족과관절염좌 환자에 대한 동씨침법과 일반침법의 효과에 대한 비교 연구

안호진,정동화,황규선,윤기붕,김태우,문장혁,백종엽,이상무,Ahn, Ho-jin,Jeong, Dong-hwa,Hwang, Kyu-seon,Yoon, Ki-bung,Kim, Tae-woo,Moon, Jang-huyk,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took $1.57{\pm}0.85$ times and General acupuncture therapy took $2.15{\pm}0.96$ times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.

자궁경부 상피종양에서 human papillomavirus 감염과 survivin 발현

윤재호,정동준,이정은,박동명,배동한,선우재근,백무준,김창진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Human papillomavirus (HPV) has been considered a causative agent of uterine cervical carcinoma. HPV is a DNA oncogenic virus, which is well known as a causative virus in uterine cervical carcinoma. The virus is classified into two groups genotypically, low risk and high risk, according to the carcinogenic potentiality, and the determination of the viral genotype is important in clinical practice. Recently, numerous genotypes can be determined by high throughput method using DNA chip. Survivin is a recently characterized inhibitor of anti-apoptosis (IAP) protein, which is abundantly expressed in most solid and hematological malignancies, but undetectable in normal adult tissues. In this study, HPV genotypes are determined by DNA chip and the expression of survivin was examined by immunohistochemistry in 80 cases of uterine cervical intraepithelial neoplasia (CIN) and invasive carcinoma to see the roles of HPV and survivin in the carciogenesis of uterine cervical epithelial neoplasia. The results were as follows: 1. HPV positive rate was 72.5%, while negative rate was 27.5% in 80 cases of CIN and invasive carcinoma. The CIN and invasive carcinoma showed higher HPV positive rate (p <0.05). 2. HPV positive rate according to the histologic grade were 60%, 65%, 77% and 90% in CINI, CINII, CINII and invasive carcinoma, respectively. HPV positive rate showed increasing tendency according to the histologic grade, though there was no statistical significance. 3. The most frequent genotype was type 16 and the next were 58, 52, 18 and 33 in order of frequency. 4. Survivin was expressed in 96.3% of CIN and invasive carcinoma. The expression rate of survivin showed no significant difference between the histologic grade of CIN and invasive carcinoma, but showed tendency of increased expression rate in invasive carcinoma. 5. Survivin was expressed in HPV positive and in HPV negative each as in 95.5% and 96.6% respectively. There was no significant difference of survivin expression between HPV positive and negative cases. The above results suggest that HPV has no effect on the regulation of survivin expresson level in the uterine cervical intraepithelial neoplasia and invasive carcinomas.

DW1029M, a novel botanical drug candidate, inhibits advanced glycation end-product formation, rat lens aldose reductase activity, and TGF-β₁ signaling

Yoon, Joobyoung,Lee, Hyunyong,Chang, Hwan Bong,Choi, Hyunsik,Kim, Yong Sung,Rho, Yang Kook,Seong, Seungkyoo,Choi, Dong Hwa,Park, Dongeun,Ku, Bonchul American Physiological Society 2014 American Journal of Physiology Vol.306 No.10

<P>DW1029M is a botanical extract consisting of Morus bark and Puerariae radix, produced by Dong-Wha Pharmaceutical, for nephroprotective drug development; it has been in phase II clinical trials in Korea. In our mechanistic investigations, we found that DW1029M inhibits advanced glycation end products (AGEs), rat lens aldose reductase (RLAR), and transforming growth factor (TGF)-beta(1) signaling, all of which are implicated in diabetic complications such as diabetic nephropathy and diabetic retinopathy. DW1029M inhibits AGE formation via Fe2+ chelation. The extract contains 13 active constituents that inhibit AGE formation, 8 active constituents that inhibit RLAR activity, and 1 inhibitor of TGF-beta(1) signaling. Our results suggest DW1029M protects against diabetic nephropathy via blockade of AGE formation, RLAR activity, and TGF-beta(1) signaling.</P>

Integer Frequency Offset Estimation of OFDM Systems

Yoon,Dae-Gung,Han,Dong-Seog 한국정보기술응용학회 2005 한국정보기술응용학회학술대회 Vol.2005 No.1

The Relationship among Engagement in Workplace Learning Activities, Openness to Learning, and the Extent of Participant Involvement in Informal Learning

Yoon,Dong-Yeol,You,Jieun,Yun,Wi Seok,Hyun,Sunhae 한국인적자원관리학회 2011 인적자원관리연구 Vol.18 No.4

