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Kim, M.C.,Lee, J.S.,Kwon, Y.M.,O, E.,Lee, Y.J.,Choi, J.G.,Wang, B.Z.,Compans, R.W.,Kang, S.M. Elsevier/North-Holland 2013 Antiviral research Vol.99 No.3
The influenza M2 ectodomain (M2e) is poorly immunogenic and has some amino acid changes among isolates from different host species. We expressed a tandem repeat construct of heterologous M2e sequences (M2e5x) derived from human, swine, and avian origin influenza A viruses on virus-like particles (M2e5x VLPs) in a membrane-anchored form. Immunization of mice with M2e5x VLPs induced protective antibodies cross-reactive to antigenically different influenza A viruses and conferred cross protection. Anti-M2e antibodies induced by heterologous M2e5x VLPs showed a wider range of cross reactivity to influenza A viruses at higher levels than those by live virus infection, homologous M2e VLPs, or M2e monoclonal antibody 14C2. Fc receptors were found to be important for mediating protection by immune sera from M2e5x VLP vaccination. The present study provides evidence that heterologous recombinant M2e5x VLPs can be more effective in inducing protective M2e immunity than natural virus infection and further supports an approach for developing an effective universal influenza vaccine.
Song, B.M.,Kang, H.M.,Lee, E.K.,Jung, S.C.,Kim, M.C.,Lee, Y.N.,Kang, S.M.,Lee, Y.J. Butterworths ; Elsevier Science Ltd 2016 Vaccine Vol.34 No.5
Highly pathogenic avian influenza (HPAI) H5 viruses derived from A/Goose/Guangdong/1/96 have been continuously circulating globally, severely affecting the public health and poultry industries. The matrix 2 protein ectodomain (M2e) is considered a promising candidate for a universal cross-protective influenza vaccine that provides more effective control over HPAI H5 viruses harboring variant hemagglutinin (HA)-antigens. Here, we evaluated the protective efficacy of a tandem repeat construct of heterologous M2e presented on virus-like particles (M2e5x VLPs) either alone or as a supplement against HPAI H5 viruses in a chicken model. Chickens immunized with M2e5x VLPs alone induced M2e-specific antibodies but were not protected against HPAI H5. The homo- and cross-protective efficacy of M2e5x VLP-supplemented vaccination of chickens was also examined. Importantly, supplementation with M2e5x VLPs induced significantly higher levels of antibodies specific for M2e and different viruses as well as provided improved protection against homologous and heterologous HPAI H5 viruses. Considering the limited efficacy of inactivated vaccines, supplement vaccination with M2e5x VLPs may be an effective measure for preventing outbreaks of HPAI viruses that have the ability to constantly change their antigenic properties in poultry.
Search for B→hνν¯ decays with semileptonic tagging at Belle
Grygier, J.,Goldenzweig, P.,Heck, M.,Adachi, I.,Aihara, H.,Al Said, S.,Asner, D. M.,Aushev, T.,Ayad, R.,Aziz, T.,Babu, V.,Badhrees, I.,Bahinipati, S.,Bakich, A. M.,Bansal, V.,Barberio, E.,Behera, P.,B American Physical Society 2017 Physical Review D Vol.96 No.9
<P>We present the results of a search for the rare decays B -> h nu(nu) over bar, where h stands for K+, K-S(0), K*(+); K*(0); pi(+); pi(0), rho(+) and rho(0). The results are obtained with 772 x 10(6) B (B) over bar pairs collected with the Belle detector at the KEKB e(+)e(-) collider. We reconstruct one B meson in a semileptonic decay and require a single h meson but nothing else on the signal side. We observe no significant signal and set upper limits on the branching fractions. The limits set on the B-0 -> K-S(0)nu(nu) over bar, B-0 -> K*(0)nu(nu) over bar, B+ -> pi(+)nu(nu) over bar, B-0 -> pi(0)nu(nu) over bar, B+ -> rho(+)nu(nu) over bar, and B-0 -> rho(0)nu(nu) over bar channels are the world's most stringent.</P>
Park, J.K.,Lee, D.H.,Cho, C.H.,Yuk, S.S.,To, E.O.,Kwon, J.H.,Noh, J.Y.,Kim, B.Y.,Choi, S.W.,Shim, B.S.,Song, M.K.,Lee, J.B.,Park, S.Y.,Choi, I.S.,Song, C.S. Elsevier Scientific Pub. Co 2014 Veterinary microbiology Vol.169 No.3
Avian influenza virus (AIV) subtype H9N2 has been evolving rapidly and vaccine escape variants have been reported to cause circulation of infections and economic losses. In the present study, we developed and evaluated ectodomain of the AIV matrix 2 (M2e) protein as a supplementing antigen for oil-based inactivated H9N2 vaccine to increase resistance against vaccine escape variants. AIV H9N2 M2e antigen was expressed in Escherichia coli and supplemented to inactivated H9N2 oil emulsion vaccine. Specific pathogen-free chickens received a single injection of inactivated H9N2 oil emulsion vaccines with or without M2e supplementation. At three weeks post vaccination, hemagglutination inhibition tests and enzyme-linked immunosorbent assays were performed to determine serological immune responses. Challenge study using a vaccine escape H9N2 variant was performed to evaluate the efficacy of M2e supplementation. M2e antigen supplemented in oil emulsion vaccine was highly immunogenic, and a single M2e-supplemented vaccination reduced challenge virus replication and shedding more effectively than non-supplemented vaccination.
