Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment

Lv Duo-Duo,Zhou Ling-Yun,Tang Hong 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Hepatocyte nuclear factor 4α (HNF4α), a member of the nuclear receptor superfamily, is described as a protein that binds to the promoters of specific genes. It controls the expression of functional genes and is also involved in the regulation of numerous cellular processes. A large number of studies have demonstrated that HNF4α is involved in many human malignancies. Abnormal expression of HNF4α is emerging as a critical factor in cancer cell proliferation, apoptosis, invasion, dedifferentiation, and metastasis. In this review, we present emerging insights into the roles of HNF4α in the occurrence, progression, and treatment of cancer; reveal various mechanisms of HNF4α in cancer (e.g., the Wnt/β-catenin, nuclear factor-κB, signal transducer and activator of transcription 3, and transforming growth factor β signaling pathways); and highlight potential clinical uses of HNF4α as a biomarker and therapeutic target for cancer.

스토리텔링을 활용한 중국 산서성 대동시 화엄거리의 공공디자인에 대한 연구

조다다(Duo-Duo Zhao),장주영(Ju-Young Chang),홍관선(Kwan-Seon Hong) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.4

중국 북쪽의 산서성 대동시는 오랜 역사문화와 지역적 특색을 가지고 있는 고도(古都)이다. 특히 화엄사 주변의 화엄거리는 예로부터 종교 문화와 상업 문화가 혼재하는 문화적으로 융성한 곳이었다. 본 연구에서는 이러한 화엄거리의 역사 문화적 전통을 회복하고 지역의 경제를 활성화하기 위한 공공디자인의 새로운 개념의 제안을 목적으로 한다. 특히 지역문화에 존재하는 역사문화적 스토리를 반영하여 화엄거리의 공공디자인에 적용하는 연구를 진행했다. 먼저 화엄거리의 발전과정을 소개하였고 그 역사 문화 이야기에 대해 수집과 발굴 작업을 진행하였다. 그리고 화엄거리 공공 디자인의 현황에 대해 분석을 진행하여 이 거리의 부족한 점과 사람들의 이목을 끌지 못하는 원인 등을 찾았다. 이어서 스토리텔링에서 이야기를 구성하는 서술 방법인 ‘기승전결’, 네 부분의 플롯을 구성하여 이 지역의 역사와 문화가 담긴 스토리에 근거한 새로운 디자인을 제안하였다. 화엄거리가 가지고 있는 역사문화적인 스토리를 발굴하여 스토리텔링에 기반한 전체적인 이미지 개선에 초점을 두고, 인문학적인 색채를 더한 거리의 공공 디자인 개념을 제시하도록 한다. The research object is Huayan Street, which is located in Datong City of Shanxi Province in Northern China. And it’s detailedly seated to the east of the Huayan Temple. This street is a multicultural area which covers religious and business culture, along with other kinds of civilization since ancient time. The purpose of this research is to restore the historical and cultural tradition, improving the economic development. This research will use the theory of narrative to analyze the public design of Huayan Street. It’s present the new design concept to reflect the cultural story of this region. First of all, the cultural stories of Huayan Street were explored and collected by introducing the history. Secondly, the drawbacks of public design of this street were found out by analyzing the current situation in Huayan Street At the end of this paper, a design solution was proposed according to the history and culture with story-telling methods from narratology which depart the street into four scenes opening, developing, changing and concluding. The innovation point of this research is apply humanism into the public design of Huayan Street and rebuild the image of Huayan Street.

중국인 초급 학습자를 위한 한국어 시간표현 대조 교육 방안

리둬둬(Ri Duo Duo) 한국어교육연구학회 2017 한국어교육연구 Vol.- No.6

This paper contrasts the Korean and Korean-hour representation of a Chinese expression for time for Chinese beginners, and we have been talking about education measures. In Chapter 1, we have been talking about the purpose and previous research, research methods for the study. Chapter 2 hours as contrasted representation of Korean and Chinese were tense and tense grasp the concept of Chinese and Korean. Past tense, learn the present tense, future tense, tense investigate the similarities and differences between the two languages. Chapter 3 examined on the Chinese and Korean. Completion phase, was to discuss the progression, operatively, repeat, Chinese is completed On Chinese 了 past, present and future everywhere was used, progression is Chinese 正在, 正, 在, 著 it has been interpreted as, operatively is awards were repeated, repetition time adverb + ∅ form. The final chapter presents a training plan for beginner learners of Chinese. I also tried to find ways of training during configuration considerations and lessons. Korean time representation is handled much in one of the most important expressions of Korean grammar lessons, beginner stage. So beginner learners do not understand the time representation as well as the failure to indicate intermediate, to advanced; it can not communicate in everyday life. In this paper, we hope to have the opportunity to treat lack saw only some details, but the Chinese novice can go a little easier time approaching the Korean expression for.

