoint in animals and humans. In Oriental medicine, Zusanli has been commonly used for the enhancement of functional recovery in stroke patients. Through 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry, an increase in cell birth in the dentate gyrus of gerbils after ischemic injury was detected. Interestingly, acupunctural treatment in ischemic gerbils resulted in a significant increase in the number of BrdU-positive cells in the dentate gyrus. The present findings indicate that acupuncture may affect cell proliferation in the dentate gyrus of gergils after ischemic injury. ⓒ 2001 Elsevier Science lreland Ltd. All rights reserved.