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- 저자 : Dubrovsky (검색결과 4 건)
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Min Jung Jung,David Alrahwan,Esther Dubrovsky,Donghwa Baek,Alberto G. Ayala,Jae Y. Ro 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Solitary fibrous tumor (SFT) is a rare, soft tissue neoplasm that rarely presents in breast tissue, with only 27 previously reported cases. To our knowledge, only one case of malignant SFT has been reported in the English literature. A 75-year-old Caucasian woman presented to our institution with a 3-month history of a palpable left breast mass. No other symptoms, including nipple discharge or skin changes, were noted. She underwent 3 previous biopsies for right breast masses, all of which were benign, with no evidence of spindle cell neoplasm, atypical hyperplasia, or malignancy. Microscopic examination of the mass demonstrated a classic area of SFT with areas of high-grade anaplastic component. In these areas, the tumor showed atypical epithelioid cells arranged in hypercellular sheets with diminished branching vasculature, nuclear pleomorphism, and increased mitotic count (up to 9/10 high-power fields). This case represents the second case of malignant SFT in the breast.
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GB20 Pharmacopuncture As a Potential Method for Brain Drug Delivery via the Perivascular Spaces
Oxana Semyachkina-Glushkovskaya,Inna Blokhina,Nikita Navolokin,Arina Evsukova,Georgy Karandin,Alexander Khorovodov,Andrey Terskov,Ivan Fedosov,Alexander Dubrovsky,Maria Tzoy,Vasily Ageev,Ilana Agranov 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.1
Background: The development of new methods of drug brain delivery is a crucial step for the effective therapy of the brain diseases. Pharma- and acupuncture are the forms of alternative therapy of the brain pathology, including an increase in the permeability of blood-brain barrier. However, the mechanisms of pharma- and acupuncture-mediated effects on the brain physiology remain not fully understood. Results: This pilot study on healthy mice clearly demonstrates the Evans Blue spreading in the mouse head and in the brain via the perivascular spaces (PVSs) of the trigeminal structure and the cribriform plate after the dye injection into the Feng Chi point (Galbladder 20, GB20). Conclusion: These results suggest that pharmacopuncture at GB20 can be a perspective method for brain drug delivery via PVSs.
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박국양,박철현,현성열,김주이,권진형,최인석,이현재,임창영,Igor Dubrovski, Ph.D. 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.4
A 25-year-old man with viral cardiomyopathy and chronic active hepatitis successfully underwent dynamic cardiomyoplasty for the first time in Korea on July 30, 1996. The patient had been intermittently dyspneic for 5 years and was admitted to our center twice because of heart failure. For the past 2 years, he was NYHA functional class III status with a left ventricular ejection fraction(LVEF) of around 30%. The patient was born with scoliosis and showed a short stature. The liver function showed elevated liver enzymes, and hepatitis B antigen was positive. The liver biopsy revealed chronic active hepatitis. The preoperative echocardiogram showed decreased left ventricular function with grade II mitral and grade II tricuspid regurgitation with dilated left and right atrium. Recently his symptoms worsened and we decided to perform a dynamic cardiomyoplasty. The left latissmus dorsi muscle(LDM) was mobilized and tested with lead placement on his right lateral decubitus position. The patient was positioned into supine and, after median sternotomy, the heart was wrapped with the mobilized muscle. The Russian made cardiomyostimulator(EKS-445) and leads (Myocardial PEMB for heart and PEMP-1 for LDM) were used. The total operation time was 8 hours and there were no perioperative episodes. Postoperatively the LDM had been trained for a 10 week period and currently the stimulation ratio is maintained at 1:4. The postoperative LVEF did not increase with the value of 30-35%. However, the patient feels better postoperatively with slightly increased activity. 25세된 말기 심부전 환자에게 한국에서는 최초로 광배근을 이용한 심근 성형술이 성공적으로 실시되었다. 환자는 약 심근수축력이 30%인 상태로 94년과 96년에 한차례씩 심부전으로 입원한 적이 있으며 수술직전 임상상태는 NYHA functional class III 였다. 간조직 검사상 만성 활동성 간염으로 판명되었으며 환자는 간염 항원이 양성으로 심장이식대상에서 제외되었다. 1996년 7월 30일 좌측 광배근을 이용하여 심근 성형술을 실시하였다. 측와위로 광배근을 박리한후 자극전극을 설치하였으며 흉골 정중 절개로 심장을 노출한 후 광배근으로 심장을 감싸주고 심근 전극을 설치한 후 좌상부 복부에 심장근육자극기를 설치하였다. 총 수술시간은 약 7시간 30분이 소요되었으며 환자는 수술후 일시적인 심방 조동(atrial flutter)을 보여 심도자실에서 동율동으로 환원시킨 것외에는 특별한 합병증은 없었다. 환자는 수술후 6주째 자극기의 빈도가 1:4인 상태에서 퇴원하였으며 통원치료중 1:1로 근육훈련을 마친 후 현재는 수술후 6개월째 자극빈도가 1:4인 상태에서 외래 추적중이다. 심초음파상 수축력의 차이는 없으나 환자의 임상 활동은 수술전보다 양호해진 상태이다.
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