Design and Implementation of 1-D and 2-D Mixed Architecture FFT Processor in Heterogeneous Multi-core SoC based on FPGA

Duo-li Zhang,Lu Huang,Yu-kun Song,Gao-ming Du 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.6

The Regulation of LexA on UV-Induced SOS Response in Myxococcus xanthus Based on Transcriptome Analysis

( Duo-hong Sheng ),( Ye Wang ),( Shu-ge Wu ),( Rui-qin Duan ),( Yue-zhong Li ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.7

SOS response is a conserved response to DNA damage in prokaryotes and is negatively regulated by LexA protein, which recognizes specifically an “SOS-box” motif present in the promoter region of SOS genes. Myxococcus xanthus DK1622 possesses a lexA gene, and while the deletion of lexA had no significant effect on either bacterial morphology, UV-C resistance, or sporulation, it did delay growth. UV-C radiation resulted in 651 upregulated genes in M. xanthus, including the typical SOS genes lexA, recA, uvrA, recN and so on, mostly enriched in the pathways of DNA replication and repair, secondary metabolism, and signal transduction. The UV-irradiated lexA mutant also showed the induced expression of SOS genes and these SOS genes enriched into a similar pathway profile to that of wild-type strain. Without irradiation treatment, the absence of LexA enhanced the expression of 122 genes that were not enriched in any pathway. Further analysis of the promoter sequence revealed that in the 122 genes, only the promoters of recA2, lexA and an operon composed of three genes (pafB, pafC and cyaA) had SOS box sequence to which the LexA protein is bound directly. These results update our current understanding of SOS response in M. xanthus and show that UV induces more genes involved in secondary metabolism and signal transduction in addition to DNA replication and repair; and while the canonical LexA-dependent regulation on SOS response has shrunk, only 5 SOS genes are directly repressed by LexA.

Circular RNA hsa_circ_0005556 Accelerates Gastric Cancer Progression by Sponging miR-4270 to Increase MMP19 Expression

Duo Shen,Hongyu Zhao,Peng Zeng,Jinyun Song,Yiqiong Yang,Xuefeng Gu,Qinghua Ji,Wei Zhao 대한위암학회 2020 Journal of gastric cancer Vol.20 No.3

Purpose: Circular RNAs (circRNAs) are a new class of RNA molecules whose function is largely unknown. There is a growing evidence that circRNAs play an important regulatory role in the progression of a variety of human cancers. However, the exact roles and the mechanisms of circRNAs in gastric cancer are not clear. In this study, we aimed to elucidate the mechanism of hsa_circ_0005556. Materials and Methods: Real-time quantitative polymerase chain reaction was used to detect the expression of hsa_circ_0005556, miR-4270, and matrix metalloproteinase-19 (MMP19) in gastric cancer tissues and cell lines. The expression of hsa_circ_0005556 in gastric cancer cells was silenced by lentivirus, and cell proliferation, invasion, migration, and tumorigenesis in nude mice were assessed to evaluate the function of hsa_circ_0005556 in gastric cancer. Results: The expression of hsa_circ_0005556 in gastric cancer tissues and gastric cancer cell lines was higher compared to normal controls. In vitro, the downregulation of hsa_circ_0005556 significantly inhibited proliferation, migration, and invasion of gastric cancer cells. In vivo, the downregulation of hsa_circ_0005556 suppressed tumor growth in nude mice. Conclusions: Our study shows that the hsa_circ_0005556/miR-4270/MMP19 axis is involved in proliferation, migration, and invasion of gastric cancer cells through the competing endogenous RNA (ceRNA) mechanism.

