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( Dong Ok Jeon ),( Ju Sang Park ),( Hyo Jin Cho ),( Jung Hee Kim ),( So Ya Paik ),( Il Dong Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Inverted colonic diverticula (ICD) are rarely reported. ICD can be confused with elevated polypoid lesions and are occasionally complicated by bleeding and colonic perforation following biopsy or endoscopic resection. We report a case of inverted diverticulitis of ascending colon misdiagnosed as subepithelial tumor. Case report: A 61-year-old man, who had history of adenomatous colon polyps and an about 3.5 cm sized subepithelial tumor in the ascending colon 5 years ago, presented for surveillance colonoscopy. He had no symptoms. Physical examination and laboratory data were normal. On follow-up colonoscopy, subepithelial tumor without change in size showed a central necrosis communicating to surface in ascendingcolon. Biopsies revealed chronic infl ammation and elongated crypts without evidence of malignancy. The abdominal CT showed 4 cm sized segmental wall thickening with enhancement in proximal ascending colon. A laparoscopic right hemicolectomy was performed to rule out malignant transformation of subepithelial tumor. Intraoperative fi ndings revealed an infl ammatory mass in proximal ascending colon. Histopathologic evaluation revealed a 3.5x3.0 cm sized diverticulum with multiple mucosal invaginations containing inspissated mucoid materials, congested subserosa and fi brinous exudated serosa without malignancy -The fi nal diagnosis was inverted colonic diverticulitis of ascending colon. Two years ago, on further history taking, patient had an episode of right lower quadrant abdominal pain, which was misdiagnosed as an infectious enterocolitis and resolved with conservative management. Maybe it was thought to be due to colonic diverticulitis. Conclusion: Because ICD may resemble polypoid lesions in the colon, they should be considered in the differential diagnosis of unusual polypoid lesions by additional imaging studies such as EUS and CT. To our knowledge, this is the fi rst case of ascending ICD complicated with diverticulitis.
Ya-Nan Jin,Wang-Jian Zhang,Xiu-Yu Cai,Mei-Su Li,Wayne R. Lawrence,Si-Yang Wang,Dong-Mei Mai,Yu-Yun Du,Dong-Hua Luo,Hao-Yuan Mo 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1
Purpose We aim to examine nasopharyngeal carcinoma (NPC) characteristics and survival outcomes in patients aged 70 years and older in the intensity-modulated radiotherapy (IMRT) era. Materials and Methods From 2006 to 2013, 126 non-metastatic NPC patients aged 70 years who were treated with IMRT +/ chemotherapy were included. Adult Comorbidity Evaluation 27 (ACE-27) was used to measure patient comorbidities. The overall survival (OS) and cancer-specific survival (CSS) were calculated with the Kaplan-Meier method, and differences were compared using the log-rank test. The Cox proportional hazards model was used to carry out multivariate analyses. Results For the entire group, only two patients (1.6%) presented stage I disease, and up to 84.1% patients had stage III-IVB disease. All patients had a comorbidity score of 0 in 24 (19.0%), 1 in 45 (35.7%), 2 in 42 (33.3%), and 3 in 15 (11.9%) patients. The main acute grade during radiotherapy was 3-4 adverse events consisting of mucositis (25.4%), bone marrow suppression (16.7%), and dermatitis (8.7%). After treatment, four patients (3.2%) developed temporal lobe injury. Five-year CSS and OS rates were 67.3% (95% confidence interval [CI], 58.6% to 77.4%) and 54.0% (95% CI, 45.6% to 63.9%), respectively. Five-year OS was significantly higher for ACE-27 score 0-1 than ACE-27 score 2-3 (72.9% and 39.9%, respectively; p < 0.001). Multivariate analyses showed ACE-27 score 0-1 was significantly associated with superior OS (hazard ratio [HR], 3.02; 95% CI, 1.64 to 5.55; p < 0.001). In addition, the rate of OS was higher for stage I-III than that of stage IV, with borderline significance (HR, 1.67; 95% CI, 0.99 to 2.82; p=0.053). But no significant advantage was observed in OS when chemotherapy was used (p > 0.05). Conclusion Our findings suggest IMRT +/– chemotherapy has a manageable toxicity and provides an acceptable survival in patients aged 70 years with NPC. ACE-27 score was significantly associated with survival outcomes in this group population.