일터학습에 있어서 비공식학습의 중요성이 대두함에 따라, 많은 기업들은 직원들의 비공식 학습을 촉진할 수 있는 다양한 학습전략응사용하고 있다. 기존의 연구들은 기업 내 공식학습과 비공식학습은 상호 연관되어 있어, 공식학습을 제공할 경우 비공식학습도 동시에 활성화된다고 주장한다. 본 연구는 직원들이 기업에서 행해지고 있는 일터학습에 참여하는 정도가 비공식학습활동에 어떠한 영향을 미치는지 연구함으로써, 일터학습의 참여도와 비공식학습의 관계를 알아보고자 하였다. 일터학습에 참여하고 있는 제약회사의 직원들을 대상으로 한 설문조사에 대하여 회귀분석을 실시한 결과, 일터학습에 참여하는 것 자체는 직원들이 비공식학습에 몰입하는 정도에 유의미한 영향을 미치지 못하는 것으로 나타났다. 특히 실천공동체와 온라인 학습의 경우 비공식학습에 부정적 영향을 미치는 것으로 나타났다. 이는 기업이 일터학습을 제공하더라도, 체계적인 형태를 갖추지 못했거나 직원들 간의 상호작용을 촉진하지 못할 경우 일터학습이 오히려 비공식학습을 저해할 수 있다는 것을 보여준다. 그러나 개인의 학습 개방성은 비공식학습의 정도에 영향을 미치는 것으로 나타나, 일터학습의 참여도가 비공식학습의 정도에 미치는 영향에 조절효과를 보이는 것으로 나타났다. 끝으로 연구결과는 관리자 직급에 있는 근로자들의 경우 그렇지 않은 직원들에 비하여 비공식학습활동에 더 많이 참여하고 있다는 것을 보여준다. 관리자 직급의 근로자들은 학습에 대한 경험이 풍부하고, 학습의 필요성에 대해서도 충분히 인식하여 비공식학습활동에도 적극적으로 참여하고 있다고 볼 수 있다. 따라서, 기업 내에서 비공식학습을 활성화시키기 위하여, 종업원들에게 일터학습을 제공하고 이것에 참여하도록 유도하는 것뿐만 아니라, 직원들 스스로 학습에 참여할 수 있는 개방적 태도를 지닐 수 있도록 지원하는 것이 중요하다는 것을 보여준다. Informal learning in the workplace is becoming more important for improving employees’ competencies and organizational performance. Many business organizations use a variety of workplace learning strategies in order to facilitate informal learning among employees. Research on workplace learning explains that formal learning and informal learning interrelate and facilitate each other. This study investigated the relationship among engagement in workplace learning activities, openness to learning, and the extent of participant involvement in informal learning. As a result of quantitative research in a pharmacy company, this study showed the following: (a) openness to learning affects participant involvement in informal learning more than engagement in workplace learning activities does; (b) among types of workplace learning, communities of practice negatively influence internal informal learning, and web-based learning also has a negative effect on involvement in internal, external informal learning and informal learning among newly hired employees, but traditional classroom training positively affects participants’ involvement in informal learning among new employees; and (c) employees at the managerial level involve in informal learning activities more than other employees. These results suggest that business organizations and corporate management should support and facilitate employees to learn with openness as well as provide them with workplace learning opportunities.

Living Dead

Yoon,Dong-yong 서강대학교 생명문화연구소 2010 생명연구 Vol.18 No.-

The present study purports to review various aspects of the cult of the dead in the iron age of Israel. The worship of the dead implies that the dead is connected with and has influence on the living world. Textual evidences on the funerary rites, communal repast with the dead (marzeah), and the veneration of the dead (rephaim) intimates that the death cult was prevalent in the realm of popular religions in ancient Israel. Some archeological evidences also allude to the ongoing practice of the death cult at ancient Israel. Funerary installations such as vessels for food might intend the provision for the deceased. Standing stones (masseboth) that were installed either at graves or at certain cultic places apparently had the function of commemoration of the ancestor as a whole. By offering provision and demonstrating their veneration to the dead, the living could reconcile with the dead in order to secure their favor.