Mitigating Recurrent Congestion via Particle Swarm Optimization Variable Speed Limit Controllers

Duo Li,Prakash Ranjitkar,Yifei Zhao 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.7

Variable speed limit (VSL) has proven to be an efficient motorway control measure to mitigate traffic congestion at motorway bottlenecks. VSL can reduce the effect of shockwave on traffic conditions through smoothing the transition between the congested downstream and upstream traffic flows. In this paper, a particle swarm optimization (PSO) based VSL method is proposed to minimize the probability of flow breakdown at bottleneck sections and ensure a maximum utilization of the current motorway infrastructure. The results show that the motorway system equipped with PSO based VSL outperformed the one with rule based VSL.

Risk of venous thromboembolism in Chinese pregnant women: Hong Kong venous thromboembolism study

Duo Huang,Emmanuel Wong,Ming-Liang Zuo,Pak-Hei Chan,Wen-Sheng Yue,Hou-Xiang Hu,Ling Chen,Li-Xue Yin,Xin-Wu Cui,Ming-Xiang Wu,Xi Su,Chung-Wah Siu,Jo-Jo Hai 대한혈액학회 2019 Blood Research Vol.54 No.3

BackgroundPrevious Caucasian studies have described venous thromboembolism in pregnancy; however, little is known about its incidence during pregnancy and early postpartum peri-od in the Chinese population. We investigated the risk of venous thromboembolism in a “real-world” cohort of pregnant Chinese women with no prior history of venous thromboembolism.MethodsIn this observational study, 15,325 pregnancies were identified in 14,162 Chinese women at Queen Mary Hospital, Hong Kong between January 2004 and September 2016. Demographic data, obstetric information, and laboratory and imaging data were retrieved and reviewed.ResultsThe mean age at pregnancy was 32.4±5.3 years, and the median age was 33 years (interquartile range, 29‒36 yr). Pre-existing or newly diagnosed diabetes mellitus was present in 627 women (4.1%); 359 (0.7%) women had pre-existing or newly detected hypertension. There was a small number of women with pre-existing heart disease and/or rheumatic conditions. Most deliveries (86.0%) were normal vaginal; the remaining were Cesarean section 2,146 (14.0%). The incidence of venous thromboembolism was 0.4 per 1,000 pregnancies, of which 83.3% were deep vein thrombosis and 16.7% were pul-monary embolism. In contrast to previous studies, 66.7% of venous thrombosis occurred in the first trimester.ConclusionChinese women had a substantially lower risk of venous thromboembolism during preg-nancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early preg-nancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization.

Two‑vector predictive current control strategy based on maximum torque per ampere control for PMSMs

Duo Jin,Housheng Zhang,Shengjie Zhu,Ao Wang,Junjie Jiang 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.8

In permanent magnet synchronous motor systems with double closed-loop maximum torque current ratio control, a PI adjuster is used as the current inner ring. Unfortunately, the current may not be tracked effectively due to controller saturation when the load suddenly changes. To counteract this effect, a novel two-vector predictive current control strategy based on maximum torque current ratio control is proposed in this paper. The control strategy introduces the model predictive current control of two voltage vectors based on maximum torque per ampere control, which is acted upon by two voltage vectors in one control period. The second selected vector is no longer limited to the null vector. The orientation and amplitude of the synthesized virtual voltage vector are adjustable. Simulation results indicate that the proposed control method has the advantages of maximum torque per ampere control and model predictive control. It optimizes the stability of the system and reduces the fluctuation of the stator current.

Comprehensive study of relationships between surface morphology parameters and contact stress

Duo Yang,Jin-Yuan Tang,Wei Zhou,Yuqin Wen 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.11

Surface roughness morphology seriously restricts workpiece interface contact performance, and therefore it is necessary to remove the fog of relationships between morphology parameters and contact stress (CS). To study the issue, use correlation analysis and BP network to set up correlation mapping model, thereafter introduce global sensitivity analysis Morris (qualitative) and Sobol (quantitative) to get “main influence parameters (MIP)”. Afterwards, construct a optimal nonlinear regression model between MIP and CS in line with complete polynomial and the idea of permutation and combination. Finally, analyze MIP influence path on CS from statistical path analysis. The paper main contributions are as follows: 1. From the perspective of theoretical analysis, a reasonable method to select parameters about CS performance characterization is proposed to avoid the empirical selection errors; 2. Correlation relationships bridge is built between MIP and CS, with quantitative influence way of parameters on contact stress studied and clarified.