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The Estimation of Breast Cancer Disease-Probability by Difference of Individual Susceptibility
Sue Kyung Park,Keun-YoungYoo,DaeHeeKang,Sei-HyunAhn,Dong-YoungNoh,Kuk-JinChoe 대한암학회 2003 Cancer Research and Treatment Vol.35 No.1
Purpose: The aims were to evaluate the main riskfactors (RFs) of breast cancer and to estimate the individualdisease-probability from combinations of RFs inKorean female.Materials and Methods: We conducted case-controlstudy of 1,687 incident cases of invasive carcinoma and1,238 controls during 1996∼2000. A breast cancer disease-probability model was established by a generalmodeling process using a multivariate logistic regressionmodel, which included the main Korean RFs and synergisticinteraction-terms.Results: The main Korean RFs selected were age,family history of second relatives, BMI, age at first fulltermpregnancy, breast-feeding, and a special test on thebreasts. Two synergisms were observed between age andbreast-feeding, and between special test and age at firstfullterm pregnancy. The disease-probability and modelare shown in Table 4, and Appendix 1.Conclusion: The availability of previous Western modelswas limited for Korean female due to the differencesinhazard-rates and the characteristics of breast cancerbetween Asian and Western females. Due to limited basicdata, i.e. incidence, hazard-rate and cancer-cohorts, thedeveloping-probability of breast cancer for Korean femaleswas not calculated. Therefore, the disease-probabilitywas calculated instead. This approach might bemore beneficial for Koreans, and help in the decisionmakingfor regular screening or hospital visit-interval,counseling in breast-cancer clinics, prescribing high-riskpopulation, and in educating for primary prevention, althoughit over-estimates the relative probability comparedto the developing-probability and the 65% predictivevalidity. (Cancer Res Treat. 2003;35:35-51)
Clinical Significance of Annexin A1 Expression in Breast Cancer
Cha Kyong Yom,한원식,Sung Won Kim,김희성,Hee-Chul Shin,Ji Na Chang,Minyoung Koo,Dong-YoungNoh,문병인 한국유방암학회 2011 Journal of breast cancer Vol.14 No.4
Purpose: The expression of Annexin A1 (ANXA1) is known to be reduced in human breast cancer; however, the role of ANXA1 expression in the development of breast cancer remains unclear. In this study, we determined the relationship between the expression features of ANXA1 and the prognostic factors of breast cancer. Methods: Human breast tissues were obtained from patients specimens who had undergone breast surgery or core needle biopsies. The patterns of ANXA1 expression were analyzed by immunohistochemical staining in relation to histopathological diagnosis, clinical characteristics and outcomes. Results: One hundred eighty-two cases were included and the mean age of the patients was 46.34 ± 11.5 years. A significant loss of ANXA1 expression was noted in both ductal carcinoma in situ (DCIS) and invasive carcinomas compared to normal breast tissues (p<0.001) and benign breast diseases (p<0.001). There was a significant alteration in ANXA1 expression according to hormone receptor status (p<0.001), cancer intrinsic type (p<0.001), and nuclear grade (p=0.004) in invasive cancer. In a univariate analysis, ANXA1 positivity tended to be related with poor breast cancer-related survival (p=0.062); however, the same results was not realized in multivariate results (p=0.406). HER2 overexpression and TNM staging were significantly associated with relapse-free survivals (RFS) in the multivariate analysis (p=0.037, p=0.048, respectively). In particular, in node-positive patients (p=0.048), HER2 overexpressed patients (p=0.013), and non-triple negative breast cancer patients (p=0.002), ANXA1 overexpression was correlated with poor RFS. Conclusion: Although significant loss of ANXA1 expression was noted in breast cancer including DCIS and invasive carcinoma, in cases of invasive cancer, overexpression of ANXA1 was related to unfavorable prognostic factors. And these results imply that ANXA1 plays dualistic roles and is involved in variable mechanisms related to cancer development and progression.