코로나19 대응 거버넌스의 성공 요인에 관한 탐색적 연구: 성과중심적 거버넌스 모형을 활용하여

윤기웅(Yoon, Ki-Woong),공동성(Kong, Dong-Sung) 한국정부학회 2020 한국행정논집 Vol.32 No.3

본 연구는 코로나19 방역 모범국이라는 평가를 받는 한국의 코로나19 대응 전략 및 성공 요인을 살펴보는 데 그 목적이 있다. 코로나19 감염병은 사회재난 중 하나로 정부가 중심이 되는 공공거버넌스의 영역이라고 볼 수 있다. 따라서 본 연구는 공공거버넌스 유형 중 하나인 성과중심적 거버넌스 모형을 활용하여 코로나19 방역의 성과(확진자와 사망자의 통제 가능 여부)에 영향을 미치는 요인들을 탐색적으로 분석한다. 분석결과 거버넌스 맥락, 정권, 행정적 준비단계, 성과향상 실행메커니즘에 포함되는 다양한 요인들이 한국의 코로나19 방역의 성과에 이바지한 것으로 나타났다. 구체적으로 살펴보면, 첫째, 거버넌스 맥락 차원에서 2015년 메르스 대응실패 이후 이루어진 법령 개정, 중앙집권체계, 정보통신기술발달 등 방역 활동에 우호적인 외부환경 요소들이 방역의 성과향상에 기여하였다. 둘째, 정권 차원에서 방역당국에 대한 대통령의 적극적 지원과 범정부적 조직/인사/예산지원은 방역당국이 효과적으로 방역에 집중할 수 있도록 하는 밑거름이 되었다. 셋째, 행정적 준비단계 차원에서 구체적으로 마련된 표준운영절차(SOP)와 담당자에 대한 교육/훈련을 통한 역량 강화는 방역 일선 담당자들의 일사불란한 대처를 가능하게 했다. 넷째, 성과향상 실행메커니즘 차원에서 방역당국은 주어진 상황 및 여건에 맞춘 적절한 대비를 하였을 뿐만 아니라 신속한 진단검사 및 역학조사를 통해 확진자를 조기 발견하여 적시에 감염병 확산을 차단할 수 있었다. 결론적으로 피해복구 단계를 제외한 예방, 대비, 대응 단계에서 적절한 조치가 이루어졌고, 이로 인해 비록 미흡한 점이 일부 있기는 하나 한국의 코로나19 방역이 어느 정도 성공적으로 작동하였다고 볼 수 있다. South Korea is being evaluated by global media and experts for its successful response to coronavirus disease 2019 (COVID-19). The purpose of this study is to examine the Korean government’s response strategy and success factors for COVID-19 using the performancebased/managerial governance model which was presented by Kong & Yoon(2018b). It found that various factors, such as governance context, governance regime, pre-governance and execution mechanisms, all together contributed to South Korea’s success in responding to COVID-19. These findings can be considered to be of theoretical significance in that they expanded the applicability of the public governance model proposed by Kong & Yoon. In addition, the case of South Korea, which has harmoniously achieved the two conflicting goals of controlling infectious disease and minimizing economic damage, provides many practical implications for how other countries should cope in the future.

Metoclopramide가 휜쥐의 血壓에 미치는 影響

임동윤,최동준,김규형,최철희,박재윤,문재규,김문석,황두환 中央醫學社 1988 中央醫學 Vol.53 No.9

Influences of metocopramide (MCP), which is a seletive dopaminergic antagonist, on blood pressure of the rat and its mechanism of action were investigated in the present study. MCP administered into a femoral vein of the rat caused markedly a dose-related fall in blood pressure followed by secondary transient pressor response. The depressor action evoked by MCP was not blocked by pretreatment of atropine or chlorisondamine, while the pressor action was inhibited significantly. Prazosin treatment reduced markedly both of depressor and pressor induced by MCP. MCP-evoked pressor action was not affected by clonidine, but the depressor response was attenuated significantly. Debrisoquin treatment made the inhibited response to MCP-induced pressor response, while did not affect the depressor action. Both of pressor and depressor responses evoked by MCP were not influenced by cyproheptadine. The hypertensive activity induced by nor epinephrine was weakened markedly by the infusion of MCP (1.50 mg/kg/30min.), but the pressor action evoked by dopamine not affected. These experimental data suggest that MCP produces biphasic responses (depressor and pressor) in blood pressure of the rat, and that the hypotensive activity is due to adrenergic alpha-receptors blockade, and that pressor activity is exerted through stimulation of cholinergic nicotinic receptors in autonmic ganglia.

Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

빌라조경 설계사례에 관한 연구 : Case Study of Jang-chung Dong Villa

김동찬,이윤수,유재설,박익수,임동민,임상재 경희대학교 부설 디자인연구원 1998 예술· 디자인학연구 Vol.1 No.1

The goal of this study is to propose a plan for the Jang-Chung Dong Villa. This Villa is located on Jang-Chung Dong Jung-Gu, Seoul. And, this place is where high-class residential area. This Site area covers about 1925.6m². This base idea of this plan is to provide a community of dwelling houses with identity and amenity in outdoor spaces in order to create the high-class environment of outdoor spaces. Design principles are established as follow; to make spaces for flexibility in the garden related activities, to provide many chances to contact with nature, and to feel pride in the villa life.