Measurements of the absolute branching fractions of B+→Xcc¯K+ and B+→D¯(*)0π+ at Belle
Kato, Y.,Iijima, T.,Adachi, I.,Aihara, H.,Al Said, S.,Asner, D. M.,Aulchenko, V.,Aushev, T.,Ayad, R.,Babu, V.,Badhrees, I.,Bakich, A. M.,Bansal, V.,Barberio, E.,Behera, P.,Bhardwaj, V.,Bhuyan, B.,Bisw American Physical Society 2018 Physical Review D Vol.97 No.1
<P>We present the measurement of the absolute branching fractions of B+ -> Xc (c) over barK+ and B+ -> (D) over bar ((*)0)pi(+) decays, using a data sample of 772 x 10(6) B (B) over bar pairs collected at the gamma(4S) resonance with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. Here, X-c (c) over bar denotes eta(c), J/psi, chi(c0), chi(c1), eta(c) (2S), psi(2S), psi(3770), X(3872), and X(3915). We do not observe significant signals for X(3872) or X(3915) and set the 90% confidence level upper limits at B(B+ -> X(3872)K+) < 2.6 x 10(-4) and B(B+ -> X(3915)K+) < 2.8 x 10(-4). These represent the most stringent upper limit for B(B+ -> X(3872)K+) to date and the first limit for B(B+ -> X(3915)K+). The measured branching fractions for eta(c) and eta(c)(2S) are the most precise to date, B(B+ -> eta K-c(+)) = (12.0 +/- 0.8 +/- 0.7) x 10(-4) and B(B+ -> eta(c)(2S)K+) = (4.8 +/- 1.1 +/- 0.3) x 10(-4), where the first and second uncertainties are statistical and systematic, respectively.</P>
A wide‐field survey of satellite galaxies around the spiral galaxy M106
Kim, E.,Kim, M.,Hwang, N.,Lee, M. G.,Chun, M.‐,Y.,Ann, H. B. Blackwell Publishing Ltd 2011 Monthly notices of the Royal Astronomical Society Vol.412 No.3
<P><B>ABSTRACT</B></P><P>We present a wide‐field survey of satellite galaxies in M106 (NGC 4258) covering a <IMG src='/wiley-blackwell_img/equation/MNR_18022_mu1.gif' alt ='inline image'/>× 2° field around M106 using Canada–France–Hawaii Telescope/MegaCam. We find 16 satellite galaxy candidates of M106. Eight of these galaxies are found to be dwarf galaxies that are much smaller and fainter than the remaining galaxies. Three of these galaxies are new findings. Surface brightness profiles of 15 out of 16 satellite galaxies can be represented well by an exponential disc profile with varying scalelength. We derive the surface number density distribution of these satellite galaxies. The central number density profile (<I>d</I> < 100 kpc) is well fitted by a power law with a power index of −2.1 ± 0.5, similar to the expected power index of isothermal distribution. The luminosity function of these satellites is represented well by the Schechter function with a faint‐end slope of −1.19<SUP>+0.03</SUP><SUB>−0.06</SUB>. Integrated photometric properties (total luminosity, total colour and disc scalelength) and the spatial distribution of these satellite galaxies are found to be roughly similar to those of the Milky Way and M31.</P>
Lee, E.H.,Seo, Y.J.,Ahn, H.C.,Kang, Y.M.,Kim, H.E.,Lee, Y.M.,Choi, B.S.,Lee, J.H. North-Holland Pub ; Elsevier Science Ltd 2010 FEBS letters Vol.584 No.21
The Yaba-like disease viruses (YLDV) are members of the Yatapoxvirus family and have double-stranded DNA genomes. The E3L protein, which is essential for pathogenesis in the vaccinia virus, consists of two domains: an N-terminal Z-DNA binding domain and a C-terminal RNA binding domain. The crystal structure of the E3L orthologue of YLDV (yabZα<SUB>E3L</SUB>) bound to Z-DNA revealed that the overall structure of yabZα<SUB>E3L</SUB> and its interaction with Z-DNA are very similar to those of hZα<SUB>ADAR1</SUB>. Here we have performed NMR hydrogen exchange experiments on the complexes between yabZα<SUB>E3L</SUB> and d(CGCGCG)<SUB>2</SUB> with a variety of protein-to-DNA molar ratios. This study revealed that yabZα<SUB>E3L</SUB> could efficiently change the B-form helix of the d(CGCGCG)<SUB>2</SUB> to left-handed Z-DNA via the active-mono B-Z transition pathway like hZα<SUB>ADAR1</SUB>1.