Dong-xia Zhao,Dong-xia Fan,Ya-ping Guo 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
In this paper, the well-posedness and stability of a 1-d 2×2 hyperbolic system under proportional feedback control is addressed. The semigroup approach and norm equivalence theorem is adopted to obtain the explicit dissipative condition for control parameters. The asymptotic spectral analysis of the system is presented. It is shown that the real part of the eigenvalues goes to some negative constant as the modulus of eigenvalues goes to +∞. Moreover, we find that there is a group of generalized eigenfunctions which forms a Riesz basis of the Hilbert state space. Hence, the spectrum determined growth condition holds, and then the exponential stability is established.
Ya-Dong Zhang,Zhong-Sheng Zhu,Dong Zhang,Zhen Zhang,Bin Ma,Shi-Chang Zhao,Feng Xue 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathwaymediated recovery from spinal cord injury (SCI). An analytical emphasis on the relationship between the sonic hedgehog (Shh) pathway and nerve regeneration was explored. A total of 126 rats were divided into normal, sham, SCI, negative control (NC), PTC1-RNAi, PTC2-RNAi and PTC1/PTC2-RNAi groups. The Basso, Beattie and Bresnahan (BBB) scale was employed to assess hind limb motor function. Quantitative real-time polymerase chain reaction and western blotting were performed to examine the mRNA and protein levels of PTC1, PTC2, Shh, glioma-associated oncogene homolog 1 (Gli-1), Smo and Nestin. Tissue morphology was analyzed using immunohistochemistry, and immunofluorescent staining was conducted to detect neurofilament protein 200 (NF-200) and glial fibrillary acidic protein (GFAP). The PTC1/PTC2-RNAi group displayed higher BBB scores than the SCI and NC groups. Shh, Gli-1, Smo and Nestin expression levels were elevated in the PTC1/PTC2-RNAi group. PTC1 and PTC2 mRNA and protein expression was lower in the PTC1/PTC2-RNAi group than in the normal, sham and SCI groups. Among the seven groups, the PTC1/PTC2-RNAi group had the largest positive area of NF-200 staining, whereas the SCI group exhibited a larger GFAP-positive area than both the normal and the sham groups. The Shh pathway may provide new insights into therapeutic indications and regenerative recovery tools for the treatment of SCI. Activation of the Hh signaling pathway by silencing PTC1 and PTC2 may reduce inflammation and may ultimately promote SCI recovery.
Risk Management Qualitatively on Railway Signal System
Ya-dong Zhang,Jin Guo 한국철도학회 2009 International Journal of Railway Vol.2 No.3
Risk management is an important part of system assurance and it is widely used in safety-related system. Railway signal system is one kind of safety-related system and its most important goal is to guarantee the safety of railway system. The method based on risk management can find and solve the security issues of railway signal system more effectively. This paper introduces the basic conception of risk management, studies the whole process of risk management and related tools and techniques and discusses some key points qualitatively combining with the particularity of railway signal system.