Abbas, E.,Abelev, B.,Adam, J.,Adamová,, D.,Adare, A. M.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agocs, A. G.,Agostinelli, A.,Ahammed, Z.,Ahmad, N.,Ahmad Masoodi, A.,Ahmed, I.,Ahn, S. A. Springer Berlin Heidelberg 2013 The European physical journal. C, Particles and fi Vol.73 No.11
<P>The ALICE Collaboration at the LHC has measured the J/<I>ψ</I> and <I>ψ</I>′ photoproduction at mid-rapidity in ultra-peripheral Pb–Pb collisions at [FORMULA OMISSION].</P><P>The charmonium is identified via its leptonic decay for events where the hadronic activity is required to be minimal. The analysis is based on an event sample corresponding to an integrated luminosity of about 23 μb<SUP>−1</SUP>. The cross section for coherent and incoherent J/<I>ψ</I> production in the rapidity interval −0.9<<I>y</I><0.9, are [FORMULA OMISSION] and [FORMULA OMISSION], respectively. The results are compared to theoretical models for J/<I>ψ</I> production and the coherent cross section is found to be in good agreement with those models incorporating moderate nuclear gluon shadowing at Bjorken-<I>x</I> around 10<SUP>−3</SUP>, such as EPS09 parametrization. In addition the cross section for the process <I>γγ</I>→<I>e</I><SUP>+</SUP><I>e</I><SUP>−</SUP> has been measured and found to be in agreement with models implementing QED at leading order.</P>
JEON, B.Y.,LEE, H‐,Y.,PARK, E‐,C.,CHOI, K.S.,JUN, J.K.,KIM, Y.,HAN, M.A.,YOON, N‐,H.,KIM, E.J.,JEON, S.M. Blackwell Publishing Ltd 2011 European journal of cancer care Vol.20 No.6
<P>JEON B.Y., LEE H‐Y., PARK E‐C., CHOI K.S., JUN J.K., KIM Y., HAN M.A., YOON N‐H., KIM E.J. & JEON S.M. (2011) <I>European Journal of Cancer Care</I><B>20</B>, 803–809</P><P><B>Satisfaction with mammography in the National Cancer Screening Programme participants of age 40s in Korea</B></P><P>The aim of this study was to evaluate satisfaction with the National Cancer Screening Programme of mammography in Korea and to examine the association between subscales of satisfaction and general satisfaction. We conducted a cross‐sectional telephone survey for women who had obtained a National Cancer Screening Programme mammographic screening at general hospitals between May and October 2008. The present study included 2005 women in their forties. We performed multivariate linear regression using dependent variable as general satisfaction and independent variables as subscales of satisfaction, such as pre‐screening information transfer, staff interpersonal skills, physical surroundings and results reporting. Participants were stratified according to the result of their mammogram as negative or positive. Mean score of satisfaction was above 2.5 of 4 for all subscales. Women who received positive results were less satisfied with all of subscale factors. Staff interpersonal skills were the most important factor that contributed to general satisfaction. Future efforts such as staff training programme of communication/attitude skills, ensuring privacy and explanation of possible discomfort of the screening would be needed.</P>