Velocity Control with SGARC 440 Alloy in the Roll Forming Process
Zhang, Ya,Kim, Dong Hong,Jung, Dong Won Trans Tech Publications, Ltd. 2015 Advanced materials research Vol.1095 No.-
<P>Cold roll-forming of metal sections is a significant field in advancing forming of strip metal, and the forming processes are influenced by many factors. The scientific design of passes is worked out by combining theoretical analysis with finite element analysis, in accordance with the principles of cold roll-forming; thus the desired high-quality bending sections are achieved through a combination of theory and practice. This study mainly addresses the velocity of the rolls for sheets that have angle sides, and the spring-back of SGARC 440 alloy sheets in the roll forming process, where we use DEFORM to simulate the sheet.</P>
Step-size adaptive parametric level set method for structural topology optimization
Chen-Dong Yang,Jian-Hu Feng,Ya-Dong Shen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.10
In the structural topology optimization (STO), the step-size of the parametric level set method (PLSM) using the explicit scheme must satisfy the Courant-Friedrichs-Lewy (CFL) condition to ensure numerical stability. However, much larger step-sizes are arbitrarily used to speed up the convergence. For this reason, a narrowband in the velocity field is defined, and the step-size adaptive parametric level set method (SAPLSM) is proposed, which multiplies different step-sizes for the velocity of different nodes. The SAPLSM satisfies the CFL condition not only on the narrowband, but also on the entire design domain. Furthermore, a narrowband annealing (NA) scheme based on “annealing” is proposed to dynamically adjust the maximum step-size during the iterations. Numerical experimental results of several benchmark problems in two-dimensional minimum compliance show that: (1) The SAPLSM is more stable than PLSM under large step-sizes and complex problems. (2) The NA scheme not only accelerates the convergence of SAPLSM but also alleviates mesh dependence.
동아여 ( Ya Ru Dong ),이국영 ( Guo Ying Li ) 한국한자한문교육학회 2012 漢字 漢文敎育 Vol.28 No.-
新加坡因爲社會語言環境的改變進行了2004年和2011年兩次大規模的華文敎改, 由"少敎多學"到"樂學善用". 作者認爲, 這只是敎學策略上的突破, 其核心問題卽新加坡小學華文識字敎學"識什마"(字種)、"識多少"(字量)、"즘마識"(字序)三個最基本的問題병沒有解決. 本論文對新加坡2007年出版的『小學華文』12冊敎材中的核心單元部分、課外閱讀輔助讀物『記憶像一個箱子』、輔助刊物『新朋友』、『新天地』、『新列車』的封面閱讀篇章和華文報刊『聯合早報』中的頭版國際、國內和敎育新聞進行字頻調査, 建立了由這四種材料構成的數據庫, 分別從字種、字量、字序、覆蓋率、復現率等方面對閱讀篇章進行統計、分析與硏究, 報告目前新加坡小學識字敎材幷不符合新加坡本地的華文字頻規律的現狀, 探討如何使新加坡小學生識字敎材設計更具新加坡特色, 更加科學化、合理化、系統化, 幷提出建立新加坡『兒童高頻字表』, 把字表中的字融入敎材編寫過程中, 科學建序;再建立『兒童常用字表』, 把타融入敎案設計過程中, 結合"滾動式"識字敎學法, 使學習者更加有趣地學習, 從而體現新加坡敎育部大力提倡和推廣的"樂學"的敎學理念和"善用"的敎學主張. Singapore changing social language environment has brought about two major reforms to the Chinese language education namely "teach less and learn more" and "making learning interesting and more relevant". The objective is to motivate pupils to learn more and encourage the capable pupils to help the weaker pupils in the learning process. However, the author believes that this reform is just a breakthrough in teaching strategies, but the core problem is not resolved. The primary school Chinese literacy teaching in Singapore has not been resolved which include 3 basic aspects like word types, word content and word order. In this thesis, the author focuses on word frequency survey taken from the following: (1) 12 core units in the primary school Chinese text books from the Singapore Ministry of Education. (2) Reading books which are widely used by Singapore primary school "Memory is like a box". (3) The front page of the auxiliary publications including "New Friends", "New World ", "New Train". (4) The front page of the Singapore Chinese newspaper "Lianhe Zaobao" which includes international, domestic and educational information. Based on the word species, the amount of words, word order and coverage of the four databases, statistics are compiled, analyzed and researched. It`s noted that the current Chinese language literacy teaching in Singapore primary schools is not so adequate. The literacy teaching materials in Singapore can be made more adequate by making them more featured, more scientific, reasonable and systematic. The author proposes the creation of two unique charts relevant to the Singapore children. Firstly "children`s high-frequency words" chart to be used for literacy teaching materials and secondly" children`s common usage words" chart to integrate with literacy teaching using`` rolling strategy`` and put it into the lesson plan design process, so that learning is made more interesting. This goes hand in hand with the Ministry of Education promotion "making learning interesting and more relevant".